Predicting Clinical Outcomes of Cirrhosis Patients with Hepatic Encephalopathy from the Fecal Microbiome
Open accessAbstract
BACKGROUND & AIMS: Gut dysbiosis plays a role in hepatic encephalopathy (HE), while its relationship at the acute episode of overt HE (AHE), the disease progression and clinical outcomes remains unclear. We aimed to identify AHE-specific microbiome and its association to patients' outcomes. METHODS: We profiled fecal microbiome changes for a cohort of 62 patients with cirrhosis and AHE i) before treatment, ii) 2-3 days after medication and iii) 2-3 months after recovery, and three control cohorts i) healthy individuals, patients with ii) compensated or iii) decompensated cirrhosis. RESULTS: Comparison of the microbiome shift from compensated, decompensated cirrhosis, AHE to recovery revealed the AHE-specific gut-dysbiosis. The gut microbiome diversity was decreased during AHE, further reduced after medication, and only partially reversed during the recovery. The relative abundance of Bacteroidetes phylum in the microbiome decreased, whereas that of Firmicute, Proteobacteria and Actinobacteria increased in patients during AHE compared with those with compensated cirrhosis. A total of 70 operational taxonomic units (OTUs) were significantly different between AHE and decompensated cirrhosis abundances. Of them, the abundance of Veillonella parvula increased the most during AHE via a metagenomics recovery of the genomes. Moreover, the relative abundances of three (Alistipes, Bacteroides, Phascolarctobacterium) and five OTUs (Clostridium-XI, Bacteroides, Bacteroides, Lactobacillus, Clostridium-sedis) at AHE were respectively associated with HE recurrence and overall survival during the subsequent one-year follow-up. CONCLUSIONS: AHE-specific gut OTUs were identified that may be involved in HE development and able to predict clinical outcomes, providing new strategies for the prevention and treatment of HE recurrence in patients with cirrhosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the GI microbiome of cirrhotic patients with hepatic encephalopathy, Alcaligenaceae, Porphyromonadaceae, Veillonellaceae, Enterococcus, Megasphaera, and Burkholderia are significantly increased, and this taxonomic shift is associated with hyperammonemia and systemic inflammation.
“Research has also shown a significant increase in Alcaligenaceae, Porphyromonadaceae, Veillonellaceae, Enterococcus, Megasphaera, and Burkholderia in the GI microbiome of cirrhotic patients with hepatic encephalopathy (HE), and this taxonomic shift has been associated with hyperammonemia and systemic inflammation [164].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [164]
Research has shown a significant increase in Alcaligenaceae, Porphyromonadaceae, Veillonellaceae, Enterococcus, Megasphaera, and Burkholderia in GI microbiomes of cirrhotic patients with HE; this taxonomic shift was associated with hyperammonaemia and systemic inflammation contributing to exacerbation of HE symptoms.
“Interestingly, research has shown a significant increase in Alcaligenaceae, Porphyromonadaceae, Veillonellaceae, Enterococcus, Megasphaera, and Burkholderia in the GI microbiomes of cirrhotic patients with HE. This taxonomic shift was associated with hyperammonaemia and systemic inflammation contributing to the exacerbation of HE symptoms (Sung et al., 2019).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Sung et al., 2019
Cognitive impairment arising due to hepatic encephalopathy is mediated by microbial disturbances and can be reversed with oral antibiotic treatment.
