Cited by 2,012Gut microbiota and healthImmune Response and InflammationAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.

The microbiome and innate immunity

Abstract

The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host-microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.

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Crossref · 10.1038/nature18847

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148 of 148 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E.
Affiliations
  • Weizmann Institute of Science (IL)
  • Tel Aviv Sourasky Medical Center (IL)
Corresponding author
Elinav, Eran
Venue
Nature
Published
2016-07-06
Volume
535
Issue
7610
Pages
65-74
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2467200611
Cited by
2,012
References
148
Citations by year
2026: 133 · 2025: 150 · 2024: 210 · 2023: 234 · 2022: 257 · 2021: 325 · 2020: 202 · 2019: 171 · 2018: 151 · 2017: 152 · 2016: 27
FWCI
15.14
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
gut microbiota, innate immunity, immune signaling, diet, host metabolism, infection response, hematopoietic cells, microbial ecology, complex diseases
MeSH terms
Gastrointestinal Microbiome, Animals, Humans, Immunity, Innate, Infections, Inflammation, Intestinal Mucosa, Lymphocytes, Neoplasms, Autoimmunity, Myeloid Cells, Metabolic Syndrome, Epigenesis, Genetic

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