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The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

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Perry, Rachel J., Samuel, Varman T., Petersen, Kitt F., Shulman, Gerald I.·2014·Nature
DOI 10.1038/nature13478
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Abstract

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cε in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

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Metadata

Authors
Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2014-06
Volume
510
Issue
7503
Pages
84-91
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature13478
OpenAlex
W1973939264
Cited by
1,136
References
30
FWCI
70.56
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014). The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. https://doi.org/10.1038/nature13478

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