Cited by 499T-cell and B-cell ImmunologyInflammatory Bowel DiseaseGut microbiota and health

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Open access

Xu, Mo, Pokrovskii, Maria, Ding, Yi, Yi, Ren, Au, Christy, Harrison, Oliver J., Galan, Carolina, Belkaid, Yasmine, Bonneau, Richard, Littman, Dan R.·2018·Nature

DOI 10.1038/nature25500PMC PMC5814346

Published version of a preprint

Open this paper in CoChat — free account Open PDF

Abstract

Both microbial and host genetic factors contribute to the pathogenesis of autoimmune diseases. There is accumulating evidence that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease, often also colonize healthy individuals. These microorganisms, including the Helicobacter species, can induce pathogenic T cells and are collectively referred to as pathobionts. However, how such T cells are constrained in healthy individuals is not yet understood. Here we report that host tolerance to a potentially pathogenic bacterium, Helicobacter hepaticus, is mediated by the induction of RORγt+FOXP3+ regulatory T (iT reg) cells that selectively restrain pro-inflammatory T helper 17 (T H 17) cells and whose function is dependent on the transcription factor c-MAF. Whereas colonization of wild-type mice by H. hepaticus promoted differentiation of RORγt-expressing microorganism-specific iT reg cells in the large intestine, in disease-susceptible IL-10-deficient mice, there was instead expansion of colitogenic T H 17 cells. Inactivation of c-MAF in the T reg cell compartment impaired differentiation and function, including IL-10 production, of bacteria-specific iT reg cells, and resulted in the accumulation of H. hepaticus-specific inflammatory T H 17 cells and spontaneous colitis. By contrast, RORγt inactivation in T reg cells had only a minor effect on the bacteria-specific T reg and T H 17 cell balance, and did not result in inflammation. Our results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iT reg-T H 17 homeostasis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature25500

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Self-citation
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1×
“HH-E2 tetramer was kindly produced by the NIH Tetramer Core Facility 37 .”
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
Read, S., Malmström, V., & Powrie, F. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,206

Flagged first, then by citations

Show all 50 references

Sorted by citations

Items 401–499 of 499

Genetic and Environmental Determinants of T Helper 17 Pathogenicity in Spondyloarthropathies
Simone, D., Stingo, A., & Ciccia, F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.703242 · Cited by 3
Deciphering the Regulatory Landscape of γδ T Cell Development by Single-Cell RNA-SequencingPreprint
Sagar, Pokrovskil, M., Herman, J. S., Naik, S., Sock, E., Lausch, U., Wegner, M., Tanriver, Y., Littman, D. R., & Grün, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/478529 · Cited by 3
Self-citation
Eliciting a potent antitumor immune response by expressing tumor antigens in a skin commensalPreprint
Chen, Y. E., Atabakhsh, K., Dimas, A., Nagashima, K., & Fischbach, M. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.17.431662 · Cited by 3
Microbiota-instructed regulatory T cell differentiation is mediated by a distinct ROR γ t + antigen presenting cell subsetPreprint
Kedmi, R., Najar, T. A., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M. V., Xu, M., Talbot, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.19.469318 · Cited by 3
Self-citation
The microbiota and immune system non-genetically affect offspring phenotypes transgenerationallyPreprint
Harris, J. C., Trigg, N. A., Goshu, B. A., Yokoyama, Y., Dohnalová, L., White, E. K., Harman, A., Thaiss, C. A., Grice, E. A., Conine, C. C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.06.535940 · Cited by 3
Decoding Peripheral Tolerance: TCR Rules for pTreg differentiation in the GutPreprint
Chi, X., Wang, C. H., Parisotto, Y. F., Nyberg, W. A., Cabric, V., Gélineau, A., Cao, Y., Owen, D. L., Ambjörnsson, J., Mathis, D. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683415 · Cited by 3
Efficacy of curcumin supplementation for the treatment and prevention of pouchitis after ileal pouch-anal anastomosis: a randomized controlled trial
He, A.-Q., Xiao, W.-Y., Zheng, T., Li, K., Li, B.-S., Wang, S., Yu, Q.-X., & Liu, G. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03676-z · Cited by 2
REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis
Hu, X., Liu, Z., Li, Y., You, Y., Yue, K., Liang, Y., Loo, C.-S., Yu, J., Leblanc, M., Wang, D., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241463 · Cited by 2
The gut microbiome in graft-versus-host disease: mechanisms of immune modulation and therapeutic approaches
Moses, A. B., & Yeh, A. C. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2631224 · Cited by 2
Palmitic acid coordinates impaired visceral adipose ICOShi Treg-mediated immunosuppression and systemic metabolic disturbance during obesity
Su, W., Liu, Y., Xm, Y., Huang, M., Xu, L., Lin, J. F., Chen, X., Hu, P., Gao, C., Wen, J., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci207089 · Cited by 2
RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens
Zhao, J., Hao, J., Chen, J., Lyu, M., Liu, H., Li, N., Song, P., Wang, W., Chu, C., Sonnenberg, G. F., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69886-z · Cited by 2
Pathobiont peacekeepers
Minton, K. (2018) · Nature reviews. Immunology · doi:10.1038/nri.2018.11 · Cited by 2
Ischemic Brain Injury and Regulatory T Cells
Ito, M., Srirat, T., Nakamura, T., Komai, K., & Yoshimura, A. (2019) · OBM Neurobiology · doi:10.21926/obm.neurobiol.1901023 · Cited by 2
Could cross‐reactivity rescue Foxp3+ regulatory T cell precursors from thymic deletion?
Usharauli, D., & Kamala, T. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12940 · Cited by 2
Three-dimensional genome structure and chromatin accessibility reorganization during in vivo induction of human T cell tolerancePreprint
Li, R., Guo, H., Hou, Y., Liu, S., Wang, M., Peng, T., Zhao, X., Lu, L., Han, Y., Shao, Y., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.11.988253 · Cited by 2
Intestinal lamina propria supports acquired eTreg suppressor functionPreprint
Gu, Y., Bartolomé-Casado, R., Xu, C., Janney, A., Heuberger, C., Pearson, C. F., Teichmann, S. A., Thornton, E. E., & Powrie, F. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.26.505428 · Cited by 2
IL-2–induced Stat3 Signaling is Critical for Effector Treg Cell ProgrammingPreprint
Dean, E. C., Ditoro, D. F., Pham, D., Gao, M., Zindl, C. L., Frey, B. F., Harbour, S. N., Figge, D. A., Miller, A. T., Glassman, C. R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.26.559434 · Cited by 2
Salmonella -superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state
Luccia, B. D., Massis, L. M., Butler, D. S. C., Narasimhan, R., Ruddle, S. J., Pham, T. H. M., Vilches-Moure, J. G., & Monack, D. M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20242431 · Cited by 1
Intestinal Dysbiosis Caused by Epithelial Fabp6 Gene Disruption Exacerbates Gut Inflammatory Disease
Kwon, K., Kim, M., Jung, Y., Yoon, M. Y., Lee, J., Yoon, S. S., Rho, M., Chung, Y. W., & Ryu, J.-H. (2025) · Immune Network · doi:10.4110/in.2025.25.e35 · Cited by 2
