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Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

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Lgr5 marks cycling, yet long-lived, hair follicle stem cells

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

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Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

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Growth differentiation factor 7 autocrine signaling promotes hepatic progenitor cell expansion in liver fibrosis

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Progress, application and challenges of liver organoids

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Standard Protocols for Characterising Primary and In Vitro‐Generated Human Hepatocytes

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Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis

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Developing a Multidisciplinary Approach for Engineering Stem Cell Organoids

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Alterations in TGF-β signaling leads to high HMGA2 levels potentially through modulation of PJA1/SMAD3 in HCC cells

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Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds

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Organoids as a tool for understanding immune-mediated intestinal regeneration and development

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Lgr5 + cell fate regulation by coordination of metabolic nuclear receptors during liver repair

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Bioengineering Liver Organoids for Diseases Modelling and Transplantation

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Toward Transplantation of Liver Organoids: From Biology and Ethics to Cost-effective Therapy

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Liver progenitor cells-mediated liver regeneration in liver cirrhosis

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Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

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Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma

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Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver

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Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species

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Drug Conjugates of Antagonistic R-Spondin 4 Mutant for Simultaneous Targeting of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors 4/5/6 for Cancer Treatment

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Modelling adult stem cells and their niche in health and disease with epithelial organoids

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Value of Organoids from Comparative Epithelia Models.

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Focus on the road to modelling cardiomyopathy in muscular dystrophy

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Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment

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Organoid models for Chinese herbal medicine studies

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Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids

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DNA-based hydrogels: Ideal biomaterials for cartilage organoids

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Cell competition promotes metastatic intestinal cancer through a multistage process

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Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research

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Liver organoids: From 3D printing to biomedical applications

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Advances, challenges and future applications of liver organoids in experimental regenerative medicine

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Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine

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Regenerative medicine for the esophagus

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Pigment epithelium-derived factor (PEDF) peptide promotes the expansion of hepatic stem/progenitor cells via ERK and STAT3-dependent signaling.

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Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

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Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification

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Generation, Maintenance and HBV Infection of Human Liver Organoids

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Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

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Alveolar Type 2 Epithelial Cell Organoids: Focus on Culture Methods

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Oncogenic Transformation of Human-Derived Gastric Organoids

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Liver Buds and Liver Organoids: New Tools for Liver Development, Disease and Medical Application

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Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles

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Regenerative medicine for the hepatobiliary system: A review

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Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells

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Hear the sounds: the role of G protein-coupled receptors in the cochlea

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Overcoming the therapeutic resistance of hepatomas by targeting the tumor microenvironment

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Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease

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Liver damage, proliferation, and progenitor cell markers in experimental necrotizing enterocolitis

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Cell therapy for end-stage liver disease: Current state and clinical challenge

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Current trends and research topics regarding organoids: A bibliometric analysis of global research from 2000 to 2023

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Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research

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Advances in lacrimal gland organoid development: Techniques and therapeutic applications

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Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks

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Transforming growth factor‐β signaling confers hepatic stellate cells progenitor features after partial hepatectomy

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A Platform for Validating Colorectal Cancer Driver Genes Using Mouse Organoids

Takeda, H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.698771 · Cited by 12

Current Trends and Research Topics Regarding Intestinal Organoids: An Overview Based on Bibliometrics

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Loss of YB-1 alleviates liver fibrosis by suppressing epithelial-mesenchymal transition in hepatic progenitor cells

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Cellular and Transcriptional Heterogeneity in the Intrahepatic Biliary Epithelium

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Paeoniflorin inhibits colorectal cancer cell stemness through the miR ‐3194‐5p/ catenin beta‐interacting protein 1 axis

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GVHD targets organoid-forming bile duct stem cells in a TGF-β–dependent manner

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The versatile and plastic liver

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R-Spondin2 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis

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Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology

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Evaluating the regenerative potential and functionality of human liver cells in mice

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Generation of Organoids from Mouse Extrahepatic Bile Ducts

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Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease.

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Regenerative hepatology: In the quest for a modern prometheus?

Papatheodoridi, Μ., Mazza, G., & Pinzani, M. (2020) · Digestive and Liver Disease · doi:10.1016/j.dld.2020.08.001 · Cited by 12

Playing Jekyll and Hyde—The Dual Role of Lipids in Fatty Liver Disease

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Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics

Fujimura, T., Enomoto, Y., Katsura, H., Ogawa, T., Baba, S., Ogata, A., Yamaoka, A., Shiroguchi, K., & Morimoto, M. (2023) · Stem Cells · doi:10.1093/stmcls/sxad044 · Cited by 12

Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells

Bertaux‐Skeirik, N., Centeno, J., Feng, R., Schumacher, M. A., Shivdasani, R. A., & Zavros, Y. L. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3603-8_3 · Cited by 12

Brain Organoids: A New, Transformative Investigational Tool for Neuroscience Research

Ghaemi, R. V., Co, I. L., McFee, M. C., & Yadav, V. G. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800174 · Cited by 12

The biological strategies for hearing re-establishment based on the stem/progenitor cells

Xia, M., Ma, J., Sun, S., Li, W., & Li, H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134406 · Cited by 12

Flow enhances phenotypic and maturation of adult rat liver organoids

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Silencing of hepatic fate-conversion factors induce tumorigenesis in reprogrammed hepatic progenitor-like cells

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Directional delivery of RSPO1 by mesenchymal stem cells ameliorates radiation-induced intestinal injury

Chen, W., Ju, S., Lu, T., Xu, Y., Zheng, X., Wang, H., Ge, Y., & Ju, S. (2017) · Cytokine · doi:10.1016/j.cyto.2017.02.004 · Cited by 12

Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells

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Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

Mugaanyi, J., Huang, J., Fang, J., Musinguzi, A., Lu, C., & Chen, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13061272 · Cited by 11

Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages

Verweij, L. H. G., Kim, S., Laskaris, D., Lin, L., van Son, G. J. F., Ringnalda, F. C. A. S., Begthel, H., van Ineveld, R. L., Winkel, C., Slack, J. P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65140-0 · Cited by 11

Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process

Hao, S., Wang, F., Huang, J., Xia, Z., Triffitt, J. T., Xu, C., Bai, L., & Su, J. (2025) · Exploration · doi:10.1002/exp.20240298 · Cited by 11

Engineering organoid microfluidic system for biomedical and health engineering: A review

Xing, Y., Liu, J., Guo, X., Liu, H., Zeng, W., Wang, Y., Zhang, C., Lu, Y., Dong, H., Ma, S., et al. (2020) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2020.11.013 · Cited by 11

Modeling pancreatic pathophysiology using genome editing of adult stem cell-derived and induced pluripotent stem cell (iPSC)-derived organoids

Hirshorn, S. T., Steele, N. G., & Zavros, Y. L. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00329.2020 · Cited by 11

Defense of COVID-19 by Human Organoids

Lv, T., Meng, F., Yu, M., Huang, H., Lin, X., & Zhao, B. T. (2021) · Phenomics · doi:10.1007/s43657-021-00015-0 · Cited by 11

Creating artificial signaling gradients to spatially pattern engineered tissues

Zheng, S. L., & Loh, K. M. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102810 · Cited by 11

Liver cell therapies: cellular sources and grafting strategies

Zhang, W., Cui, Y., Du, Y., Yang, Y., Fang, T., Lu, F., Kong, W.-X., Xiao, C., Shi, J., Reid, L. M., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1002-1 · Cited by 11

Advances in Cardiac Organoids

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