Origin and differentiation of human memory CD8 T cells after vaccination

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422

ATAC-seq: a method for assaying chromatin accessibility genome-wide

Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2129s109 · Cited by 3,289

CpG islands and the regulation of transcription

Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103

A human memory T cell subset with stem cell–like properties

Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974

Immunological memory and protective immunity: understanding their relation

Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.006 · Cited by 1,355

Homeostasis of Naive and Memory T Cells

Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193

Molecular and functional profiling of memory CD8 T cell differentiation.

Kaech, S., Hemby, S., Kersh, E., & Ahmed, R. (2002) · Cell · doi:10.1016/s0092-8674(02)01139-x · Cited by 1,081

Cytotoxic T-cell memory without antigen

Lau, L. L., Jamieson, B. D., Somasundaram, T., & Ahmed, R. (1994) · Nature · doi:10.1038/369648a0 · Cited by 657

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

Méziane, O., Alexandrova, Y., Olivenstein, R., Dupuy, F., Salahuddin, S., Thomson, E., Orlova, M., Schurr, E., Ancuța, P., Durand, M., et al. (2020) · Journal of Immunology · doi:10.4049/jimmunol.2000916 · Cited by 9

Cellular and humoral immune responsiveness to inactivated Leptospira interrogans in dogs vaccinated with a tetravalent Leptospira vaccine

Novak, A., Hindriks, E., Hoek, A., Veraart, C., Broens, E. M., Ludwig, I. S., Rutten, V. P. M. G., Sloots, A., & Broere, F. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.11.017 · Cited by 11

Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity

Singh, S. P., Parween, F., Edara, N. V., Zhang, H. H., Chen, J., Otaizo-Carrasquero, F. A., Cheng, D., Oppenheim, N. A., Ransier, A., Zhu, W., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200874 · Cited by 9

Distinct association between chronic Epstein-Barr virus infection and T cell compartments from pediatric heart, kidney, and liver transplant recipients

Yamada, M., Macedo, C., Louis, K., Shi, T., Landsittel, D. P., Nguyen, C., Shinjoh, M., Michaels, M. G., Feingold, B., Mazariegos, G. V., et al. (2023) · American Journal of Transplantation · doi:10.1016/j.ajt.2023.05.007 · Cited by 11

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes

Joslyn, L. R., Pienaar, E., DiFazio, R. M., Suliman, S., Kagina, B. M. N., Flynn, J. L., Scriba, T. J., Linderman, J. J., & Kirschner, D. E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01734 · Cited by 11

Differentiation and Function of Follicular CD8 T Cells During Human Immunodeficiency Virus Infection

Xiao, M., Chen, X., He, R., & Ye, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01095 · Cited by 11

Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence

Song, N., Sengupta, S., Khoruzhenko, S., Welsh, R. A., Kim, A., Kumar, M. R., Sønder, S. U., Sidhom, J.-W., Zhang, H., Jie, C., et al. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104210 · Cited by 12

Defining the Molecular Hallmarks of T-Cell MemoryPreprint

Zebley, C. C., Akondy, R. S., Youngblood, B., & Kissick, H. T. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037804 · Cited by 10

The Yellow Fever Vaccine Journey: Milestones and Future Directions

Srivastava, S., Jayaswal, N., Gupta, P., Sridhar, S. B., Jaiswal, P., Tariq, M., Rao, G. S. N. K., Mohanty, A., Sah, S. K., Mehta, R., et al. (2026) · Vaccines · doi:10.3390/vaccines14010065 · Cited by 10

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

Bullock, M. E., Hogan, T. V., Williams, C., Morris, S. E., Nowicka, M., Sharjeel, M., van Dorp, C. H., Yates, A. J., & Seddon, B. P. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002380 · Cited by 10

Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion

Fiorenza, S., Zheng, Y., Purushe, J., Bock, T., Sarthy, J. F., Janssens, D. H., Sheih, A., Kimble, E. L., Kirchmeier, D., Phi, T.-D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52503-2 · Cited by 10

