When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression
Open accessAbstract
Rationale Increased activity of prefrontal D1 dopamine receptors (D1R) is involved in reward-related behavior found in bipolar disorder and drug addiction. While the effects of elevated D1R are known, depressive-like behaviors also occur in these disorders after reward-seeking ends.Objectives The goal is to characterize how termination of D1R overexpression influences depressive-like behaviors.Methods An inducible (Tet.On), lentiviral vector was used to manipulate the expression of the DRD1 gene in glutamate neurons within the prefrontal cortex in male, adult rats. Sexual activity and sucrose preference were studied in both D1R elevated ON and relatively reduced OFF states. Following termination of the D1R ON state, depressive-like behavior was determined in the OFF state. Expression of the transcriptional regulator, cyclic AMP-responsive element-binding protein (CREB), was used as an indication of downstream effects in the nucleus accumbens (NA).Results ON D1R expression increased sexual activity that returned to baseline in the OFF state. Sucrose preferences increased ~6 % in ON state but fell 11 % below control levels when OFF. Consistent with a depressive-like phenotype, D1R OFF decreased activity by 40 %, impaired the ability to control (43 %) and motivation to escape shock (27 % more impaired) relative to dsRed OFF. CREB increased 29 % in the NA in the D1R OFF state relative to the ON state.Conclusions This novel approach demonstrates that elevated D1R expression increased hedonic behavior, whereas the termination of D1R overexpression often resulted in depressive-like behavior. These observations support a role for D1R expression cycling in bipolar-associated behaviors and addiction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated D1 on excitatory mPFC projection neurons is associated with increased drug seeking, taking, and drug-cue salience, as well as addiction-related behaviors such as novelty seeking, sexual activity, preferences for sweet taste, and impulsivity.
“Elevated D1 on excitatory mPFC projection neurons is associated with increased drug seeking, taking, and drug-cue salience, as well as addiction-related behaviors such as novelty seeking, sexual activity, preferences for sweet taste, and impulsivity (Freund et al., 2016, Nair et al., 2011, Sanchez et al., 2003, Sonntag et al., 2014).”
From Sensitive periods of substance abuse: Early risk for the transition to dependence (2017) · cites this paper as Freund et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
McFarland, K., Lapish, C. C., & Kalivas, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03531.2003 · Cited by 884 · see citing works
Stress dysregulation of drug reward pathways, and the transition to drug dependence
Koob, & Kreek, M. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.05030503 · Cited by 868 · see citing works
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
Kalivas, P. W., Volkow, N., & Seamans, J. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.005 · Cited by 657 · see citing works
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works
Neuroscience of affect: brain mechanisms of pleasure and displeasure
Berridge, K. C., & Kringelbach, M. L. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.017 · Cited by 532 · see citing works
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
Barrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works
Salamone, J. D., Cousins, M. S., & Bucher, S. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90108-2 · Cited by 460 · see citing works
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Berk, M., Dodd, S., Kauer‐Sant’Anna, M., Malhi, G. S., Bourin, M., Kapczinski, F., & Norman, T. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01058.x · Cited by 396 · see citing works
Ågmo, A. (1997) · Brain Research Protocols · doi:10.1016/s1385-299x(96)00036-0 · Cited by 361 · see citing works
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Sexual Dysfunction, Depression, and the Impact of Antidepressants
Kennedy, S. H., & Rizvi, S. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31819c76e9 · Cited by 338 · see citing works
Brenhouse, H. C., Sonntag, K. C., & Andersen, S. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5064-07.2008 · Cited by 287 · see citing works
Self-citationActive Avoidance Learning Requires Prefrontal Suppression of Amygdala-Mediated Defensive Reactions
Moscarello, J. M., & LeDoux, J. E. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2596-12.2013 · Cited by 277 · see citing works
Regular Induction of Hypomania by L-Dopa in “Bipolar” Manic-depressive Patients
Murphy, D. L., Brodie, H. K. H., Goodwin, F. K., & Bunney, W. E. (1971) · Nature · doi:10.1038/229135a0 · Cited by 258 · see citing works
Prefrontal Cortical Dysfunction in Abstinent Cocaine Abusers
Bolla, K. I., Ernst, M., Kiehl, K. A., Mouratidis, M., Eldreth, D. A., Contoreggi, C. S., Matochik, J. A., Kurian, V., Cadet, J. L., Kimes, A. S., et al. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.4.456 · Cited by 258 · see citing works
Modeling Depression in Animal Models
Overstreet, D. H. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_7 · Cited by 236 · see citing works
Pryce, C., Azzinnari, D., Spinelli, S., Seifritz, E., Tegethoff, M., & Meinlschmidt, G. (2011) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2011.06.006 · Cited by 227 · see citing works
Floresco, S., & Phillips, A. G. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.934 · Cited by 225 · see citing works
Dopamine and impulse control disorders in Parkinson's disease
Weintraub, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21454 · Cited by 189 · see citing works
Olson, V. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0345-05.2005 · Cited by 186 · see citing works
The “Psychic” Neuron of the Cerebral Cortex
Goldman, P. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11270.x · Cited by 179 · see citing works
D1 dopamine receptor binding in mood disorders measured by positron emission tomography
Suhara, T., Nakayama, K., Inoue, O., Fukuda, H., Shimizu, M., Mori, A., & Tateno, Y. (1992) · Psychopharmacology · doi:10.1007/bf02253582 · Cited by 163 · see citing works
Donahue, R. J., Muschamp, J. W., Russo, S. J., Nestler, E. J., & Carlezon, W. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.014 · Cited by 161 · cited 2× · see citing works
“results are often in good agreement with shifts in the threshold in the intracranial self-stimulation paradigm (Der-Avakian and Markou 2012; Donahue et al. 2014).”
Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
Barrot, M., Wallace, D. L., Bolaños, C. A., Graham, D. L., Perrotti, L. I., Neve, R. L., Chambliss, H., Yin, J. C. P., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500587102 · Cited by 161 · see citing works
Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia
John, C. S., Smith, K. L., Van'T Veer, A., Gompf, H. S., Carlezon, W. A., Cohen, B. M., Öngür, D., & Bechtholt-Gompf, A. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.105 · Cited by 136 · see citing works
Paspalas, C. D., Wang, M., & Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs152 · Cited by 136 · see citing works
Tanda, K., Nishi, A., Matsuo, N., Nakanishi, K., Yamasaki, N., Sugimoto, T., Toyama, K., Takao, K., & Miyakawa, T. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-19 · Cited by 134 · see citing works
Dopamine Agonist Withdrawal Syndrome: Implications for Patient Care
Nirenberg, M. J. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0090-z · Cited by 134 · see citing works
Nucleus accumbens dopamine and work requirements on interval schedules
Correa, M., Carlson, B. B., Wisniecki, A., & Salamone, J. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00292-9 · Cited by 130 · see citing works
Hains, A. B., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.921708 · Cited by 127 · see citing works
Opposing Role for Egr3 in Nucleus Accumbens Cell Subtypes in Cocaine Action
Chandra, R., Francis, T. C., Konkalmatt, P. R., Amgalan, A., Gancarz, A. M., Dietz, D., & Lobo, M. K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0548-15.2015 · Cited by 124 · see citing works
Andersen, S. L. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000103 · Cited by 116 · see citing works
Self-citationDepression‐Related Behavioral Tests
Powell, T. R., Fernandes, C., & Schalkwyk, L. C. (2012) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo110176 · Cited by 114 · see citing works
Young, J. W., van Enkhuizen, J., Winstanley, C. A., & Geyer, M. A. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400646 · Cited by 114 · see citing works
Loos, M., Pattij, T., Janssen, M. C. W., Counotte, D. S., Schoffelmeer, A. N. M., Smit, A. B., Spijker, S., & van Gaalen, M. M. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp167 · Cited by 110 · see citing works
Muschamp, J. W., Veer, A. V., Parsegian, A., Gallo, M. S., Chen, M., Neve, R. L., Meloni, E. G., & Carlezon, W. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5973-10.2011 · Cited by 105 · see citing works
DiNieri, J. A., Nemeth, C. L., Parsegian, A., Carle, T. L., Gurevich, V. V., Gurevich, E. V., Neve, R. L., Nestler, E. J., & Carlezon, W. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5104-08.2009 · Cited by 98 · see citing works