“For example, it is well established that the cognitive impairment arising due to hepatic encephalopathy is mediated by microbial disturbances and can be reversed with oral antibiotic treatment (414–417).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [416]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data
McMurdie, P. J., & Holmes, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061217 · Cited by 21,013 · see citing works
UPARSE: highly accurate OTU sequences from microbial amplicon reads
Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
Stamatakis, A. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl446 · Cited by 15,582 · see citing works
Erdogan, D., Heijnen, B. H. M., Bennink, R. J., Kok, M., Dinant, S., Straatsburg, I. H., Gouma, D. J., & van Gulik, T. M. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.00901.x · Cited by 11,656 · see citing works
Transection of the oesophagus for bleeding oesophageal varices
Pugh, R. N. H., Murray-Lyon, I. M., Dawson, J. L., Pietroni, M. C., & Williams, R. (1973) · Journal of British Surgery · doi:10.1002/bjs.1800600817 · Cited by 7,941 · see citing works
Kozich, J. J., Westcott, S. L., Baxter, N. T., Highlander, S. K., & Schloss, P. D. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.01043-13 · Cited by 7,004 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Kraken: ultrafast metagenomic sequence classification using exact alignments
Wood, D. E., & Salzberg, S. L. (2014) · Genome Biology · doi:10.1186/gb-2014-15-3-r46 · Cited by 4,521 · see citing works
metaSPAdes: a new versatile metagenomic assembler
Nurk, S., Meleshko, D., Korobeynikov, A., & Pevzner, P. A. (2017) · Genome Research · doi:10.1101/gr.213959.116 · Cited by 4,496 · see citing works
Emms, D. M., & Kelly, S. (2015) · Genome Biology · doi:10.1186/s13059-015-0721-2 · Cited by 3,408 · see citing works
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713 · see citing works
MUMmer4: A fast and versatile genome alignment system
Marçais, G., Delcher, A. L., Phillippy, A. M., Coston, R., Salzberg, S. L., & Zimin, A. (2018) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005944 · Cited by 2,484 · see citing works
Alterations of the human gut microbiome in liver cirrhosis
Qin, N., Yang, F., Li, A., Prifti, E., Chen, Y., Shao, L., Guo, J., Le Chatelier, E., Yao, J., Wu, L., et al. (2014) · Nature · doi:10.1038/nature13568 · Cited by 2,177 · see citing works
Ferenci, P., Lockwood, A. H., Mullen, K. D., Tarter, R. E., Weißenborn, K., & Blei, A. T. (2002) · Hepatology · doi:10.1053/jhep.2002.31250 · Cited by 2,035 · see citing works
Altered profile of human gut microbiome is associated with cirrhosis and its complications
Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., White, M. B., Monteith, P., Noble, N. A., Unser, A. B., Daita, K., Fisher, A. R., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.019 · Cited by 1,099 · see citing works
Characterization of fecal microbial communities in patients with liver cirrhosis
Chen, Y., Yang, F., Lu, H., Wang, B., Chen, Y., Lei, D., Wang, Y., Zhu, B., & Li, L. (2011) · Hepatology · doi:10.1002/hep.24423 · Cited by 1,038 · see citing works
Bajaj, J. S., Kassam, Z., Fagan, A., Gavis, E. A., Liu, E., Cox, I. J., Kheradman, R., Heuman, D. M., Wang, J., Gurry, T., et al. (2017) · Hepatology · doi:10.1002/hep.29306 · Cited by 637 · see citing works
Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis
Gustot, T., Fernández, J., García, E., Morando, F., Caraceni, P., Alessandria, C., Laleman, W., Trebicka, J., Elkrief, L., Hopf, C., et al. (2015) · Hepatology · doi:10.1002/hep.27849 · Cited by 634 · see citing works
Linkage of gut microbiome with cognition in hepatic encephalopathy
Bajaj, J. S., Ridlon, J. M., Hylemon, P. B., Thacker, L. R., Heuman, D. M., Smith, S., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00190.2011 · Cited by 547 · see citing works
Bajaj, J. S., Hylemon, P. B., Ridlon, J. M., Heuman, D. M., Daita, K., White, M. B., Monteith, P., Noble, N. A., Sikaroodi, M., & Gillevet, P. M. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2012 · Cited by 525 · see citing works
Gut microbiome and liver diseases
Tilg, H., Cani, P. D., & Mayer, E. A. (2016) · Gut · doi:10.1136/gutjnl-2016-312729 · Cited by 525 · see citing works
MAFFT: Iterative Refinement and Additional Methods
Katoh, K., & Standley, D. M. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-646-7_8 · Cited by 520 · see citing works
