Decompensated cirrhosis and microbiome interpretation
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Cirrhosis stage correlates positively with Enterobacteriaceae and negatively with Lachnospiraceae.
“These changes seem to develop progressively, as cirrhosis stage is positively correlated with Enterobacteriaceae and negatively correlated with Lachnospiraceae33,34.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [34]
The intestinal microbiota of patients with compensated cirrhosis differs from that of patients with decompensated cirrhosis, suggesting cirrhosis stage rather than underlying liver disease drives gut microbiota changes.
“The finding that the intestinal microbiota of patients with compensated cirrhosis differs from that of patients with decompensated cirrhosis34 suggests that cirrhosis stage, rather than the underlying liver disease, drives gut microbiota changes.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [34]
Cognitive impairment arising due to hepatic encephalopathy is mediated by microbial disturbances and can be reversed with oral antibiotic treatment.
“For example, it is well established that the cognitive impairment arising due to hepatic encephalopathy is mediated by microbial disturbances and can be reversed with oral antibiotic treatment (414–417).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [414]
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Cites
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- Authors
- Bajaj, J. S., Betrapally, N. S., & Gillevet, P. M.
- Affiliations
- Virginia Commonwealth University (US)
- George Mason University (US)
- Corresponding author
- Bajaj, Jasmohan S.
- Venue
- Nature
- Published
- 2015-09-16
- Volume
- 525
- Issue
- 7569
- Pages
- E1-E2
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4617624
- OpenAlex
- W2414212485
- Cited by
- 100
- References
- 16
- Citations by year
- 2025: 5 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 13 · 2020: 13 · 2019: 16 · 2018: 6 · 2017: 12 · 2016: 9 · 2015: 2
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX001076)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK087913)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- decompensated cirrhosis, gut microbiota, liver cirrhosis, oral microbiota, proton pump inhibitor therapy, biomarkers, alcoholic liver disease, alcoholism
- MeSH terms
- Humans, Liver Cirrhosis, Gastrointestinal Tract, Metagenomics, Microbiota
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