Feature detection and orientation tuning in the Drosophila central complex
Open accessAbstract
Many animals, including insects, are known to use visual landmarks to orient in their environment. In Drosophila melanogaster, behavioural genetics studies have identified a higher brain structure called the central complex as being required for the fly's innate responses to vertical visual features and its short- and long-term memory for visual patterns. But whether and how neurons of the fly central complex represent visual features are unknown. Here we use two-photon calcium imaging in head-fixed walking and flying flies to probe visuomotor responses of ring neurons--a class of central complex neurons that have been implicated in landmark-driven spatial memory in walking flies and memory for visual patterns in tethered flying flies. We show that dendrites of ring neurons are visually responsive and arranged retinotopically. Ring neuron receptive fields comprise both excitatory and inhibitory subfields, resembling those of simple cells in the mammalian primary visual cortex. Ring neurons show strong and, in some cases, direction-selective orientation tuning, with a notable preference for vertically oriented features similar to those that evoke innate responses in flies. Visual responses were diminished during flight, but, in contrast with the hypothesized role of the central complex in the control of locomotion, not modulated during walking. Taken together, these results indicate that ring neurons represent behaviourally relevant visual features in the fly's environment, enabling downstream central complex circuits to produce appropriate motor commands. More broadly, this study opens the door to mechanistic investigations of circuit computations underlying visually guided action selection in the Drosophila central complex.
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R neurons are directionally tuned, responding to the position of a cue around the animal.
“A subset of ring neurons, the R neurons, are directionally tuned, responding to the position of a cue around the animal [18].”
From A model of cue integration as vector summation in the insect brain (2023) · cites this paper as [18]
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Cites
Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex
Hubel, D. H., & Wiesel, T. N. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006837 · Cited by 13,680 · see citing works
A GAL4-Driver Line Resource for Drosophila Neurobiology
Jenett, A., Rubin, G. M., Ngo, T.-T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B. D., Cavallaro, A., Hall, D., Jeter, J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.011 · Cited by 1,449 · see citing works
ScanImage: Flexible software for operating laser scanning microscopes
Pologruto, T. A., Sabatini, B. L., & Svoboda, K. (2003) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-2-13 · Cited by 1,297 · see citing works
Refinement of Tools for Targeted Gene Expression in Drosophila
Pfeiffer, B. D., Ngo, T.-T. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010) · Genetics · doi:10.1534/genetics.110.119917 · Cited by 1,153 · see citing works
Highly selective receptive fields in mouse visual cortex
Niell, C. M., & Stryker, M. P. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0623-08.2008 · Cited by 1,081 · see citing works
Organizing activity of wingless protein in Drosophila
Struhl, G., & Basler, K. (1993) · Cell · doi:10.1016/0092-8674(93)90072-x · Cited by 846 · see citing works
A simple white noise analysis of neuronal light responses
Chichilnisky, E. J. (2001) · Network Computation in Neural Systems · doi:10.1080/net.12.2.199.213 · Cited by 788 · see citing works
A simple white noise analysis of neuronal light responses
Chichilnisky, E. J. (2001) · Network Computation in Neural Systems · doi:10.1080/713663221 · Cited by 705 · see citing works
The central complex and the genetic dissection of locomotor behaviour
Strauß, R. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00385-9 · Cited by 429 · see citing works
Active flight increases the gain of visual motion processing in Drosophila
Maimon, G., Straw, A. D., & Dickinson, M. H. (2010) · Nature Neuroscience · doi:10.1038/nn.2492 · Cited by 420 · see citing works
Distinct memory traces for two visual features in the Drosophila brain