Zhang, J., Guo, Z., Xue, Z., Sun, Z., Zhang, M., Wang, L., Wang, G., Wang, F., Xu, J., Cao, H., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2015.11 · Cited by 459 · see citing works
Piphillin: Improved Prediction of Metagenomic Content by Direct Inference from Human Microbiomes
Iwai, S., Weinmaier, T., Schmidt, B. L., Albertson, D. G., Poloso, N. J., Dabbagh, K., & DeSantis, T. Z. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166104 · Cited by 334 · see citing works
Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy
Bajaj, J. S., Betrapally, N. S., Hylemon, P. B., Heuman, D. M., Daita, K., White, M. B., Unser, A., Thacker, L. R., Sanyal, A. J., Kang, D. J., et al. (2015) · Hepatology · doi:10.1002/hep.27819 · Cited by 325 · see citing works
Córdoba, J., Cots, M. V., Simón‐Talero, M., Amorós, À., Pavesi, M., Vilstrup, H., Angeli, P., Domenicali, M., Ginès, P., Bernardi, M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.10.004 · Cited by 315 · see citing works
Microbiota, cirrhosis, and the emerging oral-gut-liver axis
Acharya, C., Sahingur, S. E., & Bajaj, J. S. (2017) · JCI Insight · doi:10.1172/jci.insight.94416 · Cited by 256 · see citing works
Romero‐Gómez, M., Montagnese, S., & Jalan, R. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.09.005 · Cited by 254 · see citing works
Impaired Gut-Liver-Brain Axis in Patients with Cirrhosis
Ahluwalia, V., Betrapally, N. S., Hylemon, P. B., White, M. B., Gillevet, P. M., Unser, A. B., Fagan, A., Daita, K., Heuman, D. M., Zhou, H., et al. (2016) · Scientific Reports · doi:10.1038/srep26800 · Cited by 213 · see citing works
Dysbiosis of small intestinal microbiota in liver cirrhosis and its association with etiology
Chen, Y., Ji, F., Guo, J., Shi, D., Fang, D., & Li, L. (2016) · Scientific Reports · doi:10.1038/srep34055 · Cited by 205 · see citing works
Engineering the gut microbiota to treat hyperammonemia
Shen, T. D., Albenberg, L. G., Bittinger, K. L., Chehoud, C., Chen, Y., Judge-Golden, C. P., Chau, L., Ni, J., Sheng, M., Lin, A. C., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79214 · Cited by 182 · see citing works
The role of microbiota in hepatic encephalopathy
Bajaj, J. S. (2014) · Gut Microbes · doi:10.4161/gmic.28684 · Cited by 181 · see citing works
Current concepts in the assessment and treatment of Hepatic Encephalopathy
Cash, W. J., McConville, P., McDermott, E., McCormick, P. A., Callender, M. E., & McDougall, N. (2009) · QJM · doi:10.1093/qjmed/hcp152 · Cited by 142 · see citing works
Bajaj, J. S., Vargas, H. E., Reddy, K. R., Lai, J. C., O’Leary, J. G., Tandon, P., Wong, F. S.-H., Mitrani, R., White, M. B., Kelly, M., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.07.022 · Cited by 127 · see citing works
Bajaj, J. S., Idilman, R., Mabudian, L., Hood, M., Fagan, A., Turan, D., White, M. B., Karakaya, F., Wang, J., Atalay, R., et al. (2018) · Hepatology · doi:10.1002/hep.29791 · Cited by 125 · see citing works
Decompensated cirrhosis and microbiome interpretation
Bajaj, J. S., Betrapally, N. S., & Gillevet, P. M. (2015) · Nature · doi:10.1038/nature14851 · Cited by 100 · see citing works
Non-alcoholic fatty liver disease phenotypes in patients with inflammatory bowel disease
Sartini, A., Gitto, S., Bianchini, M., Verga, M. C., Girolamo, M. D., Bertani, A., Buono, M. D., Schepis, F., Lei, B., Maria, N. D., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0124-2 · Cited by 97 · see citing works
Bajaj, J. S., Fagan, A., White, M. B., Wade, J. B., Hylemon, P. B., Heuman, D. M., Fuchs, M. A., John, B. V., Acharya, C., Sikaroodi, M., et al. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000102 · Cited by 67 · see citing works
Thomas, M. H., Pelleïeux, S., Vitale, N., & Olivier, J. L. (2016) · Biochimie · doi:10.1016/j.biochi.2016.07.013 · Cited by 59 · see citing works
Complete genome sequence of Veillonella parvula type strain (Te3T)
Gronow, S., Welnitz, S., Lapidus, A. L., Nolan, M., Ivanova, N., del Rio, T. G., Copeland, A., Chen, F., Tice, H. N., Pitluck, S., et al. (2010) · Standards in Genomic Sciences · doi:10.4056/sigs.521107 · Cited by 47 · see citing works
The universe of arachidonic acid metabolites in inflammatory bowel disease
Stenson, W. F. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000075 · Cited by 43 · see citing works
Hepatic Encephalopathy Involves Interactions Among the Microbiota, Gut, Brain
Victor, D. W., & Quigley, E. M. M. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.01.022 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Parker, B. J., Wearsch, P. A., Veloo, A. C. M., & Rodriguez‐Palacios, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00906 · Cited by 1,732 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Acute-on-Chronic Liver Failure Clinical Guidelines
Bajaj, J. S., O’Leary, J. G., Lai, J. C., Wong, F. S.-H., Long, M. D., Wong, R. J., & Kamath, P. S. (2022) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001595 · Cited by 247 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis
Bajaj, J. S., & Khoruts, A. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.01.017 · Cited by 170 · see citing works
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
Fukui, H. (2019) · Diseases · doi:10.3390/diseases7040058 · Cited by 151 · see citing works
Reiman, D. J., Metwally, A. A., Sun, J., & Dai, Y. D. (2020) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2020.2993761 · Cited by 128 · see citing works
Gut microbiome in primary sclerosing cholangitis: A review
Little, R., Wine, E., Kamath, B. M., Griffiths, A. M., & Ricciuto, A. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i21.2768 · Cited by 125 · see citing works
Giuffrè, M., Campigotto, M., Campisciano, G., Comar, M., & Crocè, L. S. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2019 · Cited by 121 · see citing works
Gut microbiota changes and its potential relations with thyroid carcinoma
Yu, X., Jiang, W. H., Kosik, R. O., Song, Y., Luo, Q., Qiao, T., Tong, J., Liu, S., Deng, C., Qin, S., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.04.001 · Cited by 118 · see citing works
Baltazar-Díaz, T. A., González-Hernández, L. A., Aldana-Ledesma, J. M., Rodríguez, M. P., Vega‐Magaña, N., Zepeda‐Morales, A. S. M., López-Roa, R. I., del Toro‐Arreola, S., Martínez‐López, E., Salazar-Montes, A. M., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10061231 · Cited by 99 · see citing works
The Gut-Liver Axis in Cholestatic Liver Diseases
Blesl, A., & Stadlbauer, V. (2021) · Nutrients · doi:10.3390/nu13031018 · Cited by 99 · see citing works
Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain
Xu, H., Huang, H., Zhou, Y., Zhao, H., Xu, J., Shou, D., Liu, Y., Zhou, Y., & Nie, Y. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/6699268 · Cited by 103 · see citing works
Self-citationThe Role of Intestinal Bacteria and Gut–Brain Axis in Hepatic Encephalopathy
Chen, Z., Ruan, J., Li, D., Wang, M., Han, Z., Qiu, W., & Wu, G. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.595759 · Cited by 96 · see citing works
Microbiome therapeutics for hepatic encephalopathy
Bloom, P. P., Tapper, E. B., Young, V. B., & Lok, A. S.-F. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.004 · Cited by 95 · see citing works
Jia, W., Rajani, C., Kaddurah‐Daouk, R., & Li, H. (2020) · Medicinal Research Reviews · doi:10.1002/med.21653 · Cited by 88 · see citing works
Bajaj, J. S., Shamsaddini, A., Fagan, A., Sterling, R. K., Gavis, E. A., Khoruts, A., Fuchs, M. A., Lee, H., Sikaroodi, M., & Gillevet, P. M. (2020) · Hepatology Communications · doi:10.1002/hep4.1639 · Cited by 83 · see citing works
Acharya, C., & Bajaj, J. S. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.10.056 · Cited by 78 · see citing works
Bloom, P. P., Donlan, J., Soto, M. T., Daidone, M., Hohmann, E. L., & Chung, R. T. (2022) · Hepatology Communications · doi:10.1002/hep4.1950 · Cited by 76 · see citing works
Impact of Antibiotic Resistance Genes in Gut Microbiome of Patients With Cirrhosis
Shamsaddini, A., Gillevet, P. M., Acharya, C., Fagan, A., Gavis, E. A., Sikaroodi, M., McGeorge, S., Khoruts, A., Albhaisi, S. A. M., Fuchs, M. A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.04.013 · Cited by 72 · see citing works
Fan, Y., Ju, T., Bhardwaj, T., Korver, D. R., & Willing, B. P. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03616-22 · Cited by 72 · see citing works
The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders
Losurdo, G., D’Abramo, F. S., Indellicati, G., Lillo, C., Ierardi, E., & Leo, A. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103531 · Cited by 71 · see citing works
Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury
Yang, C., Chang, H., Sung, P.-C., Ge, M.-C., Tang, H.-Y., Cheng, M., Cheng, H., Chou, H.-H., Lin, C.-Y., Lin, W., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113591 · Cited by 71 · see citing works
Self-citationThe Link between Gut Microbiota and Hepatic Encephalopathy
Won, S., Oh, K., Gupta, H., Ganesan, R., Sharma, S. P., Jeong, J., Yoon, S. J., Jeong, M. K., Min, B. H., Hyun, J. Y., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168999 · Cited by 69 · see citing works
