Cited by 2,012Gut microbiota and healthImmune Response and InflammationAdipokines, Inflammation, and Metabolic Diseases

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The microbiome and innate immunity

Thaiss, Christoph A., Zmora, Niv, Levy, Maayan, Elinav, Eran·2016·Nature

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Abstract

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host-microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.

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Authors: Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E.
Affiliations: Weizmann Institute of Science (IL)
Tel Aviv Sourasky Medical Center (IL)
Corresponding author: Elinav, Eran
ORCID: Thaiss, Christoph A.
Zmora, Niv
Levy, Maayan
Elinav, Eran
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-07-06
Volume: 535
Issue: 7610
Pages: 65-74
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature18847
OpenAlex: W2467200611
Cited by: 2,012
References: 148
Citations by year: 2026: 133 · 2025: 150 · 2024: 210 · 2023: 234 · 2022: 257 · 2021: 325 · 2020: 202 · 2019: 171 · 2018: 151 · 2017: 152 · 2016: 27
FWCI: 15.14
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: gut microbiota, innate immunity, immune signaling, diet, host metabolism, infection response, hematopoietic cells, microbial ecology, complex diseases
MeSH terms: Gastrointestinal Microbiome, Animals, Humans, Immunity, Innate, Infections, Inflammation, Intestinal Mucosa, Lymphocytes, Neoplasms, Autoimmunity, Myeloid Cells, Metabolic Syndrome, Epigenesis, Genetic

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