Liu, G., Seiler, H., Wen, A., Zars, T. D., Ito, K., Wolf, R., Heisenberg, M., & Liu, L. (2006) · Nature · doi:10.1038/nature04381 · Cited by 407 · see citing works
Visual place learning in Drosophila melanogaster
Ofstad, T. A., Zuker, C. S., & Reiser, M. B. (2011) · Nature · doi:10.1038/nature10131 · Cited by 399 · see citing works
Using translational enhancers to increase transgene expression in Drosophila
Pfeiffer, B. D., Truman, J. W., & Rubin, G. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204520109 · Cited by 397 · see citing works
Analysis of a spatial orientation memory in Drosophila
Neuser, K., Triphan, T., Mronz, M., Poeck, B., & Strauß, R. (2008) · Nature · doi:10.1038/nature07003 · Cited by 363 · see citing works
Maplike Representation of Celestial E -Vector Orientations in the Brain of an Insect
Heinze, S., & Homberg, U. (2007) · Science · doi:10.1126/science.1135531 · Cited by 360 · see citing works
Neuronal architecture of the central complex in Drosophila melanogaster
Hanesch, U., Fischbach, K., & Heisenberg, M. (2004) · Cell and Tissue Research · doi:10.1007/bf00261838 · Cited by 349 · see citing works
Two-photon calcium imaging from head-fixed Drosophila during optomotor walking behavior
Seelig, J. D., Chiappe, M. E., Lott, G. K., Dutta, A., Osborne, J. E., Reiser, M. B., & Jayaraman, V. (2010) · Nature Methods · doi:10.1038/nmeth.1468 · Cited by 345 · see citing works
Self-citationOrientation tuning curves: empirical description and estimation of parameters
Swindale, N. V. (1998) · Biological Cybernetics · doi:10.1007/s004220050411 · Cited by 287 · see citing works
Walking Modulates Speed Sensitivity in Drosophila Motion Vision
Chiappe, M. E., Seelig, J. D., Reiser, M. B., & Jayaraman, V. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.072 · Cited by 273 · see citing works
Self-citationA modular display system for insect behavioral neuroscience
Reiser, M. B., & Dickinson, M. H. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.07.019 · Cited by 272 · see citing works
Sun Compass Integration of Skylight Cues in Migratory Monarch Butterflies
Heinze, S., & Reppert, S. M. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.025 · Cited by 268 · see citing works
Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila
Nicolaï, L., Ramaekers, A., Raemaekers, T., Drozdzecki, A., Mauss, A. S., Yan, J., Landgraf, M., Annaert, W. G., & Hassan, B. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010198107 · Cited by 262 · see citing works
Local diversity and fine-scale organization of receptive fields in mouse visual cortex
Bonin, V., Histed, M. H., Yurgenson, S., & Reid, R. C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2974-11.2011 · Cited by 247 · see citing works
Living synaptic vesicle marker: Synaptotagmin‐GFP
Zhang, Y., Rodesch, C. K., & Broadie, K. S. (2002) · genesis · doi:10.1002/gene.10144 · Cited by 239 · see citing works
Feature-detecting neurons in dragonflies
O’Carroll, D. C. (1993) · Nature · doi:10.1038/362541a0 · Cited by 211 · see citing works
Mechanisms of Neuronal Computation in Mammalian Visual Cortex
Priebe, N. J., & Ferster, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.011 · Cited by 209 · see citing works
Wang, J., Zugates, C. T., Liang, I. H., Lee, C.-H. J., & Lee, T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00570-6 · Cited by 202 · see citing works
Octopamine Neurons Mediate Flight-Induced Modulation of Visual Processing in Drosophila
Suver, M. P., Mamiya, A., & Dickinson, M. H. (2012) · Current Biology · doi:10.1016/j.cub.2012.10.034 · Cited by 193 · see citing works
Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual pattern memoryPreprint
Pan, Y., Zhou, Y., Guo, C., Gong, H., Gong, Z., & Liu, L. (2009) · Learning & Memory · doi:10.1101/lm.1331809 · Cited by 186 · see citing works
A look into the cockpit of the fly: visual orientation, algorithms, and identified neurons
Egelhaaf, M., & Borst, A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04563.1993 · Cited by 161 · see citing works
Object tracking in motion-blind flies
Bahl, A., Ammer, G., Schilling, T., & Borst, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3386 · Cited by 152 · see citing works
BrainAligner: 3D registration atlases of Drosophila brains
Peng, H., Chung, P., Long, F., Qu, L., Jenett, A., Seeds, A. M., Myers, E. W., & Simpson, J. H. (2011) · Nature Methods · doi:10.1038/nmeth.1602 · Cited by 147 · see citing works
Structure of the adult central complex in Drosophila: Organization of distinct neuronal subsets
Young, J. M., & Armstrong, J. D. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22284 · Cited by 142 · see citing works
A theory of the pattern induced flight orientation of the fly Musca domestica
Poggio, T., & Reichardt, W. (1973) · Kybernetik · doi:10.1007/bf00270572 · Cited by 134 · see citing works
Pfeiffer, K., Kinoshita, M., & Homberg, U. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00276.2005 · Cited by 111 · see citing works
Neural activity in the central complex of the cockroach brain is linked to turning behaviors
Guo, P., & Ritzmann, R. E. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.080473 · Cited by 104 · see citing works
Mu, L., Ito, K., Bacon, J. P., & Strausfeld, N. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0221-12.2012 · Cited by 87 · see citing works
GABAergic Lateral Interactions Tune the Early Stages of Visual Processing in Drosophila
Freifeld, L., Clark, D. A., Schnitzer, M. J., Horowitz, M., & Clandinin, T. R. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.024 · Cited by 87 · see citing works
Swindale, N. V. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.3.225 · Cited by 80 · see citing works
Bausenwein, B., Müller, N. R., & Heisenberg, M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903400210 · Cited by 76 · see citing works
Träger, U., Wagner, R., Bausenwein, B., & Homberg, U. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21512 · Cited by 75 · see citing works
Visual Neurones for Tracking Moving Targets
COLLETT, T. (1971) · Nature · doi:10.1038/232127a0 · Cited by 71 · see citing works
Rosner, R., & Homberg, U. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5390-12.2013 · Cited by 63 · see citing works
Spatiotemporal Response Properties of Optic-Flow Processing Neurons
Weber, F., Machens, C. K., & Borst, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.017 · Cited by 28 · see citing works
Age-dependent failure of axon regeneration in organotypic culture of gerbil auditory midbrain
Hafidi, A., Lanjun, G., & Sanes, D. H. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19991105)41:2 · Cited by 26 · see citing works
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Seelig, J. D., & Jayaraman, V. (2015) · Nature · doi:10.1038/nature14446 · Cited by 718 · see citing works
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Kim, S. S., Rouault, H., Druckmann, S., & Jayaraman, V. (2017) · Science · doi:10.1126/science.aal4835 · Cited by 417 · see citing works
Self-citationWhat insects can tell us about the origins of consciousness.
Barron, A. B., & Klein, C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520084113 · Cited by 446 · see citing works
Hulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D., Takemura, S.-Y., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2021) · eLife · doi:10.7554/elife.66039 · Cited by 392 · see citing works
Self-citationAn Anatomically Constrained Model for Path Integration in the Bee Brain
Stone, T., Webb, B., Adden, A., Weddig, N. B., Honkanen, A., Templin, R., Wcislo, W., Scimeca, L., Warrant, E., & Heinze, S. (2017) · Current Biology · doi:10.1016/j.cub.2017.08.052 · Cited by 377 · see citing works
Wu, M., Nern, A., Williamson, W. R., Morimoto, M. M., Reiser, M. B., Card, G. M., & Rubin, G. M. (2016) · eLife · doi:10.7554/elife.21022 · Cited by 304 · see citing works
Wolff, T., Iyer, N. A., & Rubin, G. M. (2015) · Journal of Comparative Neurology · doi:10.1002/cne.23705 · Cited by 286 · see citing works
Angular velocity integration in a fly heading circuit
Turner-Evans, D., Wegener, S., Rouault, H., Franconville, R., Wolff, T., Seelig, J. D., Druckmann, S., & Jayaraman, V. (2017) · eLife · doi:10.7554/elife.23496 · Cited by 281 · see citing works
Self-citationA spike-timing mechanism for action selection
von Reyn, C. R., Breads, P., Peek, M. Y., Zheng, G. Z., Williamson, W. R., Yee, A. L., Leonardo, A., & Card, G. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3741 · Cited by 254 · see citing works
The insect central complex and the neural basis of navigational strategies
Honkanen, A., Adden, A., da Silva Freitas, J., & Heinze, S. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.188854 · Cited by 238 · see citing works
