The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
The microbiome and innate immunity
Abstract
The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host-microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The intestinal microbiome, for example, appears to operate as a signaling hub that, through simultaneous integration of environmental, genetic and immune signals, is capable of affecting host metabolism, immunity and response to infection (Thaiss et al., 2016).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Thaiss et al., 2016
In the citing paper
“How the microbiota modulate innate immunity is less clear as the system lacks antigen specificity, but is believed to respond broadly to the activity of microbes via tissue-level microbial sensing [90].”
In the citing paper
“Innate immunity is also regulated by the gut microbiota as evidenced by reduced numbers and compromised functions of antigen-presenting cells and microglia in germ-free animals60,69.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [69]
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,000
Zhang, J., Rodrı́guez, F., Navas, M. J., Costa-Hurtado, M., Almagro, V., Bosch-Camós, L., López, E., Cuadrado‐Matías, R., Accensi, F., Pina-Pedrero, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74651-3 · Cited by 36
Runge, S., & Rosshart, S. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702378 · Cited by 36
Dysbiosis of human microbiome and infectious diseases
Gupta, A., Singh, V., & Mani, I. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.06.016 · Cited by 36
Durairajan, S. S. K., Singh, A. K., Saravanan, U. B., Namachivayam, M., Radhakrishnan, M., Huang, J., Dhodapkar, R., & Zhang, H. (2023) · Viruses · doi:10.3390/v15061231 · Cited by 37
Ji, L., Hao, S., Wang, J., Zou, J., & Wang, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.831387 · Cited by 38
Klingensmith, N. J., & Coopersmith, C. M. (2023) · Surgical Infections · doi:10.1089/sur.2022.420 · Cited by 35
Liu, X., Wang, S., Wu, X., Zhao, Z., Chen, J., Li, M., & Qin, X. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c04063 · Cited by 35
Sun, X., Zhuang, Y., Wang, Y., Zhang, Z., An, L., & Xu, Q. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118119 · Cited by 36
Qi, X., Liu, M., Jiang, X., Gao, T., Xu, G., Zhang, H., Su, Q. Y., Du, Y., Luo, J., & Zhang, S. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103912 · Cited by 35
Strategies to increase the efficacy of using gut microbiota for the modulation of obesity
Li, J., Rajoka, M. S. R., Shao, D., Jiang, C., Jin, M., Huang, Q., Yang, H., & Shi, J. (2017) · Obesity Reviews · doi:10.1111/obr.12590 · Cited by 37
Suriano, F., Neyrinck, A. M., Verspreet, J., Olivares, M., Leclercq, S., de Wiele, T. V., Courtin, C. M., Cani, P. D., Bindels, L. B., & Delzenne, N. M. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.035 · Cited by 37
Impact of the Use and Type of Antibiotics on Acute Graft-versus-Host Disease
Nishi, K., Kanda, J., Hishizawa, M., Kitano, T., Kondo, T., Yamashita, K., & Takaori‐Kondo, A. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.06.031 · Cited by 35
Fecal Microbiota Transplantation for the Critically Ill Patient
Limketkai, B. N., Hendler, S., Ting, P., & Parian, A. M. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10228 · Cited by 36
Guo, G., Li, C., Xia, B., Jiang, S., Zhou, S., Men, X., & Ren, Y. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.03.003 · Cited by 35
Akrami, M., Menzies, R. J., Chamoto, K., Miyajima, M., Suzuki, R., Sato, H., Nishii, A., Tomura, M., Fagarasan, S., & Honjo, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010981117 · Cited by 35
Immune Gene Expression Covaries with Gut Microbiome Composition in Stickleback
Fuess, L. E., den Haan, S., Ling, F., Weber, J. N., Steinel, N. C., & Bolnick, D. I. (2021) · mBio · doi:10.1128/mbio.00145-21 · Cited by 36
Consistent Alterations of Human Fecal Microbes After Transplantation into Germ-Free Mice
Li, Y., Cao, W., Gao, N., Zhao, X., & Chen, W. (2021) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2020.06.024 · Cited by 35