Transcription factor c-Maf: a checkpoint that programs autoimmunity
Liu, N., Zhang, J., Wang, P., Jin, S., Yang, C., Yan, X., Xu, J., Wang, H., Sun, W., & Xu, D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682098 · Cited by 1
Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells
Till, J. M., Brock, O. D., & Ahern, P. P. (2025) · Discovery Immunology · doi:10.1093/discim/kyaf020 · Cited by 1
De novo Inflammatory Bowel Disease following Liver and Heart Transplantation: A Case Series Exploring the Role of IL-23 Pathway-Targeted Therapy
Shiomi, C., Kurokawa, K., Ihara, S., Nishioka, Y., Akamatsu, N., Bujo, C., Hatano, M., Ishida, J., Hayakawa, Y., Tsuji, Y., et al. (2025) · Inflammatory Intestinal Diseases · doi:10.1159/000550240 · Cited by 1
The conserved noncoding sequence CNS11 is a master control region for Rorc transcription in type 17 immune cells
Zhang, H., Chang, D., Xie, S., Li, R., Zhang, Q., Xing, Q., Xie, T., Zhang, G., Lou, X., Li, S., et al. (2026) · Science Advances · doi:10.1126/sciadv.adz6964 · Cited by 1
The different meanings of tolerating the gut microbiome
Vidal, V. M., Montes‐Cobos, E., Canto, F. B., & Bozza, M. T. (2026) · mBio · doi:10.1128/mbio.01736-24 · Cited by 1
Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut
Regina, A., Solagna, F., Estrada, M. S., Jacobs, M. M. E., Martínez‐Martínez, D., Georgomanolis, T., Alibashikj, I., Gjurgji, S., Pearson, C., Chang, D., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01533-9 · Cited by 2
Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and RORγt⁺ antigen-presenting cells coordinates intestinal immunity
Yang, W., Pires, S., Cardakli, E. D., Nagayama, M., Scott, C., Tran, N., Oguntunmibi, S., Bradstreet, T. R., Webber, A. M., Astorkia, M., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.06.007 · Cited by 1
TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation
Chi, X., Wang, C. H., Parisotto, Y. F., Nyberg, W. A., Cabric, V., Gélineau, A., Cao, Y., Owen, D. L., Ambjörnsson, J., Mathis, D. J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.001 · Cited by 6
IgE ‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper
Jappe, U., Risha, M. A., Agache, I. O., Bachert, C., Bröker, B. M., Castagnoli, R., Gadermaier, G., Goodman, R. E., Guemari, A., Hilger, C., et al. (2026) · Allergy · doi:10.1111/all.70510 · Cited by 1
T cells in harmony: Aligning the TCR repertoire pool to identify microbiota recognizing T cells
Chen, A. C., & Diehl, G. E. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.008 · Cited by 1
Identification of small compounds that inhibit multiple myeloma proliferation by targeting c-Maf transcriptional activity
Asano, K., Kikuchi, K., Takehara, M., Ogasawara, M., Yoshioka, Y., Ohnishi, K., Iwata, A., Shimizu, S., & Tanaka, M. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149135 · Cited by 1
Mouse Models Enable the Functional Investigation of Tertiary Lymphoid Structures in Cancer
Jeevanandam, A., Yin, Z., Connolly, K. A., & Joshi, N. S. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-4184-2_4 · Cited by 1
Understanding the Relationship between Bone-Remodeling T Cells and Microbiota in Breast Cancer Bone Metastases
Masset, M. E. G., Canto, F. B., & Monteiro, A. C. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1010215 · Cited by 1
Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron
Glowacki, R. W. P., Till, J. M., Brock, O. D., Makarov, V., Engelhart, M. J., & Ahern, P. P. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkaf333 · Cited by 1
Complex regulatory networks: relationships between metabolism, intracellular signaling pathways and epigenetic regulators in the control of Th1 functions
Kupriyanov, S. V., Синицкий, А. И., & Dolgushin, I. I. (2021) · Immunologiya · doi:10.33029/0206-4952-2021-42-5-562-573 · Cited by 1
Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in micePreprint
Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Mérad, M., Das, A., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/276774 · Cited by 1
Host sex and genotype modify the gut microbiome response to helminth infectionPreprint
Ling, F., Steinel, N. C., Weber, J. N., Ma, L., Smith, C. C. R., Corrêa, D. T., Zhu, B., Bolnick, D. I., & Wang, G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/608638 · Cited by 1
JunB controls intestinal effector programs in regulatory T cellsPreprint
Wheaton, J. D., & Ciofani, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/772194 · Cited by 1
Helicobacter hepaticus as disease driver in a novel CD40-mediated model of colitisPreprint
Friedrich, V., Forné, I., Matzek, D., Ring, D., Popper, B., Jochum, L. M., Spriewald, S., Straub, T., Imhof, A., Krug, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.21.053066 · Cited by 1
Intestinal Inflammation Breaks Established Immune Tolerance to a Skin CommensalPreprint
