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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

Ko, Myunggon, An, Jungeun, Bandukwala, Hozefa S., Chavez, Lukas, Äijö, Tarmo, Pastor, William A., Segal, Matthew F., Li, Huiming, Koh, Kian Peng, Lähdesmäki, Harri, Hogan, Patrick G., Aravind, L., Rao, Anjana·2013·Nature
DOI 10.1038/nature12052PMC PMC3643997
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Research works printed but not linked: 34

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  3. Ko, M. et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468, 839–843 (2010) · DOI · Paper page
  4. He, Y. F. et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333, 1303–1307 (2011) · DOI
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  9. Iyer, L. M., Abhiman, S. & Aravind, L. Natural history of eukaryotic DNA methylation systems. Prog. Mol. Biol. Transl. Sci. 101, 25–104 (2011) · DOI
  10. Cierpicki, T. et al. Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia. Nature Struct. Mol. Biol. 17, 62–68 (2010) · DOI
  11. Allen, M. D. et al. Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase. EMBO J. 25, 4503–4512 (2006) · DOI
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  14. Xu, Y. et al. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell 151, 1200–1213 (2012) · DOI · Paper page
  15. Koh, K. P. et al. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8, 200–213 (2011) · DOI · Paper page
  16. Ko, M. et al. Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc. Natl Acad. Sci. USA 108, 14566–14571 (2011) · DOI · Paper page
  17. Knappskog, S. et al. RINF (CXXC5) is overexpressed in solid tumors and is an unfavorable prognostic factor in breast cancer. Ann. Oncol. 22, 2208–2215 (2011) · DOI
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Metadata

Authors
Ko, M., An, J., Bandukwala, H. S., Chavez, L., Äijö, T., Pastor, W. A., Segal, M. F., Li, H., Koh, K. P., Lähdesmäki, H., Hogan, P. G., Aravind, L., & Rao, A.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2013-04-07
Volume
497
Issue
7447
Pages
122-126
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature12052
PMC
PMC3643997
Cited by
373
References
6
Language
en
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. https://app.cochat.ai/papers/10.1038/nature12052
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Ko, M., An, J., Bandukwala, H. S., Chavez, L., Äijö, T., Pastor, W. A., Segal, M. F., Li, H., Koh, K. P., Lähdesmäki, H., Hogan, P. G., Aravind, L., & Rao, A. (2013). Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. https://doi.org/10.1038/nature12052