Bagavant, H., Araszkiewicz, A. M., Ingram, J. K., Cizio, K., Merrill, J. T., Arriens, C., Guthridge, J. M., James, J. A., & Deshmukh, U. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635072 · Cited by 35
Ferroptosis: A mixed blessing for infectious diseases
Xiao, L.-Y., Huang, H., Fan, S., Zheng, B., Wu, J., Zhang, J., Pi, J., & Xu, J.-F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.992734 · Cited by 37
Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice
Morozova, M. V., Borisova, M. A., Snytnikova, O. A., Achasova, K. M., Litvinova, E. A., Tsentalovich, Y. P., & Kozhevnikova, E. N. (2022) · Scientific Reports · doi:10.1038/s41598-022-19219-z · Cited by 36
Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice
Li, Y., Chen, Y., Fan, Y., Chen, Y., & Chen, Y. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2172672 · Cited by 35
Pattern-recognition receptors (PRRs) in SARS-CoV-2
Isazadeh, A., Heris, J. A., Shahabi, P., Mohammadinasab, R., Shomali, N., Nasiri, H., Valedkarimi, Z., Khosroshahi, A. J., Hajazimian, S., Akbari, M., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121940 · Cited by 37
The Human Gut Microbiome in Liver Diseases
Davis, B., & Bajaj, J. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1602763 · Cited by 34
Zhu, Y. N., Wang, Q., Chen, Y., Xie, Y., Han, G., Liu, S., Song, Y., Lu, W., & Guo, Y. (2022) · ACS Applied Polymer Materials · doi:10.1021/acsapm.2c01893 · Cited by 34
Borbet, T. C., Pawline, M. B., Li, J., Ho, M. L., Yin, Y. S., Zhang, X., Novikova, E., Jackson, K., Mullins, B. J., Ruiz, V. E., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106810 · Cited by 34
Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours
Mishra, S., Tejesvi, M. V., Hekkala, J., Turunen, J., Unnisa, N. K. F., Kaisanlahti, A., Suokas, M., Leppä, S., Vihinen, P., Kuitunen, H. K., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.003 · Cited by 34
Olteanu, G., Pană, M.-A., Busnatu, Ș., Lupuliasa, D., Neacșu, S. M., Mititelu, M., Musuc, A. M., Ioniță-Mîndrican, C.-B., & Boroghină, S. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105561 · Cited by 36
Cai, X. T., Ren, F., & Yao, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114034 · Cited by 34
Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease
Kolter, J., & Henneke, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01497 · Cited by 37
Morphine Potentiates Dysbiotic Microbial and Metabolic Shifts in Acute SIV Infection
Sindberg, G. M., Callen, S. E., Banerjee, S., Meng, J., Hale, V. L., Hegde, R., Cheney, P. D., Villinger, F. J., Roy, S., & Buch, S. J. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9805-6 · Cited by 34
Comparative analysis of the fecal microbiota from different species of domesticated and wild suids
Correa‐Fiz, F., Blanco-Fuertes, M., Navas, M. J., Lacasta, A., Bishop, R. P., Githaka, N., Onzere, C., Potier, M. L., Almagro, V., Martínez, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49897-1 · Cited by 34
Lee, C. Y., Peralta‐Sánchez, J. M., Martínez‐Bueno, M., Møller, A. P., Rabelo-Ruiz, M., Zamora‐Muñoz, C., & Soler, J. J. (2020) · The ISME Journal · doi:10.1038/s41396-020-0719-y · Cited by 35
Alterations in the gut virome in patients with ankylosing spondylitis
Li, C., Zhang, Y., Yan, Q., Guo, R., Chen, C., Li, S., Zhang, Y., Meng, J., Ma, J., You, W., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154380 · Cited by 34
Corrigendum: Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.790387 · Cited by 41
Essex, M., Pascual-Leone, B. M., Löber, U., Kuhring, M., Zhang, B., Brüning, U., Fritsche‐Guenther, R., Krzanowski, M., Vernengo, F. F., Brumhard, S., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00538-0 · Cited by 34
Hsieh, M.-H., Jan, R.-L., Wu, L. S.-H., Chen, P., Kao, H.-F., Kuo, W., & Wang, J. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1598-1 · Cited by 34
Xu, P., Shi, Y., Liu, P., Yang, Y., Zhou, C., Li, G., Luo, J., Zhang, C., Cao, H., Hu, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-60564-8 · Cited by 33
Brown, R., Moore, L. J., Mani, A., Patel, S., & Salinas, I. (2021) · PLoS ONE · doi:10.1371/journal.pone.0243684 · Cited by 33
Bhuiyan, P., Chen, Y., Karim, M., Dong, H., & Qian, Y. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.04.010 · Cited by 33
