Cited by 801Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolismCancer, Hypoxia, and Metabolism

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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

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Perera, Rushika M., Stoykova, Svetlana, Nicolay, Brandon N., Ross, Kenneth N., Fitamant, Julien, Boukhali, Myriam, Lengrand, Justine, Deshpande, Vikram, Selig, Martin K., Ferrone, Cristina R., Settleman, Jeff, Stephanopoulos, Gregory, Dyson, Nicholas J., Zoncu, Roberto, Ramaswamy, Sridhar, Haas, Wilhelm, Bardeesy, Nabeel·2015·Nature

DOI 10.1038/nature14587PMC PMC5086585

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Abstract

Activation of cellular stress response pathways to maintain metabolic homeostasis is emerging as a critical growth and survival mechanism in many cancers. The pathogenesis of pancreatic ductal adenocarcinoma (PDA) requires high levels of autophagy, a conserved self-degradative process. However, the regulatory circuits that activate autophagy and reprogram PDA cell metabolism are unknown. Here we show that autophagy induction in PDA occurs as part of a broader transcriptional program that coordinates activation of lysosome biogenesis and function, and nutrient scavenging, mediated by the MiT/TFE family of transcription factors. In human PDA cells, the MiT/TFE proteins--MITF, TFE3 and TFEB--are decoupled from regulatory mechanisms that control their cytoplasmic retention. Increased nuclear import in turn drives the expression of a coherent network of genes that induce high levels of lysosomal catabolic function essential for PDA growth. Unbiased global metabolite profiling reveals that MiT/TFE-dependent autophagy-lysosome activation is specifically required to maintain intracellular amino acid pools. These results identify the MiT/TFE proteins as master regulators of metabolic reprogramming in pancreatic cancer and demonstrate that transcriptional activation of clearance pathways converging on the lysosome is a novel hallmark of aggressive malignancy.

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RETRACTED ARTICLE: Beta-Like Importins Mediate the Nuclear Translocation of Mitogen-Activated Protein Kinases
Zehorai, E., & Seger, R. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00799-13 · Cited by 34
Retracted
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Self-citation
Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry
Elias, J. E., & Gygi, S. P. (2007) · Nature Methods · doi:10.1038/nmeth1019 · Cited by 3,925
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,551
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506

Show all 49 references

Research works printed but not linked: 4

Commisso, C. et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497, 633–637 (2013) · DOI · Paper page
Settembre, C. et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429–1433 (2011) · DOI · Paper page
Ballabio, A. & Gieselmann, V. Lysosomal disorders: from storage to cellular damage. Biochim. Biophys. Acta 1793, 684–696 (2009) · DOI · Paper page
Ting, L., Rad, R., Gygi, S. P. & Haas, W. MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics. Nature Methods 8, 937–940 (2011) · DOI · Paper page