Prefrontal Cortex Modulates Desire and Dread Generated by Nucleus Accumbens Glutamate Disruption
Richard, J. M., & Berridge, K. C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.009 · Cited by 97 · see citing works
Leussis, M. P., Freund, N., Brenhouse, H. C., Thompson, B. S., & Andersen, S. L. (2012) · Developmental Neuroscience · doi:10.1159/000339162 · Cited by 95 · see citing works
Self-citationBarr, A. M., Fiorino, D. F., & Phillips, A. G. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00156-2 · Cited by 91 · see citing works
Xing, G., Zhang, L., Russell, S., & Post, R. M. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.11.006 · Cited by 85 · see citing works
Animal models of bipolar disorder
Kato, T., Kubota, M., & Kasahara, T. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.03.003 · Cited by 78 · see citing works
Controlling stress: how the brain protects itself from depression
Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn0305-261 · Cited by 70 · see citing works
Roles of Nucleus Accumbens CREB and Dynorphin in Dysregulation of MotivationPreprint
Muschamp, J. W., & Carlezon, W. A. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012005 · Cited by 70 · see citing works
Brenhouse, H., Lukkes, J., & Andersen, S. (2013) · Brain Sciences · doi:10.3390/brainsci3010143 · Cited by 68 · see citing works
Self-citationGönül, A. S., Coburn, K. L., & Kula, M. (2009) · International Review of Psychiatry · doi:10.1080/09540260902962131 · Cited by 67 · see citing works
Sonntag, K. C., Brenhouse, H. C., Freund, N., Thompson, B. S., Puhl, M., & Andersen, S. L. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3399-8 · Cited by 64 · see citing works
Self-citationDopamine receptors and learned helplessness in the rat
Kram, M., Kramer, G. L., Ronan, P. J., Steciuk, M. R., & Petty, F. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00222-6 · Cited by 62 · see citing works
Cyclin-Dependent Kinase 5 in the Ventral Tegmental Area Regulates Depression-Related Behaviors
Zhong, P., Liu, X., Zhang, Z., Hu, Y. C., Liu, S. J., Lezama-Ruiz, M., Joksimovic, M., & Liu, Q.-S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3673-13.2014 · Cited by 53 · see citing works
Pantazopoulos, H., Stone, D., Walsh, J. P., & Benes, F. M. (2004) · Synapse · doi:10.1002/syn.20076 · Cited by 49 · see citing works
Freund, N., Thompson, B. S., DeNormandie, J., Vaccarro, K., & Andersen, S. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.066 · Cited by 47 · see citing works
Self-citationStoker, A. K., & Markou, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.042 · Cited by 43 · see citing works
Altered Dopamine Modulation of Inhibition in the Prefrontal Cortex of Cocaine-Sensitized Rats
Kroener, S., & Lavı́n, A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.107 · Cited by 41 · see citing works
Minton, G. O., Young, A. H., McQuade, R., Fairchild, G. F., Ingram, C. D., & Gartside, S. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.53 · Cited by 32 · see citing works
Mania and sexual risk: associations with behavioral self-regulation
Dvorak, R. D., Wray, T. B., Kuvaas, N. J., & Kilwein, T. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.023 · Cited by 29 · see citing works
The Addiction-Related Gene Ankk1 is Oppositely Regulated by D1R- and D2R-Like Dopamine Receptors
Ponce, G., Quiñones‐Lombraña, A., Martín-Palanco, N. G., Solsona, E. R., Jiménez‐Arriero, M. Á., Palomo, T., & Hoenicka, J. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9545-9 · Cited by 16 · see citing works
Dell’Osso, B. M., Ketter, T. A., Cremaschi, L., Spagnolin, G., & Altamura, A. C. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0378-z · Cited by 16 · see citing works
Basco, M. R., & Hoyos, C. C.-D. (2012) · Journal of Child and Adolescent Psychiatric Nursing · doi:10.1111/j.1744-6171.2011.00312.x · Cited by 16 · see citing works
Yao, J., Pan, Y., Ding, M., Pang, H., & Wang, B. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.08.031 · Cited by 4 · see citing works
DelBello, M. P., Adler, C. M., Cerullo, M. A., Fleck, D. E., & Strakowski, S. M. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00493-9 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Sensitive periods of substance abuse: Early risk for the transition to dependence
Jordan, C. J., & Andersen, S. L. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.10.004 · Cited by 455 · see citing works
“Furthermore, a reduction in D1 receptor expression on mPFC → NAc projections in adolescence is observed following maternal separation (Brenhouse et al., 2008, 2013), and may represent a depressive affect state (Freund et al., 2016).”