Functional Impairment of 'Helpless' CD8 Memory T Cells is Transient and Driven by Prolonged But Finite Cognate Antigen Presentation

van der Heide, V., Laghlali, G., Davenport, B., Cubitt, B., Roudko, V., Choo, D. K., Jhun, K., Humblin, É., Vaidya, A. B., Angeliadis, K., et al. (2024) · Immunity · doi:10.1016/j.immuni.2025.05.025 · Cited by 9

Identification of Novel Yellow Fever Class II Epitopes in YF-17D Vaccinees

Mateus, J., Grifoni, A., Voic, H., Angelo, M. A., Phillips, E. J., Mallal, S. A., Sidney, J., Sette, A., & Weiskopf, D. (2020) · Viruses · doi:10.3390/v12111300 · Cited by 10

Photonic Hyperthermia Synergizes with Immune‐Activators to Augment Tumor‐Localized Immunotherapy

Li, T., Hu, Z., Song, F., Wu, C., Miao, Q.-Z., Wang, Z., Feng, W., Guo, J., & Chen, Y. (2023) · Small Methods · doi:10.1002/smtd.202300116 · Cited by 10

Virulence of a virus: How it depends on growth rate, effectors, memory cells, and immune escape

Iwasa, Y., Hara, A., & Ozone, S. (2021) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2021.110875 · Cited by 10

CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development

Cobbold, S. P., Adams, E., Howie, D., & Waldmann, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01381 · Cited by 10

Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New Promises

O’Connell, A. K., & Douam, F. (2020) · Vaccines · doi:10.3390/vaccines8010036 · Cited by 11

Immunological memory to vaccines

Crotty, S. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.019 · Cited by 9

Effect of cellular aging on memory T-cell homeostasis

Swain, A. C., Borghans, J. A. M., & de Boer, R. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947242 · Cited by 9

Generating and measuring effective vaccine-elicited HIV-specific CD8+ T cell responses

Borgo, G. M., & Rutishauser, R. L. (2023) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000824 · Cited by 11

Antigen exposure reshapes chromatin architecture in central memory CD8 + T cells and imprints enhanced recall capacity

Zhu, S., Liu, J., Patel, V., Zhao, X., Peng, W., & Xue, H. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313476120 · Cited by 8

Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?

Rogan, D. C., & Connors, M. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00545-2 · Cited by 9

Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and MemoryPreprint

Morrison, T. A., Hudson, W. H., Chisolm, D. A., Kanno, Y., Shih, H., Ahmed, R., Henao‐Mejia, J., Hafner, M., & O’Shea, J. J. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037952 · Cited by 9

Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T CellsPreprint

Tsuda, S., & Pipkin, M. E. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037945 · Cited by 10

Relationship between Vitamin D and Immunity in Older People with COVID-19

Lauretani, F., Salvi, M., Zucchini, I., Testa, C., Cattabiani, C., Arisi, A., & Maggio, M. G. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20085432 · Cited by 8

Functional diversification and dynamics of CAR-T cells in patients with B-ALL

Li, Z., Zhao, L., Zhang, Y., Zhu, L., Mu, W., Ge, T., Jin, J., Tan, J., Cheng, J., Wang, J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113263 · Cited by 10

Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity

Pan, Y., Bartolo, L., Xu, R., Patel, B. V., Zarnitsyna, V. I., & Su, L. F. (2024) · JCI Insight · doi:10.1172/jci.insight.180667 · Cited by 9

Chronic viral infection alters PD-1 locus subnuclear localization in cytotoxic CD8+ T cells

Sacristán, C., Youngblood, B., Lu, P., Bally, A. P. R., Xu, J., McGary, K., Hewitt, S. L., Boss, J. M., Skok, J. A., Ahmed, R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114547 · Cited by 8

Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adults

van de Sandt, C. E., McQuilten, H. A., Aban, M., Nguyen, T. H. O., Valkenburg, S., Grant, E. J., Sant, S. A., Rossjohn, J., Gras, S., Crowe, J., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105697 · Cited by 9

Regulation of CD45 isoforms during human effector and memory CD8 T cell differentiation: Implications for T cell nomenclature