A Metagenome-Wide Association Study of the Gut Microbiome and Metabolic Syndrome
Qin, Q., Su, Y., Yang, Y., Chen, J., Li, T., Gao, X., Yan, H., Wang, Y., Wang, J., Wang, S., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.682721 · Cited by 64 · see citing works
Microbiota transplant for hepatic encephalopathy in cirrhosis: The THEMATIC trial
Bajaj, J. S., Fagan, A., Gavis, E. A., Sterling, R. K., Gallagher, M. L., Lee, H. M., Matherly, S. C., Siddiqui, M. S., Bartels, A., Mousel, T., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2024.12.047 · Cited by 68 · see citing works
Gut microbiome-brain-cirrhosis axis
Smith, M. L., Wade, J. B., Wolstenholme, J. T., & Bajaj, J. S. (2023) · Hepatology · doi:10.1097/hep.0000000000000344 · Cited by 60 · see citing works
Yu, X. M., Jin, Y., Zhou, W., Xiao, T., Wu, Z., Su, J., Gao, H., Shen, P., Zheng, B., Luo, Q., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.761192 · Cited by 54 · see citing works
Advances in Gut Microbiota of Viral Hepatitis Cirrhosis
Wang, Y., Pan, C. Q., & Xing, H. (2019) · BioMed Research International · doi:10.1155/2019/9726786 · Cited by 52 · see citing works
Hassouneh, R., & Bajaj, J. S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020330 · Cited by 53 · see citing works
Boeri, L., Izzo, L., Sardelli, L., Tunesi, M., Albani, D., & Giordano, C. (2019) · Bioengineering · doi:10.3390/bioengineering6040091 · Cited by 45 · see citing works
The Gut Microbiota: How Does It Influence the Development and Progression of Liver Diseases
Kanmani, P., Kanmani, S., & Kim, H. (2020) · Biomedicines · doi:10.3390/biomedicines8110501 · Cited by 44 · see citing works
Bloom, P. P., Luévano, J. M., Miller, K. J., & Chung, R. T. (2021) · Annals of Hepatology · doi:10.1016/j.aohep.2021.100333 · Cited by 43 · see citing works
Li, M., Li, K., Tang, S., Lv, Y., Wang, Q., Wang, Z., Luo, B., Niu, J., Zhu, Y., Guo, W., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100448 · Cited by 42 · see citing works
Gut microbiota combined with metabolomics reveal the mechanism of curcumol on liver fibrosis in mice
Zheng, Y., Wang, J., Wang, J., Jiang, R., & Zhao, T. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113204 · Cited by 41 · see citing works
Wang, Q., Chen, C., Zuo, S., Cao, K., & Li, H. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04262-9 · Cited by 41 · see citing works
Alterations in the gut microbiota and the efficacy of adjuvant probiotic therapy in liver cirrhosis
Wu, Z., Zhou, H., Liu, D., & Deng, F. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1218552 · Cited by 41 · see citing works
A novel therapeutic concern: Antibiotic resistance genes in common chronic diseases
Pan, X., Zhou, Z., Liu, B., & Wu, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1037389 · Cited by 40 · see citing works
Older, E. A., Mitchell, M. K., Campbell, A., Lian, X., Madden, M., Wang, Y., van de Wal, L. E., Zaw, T., VanderVeen, B. N., Tatum, R., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2517380 · Cited by 40 · see citing works
Saboo, K., Petrakov, N. V., Shamsaddini, A., Fagan, A., Gavis, E. A., Sikaroodi, M., McGeorge, S., Gillevet, P. M., Iyer, R. K., & Bajaj, J. S. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.011 · Cited by 35 · see citing works
Gut microbiota in alcohol-related liver disease: pathophysiology and gut-brain cross talk
Zhu, L., Wang, Y., Pan, C. Q., & Xing, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1258062 · Cited by 31 · see citing works
Tang, J.-L., Song, X.-P., Zhao, M., Chen, H., Wang, Y.-Y., Zhao, B., Yu, S.-M., Ma, T.-W., & Gao, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1005842 · Cited by 31 · see citing works
Gut Microbes and Hepatic Encephalopathy: From the Old Concepts to New Perspectives
Rocco, A., Sgamato, C., Compare, D., Coccoli, P., Nardone, O. M., & Nardone, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.748253 · Cited by 30 · see citing works
Shin, S. Y., Park, S., Moon, J. M., Kim, K., Kim, J. W., Chun, J., Lee, T. H., & Choi, C. H. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm21202 · Cited by 30 · see citing works
Liu, Y., Chen, Z., Li, C., Sun, T., Luo, X., Jiang, B., Liu, M., Wang, Q., Li, T., Cao, J., et al. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03589-5 · Cited by 29 · see citing works
Bajaj, J. S., Torre, A., Rojas, M. L., Fagan, A., Nandez, I. E., Gavis, E. A., Osorio, O. D. L., White, M. B., Fuchs, M. A., Sikaroodi, M., et al. (2020) · Liver International · doi:10.1111/liv.14437 · Cited by 28 · see citing works
Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease
Baumann, A., Nier, A., Hernández-Arriaga, A. M., Brandt, A., Pisarello, M. J. L., Jin, C. J., Pilar, E., Camarinha‐Silva, A., Schattenberg, J. M., & Bergheim, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-97346-9 · Cited by 28 · see citing works
Wang, M., Ma, W., Wang, Y., Ma, X., Xue, Y.-F., Guan, J. Z., & Chen, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1091167 · Cited by 26 · see citing works
Gairing, S. J., Schleicher, E. M., Galle, P. R., & Labenz, C. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000096 · Cited by 26 · see citing works
Álvares‐da‐Silva, M. R., de Oliveira, C. P. M. S., Fagan, A., Longo, L., Thoen, R. U., Zitelli, P. M., Ferreira, R. M. T., McGeorge, S., Shamsaddini, A., Farias, A. Q., et al. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.03.045 · Cited by 24 · see citing works
Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain
Shahbazi, A., Sepehrinezhad, A., Vahdani, E., Jamali, R., Ghasempour, M., Massoudian, S., Negah, S. S., & Larsen, F. S. (2023) · Biomedicines · doi:10.3390/biomedicines11051272 · Cited by 24 · see citing works
Tian, Y., He, Y., Xiong, H., & Sun, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02671 · Cited by 21 · see citing works
Shen, W. X., Liang, S. R., Jiang, Y., & Chen, Y. (2022) · Patterns · doi:10.1016/j.patter.2022.100658 · Cited by 21 · see citing works
Bajaj, J. S., Rodríguez, M. P., Reau, A. L., Phillips, W., Fuchs, M. A., Davis, B., Sterling, R. K., Sikaroodi, M., Fagan, A., Shamsaddini, A., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-328403 · Cited by 22 · see citing works
Lactitol Supplementation Modulates Intestinal Microbiome in Liver Cirrhotic Patients
Lu, H., Chen, L., Pan, X., Yao, Y., Zhang, H., Zhu, X., Lou, X., Zhu, C., Wang, J., Li, L., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.762930 · Cited by 19 · see citing works
PSC associated inflammatory bowel disease: a distinct entity
Maal, A. B., Tamimi, A., Iravani, S., Memarnejadian, A., Sorouri, M., Aghdaei, H. A., Zali, M. R., Hossein‐Khannazer, N., & Vosough, M. (2022) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2022.2031979 · Cited by 19 · see citing works
Bajaj, J. S., Rodríguez, M. P., Fagan, A., McGeorge, S., Sterling, R. K., Lee, H. M., Luketic, V. A., Fuchs, M. A., Davis, B., Sikaroodi, M., et al. (2022) · Hepatology · doi:10.1002/hep.32571 · Cited by 18 · see citing works
Wu, Y., He, X., Chen, H., Lin, Y., Zheng, C., & Zheng, B. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134305 · Cited by 16 · see citing works
Self-citationIdentification of the Microbiome Associated with Prognosis in Patients with Chronic Liver Disease
Yamamoto, K., Honda, T., Inukai, Y., Yokoyama, S., Ito, T., Imai, N., Ishizu, Y., Nakamura, M., & Kawashima, H. (2024) · Microorganisms · doi:10.3390/microorganisms12030610 · Cited by 16 · see citing works
Gastrointestinal disorders and intestinal bacteria: Advances in research and applications in therapy
Ohkusa, T., Nishikawa, Y., & Sato, N. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.935676 · Cited by 15 · see citing works
El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Alkafaas, S. S., Dladla, M., Ghosh, S., Mohammed, D. M., Ibrahim, E. H., Fahmy, M. A., Elkelish, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1713426 · Cited by 13 · see citing works
Reuter, B., & Bajaj, J. S. (2020) · Clinics in Liver Disease · doi:10.1016/j.cld.2020.04.006 · Cited by 13 · see citing works
Hua, X., & Feng, H. (2022) · Medicine · doi:10.1097/md.0000000000029935 · Cited by 12 · see citing works
Intestinal dysbiosis and probiotic use: its place in hepatic encephalopathy in cirrhosis
Dazıroğlu, M. E. Ç. (2023) · Annals of Gastroenterology · doi:10.20524/aog.2023.0776 · Cited by 11 · see citing works
Xie, X., Zhang, B.-Y., Feng, S. Y., Fan, Z.-J., & Wang, G. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.03150-24 · Cited by 10 · see citing works
Hsieh, H., Gong, Y., Chi, C.-Y., Hsieh, S., Chen, W., Ku, C., Cheng, H., Lin, L., & Sung, C. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-13289-9 · Cited by 10 · see citing works
Self-citationWidjaja, F., & Rietjens, I. M. C. M. (2023) · Biomedicines · doi:10.3390/biomedicines11102658 · Cited by 10 · see citing works
Kuo, C., Lin, C.-Y., Chen, C.-W., Hsu, C.-Y., Hsieh, S., Chiu, C., & Lin, W. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111063 · Cited by 10 · see citing works
Self-citationGut Microbiota as Biosensors in Patients With Cirrhosis