Luo, B., Zhang, Y., Zhang, C., Liu, X., & Shi, C. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.04.001 · Cited by 33
The interplay between fasting, gut microbiota, and lipid profile
Mohammadzadeh, A., Roshanravan, N., Alamdari, N. M., Safaiyan, A., Mosharkesh, E., Hadi, A., Barati, M., & Ostadrahimi, A. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14591 · Cited by 35
Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis
Maglione, A., Zuccalà, M., Tosi, M., Clerico, M., & Rolla, S. (2021) · Genes · doi:10.3390/genes12081181 · Cited by 34
Gopi, N., Iswarya, A., Vijayakumar, S., Jayanthi, S., Nor, S. A. M., Velusamy, P., & Vaseeharan, B. (2022) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2022.109379 · Cited by 33
Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota
Chen, M., Lin, W., Li, N., Wang, Q., Zhu, S., Zeng, A., & Song, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.945533 · Cited by 33
Marć, M. A., Jastrząb, R., & Mytych, J. (2022) · Nutrients · doi:10.3390/nu14193967 · Cited by 33
Ruan, D., Wu, S., Fouad, A. M., Zhu, Y., Huang, W., Chen, Z., Gou, Z., Wang, Y., Yongquan, H., Yan, S., et al. (2022) · Food & Function · doi:10.1039/d2fo02598a · Cited by 33
Host–microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice
Molinaro, A., Caesar, R., Mannerås-Holm, L., Tremaroli, V., Cani, P. D., & Bäckhed, F. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.016 · Cited by 33
CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis
Hartjes, L., & Ruland, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00419 · Cited by 35
Shifting Climates, Foods, and Diseases: The Human Microbiome through Evolution
Amato, K. R., Jeyakumar, T., Poinar, H. N., & Gros, P. (2019) · BioEssays · doi:10.1002/bies.201900034 · Cited by 36
Martino, C., Kellman, B. P., Sandoval, D. R., Clausen, T. M., Marotz, C. A., Song, S. J., Wandro, S., Zaramela, L. S., Benítez, R. A. S., Zhu, Q., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.17.238444 · Cited by 33
The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases
Gonçalves, S. M., Lagrou, K., Duarte-Oliveira, C., Maertens, J. A., Cunha, C., & Carvalho, A. (2017) · Virulence · doi:10.1080/21505594.2016.1257458 · Cited by 32
Gut microbiota: A double-edged sword in immune checkpoint blockade immunotherapy against tumors
Wang, J., Zhu, N., Su, L., & Yang, R. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216582 · Cited by 35
Chen, P., Yang, C., Ren, K., Xu, M., Pan, C., Ye, X., & Li, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1504948 · Cited by 33
Yang, W., Petersen, C., Pees, B., Zimmermann, J., Waschina, S., Dirksen, P., Rosenstiel, P. C., Tholey, A., Leippe, M., Dierking, K., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01793 · Cited by 33
How gut microbiome interactions affect nutritional traits of Drosophila melanogaster
McMullen, J. G., Peters-Schulze, G., Cai, J., Patterson, A. D., & Douglas, A. E. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.227843 · Cited by 36
Gut microbiota-derived metabolites and colorectal cancer: New insights and updates
Mohseni, A. H., Taghinezhad‐S, S., & Fu, X. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104569 · Cited by 32
Li, J., Han, J., Yan, X., Shao, D., Hu, X., & Shi, J. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.04.070 · Cited by 32
Ejima, R., Akiyama, M., Sato, H., Tomioka, S., Yakabe, K., Kimizuka, T., Seki, N., Fujimura, Y., Hirayama, A., Fukuda, S., et al. (2021) · Nutrients · doi:10.3390/nu13082812 · Cited by 32
Petakh, P., Kamyshna, I. I., Nykyforuk, A., Yao, R., Imbery, J. F., Oksenych, V., Korda, M. M., & Kamyshnyi, O. (2022) · Viruses · doi:10.3390/v14030477 · Cited by 33
Zhang, H., Liu, X., Zheng, Y., Zha, X., Elsabagh, M., Zhang, Y., Ma, Y., Loor, J. J., Wang, M., & Wang, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113550 · Cited by 32
Gut microbiota plasticity in insular lizards under reversed island syndrome
Buglione, M., Ricca, E., Petrelli, S., Baccigalupi, L., Troiano, C., Saggese, A., Rivieccio, E., & Fulgione, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-16955-0 · Cited by 32