McGuire, D. J., Akondy, R. S., Yang, S., Edupuganti, S., Nagar, S., Michael, G., Rosa, S. C. D., Newell, E. W., Färber, D. L., Kissick, H. T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322982122 · Cited by 10

Serial Sampling of the Small Airway Epithelium to Identify Persistent Smoking-dysregulated Genes

Strulovici‐Barel, Y., Rostami, M. R., Kaner, R. J., Mezey, J. G., & Crystal, R. G. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202204-0786oc · Cited by 8

PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age

Zhang, H., Okuyama, H., Jain, A. K., Jadhav, R. R., Wu, B., Sturmlechner, I., Morales, J., Ohtsuki, S., Weyand, C. M., & Goronzy, J. J. (2024) · JCI Insight · doi:10.1172/jci.insight.172848 · Cited by 8

Epigenomics and Early Life Human Humoral Immunity: Novel Paradigms and Research Opportunities

Gutierrez, M. J., Niño, G., Hong, X., & Wang, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01766 · Cited by 9

Turnover of Murine Cytomegalovirus–Expanded CD8+ T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response

Baliu‐Piqué, M., Drylewicz, J., Zheng, X., Borkner, L., Swain, A. C., Otto, S. A., de Boer, R. J., Tesselaar, K., Čičin‐Šain, L., & Borghans, J. A. M. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100883 · Cited by 8

A metabolic blueprint of COVID-19 and long-term vaccine efficacy

Berber, E., Sumbria, D., & Kökkaya, S. (2022) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmpt-2022-0148 · Cited by 8

Parallels Between the Antiviral State and the Irradiated State

McGee, H. M., Marciscano, A. E. E., Campbell, A. M., Monjazeb, A. M., Kaech, S. M., & Teijaro, J. R. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa190 · Cited by 8

A novel adjuvant formulation induces robust Th1/Th17 memory and mucosal recall responses in Non-Human PrimatesPreprint

Woodworth, J. S., Contreras, V., Christensen, D., Naninck, T., Kahlaoui, N., Gallouët, A.-S., Langlois, S., Burban, E., Joly, C., Gros, W., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.23.529651 · Cited by 8

Metabolic Signaling as a Driver of T Cell Aging

Choi, M. S., Choi, S., Cho, M., & Kim, C. (2025) · Immune Network · doi:10.4110/in.2025.25.e14 · Cited by 8

Longitudinal single cell profiling of epitope specific memory CD4+ T cell responses to recombinant zoster vaccine

Wen, X., Hu, A. K., Presnell, S., Ford, E. S., Koelle, D. M., & Kwok, W. W. (2025) · Nature Communications · doi:10.1038/s41467-025-57562-7 · Cited by 7

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Zhang, Z., Li, L., Ge, Y.-C., Chen, A., Diao, S., Yang, Y., Chen, Q., Zhou, Y., Shao, J., Meng, F., et al. (2025) · Advanced Science · doi:10.1002/advs.202413387 · Cited by 7

Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses

Winheim, E., Santos‐Peral, A., Ehm, T., Rinke, L., Riemer, S., Zaucha, M., Goresch, S., Lehmann, L., Eisenächer, K., Pritsch, M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422236122 · Cited by 8

Surface CD69‐Negative CD4 and CD8 Bone Marrow‐Resident Human Memory T Cells

Revueltas, E. S., Ferreira‐Gomes, M., Guerra, G. M., Durek, P., Heinrich, F., Subirana, A. C., Tokoyoda, K., Dong, J., Reinke, S., Hardt, S., et al. (2025) · European Journal of Immunology · doi:10.1002/eji.202451529 · Cited by 8

Epigenetic priming as a driver of memory recall and dysfunction in T cells

Metzemaekers, M., Rinzema, N. J., & Stadhouders, R. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241433 · Cited by 8

Ultra-low level HIV p24 drives immune activation in antiretroviral therapy-treated people living with HIV

Richter, E., König, J., Büning, A., Bechtel, T., Casado, A., Pušnik, J., Crowell, T. A., Jessen, H. K., Rockstroh, J. K., Boesecke, C., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01261-3 · Cited by 7

Using a Systems Biology Approach To Study Host-Pathogen Interactions

Yeung, A. T. Y., Hale, C., Clare, S., Palmer, S., Scott, J. B., Baker, S. G., & Dougan, G. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.bai-0021-2019 · Cited by 7

Infection History Determines Susceptibility to Unrelated Diseases

Rakebrandt, N., & Joller, N. (2019) · BioEssays · doi:10.1002/bies.201800191 · Cited by 8

Clinical implication of naive and memory T cells in locally advanced cervical cancer: A proxy for tumor biology and short-term response prediction

WANG, Y., FAN, P., FENG, Y., YAO, X., PENG, Y., & WANG, R. (2023) · Biocell · doi:10.32604/biocell.2023.027201 · Cited by 7

Systems vaccinology studies – achievements and future potential

Sugrue, J. A., & Duffy, D. (2024) · Microbes and Infection · doi:10.1016/j.micinf.2024.105318 · Cited by 8

Vaccination reshapes the virus-specific T cell repertoire in unexposed adultsPreprint

Pan, Y., Aiamkitsumrit, B., Bartolo, L., Wang, Y., Lavery, C. L. M., Marc, A., Holec, P. V., Rappazzo, C. G., Eilola, T., Gimotty, P. A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.01.322958 · Cited by 7

Characterisation of clinical response and transcriptional profiling of proliferating CD8 T cells in the blood of cancer patients after PD-1 monotherapy or combination therapy

Obeng, R. C., Nasti, T. H., Martens, K. L., Li, P., Mariniello, A., Chang, D. Y., Eberhardt, C. S., McGuire, D. J., Kissick, H. T., Daugherty, C., et al. (2024) · BMJ Oncology · doi:10.1136/bmjonc-2024-000328 · Cited by 6

Single-Cell RNA-Sequencing Reveals Heterogeneity and Transcriptional Dynamics in Porcine Circulating CD8+ T Cells

Han, P., Guo, Y., Zhang, W., Wang, D., Wu, Y., Li, X., & Zhu, M. (2024) · Cells · doi:10.3390/cells13080692 · Cited by 7

Epigenetic regulation of immune cells in central nervous system: from steady state to pathology

Zhao, L., Schepp, C. L., Iskandar, M., Tao, Y., & Dey, M. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106005 · Cited by 6

The roles of tissue-resident memory T cells (TRMs) in diseases and vaccine development: A comprehensive review

Wei, H., Wang, Y., Jiang, S., Zhang, X., & Zhang, J. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127605 · Cited by 6

Quantifying the waning of humoral immunity

Saha, A., Ahmed, H., Hirst, C., Koelle, K., Handel, A., Teunis, P. F. M., & Antia, R. (2025) · Immunity · doi:10.1016/j.immuni.2025.11.007 · Cited by 8

Phenotypic and Immunometabolic Aspects on Stem Cell Memory and Resident Memory CD8+ T Cells

Manna, M. P. L., Azgomi, M. S., Tamburini, B., Badami, G. D., Mohammadnezhad, L., Dieli, F., & Caccamo, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884148 · Cited by 6

The profile and prognostic significance of bone marrow T-cell differentiation subsets in adult AML at diagnosis

Sun, K., Shi, Z.-Y., Wang, Y., Xie, D., Liu, Y., Jiang, Q., Jiang, H., Huang, X., & Qin, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1418792 · Cited by 6

A mass cytometry method pairing T cell receptor and differentiation state analysis

Castillo, J. G., DeBarge, R., Mende, A., Tenvooren, I., Marquez, D. M., Straub, A., Busch, D. H., Spitzer, M. H., & DuPage, M. J. P. (2024) · Nature Immunology · doi:10.1038/s41590-024-01937-3 · Cited by 7

CD8 T Cell Vaccines and a Cytomegalovirus-Based Vector Approach

Šustić, M., Brdovčak, M. C., Krmpotić, A., & Jonjić, S. (2021) · Life · doi:10.3390/life11101097 · Cited by 6

Vaccination Provides Superior in vivo Recall Capacity of SARS-CoV-2 Specific Memory CD8 T Cells

Kavazović, I., Dimitropoulos, C., Gašparini, D., Filipović, M. R., Barković, I., Köster, J., Lemmermann, N. A. W., Babić, M., Cekinović, Đ., & Wensveen, F. M. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112395 · Cited by 6

Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20

Preiss, N. K., Kamal, Y., Wilkins, O. M., Li, C., Kolling, F., Trask, H. W., Usherwood, Y.-K., Cheng, C., Frost, H. R., & Usherwood, E. J. (2023) · Life Science Alliance · doi:10.26508/lsa.202201683 · Cited by 7

Human small intestine contains 2 functionally distinct regulatory T-cell subsets

Chauhan, S. K., Bartolomé-Casado, R., Landsverk, O. J. B., Johannessen, H., Phung, D., Nilsen, H. R., Sætre, F., Jahnsen, J., Horneland, R., Yaqub, S., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.02.030 · Cited by 9

A Single-Cell Perspective on Memory T-Cell DifferentiationPreprint

Kretschmer, L., Busch, D. H., & Buchholz, V. R. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038067 · Cited by 6

Measurement of gluconeogenesis by 2H2O labeling and mass isotopomer distribution analysis

Ziari, N., & Hellerstein, M. K. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105206 · Cited by 5

Immunostimulatory Pickering emulsion for oral vaccine delivery

Xie, J., Li, X., Funk, G. A., Song, S. J., Shah, U., Ahlquist, C. S. E., & Kim, H. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125890 · Cited by 5

Antigen-specific T H 17 cells offset the age-related decline in durable T cell immunity

Sturmlechner, I., Jain, A. K., Jiang, J., Okuyama, H., Mu, Y., Own, M., Weyand, C. M., & Goronzy, J. J. (2026) · Science Advances · doi:10.1126/sciadv.aea7131 · Cited by 5

Nonoxidative pentose phosphate pathway regulates CD8 + T cell immunity by maintaining NADPH homeostasis

Feng, J., Zhang, Q., Luo, L., Gu, Z., Liu, W., Xu, J., Qi, M., Meng, Z., Li, L., Lin, L., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2526325123 · Cited by 5

New insights into progenitor exhausted T cell populations

Ahmed, R., Hofmann, M., Kallies, A., Oxenius, A., Philip, M., Wherry, E. J., Ye, L., & Zehn, D. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01328-9 · Cited by 7

Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection

Gill, A. L., Hudson, W., Valanparambil, R., Ahn, E., McGuire, D., Wieland, A., McManus, D., Kissick, H., Akondy, R. S., & Ahmed, R. (2022) · Journal of Virology · doi:10.1128/jvi.01556-22 · Cited by 4

Strategies for uncovering stable isotope tracing patterns between cell populations

MacPherson, S., Duncan, K. D., Goodlett, D. R., & Lum, J. J. (2023) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2023.102991 · Cited by 5

T cell memory revisited using single telomere length analysis

Roger, L., Miners, K. L., Leonard, L., Grimstead, J. W., Price, D. A., Baird, D. M., & Ladell, K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1100535 · Cited by 5

Modeling the Effect of Memory in the Adaptive Immune Response

Wyatt, A., & Levy, D. (2020) · Bulletin of Mathematical Biology · doi:10.1007/s11538-020-00798-9 · Cited by 4

Differential ATAC-seq and ChIP-seq peak detection using ROTS

Faux, T., Rytkönen, K. T., Mahmoudian, M., Paulin, N., Junttila, S., Laiho, A., & Elo, L. L. (2021) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqab059 · Cited by 5

Shared acute phase traits in effector and memory human CD8 T cells

Marraco, S. A. F., Alpern, D., Lofek, S., Lourenço, J., Bovay, A., Hajjami, H. M.-E., Delorenzi, M., Deplancke, B., & Speiser, D. E. (2021) · Current Research in Immunology · doi:10.1016/j.crimmu.2021.12.002 · Cited by 4

Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults

Lü, J., Chen, G., Sorokina, A., Nguyen, T. B. V., Wallace, T., Nguyen, C., Dunn, C., Wang, S., Ellis, S., Shi, G., et al. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00307-7 · Cited by 5

Challenges and opportunities of CAR T-cell therapies for CLL

Zhao, Z., Grégoire, C., de Oliveira, B. C., Chung, K., & Melenhorst, J. J. (2023) · Seminars in Hematology · doi:10.1053/j.seminhematol.2023.01.002 · Cited by 5

Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8+ T-cell activation and exhaustion

Belizário, J. E., & Rodrigues, M. F. S. D. (2020) · Therapeutic Advances in Vaccines and Immunotherapy · doi:10.1177/2515135520904238 · Cited by 6

Immunotherapy With 5, 15-DPP Mediates Macrophage M1 Polarization and Modulates Subsequent Mycobacterium tuberculosis Infectivity in rBCG30 Immunized Mice

Ahmad, F., Umar, M. S., Khan, N., Jamal, F., Gupta, P., Zubair, S., Gupta, U. D., & Owais, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706727 · Cited by 6

Steroid injections in pain management: influence on coronavirus disease 2019 vaccines

Hong, S. M., Park, Y. W., & Choi, E. J. (2021) · The Korean journal of pain · doi:10.3344/kjp.2022.35.1.14 · Cited by 5

Dissecting the heterogeneity of exhausted T cells at the molecular level

Kagoya, Y. (2022) · International Immunology · doi:10.1093/intimm/dxac016 · Cited by 5

Deuterated water (2H2O, heavy water) labelling to investigate human cell dynamics in vivo - lessons in protocol design and toxicity from the current literature

Song, A., Zhang, Y., Busch, R., Asquith, B., & Macallan, D. C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1544193 · Cited by 4

Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan

Menon, T., McQuilten, H. A., Samir, J., Nguyen, T. H. O., Lim, R., Kaur, J., Rizzetto, S., Eltahla, A. A., Thomas, P. G., Lappas, M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2501167122 · Cited by 4

Human T Cell Responses to Flavivirus Vaccines

Wullimann, D., & Ljunggren, H. (2025) · European Journal of Immunology · doi:10.1002/eji.70027 · Cited by 7

Varying Immunizations With Plasmodium Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8+ T Cell Dynamics

Frank, R., Gabel, M., Heiss, K., Mueller, A., & Graw, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01137 · Cited by 5

Picking up speed: cell cycle regulation during effector CD8+ T cell differentiation

Kretschmer, L., Fuchs, N., Busch, D. H., & Buchholz, V. R. (2023) · Medical Microbiology and Immunology · doi:10.1007/s00430-023-00768-7 · Cited by 5

Vaccine Immunology

Siegrist, C., & Eberhardt, C. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00002-5 · Cited by 4

Modeling the Development of Cellular Exhaustion and Tumor-Immune Stalemate

Simmons, T., & Levy, D. (2023) · Bulletin of Mathematical Biology · doi:10.1007/s11538-023-01207-7 · Cited by 4

Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors

Wang, Y., Guo, L., Fan, G., Yang, H., Zhang, Q., Ren, X., Zhang, H., Wang, G., Zhang, X., Huang, T., et al. (2024) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2024.02.005 · Cited by 4

SifiNet: a robust and accurate method to identify feature gene sets and annotate cells

Gao, Q., Ji, Z., Wang, L., Owzar, K., Li, Q.-J., Chan, C. C. W., & Xie, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae307 · Cited by 3

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

Zheng, Y., Sasidharan-Nair, V., Buchta, T., Bonifacius, A., Khan, F., Pietzsch, B., Ahmadi, H., Beckstette, M., Niemz, J., Hilgendorf, P., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012581 · Cited by 4

Analysis of the immune response in COVID-19

Hromić‐Jahjefendić, A., & Aljabali, A. A. A. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.10.004 · Cited by 4

Compromised long‐lived memory CD8 + T cells are associated with reduced IL‐7 responsiveness in HIV‐infected immunological nonresponders

