The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor
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Abstract
Neural representations of head direction (HD) have been discovered in many species. Theoretical work has proposed that the dynamics associated with these representations are generated, maintained, and updated by recurrent network structures called ring attractors. We evaluated this theorized structure-function relationship by performing electron-microscopy-based circuit reconstruction and RNA profiling of identified cell types in the HD system of Drosophila melanogaster. We identified motifs that have been hypothesized to maintain the HD representation in darkness, update it when the animal turns, and tether it to visual cues. Functional studies provided support for the proposed roles of individual excitatory or inhibitory circuit elements in shaping activity. We also discovered recurrent connections between neuronal arbors with mixed pre- and postsynaptic specializations. Our results confirm that the Drosophila HD network contains the core components of a ring attractor while also revealing unpredicted structural features that might enhance the network's computational power.
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Co-transmission of a fast-acting transmitter and a neuropeptide was more common.
“Co-transmission of a fast-acting transmitter and a neuropeptide was more common, e.g., Kenyon cells (at least acetylcholine, sparkly and short neuropeptide F),21,25,55,164 the dorsal paired medial (DPM) neuron (GABA, serotonin, sparkly, nplp1, proctolin, orcokinin, eclosion hormone, CG34136)25,56,60 and most central complex, mushroom body output and mushroom body dopaminergic neurons.25,157”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [157]
The Results section identifies fast-acting transmitters in several central-complex neuron types and points to supplemental information for neuropeptide signaling, but the passages in our copy do not say that these neurons co-transmit a neuropeptide or that such co-transmission is more common. Searches for neuropeptide signaling, co-release, and named peptides did not establish that comparison; page numbers were unavailable. (LLM, conf=0.72)
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A connectome and analysis of the adult Drosophila central brain
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“We acquire the majority of neurotransmitter to neuron assignments used for training and evaluation from published reconstructions in the full adult fly brain (FAFB) dataset (Bates et al., 2020; Dolan et al., 2018; Felsenberg et al., 2018; Frechter et al., 2019; Huoviala et al., 2018; Dolan et al., 2019; Marin et al.,…”
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- Authors
- Turner-Evans, D. B., Jensen, K. T., Ali, S., Paterson, T., Sheridan, A., Ray, R. P., Wolff, T., Lauritzen, J. S., Rubin, G. M., Bock, D. D., & Jayaraman, V.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Vermont (US)
- Corresponding author
- Jayaraman, Vivek
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 108
- Issue
- 1
- Pages
- 145-163.e10
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8356802
- OpenAlex
- W3084308099
- Cited by
- 168
- References
- 128
- Citations by year
- 2026: 21 · 2025: 29 · 2024: 36 · 2023: 33 · 2022: 20 · 2021: 15 · 2020: 10 · 2019: 3
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Update notices
- erratum (2021-05-05)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- ring attractor, Drosophila melanogaster, recurrent neural circuits, circuit reconstruction, RNA profiling, neuronal ultrastructure, visual cue integration, synaptic specializations
- MeSH terms
- Animals, Brain, Drosophila melanogaster, Microscopy, Electron, Nerve Net, Neural Pathways, Neurons, Synapses, Visual Pathways, Microscopy, Confocal, Head Movements, Microscopy, Fluorescence, Multiphoton, Spatial Navigation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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