Insects have the capacity for subjective experience
Klein, C., & Barron, A. B. (2016) · Animal Sentience · doi:10.51291/2377-7478.1113 · Cited by 243 · see citing works
Principles of insect path integration
Heinze, S., Narendra, A., & Cheung, A. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.058 · Cited by 195 · see citing works
Generation of stable heading representations in diverse visual scenes
Kim, S. S., Hermundstad, A. M., Romani, S., Abbott, L. F., & Jayaraman, V. (2019) · Nature · doi:10.1038/s41586-019-1767-1 · Cited by 172 · see citing works
Self-citationSensorimotor experience remaps visual input to a heading-direction network
Fisher, Y. E., Lu, J., D’Alessandro, I., & Wilson, R. I. (2019) · Nature · doi:10.1038/s41586-019-1772-4 · Cited by 165 · see citing works
Wolff, T., & Rubin, G. M. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24512 · Cited by 156 · see citing works
The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor
Turner-Evans, D. B., Jensen, K. T., Ali, S., Paterson, T., Sheridan, A., Ray, R. P., Wolff, T., Lauritzen, J. S., Rubin, G. M., Bock, D. D., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.006 · Cited by 168 · see citing works
Self-citationThe neuroanatomical ultrastructure and function of a biological ring attractor
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Harris, R. M., Pfeiffer, B. D., Rubin, G. M., & Truman, J. W. (2015) · eLife · doi:10.7554/elife.04493 · Cited by 125 · see citing works
“…and attP2 (Liu et al., 2012); pJFRC40-13XLexAop2-FRT>-STOP-FRT>-myr::GFP in attP40 and su(Hw)attP5 (Pfeiffer et al., 2010; Nern et al., 2011); pJFRC67-3XUAS-IVS-Syt::GFP in attP18 (Zhang et al., 2002; Pfeiffer et al., 2010; Seelig and Jayaraman, 2013); tsh-GAL80 (Clyne and Miesenböck, 2008).”
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Ache, J. M., Polsky, J., Alghailani, S., Parekh, R., Breads, P., Peek, M. Y., Bock, D. D., von Reyn, C. R., & Card, G. M. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.079 · Cited by 153 · see citing works
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Green, J., Vijayan, V., Mussells Pires, P., Adachi, A., & Maimon, G. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0444-x · Cited by 137 · see citing works
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Fisher, Y. E., Silies, M., & Clandinin, T. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.033 · Cited by 117 · see citing works
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Schlegel, P., Yin, Y., Bates, A. S., Dorkenwald, S., Eichler, K., Brooks, P., Han, D. S., Gkantia, M., dos Santos, M., Munnelly, E. J., et al. (2023) · doi:10.1101/2023.06.27.546055 · Cited by 102 · see citing works
Ring Attractor Dynamics Emerge from a Spiking Model of the Entire Protocerebral Bridge
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A decentralised neural model explaining optimal integration of navigational strategies in insects
Sun, X., Yue, S., & Mangan, M. (2020) · eLife · doi:10.7554/elife.54026 · Cited by 96 · see citing works
SPARC enables genetic manipulation of precise proportions of cells
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Comparative Neuroanatomy of the Lateral Accessory Lobe in the Insect Brain
Namiki, S., & Kanzaki, R. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00244 · Cited by 78 · see citing works
Flexible navigational computations in the Drosophila central complex
Fisher, Y. E. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.12.001 · Cited by 74 · see citing works
Dopamine promotes head direction plasticity during orienting movements
Fisher, Y. E., Marquis, M., D’Alessandro, I., & Wilson, R. I. (2022) · Nature · doi:10.1038/s41586-022-05485-4 · Cited by 67 · see citing works
A unified mechanism for innate and learned visual landmark guidance in the insect central complex
Goulard, R., Buehlmann, C., Niven, J. E., Graham, P., & Webb, B. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009383 · Cited by 51 · see citing works
Hulse, B. K., Haberkern, H., Franconville, R., Turner-Evans, D. B., Takemura, S., Wolff, T., Noorman, M., Dreher, M., Dan, C., Parekh, R., et al. (2020) · doi:10.1101/2020.12.08.413955 · Cited by 392 · see citing works
“For readability, synapse densities of TuBu and ER types that arborize in the BUs (top) versus the BUi or Bua (bottom) are displayed separately.”
