The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Blocking FSH induces thermogenic adipose tissue and reduces body fat
Open accessAbstract
Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.
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Cited by
The Global Epidemic of the Metabolic Syndrome
Saklayen, M. G. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0812-z · Cited by 3,990
Changes in body composition and weight during the menopause transition
Greendale, G. A., Sternfeld, B., Huang, M., Han, W., Karvonen-Gutierrez, C., Ruppert, K., Cauley, J. A., Finkelstein, J. S., Jiang, S.-F., & Karlamangla, A. S. (2019) · JCI Insight · doi:10.1172/jci.insight.124865 · Cited by 491
FSH blockade improves cognition in mice with Alzheimer’s disease
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Metadata
- Authors
- Liu, P., Ji, Y., Yuen, T., Rendina-Ruedy, E., DeMambro, V. E., Dhawan, S., Abu-Amer, W., Izadmehr, S., Zhou, B., Shin, A. C., Latif, R., Thangeswaran, P., Gupta, A., Li, J., Shnayder, V., Robinson, S. T., Yu, Y. E., Zhang, X., Yang, F., Lu, P., Zhou, Y., Zhu, L.-L., Oberlin, D. J., Davies, T. F., Reagan, M. R., Brown, A., Kumar, T. R., Epstein, S., Iqbal, J., Avadhani, N. G., New, M. I., Molina, H., van Klinken, J. B., Guo, E. X., Buettner, C., Haider, S., Bian, Z., Sun, L., Rosen, C. J., & Zaidi, M.
- Venue
- Nature
- Published
- 2017-05-24
- Volume
- 546
- Issue
- 7656
- Pages
- 107-112
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2618352462
- Cited by
- 341
- References
- 53
- FWCI
- 21.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, P., Ji, Y., Yuen, T., Rendina-Ruedy, E., DeMambro, V. E., Dhawan, S., Abu-Amer, W., Izadmehr, S., Zhou, B., Shin, A. C., Latif, R., Thangeswaran, P., Gupta, A., Li, J., Shnayder, V., Robinson, S. T., Yu, Y. E., Zhang, X., Yang, F., . . . Zaidi, M. (2017). Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature. https://doi.org/10.1038/nature22342
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
