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Chemical and structural effects of base modifications in messenger RNA
Open accessAbstract
A growing number of nucleobase modifications in messenger RNA have been revealed through advances in detection and RNA sequencing. Although some of the biochemical pathways that involve modified bases have been identified, research into the world of RNA modification — the epitranscriptome — is still in an early phase. A variety of chemical tools are being used to characterize base modifications, and the structural effects of known base modifications on RNA pairing, thermodynamics and folding are being determined in relation to their putative biological roles.
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mRNA structure regulates protein expression through changes in functional half-life
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The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark
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Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II–associated methyltransferase
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Metadata
- Authors
- Harcourt, E. M., Kietrys, A. M., & Kool, E. T.
- Venue
- Nature
- Published
- 2017-01-18
- Volume
- 541
- Issue
- 7637
- Pages
- 339-346
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2572064190
- Cited by
- 204
- References
- 12
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- green
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