Merana, G. R., Dhariwala, M. O., Dwyer, L. R., Weckel, A., Gonzalez, J. R., Palacios-Calderon, Y., Kattah, M. G., Ma, A. I., & Scharschmidt, T. C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3863579 · Cited by 1
Single-Cell Transcriptome Analysis Reveals Heterogeneity and Convergence of the Tumor Microenvironment in CRCPreprint
Xie, S., Cai, Y., Chen, D., Xiang, Y., Cai, W., Yang, B., Mao, J., & Ye, J. (2021) · Research Square · doi:10.21203/rs.3.rs-836574/v1 · Cited by 1
GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathologyPreprint
Earley, Z. M., Lisicka, W., Sifakis, J. J., Aguirre‐Gamboa, R., Kowalczyk, A., Barlow, J. T., Shaw, D. G., Discepolo, V., Tan, I. L., Gona, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.28.466194 · Cited by 1
Disease tolerant mice shelter a pathogenic intestinal microbiota able to trigger lethal disease in low tolerant hostsPreprint
Vidal, V. M., Ferreira, L. M., Yılmaz, B., Montes‐Cobos, E., Gama, A. M. D. S., Kitoko, J. Z., Rosa, S. G., Teixeira, G. A., de Farias, J. N., Raghavan, V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.20.639353 · Cited by 1
Self-citation
Use of lung microbiota strains to shape local immunity at steady state and during Mycobacterium tuberculosis infection in the mouse model
Bernard, L. (2020) · theses.fr (ABES) · doi:10.70675/589a776dz18d9z4813z9d6fzd73632aa4df7 · Cited by 1
Coincident epithelial signals restrain commensal-specific CD8αβ + T cells in the intestinePreprint
Olsen, T. M., Dufort, M. J., Verma, S., Makani, V. K. K., Cameron, B., Gralen, A. R., Johnson, A. J., Joglekar, A. V., Byrd, A. L., Lacy‐Hulbert, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.29.720676 · Cited by 1
Self-citation
CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation
Chai, J. N. (2018) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/v4y0-9r96
Anti-CTLA-4 Induced Inflammatory Bowel Disease: Is There A More Etiological Treatment? Lessons From CTLA-4 Haploinsufficiency
Germanidis, G. S. (2018) · Gastroenterology Medicine & Research · doi:10.31031/gmr.2018.01.000525
T Follicular Regulatory Cells Promote the Germinal Center Reaction and Allergic IgE Response While Repressing Abnormal Differentiation of T Follicular Helper Cells
Xie, M. M. (2019) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1758
Enteropathy-induced regulatory T cells inhibit intestinal CD4+ T cell responses against oral vaccinesPreprint
Bhattacharjee, A., Burr, A. B. P., Overacre-Delgoffe, A. E., Tometich, J. T., Yang, D., Huckestein, B. R., Linehan, J. L., Spencer, S. P., Hall, J. A., Harrison, O. J., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.03.130831
Self-citation
RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammationPreprint
Ma, S., Patel, S. A., Chen, N., Patel, P. R., Cho, B. S., Abbasi, N., Chang, J. T., & Huang, W. J. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.14.444071
Gut regulatory T cells mediate immunological tolerance in Salmonella -infected superspreader hosts by suppressing cytotoxic activity of T cellsPreprint
Massis, L. M., Ruddle, S. J., Brewer, S. M., Schade, R., Narasimhan, R., Honeycutt, J. D., Pham, T. H. M., McKenna, J. A., Brubaker, S. W., Chairatana, P., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.16.452606
Commensal Candida Albicans Positively Calibrate Systemic Th17 Immunological ResponsesPreprint
Shao, T., Ang, W. X. G., Jiang, T. T., Huang, F. S., Kinder, J. M., Pham, G. H., Burg, A. R., Ruff, B. P., Hershey, G. K. K., Haslam, D. B., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3305548
Faculty Opinions recommendation of An immunologic mode of multigenerational transmission governs a gut treg setpoint.
Nutt, S. L. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.737934649.793578393
MicroRNA-143-3p alleviates murine collagen-induced arthritis by polarizing naive CD4+T cells into Treg cellsPreprint
Shen, M. Y., Jiang, B. P., Zhang, M. F., Wang, X., Zhu, H., Gu, Z. N., Zhou, X. P., Lu, Y., & Ling, Z. (2021) · doi:10.22541/au.162073400.01684976/v1
Faculty Opinions recommendation of Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Caspi, R. R., & Salvador, R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735551059.793563666
Faculty Opinions recommendation of Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Saas, P., & Perruche, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735551059.793564474
Faculty Opinions recommendation of The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Saas, P., & Daguindau, É. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734959099.793559386
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prismPreprint
Nakonechnaya, T. O., Moltedo, B., Putintseva, E. V., Leyn, S., Bolotin, D. A., Britanova, O. V., Shugay, M., & Chudakov, D. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.15.544726