Burcher, K. M., Burcher, J. T., Inscore, L., Bloomer, C. H., Furdui, C. M., & Porosnicu, M. (2022) · Cancers · doi:10.3390/cancers14174116 · Cited by 34
Zhao, R., Qiu, Z., Bai, X., Lu, X., Qiao, Y., & Lu, X. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.10.022 · Cited by 33
Mast Cell Cytokines in Acute and Chronic Gingival Tissue Inflammation: Role of IL-33 and IL-37
Trimarchi, M., Lauritano, D., Ronconi, G., Caraffa, A., Gallenga, C. E., Frydas, I., Kritas, S. K., Calvisi, V., & Conti, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113242 · Cited by 33
Ben‐Azu, B., del Re, E. C., VanderZwaag, J., Carrier, M., Keshavan, M. S., Khakpour, M., & Tremblay, M. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1139357 · Cited by 32
Galloway-Peña, J., Jenq, R. R., & Shelburne, S. A. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3173 · Cited by 32
Zhang, M., Zhao, J., Deng, J., Duan, Z., Zhu, C., & Fan, D. (2019) · Food & Function · doi:10.1039/c9fo00242a · Cited by 32
Gut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions
Zhao, Q., Wu, J., Ding, Y., Pang, Y., & Jiang, C. (2023) · Life Metabolism · doi:10.1093/lifemeta/load032 · Cited by 31
Onisiforou, A., Charalambous, E. G., & Zanos, P. (2025) · Microorganisms · doi:10.3390/microorganisms13010090 · Cited by 32
Mass Azithromycin Distribution and Community Microbiome: A Cluster-Randomized Trial
Doan, T. A., Hinterwirth, A. J., Arzika, A. M., Cotter, S. Y., Ray, K. J., O’Brien, K. S., Zhong, L., Chow, E. D., Zhou, Z., Cummings, M. E., et al. (2018) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofy182 · Cited by 31
Ruiz‐Rodríguez, M., Martín‐Vivaldi, M., Martínez‐Bueno, M., & Soler, J. J. (2018) · Genes · doi:10.3390/genes9080381 · Cited by 31
The Fecal Metagenomics of Malayan Pangolins Identifies an Extensive Adaptation to Myrmecophagy
Ma, J., Jiang, H., Li, L., Zhang, X., Li, G.-Y., Li, H., Jin, X.-J., & Chen, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02793 · Cited by 31
Organ transplantation and gut microbiota: current reviews and future challenges.
Xiao, J., Peng, Z., Liao, Y., Sun, H., Chen, W., Chen, X., Wei, Z., Yang, C., Nussler, A. K., Liu, J., et al. (2018) · Europe PMC (PubMed Central) · Cited by 31
Wu, Q., Chen, T., El-Nezami, H. S., & Savidge, T. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.04.007 · Cited by 31
The Microbiome and Its Implications in Cancer Immunotherapy
Choudhry, H. (2021) · Molecules · doi:10.3390/molecules26010206 · Cited by 31
Interplay of Microbiota and Citrullination in the Immunopathogenesis of Rheumatoid Arthritis
Alghamdi, M. A., & Redwan, E. M. M. M. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09802-7 · Cited by 31
Why do insects evolve immune priming? A search for crossroads
Prakash, A., & Khan, I. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104246 · Cited by 31
β-1,6-Glucan From Pleurotus eryngii Modulates the Immunity and Gut Microbiota
Wang, X., Qu, Y., Wang, Y., Wang, X., Xu, J., Zhao, H., Zheng, D., Sun, L., Tai, G., Zhou, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.859923 · Cited by 31
Role of natural killer cells in antibacterial immunity
Schmidt, S., Ullrich, E., Bochennek, K., Zimmermann, S. Y., & Lehrnbecher, T. (2016) · Expert Review of Hematology · doi:10.1080/17474086.2016.1254546 · Cited by 31
Pan, H., Li, R., Li, T., Wang, J., & Liu, L. (2017) · Engineering · doi:10.1016/j.eng.2017.01.006 · Cited by 31
Schalich, K. M., Buendia, M. A., Kaur, H., Choksi, Y. A., Washington, M. K., Codreanu, G. S., Sherrod, S. D., MCLEAN, J. A. J., Peek, R. M., Acra, S. A., et al. (2024) · mBio · doi:10.1128/mbio.00298-24 · Cited by 32
Hicks, C., Leonardi, M., Chua, X., Mari‐Breedt, L., Espada, M., El-Omar, E. M., Condous, G., & El‐Assaad, F. (2024) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17979 · Cited by 30
Comparison of total immunoglobulin A levels in different samples in Leghorn and broiler chickens
Merino-Guzmán, R., Latorre, J. D., Delgado, R., Hernández-Velasco, X., Wolfenden, A. D., Teague, K. D., Graham, L. E., Mahaffey, B. D., Baxter, M. F. A., Hargis, B. M., et al. (2016) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2016.11.021 · Cited by 30
