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c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
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Abstract
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune diseases. There is accumulating evidence that microbial species that potentiate chronic inflammation, as in inflammatory bowel disease, often also colonize healthy individuals. These microorganisms, including the Helicobacter species, can induce pathogenic T cells and are collectively referred to as pathobionts. However, how such T cells are constrained in healthy individuals is not yet understood. Here we report that host tolerance to a potentially pathogenic bacterium, Helicobacter hepaticus, is mediated by the induction of RORγt+FOXP3+ regulatory T (iT reg) cells that selectively restrain pro-inflammatory T helper 17 (T H 17) cells and whose function is dependent on the transcription factor c-MAF. Whereas colonization of wild-type mice by H. hepaticus promoted differentiation of RORγt-expressing microorganism-specific iT reg cells in the large intestine, in disease-susceptible IL-10-deficient mice, there was instead expansion of colitogenic T H 17 cells. Inactivation of c-MAF in the T reg cell compartment impaired differentiation and function, including IL-10 production, of bacteria-specific iT reg cells, and resulted in the accumulation of H. hepaticus-specific inflammatory T H 17 cells and spontaneous colitis. By contrast, RORγt inactivation in T reg cells had only a minor effect on the bacteria-specific T reg and T H 17 cell balance, and did not result in inflammation. Our results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iT reg-T H 17 homeostasis.
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“This conclusion is further supported by the findings that GM-CSF+ T cells co-express a great variety of other cytokines including IL-2, IL-3, IL-4, IL-6, IL-13, IL-17A, IL-22, IFNγ, and TNF [33, 36, 76, 175].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [33]
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“Hence, we propose GM-CSF expression as part of a general pathogenic program together with other pro-inflammatory molecules such as BHLHE40, IFNγ, and CXCR6 that can be induced across multiple T helper cell subsets [33, 38, 177].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [33]
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Self-citationPhenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1×
“HH-E2 tetramer was kindly produced by the NIH Tetramer Core Facility 37 .”
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
Read, S., Malmström, V., & Powrie, F. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,206
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Song, X., Sun, X., Oh, S. F., Wu, M., Zhang, Y., Zheng, W., Geva-Zatorsky, N., Jupp, R., Mathis, D., Benoist, C., et al. (2020) · Nature · doi:10.1038/s41586-019-1865-0 · Cited by 1,024
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Kitamoto, S., Nagao‐Kitamoto, H., Jiao, Y., Gillilland, M. G., Hayashi, A., Imai, J., Sugihara, K., Miyoshi, M., Brazil, J. C., Kuffa, P., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.048 · Cited by 703
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Ansaldo, E., Slayden, L. C., Ching, K. L., Koch, M. A., Wolf, N. K., Plichta, D. R., Brown, E. M., Graham, D. B., Xavier, R. J., Moon, J. J., et al. (2019) · Science · doi:10.1126/science.aaw7479 · Cited by 566
Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549
Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)
Ratajczak, W., Rył, A., Mizerski, A., Walczakiewicz, K., Sipak‐Szmigiel, O., & Laszczyńska, M. (2019) · Acta Biochimica Polonica · doi:10.18388/abp.2018_2648 · Cited by 542
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Wheeler, M. A., Clark, I. C., Tjon, E. C., Li, Z., Zandee, S. E. J., Couturier, C. P., Watson, B. R., Scalisi, G., Alkwai, S., Rothhammer, V., et al. (2020) · Nature · doi:10.1038/s41586-020-1999-0 · Cited by 501
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Moschen, A. R., Tilg, H., & Raine, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0084-8 · Cited by 488
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Lee, J., Hall, J. A., Kroehling, L., Wu, L., Najar, T. A., Nguyen, H. H., Lin, W.-Y., Yeung, S. T., Silva, H. M., Li, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.026 · Cited by 476
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Esterházy, D., Canesso, M. C. C., Mesin, L., Muller, P. A., Castro, T. B. R., Lockhart, A. A. K., Eljalby, M., Faria, A. M. C., & Mucida, D. (2019) · Nature · doi:10.1038/s41586-019-1125-3 · Cited by 326
Savage, P. A., Klawon, D. E. J., & Miller, C. H. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100219-020937 · Cited by 321