Self-citationDopamine, Immunity, and Disease
Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J. R., & Gaskill, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 319 · see citing works
Test–retest measurements of dopamine D1-type receptors using simultaneous PET/MRI imaging
Kaller, S., Rullmann, M., Patt, M., Becker, G.-A., Luthardt, J., Girbardt, J., Meyer, P. M., Werner, P., Barthel, H., Bresch, A., et al. (2017) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-017-3645-0 · Cited by 152 · see citing works
Animal models for bipolar disorder: from bedside to the cage
Beyer, D. K. E., & Freund, N. (2017) · International Journal of Bipolar Disorders · doi:10.1186/s40345-017-0104-6 · Cited by 110 · see citing works
Self-citationDysregulation of brain dopamine systems in major depressive disorder
Delva, N. C., & Stanwood, G. D. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221991830 · Cited by 90 · see citing works
Stress, sensitive periods, and substance abuse
Andersen, S. L. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100140 · Cited by 92 · see citing works
Self-citationShuto, T., Kuroiwa, M., Sotogaku, N., Kawahara, Y., Oh, Y., Jang, J.-H., Shin, C.-H., Ohnishi, Y. N., Hanada, Y., Miyakawa, T., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0316-x · Cited by 66 · see citing works
Andersen, S. L. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.012 · Cited by 67 · see citing works
Self-citationLukkes, J. L., Meda, S., Thompson, B. S., Freund, N., & Andersen, S. L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.053 · Cited by 46 · see citing works
Self-citationBipolar Disorder: Its Etiology and How to Model in Rodents
Freund, N., & Juckel, G. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9554-7_4 · Cited by 36 · see citing works
Self-citationKang, S., Wu, M. M., Galvez, R., & Gulley, J. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.044 · Cited by 26 · see citing works
Bai, M., Zhu, X., Zhang, L., Zhang, Y., Xue, L., Wang, Y., Zhong, M., & Zhang, X. (2017) · Brain and Behavior · doi:10.1002/brb3.808 · Cited by 23 · see citing works
Beyer, D. K. E., Mattukat, A., & Freund, N. (2021) · International Journal of Bipolar Disorders · doi:10.1186/s40345-020-00212-2 · Cited by 18 · see citing works
Self-citationMaya-Romero, A., Dodd, G. E., Landin, J. D., Zaremba, H., Allen, O. F., Bilbow, M. A., Hammaker, R. D., & Santerre, J. L. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113687 · Cited by 17 · see citing works
Risky decision-making following prefrontal D1 receptor manipulation
Beyer, D. K. E., Horn, L., Klinker, N., & Freund, N. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0187 · Cited by 10 · see citing works
Self-citationScheggi, S., Pelliccia, T., Cuomo, A., Montis, M. G. D., & Gambarana, C. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00849 · Cited by 9 · see citing works
Treatment-induced mood switching in affective disorders
Tang, S. W., Tang, W. H., & Leonard, B. E. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.47 · Cited by 9 · see citing works
Prefrontal Dopaminergic Regulation of Cue-Guided Risky Decision-Making Performance in Rats
Yang, M., Fu, Q., Ma, C., & Li, B. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.934834 · Cited by 8 · see citing works
Astorino, M. F., Calabrò, M., Infortuna, C., Muscatello, M. R. A., Briuglia, S., Cicero, N., Fabbri, C., Serretti, A., & Crisafulli, C. (2025) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.33045 · Cited by 8 · see citing works
Rodent models for mood disorders – understanding molecular changes by investigating social behavior
Reinhardt, P. R., Theis, C. D. C., Juckel, G., & Freund, N. (2023) · Biological Chemistry · doi:10.1515/hsz-2023-0190 · Cited by 7 · see citing works
Self-citationChe, Y.-X., Jin, X., Xiao, R.-H., Ming, Z., Ma, X., Guo, F., & Li, Y. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00854-7 · Cited by 6 · see citing works
Gilbert, K. F., Amontree, M., Deasy, S., Ma, J., & Conant, K. E. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16570 · Cited by 5 · see citing works
Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review
Gonçalves, M. C. B., Glaser, T., de Oliveira, S. L. B., & Ulrich, H. (2020) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2020.0009 · Cited by 5 · see citing works
Meda, S., Freund, N., Norman, K. J., Thompson, B. S., Sonntag, K., & Andersen, S. L. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02254 · Cited by 3 · see citing works
Self-citationIntra-individual variability in animal models of bipolar disorder
Hawken, E. R., Brietzke, E. M., & Soares, C. N. (2019) · International Journal of Bipolar Disorders · doi:10.1186/s40345-019-0144-1 · Cited by 2 · see citing works
Schmerder, K., & Freund, N. (2022) · Neuromethods · doi:10.1007/978-1-0716-2748-8_13 · Cited by 2 · see citing works
Self-citationDeveloping a Rat Model for Bipolar Disorder
Aslan, J., Reinhardt, P. R., Koch, J., Sonntag, K., & Freund, N. (2025) · Journal of Visualized Experiments · doi:10.3791/68307 · Cited by 1 · see citing works
Self-citationUntersuchung des Sozialverhaltens in einem Rattenmodell der bipolaren Störung
Theis, C. D. C., Reinhardt, P. R., & Freund, N. (2025) · Pharmacopsychiatry · doi:10.1055/s-0045-1807292
Self-citationThe Midbrain Dopaminergic System in Behavioral Models of Depression
Ivlieva, N. Y. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700904
Tierversuche und ihre Bedeutung für das Verständnis psychischer Störungen
Mundorf, A., Peterburs, J., & Ocklenburg, S. (2026) · Springer eBooks · doi:10.1007/978-3-662-73259-5_10
- Authors
- Freund, N., Thompson, B. S., Sonntag, K., Meda, S., & Andersen, S. L.
- Affiliations
- Harvard University (US)
- Corresponding author
- Freund, Nadja
- Venue
- Psychopharmacology
- Published
- 2016-01-14
- Volume
- 233
- Issue
- 7
- Pages
- 1191-1201
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC4915915
- OpenAlex
- W2233375039
- Cited by
- 31
- References
- 73
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA-026485)
- Leopoldina Fellowship Program (LPDS-40)
- van Ameringen Foundation
- NARSAD (Young Investigator Grant 2012)
- Simches Family Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- dopamine D1 receptor, prefrontal cortex, depression-like behavior, sexual behavior, sucrose preference, hedonic behavior, escape motivation, CREB, nucleus accumbens, bipolar disorder, drug addiction, glutamatergic neurons
- MeSH terms
- Animals, Behavior, Animal, Depression, Male, Motor Activity, Neurons, Nucleus Accumbens, Reward, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Dopamine D1, Glutamic Acid, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