Zhou, M., Huang, H.-H., Song, J., Tu, B., Fan, X., Li, J., Jin, J., Cao, W., Hu, W., Yang, T., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202149203 · Cited by 4

CD8+ T Cell Response Quality Is Related to Parasite Control in an Animal Model of Single and Mixed Chronic Trypanosoma cruzi Infections

Mateus, J., Nocua, P. A., Lasso, P., López, M. C., Thomas, M. C., Egui, A., Cuervo, C., González, J. M., Puerta, C. J., & Cuéllar, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.723121 · Cited by 4

The Memory T Cell “Communication Web” in Context with Gastrointestinal Disorders—How Memory T Cells Affect Their Surroundings and How They Are Influenced by It

Knauss, A., Gabel, M., Neurath, M. F., & Weigmann, B. (2022) · Cells · doi:10.3390/cells11182780 · Cited by 5

Systems Biological Approaches for Mucosal Vaccine Development

Pulendran, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-811924-2.00045-6 · Cited by 4

Decreased expression of programmed death-1 on CD8+ effector memory T lymphocytes correlates with the pathogenesis of type 1 diabetes

Shan, Y., Kong, Y., Zhou, Y., Guo, J., Shi, Q., Li, S., Guo, H., Huang, Y., Ding, S., Liu, C., et al. (2021) · Acta Diabetologica · doi:10.1007/s00592-021-01711-z · Cited by 4

A unique epigenomic landscape defines CD8 + tissue-resident memory T cellsPreprint

Buquicchio, F. A., Fonseca, R., Belk, J. A., Evrard, M., Obers, A., Qi, Y., Dániel, B., Yost, K. E., Satpathy, A. T., & Mackay, L. K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.04.490680 · Cited by 4

SARS-CoV-2 mRNA Dual Immunization Induces Innate Transcriptional Signatures, Establishes T-Cell Memory and Coordinates the Recall Response

Papadatou, I., Geropeppa, M., Verrou, K., Tzanoudaki, M., Lagousi, T., Liatsis, E., & Spoulou, V. I. (2023) · Vaccines · doi:10.3390/vaccines11010103 · Cited by 4

Pre-existing T Cell Memory to Novel Pathogens

Afroz, S., Bartolo, L., & Su, L. F. (2023) · ImmunoHorizons · doi:10.4049/immunohorizons.2200003 · Cited by 3

The multifaceted landscape of T cell exhaustion in organ transplantation: From molecular mechanisms (epigenetics, transcription, metabolism) to induction strategies

Wang, Y., Wu, Y., Shen, Y., Chen, Y., Zhao, Y., Zeng, X., & He, K. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101965 · Cited by 3

Functions and features of circulating memory T cells

Jameson, S. C., & Hamilton, S. E. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.014 · Cited by 4

Characterization of long-lived human memory CD8 T cells specific to yellow fever virus (LYM5P.707)

Yang, S., Akondy, R. S., Youngblood, B., Edupuganti, S., Mulligan, M. J., & Ahmed, R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.134.12

Effector CD8 T cells dedifferentiate into long-lived memory cells

Youngblood, B., Hale, J. S., Kissick, H. T., Ahn, E., Xu, X., Wieland, A., Araki, K., West, E. E., Ghoneim, H. E., Fan, Y., et al. (2017) · Nature · doi:10.1038/nature25144 · Cited by 481

The human CD8 T stem cell-like memory phenotype appears in the acute phase in Yellow Fever virus vaccinationPreprint

Marraco, S. A. F., Bovay, A., Nassiri, S., Hajjami, H. M.-E., Ouertatani-Sakouhi, H., Held, W., & Speiser, D. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/808774 · Cited by 2

Long-lasting stem cell–like memory CD8 + T cells with a naïve-like profile upon yellow fever vaccination

Fuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3700 · Cited by 206

Longitudinal human CD8+ T-cell fate following yellow fever vaccination 3548

Eriksson, C., Hård, J., Blom, K. G., Hagemann-Jensen, M., Ziegenhain, C., Ljunggren, H., Mold, J. E., Michaëlsson, J., & Frisén, J. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf283.1339