Bachmann, M., Waibler, Z., Pleli, T., Pfeilschifter, J. M., & Mühl, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00890 · Cited by 30
Vagococcus martis sp. nov., isolated from the small intestine of a marten, Martes flavigula
Tak, E. J., Kim, H. S., Lee, J., Kang, W., Hyun, D., Kim, P. S., Shin, N., & Bae, J. (2017) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.002131 · Cited by 30
Read, T., Fortun‐Lamothe, L., Pascal, G., Boulch, M. L., Cauquil, L., Gabinaud, B., Bannelier, C., Balmisse, E., Destombes, N., Bouchez, O., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00973 · Cited by 30
Puértolas-Balint, F., & Schroeder, B. O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01164 · Cited by 30
Wang, Y., Hosomi, K., Shimoyama, A., Yoshii, K., Yamaura, H., Nagatake, T., Nishino, T., Kiyono, H., Fukase, K., & Kunisawa, J. (2020) · Vaccines · doi:10.3390/vaccines8030395 · Cited by 30
Suwabe, T. (2020) · Clinical and Experimental Nephrology · doi:10.1007/s10157-020-01928-2 · Cited by 30
TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease
Niederkorn, M., Agarwal, P., & Starczynowski, D. T. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.08.010 · Cited by 31
Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19
Luo, J., Shan, L., & Jin, F. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1847-7 · Cited by 31
Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women
Rehman, S., Ravinayagam, V., Nahvi, I., Al-Dossary, H. A., AlShammari, M. M., Amiri, M. S. A., Kishore, U., & Al-Suhaimi, E. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680845 · Cited by 33
Combined Signature of the Urinary Microbiome and Metabolome in Patients With Interstitial Cystitis
Xu, H., Tamrat, N. E., Gao, J., Xu, J., Zhou, Y., Zhang, S., Chen, Z., Shao, Y., Ding, L., Shen, B., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.711746 · Cited by 30
Recent advances in understanding the effects of nanomaterials on gut microbiota
Xie, J., Zhao, M., Wang, C., Yong, Y., & Gu, Z. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134976 · Cited by 30
Muthyala, S. D. V., Shankar, S., Klemashevich, C. L., Blazier, J. C., Hillhouse, A., & Wu, C. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108999 · Cited by 33
Mycobiome Dysbiosis in Women with Intrauterine Adhesions
Liu, N., Zhao, X., Tan, J.-C., Liu, S., Li, B.-W., Xu, W., Peng, L., Gu, P., Li, W., Shapiro, R. S., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01324-22 · Cited by 30
Intratumoral microbiota: new frontiers in tumor immunity
Zhang, Z., Liao, Y., & Tang, D. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac063 · Cited by 30
Zhang, H., Lang, X., Zhang, Y., & Wang, C. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1062077 · Cited by 30
Abenavoli, L., Scarpellini, E., Paravati, M. R., Scarlata, G. G. M., Boccuto, L., Tilocca, B., Roncada, P., & Luzza, F. (2023) · Nutrients · doi:10.3390/nu15163569 · Cited by 30
Bacteriocins: Curial guardians of gastrointestinal tract
Gu, Q., Yan, J., Lou, Y., Zhang, Z., Li, Y., Zhu, Z., Liu, M., Wu, D., Liang, Y., Pu, J., et al. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13292 · Cited by 30
Metadata
- Authors
- Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E.
- Affiliations
- Weizmann Institute of Science (IL)
- Tel Aviv Sourasky Medical Center (IL)
- Corresponding author
- Elinav, Eran
- Venue
- Nature
- Published
- 2016-07-06
- Volume
- 535
- Issue
- 7610
- Pages
- 65-74
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2467200611
- Cited by
- 2,012
- References
- 148
- Citations by year
- 2026: 133 · 2025: 150 · 2024: 210 · 2023: 234 · 2022: 257 · 2021: 325 · 2020: 202 · 2019: 171 · 2018: 151 · 2017: 152 · 2016: 27
- FWCI
- 15.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, innate immunity, immune signaling, diet, host metabolism, infection response, hematopoietic cells, microbial ecology, complex diseases
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Immunity, Innate, Infections, Inflammation, Intestinal Mucosa, Lymphocytes, Neoplasms, Autoimmunity, Myeloid Cells, Metabolic Syndrome, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review