BackgroundInfluentialSelf-citationA computational model of the integration of landmarks and motion in the insect central complex
Cope, A. J., Sabo, C., Vasilaki, E., Barron, A. B., & Marshall, J. A. R. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172325 · Cited by 51 · see citing works
Neural networks for navigation: From connections to computations
Wilson, R. I. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-032645 · Cited by 38 · see citing works
A neural circuit architecture for rapid learning in goal-directed navigation
Dan, C., Hulse, B. K., Kappagantula, R., Jayaraman, V., & Hermundstad, A. M. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.036 · Cited by 51 · see citing works
“Visual ring neurons have feature-tuned receptive fields that tile space, 45–47 and they synapse onto compass neurons via all-to-all inhibitory connections in the EB 24 (Figure 2B).”
BackgroundThe fly connectome reveals a path to the effectome
Pospisil, D. A., Aragon, M. J., Dorkenwald, S., Matsliah, A., Sterling, A. R., Schlegel, P., Yu, S.-C., McKellar, C. E., Costa, M., Eichler, K., et al. (2024) · Nature · doi:10.1038/s41586-024-07982-0 · Cited by 36 · see citing works
Towards a common terminology for arthropod spatial orientation
Grob, R., el Jundi, B., & Fleischmann, P. N. (2021) · Ethology Ecology & Evolution · doi:10.1080/03949370.2021.1905075 · Cited by 22 · see citing works
Maintaining a stable head direction representation in naturalistic visual environments
Haberkern, H., Chitnis, S. S., Hubbard, P. M., Goulet, T., Hermundstad, A. M., & Jayaraman, V. (2022) · doi:10.1101/2022.05.17.492284 · Cited by 21 · see citing works
Self-citationA neural circuit architecture for rapid behavioral flexibility in goal-directed navigation
Dan, C., Hulse, B. K., Kappagantula, R., Jayaraman, V., & Hermundstad, A. M. (2021) · doi:10.1101/2021.08.18.456004 · Cited by 51 · see citing works
“Visual ring neurons have feature-tuned receptive fields that tile space [65–67], and they synapse onto compass neurons via all-to-all inhibitory connections in the EB [29]”
BackgroundSelf-citationA model of cue integration as vector summation in the insect brain
Mitchell, R., Shaverdian, S., Dacke, M., & Webb, B. (2023) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2023.0767 · Cited by 13 · see citing works
“A subset of ring neurons, the R neurons, are directionally tuned, responding to the position of a cue around the animal [18].”
BackgroundMultimodal cue integration and learning in a neural representation of head direction
Basnak, M. A., Kutschireiter, A., Okubo, T. S., Chen, A., Gorelik, P., Drugowitsch, J., & Wilson, R. I. (2025) · Nature Neuroscience · doi:10.1038/s41593-024-01823-z · Cited by 13 · see citing works
- Authors
- Seelig, J. D., & Jayaraman, V.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jayaraman, Vivek
- Venue
- Nature
- Published
- 2013-10-09
- Volume
- 503
- Issue
- 7475
- Pages
- 262-266
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3830704
- OpenAlex
- W2083890928
- Cited by
- 290
- References
- 45
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 14 · 2023: 23 · 2022: 22 · 2021: 27 · 2020: 26 · 2019: 30 · 2018: 23 · 2017: 36 · 2016: 19 · 2015: 23 · 2014: 19 · 2013: 1
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Drosophila melanogaster, central complex, visual feature representation, orientation tuning, direction selectivity, receptive fields, retinotopy, simple cells, visual landmarks, flight, walking
- MeSH terms
- Animals, Brain, Drosophila melanogaster, Flight, Animal, Memory, Neurons, Orientation, Psychomotor Performance, Walking
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