Bajaj, J. S. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.016 · Cited by 10 · see citing works
Bajaj, J. S., Acharya, C., Sikaroodi, M., Gillevet, P. M., & Thacker, L. R. (2020) · GastroHep · doi:10.1002/ygh2.390 · Cited by 9 · see citing works
Naik, A., & Misra, S. K. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c02736 · Cited by 8 · see citing works
The Interplay between Cardiovascular Disease, Exercise, and the Gut Microbiome
Longoria, C. R., Guers, J. J., & Campbell, S. C. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2311365 · Cited by 8 · see citing works
Predicting superagers: a machine learning approach utilizing gut microbiome features
Kim, H. E., Kim, B. R., Hong, S. H., Song, S. Y., Jeong, J. H., & Kim, G. H. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1444998 · Cited by 8 · see citing works
Hou, L., Fu, Y., Zhao, C., Fan, L., Hu, H., & Yin, S. (2025) · Environment International · doi:10.1016/j.envint.2025.109511 · Cited by 8 · see citing works
Liang, H., Ze, X., Wang, S., Wang, Y., Peng, C., Cheng, R., Jiang, F., Wu, S., He, R., He, F., et al. (2022) · Nutrients · doi:10.3390/nu14173651 · Cited by 8 · see citing works
Cheng, C., Yin, Y., & Bian, G. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1018284 · Cited by 8 · see citing works
Mi, Q., Deng, X., Wang, P., Pan, H., Huang, Y., Hu, H., Li, A., Zhang, Q., & Wang, S. (2024) · Frontiers in Animal Science · doi:10.3389/fanim.2024.1465305 · Cited by 7 · see citing works
Xu, X., Zhu, T., Jing, C., Jiang, M., Fu, Y., Xie, F., Meng, Q., & Li, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1423780 · Cited by 6 · see citing works
Fecal microbiota transplant in liver diseases: Current evidence and future directions
Karna, R., & Babich, M. (2024) · Clinical Liver Disease · doi:10.1097/cld.0000000000000154 · Cited by 6 · see citing works
Pathogenetic relationship between the condition gut microbiota and liver diseases
Ventslovayte, N. D., Goryacheva, L. G., Гончар, Н. В., Александровна, Г. В., & Александровна, Е. Н. (2022) · Infectious diseases News Opinions Training · doi:10.33029/2305-3496-2022-11-2-97-105 · Cited by 6 · see citing works
The Three Villages of Hepatic Encephalopathy
Bajaj, J. S. (2021) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001212 · Cited by 6 · see citing works
Zhang, M., Yin, Y. S., May, K. S., Wang, S., Purcell, H. J., Zhang, X., Blaser, M. J., & den Hartigh, L. J. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102029 · Cited by 5 · see citing works
Xu, X., Jiang, M., Fu, Y., Xie, F., Li, J., & Meng, Q. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i1.100377 · Cited by 5 · see citing works
Hepatic encephalopathy: risk identification and prophylaxis approaches
Torre, A., Córdova‐Gallardo, J., & Martínez‐Sánchez, F. D. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01531-y · Cited by 5 · see citing works
Baltazar-Díaz, T. A., Riggen-Bueno, V., Cortina-Romero, D. B., del Toro‐Arreola, S., Haramati, J., Bastidas‐Ramírez, B. E., & Bueno‐Topete, M. R. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad113 · Cited by 5 · see citing works
Viral Liver Disease and Intestinal Gut–Liver Axis
Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2024) · Gastrointestinal Disorders · doi:10.3390/gidisord6010005 · Cited by 5 · see citing works
Castaño-Jiménez, P. A., Baltazar-Díaz, T. A., González-Hernández, L. A., García-Salcido, R., Klimov‐Kravtchenko, K., Andrade-Villanueva, J. F., Arellano-Arteaga, K. J., Padilla-Sánchez, M. P., del Toro‐Arreola, S., & Bueno‐Topete, M. R. (2025) · Microorganisms · doi:10.3390/microorganisms13051138 · Cited by 4 · see citing works
Wang, H., Li, L., Wu, J., Yuan, X., Hong, L., Pu, L., Qin, S., Li, L., Yang, H., & Zhang, J. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105275 · Cited by 4 · see citing works
Fecal microbiota transplantation in the treatment of hepatic encephalopathy: A perspective
Samanta, A., & Sarma, M. S. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i5.678 · Cited by 4 · see citing works
Wu, S., Lu, L., Xi, H., Wu, X., He, Y., Sun, X., & Wu, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34330 · Cited by 4 · see citing works
How the gut-liver axis shapes hepatic encephalopathy: mechanistic and therapeutic perspectives
Galicia, A. E. M., Rincón-Sánchez, M. N., Ramírez-Mejía, M. M., & Méndez‐Sánchez, N. (2025) · Exploration of Digestive Diseases · doi:10.37349/edd.2025.100597 · Cited by 3 · see citing works
Does Gut Microbiome have an Effect on Wilson’s Disease Phenotype?
