Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Konermann, Silvana, Brigham, Mark D., Trevino, Alexandro E., Joung, Julia, Abudayyeh, Omar O., Barcena, Clea, Hsu, Patrick D., Habib, Naomi, Gootenberg, Jonathan S., Nishimasu, Hiroshi, Nureki, Osamu, Zhang, Feng·2015·Nature
Cited by (1,005)
Items 201–300 of 1,005
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- On the Origin of CRISPR-Cas Technology: From Prokaryotes to MammalsFrancisco J. M. Mojica, Lluís Montoliu · 2016 · Trends in Microbiology
- A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9Basudeb Maji, Soumyashree A. Gangopadhyay, Miseon Lee, Meng‐Chao Shi, Peng Wu, Robert Heler, Beverly Y. Mok, Donghyun Lim, Sachini U. Siriwardena, Bishwajit Paul et al. · 2019 · Cell
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- Rational designs of in vivo CRISPR-Cas delivery systemsCong‐Fei Xu, Guojun Chen, Ying‐Li Luo, Yue Zhang, Gui Zhao, Zi-Dong Lu, Anna Czarna, Zhen Gu, Jun Wang · 2019 · Advanced Drug Delivery Reviews
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- Development of CRISPR-Cas systems for genome editing and beyondF. Zhang · 2019 · Quarterly Reviews of Biophysics
- Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9Ceasar, S. Antony, Rajan, Vinothkumar, Prykhozhij, Sergey V., Berman, Jason N., Ignacimuthu, S. · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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- CRISPR/Cas9 Immune System as a Tool for Genome EngineeringMagdalena Hryhorowicz, Daniel Lipiński, Joanna Zeyland, Ryszard Słomski · 2016 · Archivum Immunologiae et Therapiae Experimentalis
- CRISPR–Cas: a tool for cancer research and therapeuticsHao Yin, Wen Xue, Daniel G. Anderson · 2019 · Nature Reviews Clinical Oncology
- CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvementChao Li, Eleanor J. Brant, Hikmet Budak, Baohong Zhang · 2021 · Journal of Zhejiang University SCIENCE B
- Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and DifferentiationDiego Balboa, Jere Weltner, Solja Eurola, Ras Trokovic, Kirmo Wartiovaara, Timo Otonkoski · 2015 · Stem Cell Reports
- Multidimensional chemical control of CRISPR–Cas9Basudeb Maji, Christopher L Moore, Bernd Zetsche, Sara E. Volz, Feng Zhang, Matthew D. Shoulders, Amit Choudhary · 2016 · Nature Chemical Biology
- RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressorsPratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas C. Rouse, Matthew P. Gemberling, Matthew L. Oliver, Charles A. Gersbach · 2018 · Nature Communications
- Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal AdenocarcinomaChenxi Tian, Daniel Öhlund, Steffen Rickelt, Tommy Lidström, Ying Huang, Liangliang Hao, Renee Tan Zhao, Oskar Franklin, Sangeeta N. Bhatia, David A. Tuveson et al. · 2020 · Cancer Research
- Advances in CRISPR therapeuticsMichael Chavez, Xinyi Chen, Paul B. Finn, Lei S. Qi · 2022 · Nature Reviews Nephrology
- Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editingCarlson-Stevermer, Jared, Abdeen, Amr A., Kohlenberg, Lucille, Goedland, Madelyn, Molugu, Kaivalya, Lou, Meng, Saha, Krishanu · 2017 · Nature Communications
- How the epigenome integrates information and reshapes the synapseRianne R. Campbell, Marcelo A. Wood · 2019 · Nature reviews. Neuroscience
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- CRISPR–Cas9-based photoactivatable transcription systems to induce neuronal differentiationYuta Nihongaki, Yuichi Furuhata, Takahiro Otabe, Saki Hasegawa, Keitaro Yoshimoto, Moritoshi Sato · 2017 · Nature Methods
- Systematic identification of silencers in human cellsBaoxu Pang, Michael P. Snyder · 2020 · Nature Genetics
- Genome editing of crops: A renewed opportunity for food securityFawzy Georges, Heather Ray · 2017 · GM crops & food