Blimp-1 and c-Maf regulate common and unique gene networks to protect against distinct pathways of pathobiont-induced colitisPreprint
Alvarez-Martinez, M., Cox, L. S., Pearson, C. F., Branchett, W. J., Chakravarty, P., Wu, X., Slawinski, H., Al‐Dibouni, A., Samelis, V. A., Gabryšová, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.14.557705
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prismPreprint
Nakonechnaya, T. O., Moltedo, B., Putintseva, E. V., Leyn, S., Bolotin, D. A., Britanova, O. V., Shugay, M., & Chudakov, D. M. (2023) · eLife · doi:10.7554/elife.89382.1
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prismPreprint
Nakonechnaya, T. O., Moltedo, B., Putintseva, E. V., Leyn, S., Bolotin, D. A., Britanova, O. V., Shugay, M., & Chudakov, D. M. (2024) · eLife · doi:10.7554/elife.89382.2
Oligodeoxynucleotides containing CpG motifs (CpG‐ODN) restores immune regulatory functions of airway macrophages of patients with asthma
Zhang, H., Wang, L., Zhang, A., Wang, X., Liao, Y., Chen, X., Xu, X., Yang, L., Liu, Y., Tang, A., et al. (2024) · Immunology · doi:10.1111/imm.13792
A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in micePreprint
Pathak, S., Hogan, T. V., Rane, S., Huang, Y., Sinclair, C., Barry, S., Carnevalli, L. S., Yates, A. J., & Seddon, B. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.10.602914
Development of Regulatory T Cells in the Thymus and Periphery
van der Veeken, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00093-4
Virus-induced perturbations in the mouse microbiome are impacted by microbial experience
Roach, S. N., Phillips, W., Pross, L. M., Sanders, A. E., Pierson, M. J., Hunter, R. C., & Langlois, R. A. (2025) · mSphere · doi:10.1128/msphere.00563-24 · Cited by 1
Immune phenotype-guided identification of disease-associated pathobionts in Crohn’s diseasePreprint
Nagao‐Kitamoto, H., Sugihara, K., Kitamoto, S., Ebihara, S., Kim, Y., Newman, K. L., Alonso, U. A., Suzuki, T., Kioi, Y., Yunesi, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.01.646605
The role of the T helper 17 and T regulatory cell ratio in the gut-thyroid axis
Williams, J., Melén, A. G., & Barrow, M. (2025) · Clinical Immunology Communications · doi:10.1016/j.clicom.2025.06.002
Differential susceptibility to colonic ulceration in mice with genetic deletion of Prostaglandin E synthasePreprint
Nakanishi, M., Martinez, M. J., Sztachelski, P., Leclerc, M., & Rosenberg, D. W. (2025) · Research Square · doi:10.21203/rs.3.rs-6977322/v1
Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunityPreprint
Colson, T. R., Cameron, J. J., Muendlein, H. I., Nolan, M.-A., Leiriao, J. L., Kim, J. H., Poltorak, A. N., & Li, X. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.24.665398
Immunometabolism Governs T Cell Immunity
Raynor, J. L., Shi, H., & Chi, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00275-1
Foxp3 and BATF cooperatively direct cis -regulatory programs and gene expression for functional differentiation of Treg cellsPreprint
Murakami, R., Hayatsu, N., Miyao, T., Liu, Z., Shibata, S., Matsuda, M., Iizuka, Y., Yoshida, H., Hasegawa, Y., Ise, W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.13.669552
A Novel Approach of T Cell Receptor Classification Reveals Dynamic Interactions Amongst Diet, Microbiota, and Host T Cells
Jung, J., & Yi, J. (2025) · Immune Network · doi:10.4110/in.2025.25.e27
Helicobacter hepaticus CdtB promoted brain impairment in BALB/c mice via gut-brain axis
Zhang, Y., Yang, L., Wang, Y., Yin, J., Wang, T., Zhu, L., & Zhang, Q. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00745-w
Foreign epitope–specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope
Krueger, P. D., Osum, K. C., Fife, B. T., & Jenkins, M. K. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf254
The murine intestinal pathobiont Helicobacter hepaticus attenuates DSS colitis in a CD4+ T cell-dependent mannerPreprint
Heawood, A. L. L., Ahlback, A., Frede, A., Li, X., McGuinness, D. H., Cole, J. J., Tshivolo, T. R., Webster, H. C., & Maloy, K. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.29.685394
Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiationPreprint
Carroll, S. L., Ly, A., Liu, A. K., Canesso, M. C. C., Victora, G. D., Mucida, D., & Barton, G. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.04.686414
Chlamydia muridarum Infection Impacts Murine Models of Intestinal Inflammation and Cancer
Leung, G., Carrasco, S. E., Mourino, A. J., Aydın, M., Mammone, R. M., Sonnenberg, G. F., Diehl, G. E., Artis, D., Yano, H., Arbona, R. J. R., et al. (2025) · Journal of the American Association for Laboratory Animal Science · doi:10.30802/aalas-jaalas-25-078
Additional file 2 of Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation
Tsou, A. M., Goettel, J. A., Bao, B., Biswas, A., Kang, Y. H., Redhu, N. S., Peng, K., Putzel, G., Saltzman, J. S., Kelly, R., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16928817