Gao, S., Zhou, M., Zhang, H., & Tang, Z. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673282452240122103156 · Cited by 3 · see citing works
Yang, X., Zhao, Q., Wang, X., Zhang, Y., Ma, J., Liu, Y., & Wang, H. (2025) · Technology and Health Care · doi:10.1177/09287329241301680 · Cited by 3 · see citing works
Zhou, M., Luo, Y., Qiu, J., Wang, H., Li, X., Zhang, K., Li, X., Yaqoob, M. U., & Wang, M. (2025) · Poultry Science · doi:10.1016/j.psj.2024.104755 · Cited by 3 · see citing works
Modulation of duodenal and jejunal microbiota by rifaximin in mice with CCl4-induced liver fibrosis
Ikeuchi, K., Tsutsumi, T., Ishizaka, A., Mizutani, T., Sedohara, A., Koga, M., Tamaoki, S., & Yotsuyanagi, H. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00541-4 · Cited by 3 · see citing works
Du, Y., Wang, M., Xu, J., Zhong, R., Jia, J., Huang, J., Yao, C., Huang, L., Huang, G., Ke, X., et al. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115392 · Cited by 3 · see citing works
Deng, L., Guo, X., Chen, J., Li, B., Na, L., Xia, J., Ou, M., & Hong, Z. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1458754 · Cited by 3 · see citing works
Meng, Y., Liu, Y., Xia, T., Geng, B., Tian, Y., Cao, H., Yan, J., Pang, X., Liang, K., Yan, Y., et al. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250224 · Cited by 2 · see citing works
A permutable MLP-like architecture for disease prediction from gut metagenomic data
Jiang, C. F., Yang, J. P., Peng, X., & Li, X. (2024) · BMC Bioinformatics · doi:10.1186/s12859-024-05856-w · Cited by 2 · see citing works
- Authors
- Sung, C. M., Lin, Y.-F., Chen, K.-F., Ke, H.-M., Huang, H.-Y., Gong, Y.-N., Tsai, W.-S., You, J.-F., Lu, M. J., Cheng, H.-T., Lin, C.-Y., Kuo, C.-J., Tsai, I. J., & Hsieh, S.-Y.
- Affiliations
- Chang Gung University (TW)
- Biodiversity Research Center, Academia Sinica (TW)
- Chang Gung Memorial Hospital (TW)
- Corresponding author
- Tsai, Isheng J.
- Hsieh, Sen-Yung
- ORCID
- Venue
- Cellular and Molecular Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2019
- Volume
- 8
- Issue
- 2
- Pages
- 301-318.e2
- ISSN
- 2352-345X (ISSN-L)
- PMC
- PMC6718362
- OpenAlex
- W2938740358
- Cited by
- 127
- References
- 45
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 17 · 2023: 22 · 2022: 24 · 2021: 21 · 2020: 13 · 2019: 5
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cellular and Molecular Gastroenterology and Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Health Research Institutes (NHRI-EX106-10619SC)
- Chang Gung Medical Foundation (CMRPG 3E1411-3, 3H1031-3)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- hepatic encephalopathy, liver cirrhosis, gut microbiota, gut dysbiosis, fecal microbiota, decompensated cirrhosis, clinical outcome prediction, Veillonella parvula, Bacteroides, Phascolarctobacterium, Clostridium, Lactobacillus, overall survival, microbiome diversity
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Bacteria, Feces, Female, Hepatic Encephalopathy, Humans, Liver Cirrhosis, Male, Middle Aged, Prognosis, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