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Yu, Q., Wang, T., & Jiang, Y. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1363848 · Cited by 1
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Wang, Y., Ni, J.-C., Zhao, Y.-Q., Yang, X., Niu, Z., Yang, X., Dong, X.-X., Zhao, Y., Hao, X., & Ding, X. (2023) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2023.2269370 · Cited by 1
A red-emitting, microenvironment-insensitive fluorophore for lysosome-specific imaging in live cells
Mansuri, S., Ojha, S., & Kanvah, S. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00296f · Cited by 1
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Lee, S.-W., Ekstrom, T. J., Manalo, E. C., Ye, S., Berry, M., Grygoryev, D., Szczepaniak, M., Lee, J., Marmolejo, C. A. O., Haverlack, S., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101536 · Cited by 1
Role of Autophagy in the Mechanisms of Chemoresistance of Tumor Cells Induced by the Use of Anthracycline Antibiotics
Александровна, П. Н., Ivanova, E. S., & Zamkova, M. A. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925601005 · Cited by 1
Autophagy in cancer cachexia: From mechanisms to therapeutic opportunities
Ballarò, R., Penna, F., & Beltrà, M. (2025) · International review of cytology · doi:10.1016/bs.ircmb.2025.08.008 · Cited by 1
The lipid phosphatase INPP4B controls pancreatic cancer cell migration and invasion by regulating fibronectin exocytosis
Saffi, G. T., Kleine, N., & Salmena, L. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110716 · Cited by 1
Spatial gene expression profiling reveals the distinct microenvironment of tuberous sclerosis complex-associated angiomyolipoma
Watanabe, R., Fukumoto, T., Miura, N., Kurata, M., Kitazawa, R., Kikugawa, T., & Saika, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-26541-9 · Cited by 1
Role of nuclear import proteins in maintaining proteostasis and disease pathogenesis
Zhao, X., Pu, L., Zeng, X., & Nie, J. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117831 · Cited by 1
A comprehensive in silico investigation into the deleterious nonsynonymous single nucleotide polymorphisms of the human transcription factor EB (TFEB) gene and their predicted association with cancer
Fuad, M., Akter, S., Mahmud, Z., Tamanna, S., Sayem, M., Zim, A. R. I., & Howlader, M. Z. H. (2026) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2026.100686 · Cited by 2
Loss of UFL1 drives chromosome instability and tumorigenesis of prostate cancer
Li, J., Yang, F., Zhang, X., Xu, L., Zheng, H., Liu, L., Wan, X., Xu, T., Jiang, G., & Wang, H. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2523965123 · Cited by 2
Meliazedins A-H, limonoids with cytotoxicity and inhibitory activity on lysosomal acidification from Melia azedarach L.
Zhang, Y., Zhao, Q., Sun, X., Chen, M., Wei, Y., Zhang, W., Ding, X., Chen, D., Hua, H., & Hao, X. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107263 · Cited by 1
The Lysosome–Cathepsin Axis in Pancreatic Cancer: Mechanisms of Stromal Remodeling, Immune Evasion, and Therapy Resistance
Jeram, N. M., Senjor, E., Kos, J., & Nanut, M. P. (2026) · Biomolecules · doi:10.3390/biom16060824 · Cited by 1
Spiky Magnetic Titania Particles for Integrated Exosome Capture and Metabolic Profiling Toward Cancer Diagnosis
Liu, F., Lin, X., Liu, L., Xie, X., Xue, L., Li, K., Ren, Z., Su, J., Deng, Y., & Deng, C. (2026) · Small · doi:10.1002/smll.74402 · Cited by 2
Endoplasmic Reticulum Stress and Autophagy in Cancer
Tan, M., Tan, H. K., & Muhammad, T. S. T. (2020) · Springer eBooks · doi:10.1007/978-3-030-30845-2_18 · Cited by 1
[Role of cytoskeleton in autophagy].
Yan, Z., Zeng, Y., Shen, Y., & Liu, X. (2018) · PubMed Central · doi:10.7507/1001-5515.201706012 · Cited by 1
Tumor cell metabolism and autophagy as therapeutic targets
Poojary, S. S., & Singh, M. K. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00003-1 · Cited by 1
MET Oncogene Enhances Pro-Migratory Functions by Counteracting NMDAR2B Cleavage
Gallo, S., Vitacolonna, A., Comoglio, P. M., & Crepaldi, T. (2023) · Cells · doi:10.3390/cells13010028 · Cited by 1
HIF-3α Facilitates the Proliferation and Migration in Pancreatic Cancer by Inhibiting Autophagy Through Downregulating TP53INP2
Zhou, X., Ling, Y., Huang, L., Yang, F., Zhang, Y., & Lan, Y. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01624-y · Cited by 1
Autophagy in Model Organisms: Insights into Cancer
Possik, E., & Pause, A. (2016) · InTech eBooks · doi:10.5772/64541 · Cited by 1
Zooming in on the cell biology of disease
Perera, R. M. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-09-0459 · Cited by 1
Self-citation
Identification of Key Differentially Expressed mRNAs, miRNAs, lncRNAs, and circRNAs for Xp11 Translocation Renal Cell Carcinoma (RCC) Based on Whole-Transcriptome Sequencing
Deng, C., Wei, C., Hou, Y., Xiong, M., Ni, D., Huang, Y., Wang, M., Yang, X. W., Chen, K., & Chen, Z. (2023) · Genes · doi:10.3390/genes14030723 · Cited by 1
Editorial: Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
Lane, J. D., & Agostinis, P. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00302 · Cited by 1
Transcriptional regulation of mTORC1 in cancer
Malta, C. D., & Ballabio, A. (2018) · Oncotarget · doi:10.18632/oncotarget.26229 · Cited by 1
TFE3 Regulates the Function of Autophagy-Lysosome to Drive Invasion and Metastasis of Papillary Thyroid CarcinomaPreprint
Lu, H., Zhu, C., Ruan, Y., Fan, L., Wei, K., Chen, Q., & Wei, Q. (2021) · Research Square · doi:10.21203/rs.3.rs-414298/v1 · Cited by 1
Identification of TFEB gene genetic variants in acute myocardial infarctionPreprint
Zhang, J., Zhang, Y., He, X., Wang, S., Pang, S., & Yan, B. (2020) · doi:10.21203/rs.3.rs-23023/v1 · Cited by 1
Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery diseasePreprint
Jiang, J., Hiron, T. K., Agbaedeng, T. A., Malhotra, Y., Drydale, E., Bancroft, J. M., Ng, E., Reschen, M. E., Davison, L. J., & O’Callaghan, C. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.14.557845 · Cited by 1

Authors: Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., Settleman, J., Stephanopoulos, G., Dyson, N. J., Zoncu, R., Ramaswamy, S., Haas, W., & Bardeesy, N.
Affiliations: Harvard University (US)
Massachusetts General Hospital (US)
Massachusetts Institute of Technology (US)
University of California, Berkeley (US)
Corresponding author: Bardeesy, Nabeel
ORCID: Perera, Rushika M.
Nicolay, Brandon N.
Ross, Kenneth N.
Boukhali, Myriam
Deshpande, Vikram
Selig, Martin K.
Ferrone, Cristina R.
Stephanopoulos, Gregory
Dyson, Nicholas J.
Zoncu, Roberto
Haas, Wilhelm
Bardeesy, Nabeel
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2015-07-13
Volume: 524
Issue: 7565
Pages: 361-365
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature14587
PMC: PMC5086585
OpenAlex: W1678795445
Cited by: 799
References: 49
Citations by year: 2026: 42 · 2025: 59 · 2024: 64 · 2023: 62 · 2022: 84 · 2021: 107 · 2020: 85 · 2019: 76 · 2018: 77 · 2017: 65 · 2016: 63 · 2015: 13
FWCI: 57.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
RePEc: Research Papers in Economics (submittedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
PMC
Funders: Hirshberg Foundation for Pancreatic Cancer Research
National Institutes of Health (P50CA1270003)
National Cancer Institute (P50CA127003, P50CA1270003, R01CA133557, DP2CA195761, P01CA117969)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: autophagy, lysosomal biogenesis, pancreatic ductal adenocarcinoma, cancer metabolism, metabolic reprogramming, TFEB, TFE3, MITF, nuclear import, amino acid metabolism, cellular stress response, lysosomal catabolism
MeSH terms: Amino Acids, Animals, Autophagy, Energy Metabolism, Female, Homeostasis, Humans, Lysosomes, Neoplasm Transplantation, Pancreatic Neoplasms, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Neoplastic, Carcinoma, Pancreatic Ductal, Active Transport, Cell Nucleus, Cell Line, Tumor, Mice, Microphthalmia-Associated Transcription Factor, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Heterografts

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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

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