- Emerging roles of long non-coding RNAs in plant response to biotic and abiotic stressesNaghmeh Nejat, Nitin L. Mantri · 2017 · Critical Reviews in Biotechnology
- Current and Future Treatment Strategies for RhabdomyosarcomaCeline Y. Chen, Heathcliff Dorado García, Monika Scheer, Anton George Henssen · 2019 · Frontiers in Oncology
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- CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to PluripotencyPeng Liu, Meng Chen, Yanxia Liu, Lei S. Qi, Sheng Ding · 2018 · Cell stem cell
- Applications of CRISPR/Cas System to Bacterial Metabolic EngineeringSuhyung Cho, Jongoh Shin, Byung‐Kwan Cho · 2018 · International Journal of Molecular Sciences
- A split prime editor with untethered reverse transcriptase and circular RNA templateBin Liu, Xiaolong Dong, Haoyang Cheng, Chunwei Zheng, Zexiang Chen, Tomás Rodríguez, Shun‐Qing Liang, Wen Xue, Erik J. Sontheimer · 2022 · Nature Biotechnology
- Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in miceRoman Maresch, Sebastian Mueller, Christian Veltkamp, Rupert Öllinger, Mathias Friedrich, Irina Heid, Katja Steiger, Julia Weber, Thomas Engleitner, Maxim Barenboim et al. · 2016 · Nature Communications
- Zebrafish Genome Engineering Using the CRISPR–Cas9 SystemMingyu Li, Liyuan Zhao, Patrick Page-McCaw, Wenbiao Chen · 2016 · Trends in Genetics
- Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mappingJiazhang Lian, J. Carl Schultz, Mingfeng Cao, Mohammad HamediRad, Huimin Zhao · 2019 · Nature Communications
- High-Throughput Discovery and Characterization of Human Transcriptional EffectorsJosh Tycko, Nicole V. DelRosso, Gaelen T. Hess, Aradhana, Abhimanyu Banerjee, Adi Xiyal Mukund, Mike V. Van, Braeden K. Ego, David Yao, Kaitlyn Spees et al. · 2020 · Cell
- Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interferenceRodolphe Barrangou, Amanda Birmingham, Stefan Wiemann, Roderick L. Beijersbergen, Veit Hornung, Anja van Brabant Smith · 2015 · Nucleic Acids Research
- Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labelingAlbert W. Cheng, Nathaniel Jillette, Phoebe L. Lee, Dylan M. Plaskon, Yasuhiro Fujiwara, Wenbo Wang, Aziz Taghbalout, Haoyi Wang · 2016 · Cell Research
- Engineering microbial hosts for production of bacterial natural productsMingzi M. Zhang, Yajie Wang, Ee Lui Ang, Huimin Zhao · 2016 · Natural Product Reports
- Genetic interaction mapping in mammalian cells using CRISPR interferenceDan Du, Assen Roguev, David Ezra Gordon, Meng Chen, Sihan Chen, Michael Shales, John Paul Shen, Trey Ideker, Prashant Mali, Lei S. Qi et al. · 2017 · Nature Methods
- CRISPR-based functional genomics for neurological diseaseKampmann, Martin · 2020 · Nature Reviews Neurology
- Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 systemShipeng Shao, Weiwei Zhang, Huan Hu, Boxin Xue, Jinshan Qin, Chaoying Sun, Yuao Sun, Wensheng Wei, Yujie Sun · 2016 · Nucleic Acids Research
- The regulatory network behind MHC class I expressionMarlieke L.M. Jongsma, Greta Guarda, Robbert M. Spaapen · 2017 · Molecular Immunology
- CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirsYonggang Zhang, Chaoran Yin, Ting Zhang, Fang Li, Wensheng Yang, Rafal Kaminski, Philip Regis Fagan, Raj Putatunda, Won‐Bin Young, Kamel Khalili et al. · 2015 · Scientific Reports
- Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memoryJanine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier et al. · 2018 · Nature Communications
- Structural basis for the altered PAM specificities of engineered CRISPR-cas9Hirano, Seiichi, Nishimasu, Hiroshi, Ishitani, Ryuichiro, Nureki, Osamu · 2016 · Molecular Cell
- Rapid and reversible epigenome editing by endogenous chromatin regulatorsSimon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree · 2017 · Nature Communications
- CRISPR interference-based specific and efficient gene inactivation in the brainYi Zheng, Wei Shen, Jian Zhang, Bo Yang, Yaonan Liu, Huihui Qi, Xia Yu, Si‐Yao Lu, Yun Chen, Yuzhou Xu et al. · 2018 · Nature Neuroscience
- Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiationJiawei Shao, Meiyan Wang, Guiling Yu, Sucheng Zhu, Yuanhuan Yu, Boon Chin Heng, Jiali Wu, Haifeng Ye · 2018 · Proceedings of the National Academy of Sciences
- Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challengesDavid C. Luther, Y.W. Lee, Harini Nagaraj, Federica Scaletti, Vincent M. Rotello · 2018 · Expert Opinion on Drug Delivery
- Current status and perspectives of genome editing technology for microalgaeJeon, Seungjib, Lim, Jong-Min, Lee, Hyung-Gwan, Shin, Sung-Eun, Kang, Nam Kyu, Park, Youn-Il, Oh, Hee-Mock, Jeong, Won-Joong, Jeong, Byeong-ryool, Chang, Yong Keun · 2017 · Biotechnology for Biofuels
- Dual gene activation and knockout screen reveals directional dependencies in genetic networksMichael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T. Wagner, David Wu, Xiulei Mo, Anne Biton, Noah Zaitlen, Haian Fu et al. · 2018 · Nature Biotechnology
- A CRISPR/Cas13a-powered catalytic electrochemical biosensor for successive and highly sensitive RNA diagnosticsYan Sheng, Tenghua Zhang, Shihong Zhang, Midori Johnston, Xiaohe Zheng, Yuanyue Shan, Tong Liu, Zena Huang, Feiyang Qian, Zihui Xie et al. · 2021 · Biosensors and Bioelectronics
- The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AMLEmily Heikamp, Jill A. Henrich, Florian Perner, Eric M. C. Wong, Charlie Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann et al. · 2021 · Blood
- Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinomaDerek Lee, Mingjing Xu, David Kung‐Chun Chiu, Robin Kit‐Ho Lai, Aki Pui‐Wah Tse, Lynna Lan Li, Cheuk‐Ting Law, Felice Ho‐Ching Tsang, Larry Lai Wei, Cerise Yuen‐Ki Chan et al. · 2017 · Journal of Clinical Investigation
- CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in miceChih‐Hao Wang, Morten Lundh, Accalia Fu, Rókus Kriszt, Tian Lian Huang, Matthew D. Lynes, Luiz Osório Leiria, Farnaz Shamsi, Justin Darcy, Bennett P. Greenwood et al. · 2020 · Science Translational Medicine
- A novel fluorescence biosensor based on CRISPR/Cas12a integrated MXenes for detecting Aflatoxin B1Zhihui Wu, Da‐Wen Sun, Hongbin Pu, Qingyi Wei · 2022 · Talanta
- Rewiring human cellular input–output using modular extracellular sensorsKelly A. Schwarz, Nichole M. Daringer, Taylor B. Dolberg, Joshua N. Leonard · 2016 · Nature Chemical Biology
- QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasisKwontae You, Lingfei Wang, Chih‐Hung Chou, Kai Liu, Toru Nakata, Alok Jaiswal, Junmei Yao, Ariel J. Lefkovith, Abdifatah S. Omar, Jacqueline Perrigoue et al. · 2020 · Science
- Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and PerspectivesWendy Dong, Boris Kantor · 2021 · Viruses
- TALENs—an indispensable tool in the era of CRISPR: a mini reviewAnuradha Bhardwaj, Vikrant Nain · 2021 · Journal of Genetic Engineering and Biotechnology
- Advances in computational approaches for prioritizing driver mutations and significantly mutated genes in cancer genomesFeixiong Cheng, Junfei Zhao, Zhongming Zhao · 2015 · Briefings in Bioinformatics
- CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual lociYi Fu, Pedro P. Rocha, Vincent Mingyi Luo, Ramya Raviram, Yan Deng, Esteban O. Mazzoni, Jane A. Skok · 2016 · Nature Communications
- Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elementsJosh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa Truong, Alexandro E. Trevino et al. · 2019 · Nature Communications
- CRISPR technologies for bacterial systems: Current achievements and future directionsKyeong Rok Choi, Sang Yup Lee · 2016 · Biotechnology Advances
- Mechanisms of Acquired BRAF Inhibitor Resistance in Melanoma: A Systematic ReviewIlaria Proietti, Nevena Skroza, Nicoletta Bernardini, Ersilia Tolino, Veronica Balduzzi, Anna Marchesiello, Simone Michelini, Salvatore Volpe, Alessandra Mambrin, Giorgio Mangino et al. · 2020 · Cancers
- Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposasesGeorge D. Lampe, Rebeca T. King, Tyler S. Halpin-Healy, Sanne E. Klompe, Marcus I. Hogan, Phuc Leo H. Vo, Stephen Tang, Alejandro Chavez, Samuel H. Sternberg · 2023 · Nature Biotechnology
- Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopmentXiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos et al. · 2023 · Nature
- Improved plant cytosine base editors with high editing activity, purity, and specificityRen, Qiurong, Sretenovic, Simon, Liu, Guanqing, Zhong, Zhaohui, Wang, Jiaheng, Huang, Lan, Tang, Xu, Guo, Yachong, Liu, Li, Wu, Yuechao et al. · 2021 · Plant Biotechnology Journal
- DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like StateFan Yang, Xin Huang, Ruge Zang, Jiayu Chen, Miguel Fidalgo, Carlos Sánchez-Priego, Jihong Yang, Alexander Caichen, Fanglin Ma, Todd S. Macfarlan et al. · 2020 · Cell stem cell
- G Protein‐Coupled receptors and heterotrimeric G proteins as cancer driversNadia Arang, Jorge Silvio Gutkind · 2020 · FEBS Letters
- Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVsAntoine Rebendenne, Priyanka Roy, Boris Bonaventure, Ana Luiza Chaves Valadão, Lowiese M. B. Desmarets, Mary Arnaud‐Arnould, Yves Rouillé, Marine Tauziet, Donatella Giovannini, Jawida Touhami et al. · 2022 · Nature Genetics
- CRISPR-Cas9 for in vivo Gene Therapy: Promise and HurdlesWei-Jing Dai, Liyao Zhu, Zhongyi Yan, Yong Xu, Qilong Wang, Xiaojie Lu · 2016 · Molecular Therapy — Nucleic Acids
- Editing the Epigenome: Reshaping the Genomic LandscapeLiad Holtzman, Charles A. Gersbach · 2018 · Annual Review of Genomics and Human Genetics
- Delivery of CRISPR/Cas9 for therapeutic genome editingXu, Xiaojie, Wan, Tao, Xin, Huhu, Li, Da, Pan, Hongming, Wu, Jun, Ping, Yuan · 2019 · The Journal of Gene Medicine
- Opportunities and challenges in modeling human brain disorders in transgenic primatesCharles G.B. Jennings, Rogier Landman, Yang Zhou, Jitendra Sharma, Julia B. Hyman, J. Anthony Movshon, Zilong Qiu, Angela Roberts, Anna Wang Roe, Xiaoqin Wang et al. · 2016 · Nature Neuroscience
- Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infectionScott B. Biering, Sylvia A. Sarnik, Eleanor Wang, James R. Zengel, Sarah R. Leist, Alexandra Schäfer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau et al. · 2022 · Nature Genetics
- CRISPR-Cas-mediated transcriptional modulation: The therapeutic promises of CRISPRa and CRISPRiLouise Bendixen, Trine I. Jensen, Rasmus Otkjær Bak · 2023 · Molecular Therapy
- A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host FactorBrook E. Heaton, Edward M. Kennedy, Rebekah E. Dumm, Alfred T. Harding, Matthew T. Sacco, David M Sachs, Nicholas S. Heaton · 2017 · Cell Reports
- Transgenic mice for in vivo epigenome editing with CRISPR-based systemsMatthew P. Gemberling, Keith Siklenka, Erica Rodriguez, Katherine R. Tonn Eisinger, Alejandro Barrera, Fang Liu, Ariel Kantor, Liqing Li, Valentina Cigliola, Mariah F. Hazlett et al. · 2021 · Nature Methods
- Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survivalVasilena Gocheva, Alexandra Naba, Arjun J. Bhutkar, Talia Guardia, Kathryn M. Miller, Carman Man-Chung Li, Talya L. Dayton, Francisco J. Sánchez Rivera, Caroline Kim-Kiselak, Noor Jailkhani et al. · 2017 · Proceedings of the National Academy of Sciences
- Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancerPeng Zou, Yiqun Xia, Jiansong Ji, Weiqian Chen, Jin‐San Zhang, Xi Chen, Vinothkumar Rajamanickam, Gaozhi Chen, Zhe Wang, Lingfeng Chen et al. · 2016 · Cancer Letters
- Gene Regulatory Elements, Major Drivers of Human DiseaseSumantra Chatterjee, Nadav Ahituv · 2017 · Annual Review of Genomics and Human Genetics
- The chemistry of Cas9 and its CRISPR colleaguesJanice S. Chen, Jennifer A. Doudna · 2017 · Nature Reviews Chemistry
- CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screensGeorg Michlits, Maria Hubmann, Szu-Hsien Sam Wu, Gintautas Vainorius, Elena Budusan, Sergei Zhuk, Thomas Rainer Burkard, Maria Novatchkova, Martin Aichinger, YiQing Lü et al. · 2017 · Nature Methods
- Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light‐Activated Guide RNAWenyuan Zhou, Wes Brown, Anirban Bardhan, Michael Delaney, Amber S. Ilk, Randy R. Rauen, Shoeb I. Kahn, Michael Tsang, Alexander Deiters · 2020 · Angewandte Chemie International Edition
- CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in gliomaSiyuan John Liu, Martina Malatesta, Brian V. Lien, Parna Saha, Shivani S. Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A. Horlbeck et al. · 2020 · Genome biology
- CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model miceTetsushi Yamagata, Matthieu Raveau, Kenta Kobayashi, Hiroyuki Miyamoto, Tetsuya Tatsukawa, Ikuo Ogiwara, Shigeyoshi Itohara, Takao K. Hensch, Kazuhiro Yamakawa · 2020 · Neurobiology of Disease
- A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene RegulationKatherine E. Savell, Svitlana V. Bach, Morgan E. Zipperly, Jasmin S. Revanna, Nicholas A. Goska, Jennifer J. Tuscher, Corey G. Duke, Faraz A. Sultan, Julia N. Burke, Derek Williams et al. · 2019 · eNeuro
- Epigenetics and addictionHamilton, Peter J, Nestler, Eric J · 2019 · Current Opinion in Neurobiology
- In Vivo Transcriptional Activation Using CRISPR/Cas9 in DrosophilaShuailiang Lin, Ben Ewen‐Campen, Xiaochun Ni, Benjamin E. Housden, Norbert Perrimon · 2015 · Genetics
- Synthetic gene circuits for the detection, elimination and prevention of diseaseFerdinand Sedlmayer, Dominique Aubel, Martin Fussenegger · 2018 · Nature Biomedical Engineering
- Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function StudiesJonathan D. Zirin, Yanhui Hu, Luping Liu, Donghui Yang‐Zhou, Ryan Colbeth, Dong Yan, Ben Ewen‐Campen, Rong Tao, Eric Vogt, Sara VanNest et al. · 2020 · Genetics
- Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinomaJiaqiang Dong, Jiong Li, Yang Li, Zhikun Ma, Yongxin Yu, Cun‐Yu Wang · 2021 · Nature Communications
- LADL: light-activated dynamic looping for endogenous gene expression controlKim, Ji Hun, Rege, Mayuri, Valeri, Jacqueline, Dunagin, Margaret C., Metzger, Aryeh, Titus, Katelyn R., Gilgenast, Thomas G., Gong, Wanfeng, Beagan, Jonathan A., Raj, Arjun et al. · 2019 · Nature Methods
- RNAi/CRISPR Screens: from a Pool to a Valid HitAnne M. Schuster, Hélène Erasimus, Sabrina Fritah, Petr V. Nazarov, Eric Van Dyck, Simone P. Niclou, Anna Golebiewska · 2018 · Trends in biotechnology
- In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsyGaia Colasante, Yichen Qiu, Luca Massimino, Claudia Di Berardino, Jonathan H. Cornford, Albert Snowball, Mikail Weston, Steffan P. Jones, Serena Gea Giannelli, Andreas Lieb et al. · 2020 · Brain
- A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cellsTina Lebar, Duško Lainšček, Estera Merljak, Jana Aupič, Roman Jerala · 2020 · Nature Chemical Biology
- An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysisTomohiro Hino, Satoshi N. Omura, Ryoya Nakagawa, Tomoki Togashi, Satoru N. Takeda, Takafumi Hiramoto, Satoshi Tasaka, Hisato Hirano, Takeshi Tokuyama, Hideki Uosaki et al. · 2023 · Cell