Additional file 1 of Gut microbiota modulates bleomycin-induced acute lung injury response in mice
Yoon, Y. M., Hrusch, C. L., Fei, N., Barrón, G. M., Mills, K. A. M., Hollinger, M. K., Velez, T. E., Leone, V. A., Chang, E. B., & Sperling, A. I. (2023) · Figshare · doi:10.6084/m9.figshare.22610935
An elementary model of homeostasis and immunity that generates symbiosisPreprint
Eberl, G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.15.695950
TCR signal strength determines T reg instability and discrimination of self versus non-self antigensPreprint
Li, L., Guo, J. F., He, R., Chai, X., Guo, C., Xu, W., Cao, X. L., Jin, Q., Zhang, F., Hou, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.12.705537
A Study on the Role of the Intestinal MAdCAM-1/alpha4beta7 Axis in Tumor Immunosurveillance During PD-1 Blockade
Rauber, C. (2019) · theses.fr (ABES) · doi:10.70675/5fb4cecbz179az43d6z9448zfb2d158b7f02
Signature moléculaire des lymphocytes B régulateurs en physiologie et en pathologie
Grasseau, A. (2020) · doi:10.70675/8cd4f580za2b1z4a35z8c3fz199055e7f4b3
Etude du rôle de la signalisation du TGF-beta au sein des lymphocytes T dans la tolérance au microbiote intestinal
Benech, N. (2021) · theses.fr (ABES) · doi:10.70675/1b31a851z0f22z458ez95d5z183bb456b0ea
Dynamique de la réponse immunitaire au cours du traitement par anticorps bloquant PD-1 dans le cancer : mécanismes et recherche de biomarqueurs
Goubet, A. (2021) · theses.fr (ABES) · doi:10.70675/8b8c4cd9z2b3dz4bfbz87e8z0d21af425571
Gut microbiota-related biomarkers in immuno-oncology
Silva, C. A. C. (2023) · theses.fr (ABES) · doi:10.70675/9022496ez0bbbz4f94z9760z4ae0a6ee5e7a
Microscopie électronique à balayage appliquée en microbiologie clinique : le grand retour !
Haddad, G. (2022) · theses.fr (ABES) · doi:10.70675/0fdc30ffz897az4e11z8b14z2ad50de7751c
Peyer’s patch immune response during malnutrition and infection by Salmonella enterica Typhimurium
Hidalgo-Villeda, F. (2022) · theses.fr (ABES) · doi:10.70675/981ec17dz4d78z44e3za178zc9a677670d20
Prévention de l’inflammation chronique associée aux cancers intestinaux par l’action du TGF-β sur les lymphocytes T RORγtpos
Thevin, V. (2024) · theses.fr (ABES) · doi:10.70675/5e2f8221z1d95z45acz9e89z3bc81dc0ad9a
T Cell Clonal Groups are Broadly Dispersed in Colon, Phenotypically Diverse, and Altered in Ulcerative ColitisPreprint
Fischer, J., Spindler, M. P., Britton, G. J., Weiler, J., Tankelevich, M., Dai, D. S., Canales-Herrerías, P., Jha, D., Rajpal, U., Mehandru, S., et al. (2026) · medRxiv · doi:10.64898/2026.04.10.26350469
B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine
Lyu, M., & Sonnenberg, G. F. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20251094
In vitro generation of RORγt+ regulatory T cells reveals enhanced immunosuppressive function and OXPHOS-dependent metabolism
Cipelli, M., da Silva, E. M., Paredes, L. C., do Amaral, M. A., Padovani, B. N., Menezes-Silva, L., Andrade‐Oliveira, V., & Câmara, N. O. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1742866
Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota
Yi, J. (2026) · International Reviews of Immunology · doi:10.1080/08830185.2026.2677909
Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses
Saad, M., Thoms, A., Yin, Y. S., Mamede, I., Rahman, A., Chen, R., Carrasco, S. E., Darcy, P. W., Goto, N., Tavazoie, S. F., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20261199
Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy
Weingarden, A. R., Dahlberg, F., Broude, C. N., Meng, X., Jain, S., Weakley, A. M., Cabrera, A. V., Dileepan, T., Fischbach, M. A., & Jenkins, M. K. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag172
Novel attenuating intestinal oxidative stress strategy: Selenium nanoparticles combined with curcumin impeding the endoplasmic reticulum stress & apoptotic pathways
Sun, Z.-Y., Lu, L., Li, S.-N., Li, R.-C., Kong, L.-Q., & Zuo, R.-N. (2026) · PharmaNutrition · doi:10.1016/j.phanu.2026.100530
Mucosal immunity: mechanism and application in cancer immunotherapy
Xu, M., Xia, R., Wei, Y., Peng, X., & Wei, X. (2026) · Journal of Hematology & Oncology · doi:10.1186/s13045-026-01829-z
Self-citation
Microbiome and Gut Immunity: T Cells
Palatella, M., Wagner, S., Busch, D. H., & Huehn, J. (2026) · Springer eBooks · doi:10.1007/978-3-032-26410-7_9
Regulatory T cell heterogeneity: who they are, where they come from, and where they go
Yang, F., Ikeda, Y., Guo, Z., & Bednar, K. J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1929923
A microbiome-reactive TMIGD2hi Th17 subset is spatially enriched at the intestinal epithelium and expanded in inflammatory bowel disease
Pedersen, T. K., Jain, T., Segerstolpe, Å., Lin, C., Shih, A. R., Yuan, L., Ashenberg, O., Kaper, M. E., Twardus, S. W., Ricciardi, R., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.09.026