Overacre-Delgoffe, A. E., Bumgarner, H. J., Cillo, A. R., Burr, A. H. P., Tometich, J. T., Bhattacharjee, A., Bruno, T. C., Vignali, D. A. A., & Hand, T. W. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.003 · Cited by 318
Plichta, D. R., Graham, D. B., Subramanian, S., & Xavier, R. J. (2019) · Cell · doi:10.1016/j.cell.2019.07.045 · Cited by 316
The microbiome in threatened species conservation
West, A. G., Waite, D. W., Deines, P., Bourne, D. G., Digby, A., McKenzie, V. J., & Taylor, M. W. (2018) · Biological Conservation · doi:10.1016/j.biocon.2018.11.016 · Cited by 324
Mining the microbiota for microbial and metabolite-based immunotherapies
Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306
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Ansaldo, E., Farley, T. K., & Belkaid, Y. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-112348 · Cited by 312
Self-citationILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Lyu, M., Suzuki, H., Kang, L., Gaspal, F., Zhou, W., Goc, J., Zhou, L., Zhou, J., Zhang, W., Bank, J. L. C., et al. (2022) · Nature · doi:10.1038/s41586-022-05141-x · Cited by 304
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Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286
Self-citationIntestinal epithelial cells: At the interface of the microbiota and mucosal immunity
Soderholm, A. T., & Pedicord, V. A. (2019) · Immunology · doi:10.1111/imm.13117 · Cited by 281
Chen, Y., Cui, W., Xiao, L., & Yang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.761981 · Cited by 293
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Akagbosu, B., Tayyebi, Z., Shibu, G., Paucar Iza, Y. A., Deep, D., Parisotto, Y. F., Fisher, L., Pasolli, H. A., Thevin, V., Elmentaite, R., et al. (2022) · Nature · doi:10.1038/s41586-022-05309-5 · Cited by 273
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
Imam, T., Park, S., Kaplan, M. H., & Olson, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01212 · Cited by 280
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Liu, S., Zhao, W., Lan, P., & Mou, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00745-3 · Cited by 279
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Kedmi, R., Najar, T. A., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M. V., Xu, M., Talbot, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05089-y · Cited by 270
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Zhang, Z., Tang, H., Chen, P., Xie, H., & Tao, Y. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0074-5 · Cited by 263
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Moreau, J. M., Velegraki, M., Bolyard, C. M., Rosenblum, M. D., & Li, Z. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi4613 · Cited by 260
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Fung, T. C. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104714 · Cited by 234
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Wei, H.-X., Wang, B., & Li, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01315 · Cited by 218
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Shi, H., & Chi, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02716 · Cited by 211
Buret, A. G., Motta, J., Allain, T., Ferraz, J. G., & Wallace, J. L. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-018-0495-4 · Cited by 213
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Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 222
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Neumann, C., Scheffold, A., & Rutz, S. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101344 · Cited by 211
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Chen, Y. E., Bousbaine, D., Veinbachs, A., Atabakhsh, K., Dimas, A., Yu, V. K., Zhao, A., Enright, N. J., Nagashima, K., Belkaid, Y., et al. (2023) · Science · doi:10.1126/science.abp9563 · Cited by 191
Self-citationProfound Treg perturbations correlate with COVID-19 severity
Galván-Peña, S., Léon, J., Chowdhary, K., Michelson, D. A., Vijaykumar, B., Yang, L., Magnuson, A. M., Chen, F., Manickas-Hill, Z., Trocha, A. K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111315118 · Cited by 189
Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00986-0 · Cited by 187
Neumann, C., Blume, J., Roy, U., Teh, P. P., Vasanthakumar, A., Beller, A. V., Liao, Y., Heinrich, F., Arenzana, T. L., Hackney, J. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0316-2 · Cited by 179
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Ramanan, D., Sefik, E., Galván-Peña, S., Wu, M., Yang, L., Yang, Z., Kostic, A. D., Golovkina, T. V., Kasper, D. L., Mathis, D. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.030 · Cited by 179
Ladinsky, M. S., Araújo, L. P., Zhang, X., Veltri, J., Galán-Díez, M., Soualhi, S., Lee, C., Irie, K., Pinker, E. Y., Narushima, S., et al. (2019) · Science · doi:10.1126/science.aat4042 · Cited by 176
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Yan, Y., Ramanan, D., Rozenberg, M., McGovern, K., Rastelli, D., Vijaykumar, B., Yaghi, O., Voisin, T., Mosaheb, M., Chiu, I., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.002 · Cited by 165
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Zuberbuehler, M. K., Parker, M. E., Wheaton, J. D., Espinosa, J. R., Salzler, H. R., Park, E., & Ciofani, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0274-0 · Cited by 138
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Perucha, E., Melchiotti, R., Bibby, J. A., Wu, W. H., Frederiksen, K. S., Roberts, C. A., Hall, Z., Friec, G. L., Robertson, K. A., Lavender, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08332-9 · Cited by 132
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Miyamoto, Y., Kikuta, J., Matsui, T., Hasegawa, T., Fujii, K., Okuzaki, D., Liu, Y.-C., Yoshioka, T., Seno, S., Motooka, D., et al. (2024) · Nature · doi:10.1038/s41586-024-07372-6 · Cited by 135
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Trujillo-Ochoa, J. L., Kazemian, M., & Afzali, B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00893-7 · Cited by 142
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Advances and novel developments in mechanisms of allergic inflammation
Han, X., Krempski, J. W., & Nadeau, K. (2020) · Allergy · doi:10.1111/all.14632 · Cited by 129
Regulatory T cells in the face of the intestinal microbiota
Ramanan, D., Pratama, A., Zhu, Y., Venezia, O., Sassone-Corsi, M., Chowdhary, K., Galván-Peña, S., Sefik, E., Brown, C., Gélineau, A., et al. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00890-w · Cited by 126
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Hanna, B. S., Wang, G., Galván-Peña, S., Mann, A. O., Ramirez, R. N., Muñoz-Rojas, A. R., Smith, K., Wan, M., Benoist, C., & Mathis, D. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.033 · Cited by 126
Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease
Zhang, W., Liu, X., Zhu, Y., Liu, X., Gu, Y., Dai, X., & Li, B. (2021) · European Journal of Immunology · doi:10.1002/eji.202048794 · Cited by 130
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Ivanov, I. I., Tuganbaev, T., Skelly, A. N., & Honda, K. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011829 · Cited by 133
Gut Microbiota-Kidney Cross-Talk in Acute Kidney Injury
Gong, J., Noel, S., Pluznick, J. L., Hamad, A. R. A., & Rabb, H. (2018) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2018.10.009 · Cited by 119
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Wu, L., Hollinshead, K. E. R., Hao, Y., Au, C., Kroehling, L., Ng, C., Lin, W.-Y., Li, D., Silva, H. M., Shin, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.014 · Cited by 119
Self-citationCampbell, C., Dikiy, S., Bhattarai, S. K., Chinen, T., Matheis, F., Calafiore, M., Hoyos, B. E., Hanash, A. M., Mucida, D., Bucci, V., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.013 · Cited by 121
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Lu, L., Chen, X., Liu, Y., & Yu, X. (2021) · The FASEB Journal · doi:10.1096/fj.202100451r · Cited by 127
Sivasami, P., Elkins, C. M., Diaz-Saldana, P. P., Goss, K. L., Peng, A. C.-Y., Hamersky, M., Bae, J., Xu, M., Pollack, B. P., Horwitz, E. M., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.021 · Cited by 121
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Faustino, L., Griffith, J. W., Rahimi, R. A., Nepal, K., Hamilos, D. L., Cho, J. L., Medoff, B. D., Moon, J. J., Vignali, D. A. A., & Luster, A. D. (2020) · Nature Immunology · doi:10.1038/s41590-020-0785-3 · Cited by 121
Bernshtein, B., Curato, C., Ιωάννου, Μ., Thaiss, C. A., Gross-Vered, M., Kolesnikov, M., Wang, Q., David, E., Chappell‐Maor, L., Harmelin, A., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau6571 · Cited by 116
Brockmann, L., Tran, A., Huang, Y., Edwards, M., Ronda, C., Wang, H. H., & Ivanov, I. I. (2023) · Immunity · doi:10.1016/j.immuni.2023.11.003 · Cited by 115
Wegorzewska, M. M., Glowacki, R. W. P., Hsieh, S. A., Donermeyer, D. L., Hickey, C. A., Horvath, S. C., Martens, E. C., Stappenbeck, T. S., & Allen, P. M. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau9079 · Cited by 107
Liu, Q., Zhu, F., Liu, X., Lu, Y., Yao, K., Tian, N., Tong, L., Figge, D. A., Wang, X., Han, Y., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00575-z · Cited by 122
Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer
Brevi, A., Cogrossi, L. L., Grazia, G., Masciovecchio, D., Impellizzieri, D., Lacanfora, L., Grioni, M., & Bellone, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.565470 · Cited by 114
Britton, G. J., Contijoch, E. J., Spindler, M. P., Aggarwala, V., Dogan, B., Bongers, G., Mateo, L. S., Baltus, A. E., Das, A., Gevers, D., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922189117 · Cited by 106
Lo, B. C., Kryczek, I., