Cited by 177Cancer, Hypoxia, and MetabolismMetabolomics and Mass Spectrometry StudiesCancer and biochemical research

A landscape of metabolic variation across tumor types

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Reznik, Ed, Luna, Augustin, Aksoy, Bülent Arman, Liu, Eric Minwei, La, Konnor, Ostrovnaya, Irina, Creighton, Chad J., Hakimi, A. Ari +1 more·2018·Cell Systems

Abstract

Tumor metabolism is reorganized to support proliferation in the face of growth-related stress. Unlike the widespread profiling of changes to metabolic enzyme levels in cancer, comparatively less attention has been paid to the substrates/products of enzyme-catalyzed reactions, small-molecule metabolites. We developed an informatic pipeline to concurrently analyze metabolomics data from over 900 tissue samples spanning seven cancer types, revealing extensive heterogeneity in metabolic changes relative to normal tissue across cancers of different tissues of origin. Despite this heterogeneity, a number of metabolites were recurrently differentially abundant across many cancers, such as lactate and acyl-carnitine species. Through joint analysis of metabolomic data alongside clinical features of patient samples, we also identified a small number of metabolites, including several polyamines and kynurenine, which were associated with aggressive tumors across several tumor types. Our findings offer a glimpse onto common patterns of metabolic reprogramming across cancers, and the work serves as a large-scale resource accessible via a web application (http://www.sanderlab.org/pancanmet).

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Authors
Reznik, E., Luna, A., Aksoy, B. A., Liu, E. M., La, K., Ostrovnaya, I., Creighton, C. J., Hakimi, A. A., & Sander, C.
Affiliations
  • Memorial Sloan Kettering Cancer Center (US)
  • Harvard University (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • Weill Cornell Medicine (US)
  • Baylor College of Medicine (US)
Corresponding author
  • Reznik, Ed
  • Sander, Chris
Venue
Cell Systems
Publisher
Elsevier BV
Published
2018-03
Volume
6
Issue
3
Pages
301-313.e3
ISSN
2405-4712 (ISSN-L)
OpenAlex
W2785402763
Cited by
172
References
70
Citations by year
2026: 10 · 2025: 15 · 2024: 27 · 2023: 22 · 2022: 24 · 2021: 29 · 2020: 15 · 2019: 24 · 2018: 6
FWCI
5.59
Type
journal article
Language
en
Open access
Locations
  • Cell Systems (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (CA125123)
  • National Cancer Institute (P30-CA008748)
  • National Institute of General Medical Sciences (P41 GM103504)
  • Israel National Road Safety Authority (F32 CA192901)
  • Marie-Josée and Henry R. Kravis Center for Molecular Oncology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
cancer metabolism, tumor metabolic reprogramming, small molecule metabolites, lactate, acylcarnitines, polyamines, kynurenine, tumor aggressiveness, cancer metabolomics
MeSH terms
Algorithms, Humans, Neoplasms, Software, Computational Biology, Metabolomics

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