Authors: Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Harrison, O. J., Galan, C., Belkaid, Y., Bonneau, R., & Littman, D. R.
Affiliations: New York University (US)
University of Rochester Medicine (US)
Courant Institute of Mathematical Sciences (US)
Howard Hughes Medical Institute (US)
National Institutes of Health (US)
Corresponding author: Littman, Dan R.
ORCID: Pokrovskii, Maria
Ding, Yi
Yi, Ren
Harrison, Oliver J.
Galan, Carolina
Belkaid, Yasmine
Bonneau, Richard
Littman, Dan R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-02
Volume: 554
Issue: 7692
Pages: 373-377
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature25500
PMC: PMC5814346
OpenAlex: W2786985471
Cited by: 498
References: 50
Citations by year: 2026: 33 · 2025: 63 · 2024: 45 · 2023: 66 · 2022: 64 · 2021: 64 · 2020: 65 · 2019: 66 · 2018: 32
FWCI: 24.38
Type: journal article
Language: en
Update notices: correction (2019-02-05)
Open access: green
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Cancer Research Institute
National Institutes of Health (1s10od018338-01, 1s10od010584-01a1)
School of Medicine, New York University (P30CA016087)
National Cancer Institute (P30CA016087)
National Institute of Allergy and Infectious Diseases (T32AI100853)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103358)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: c-Maf, regulatory T cells, Helicobacter hepaticus, pathobionts, inflammatory bowel disease, Th17 cells, IL-10, RORγt, Foxp3, gut microbiota, immune tolerance, commensal bacteria, spontaneous colitis, IL-10-deficient mice, microbiota-targeted therapy
MeSH terms: Animals, Colitis, Female, Homeostasis, Immune Tolerance, Intestines, Male, Interleukin-10, Helicobacter hepaticus, T-Lymphocytes, Regulatory, Proto-Oncogene Proteins c-maf, Mice, Forkhead Transcription Factors, Host-Pathogen Interactions, Bioengineering, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks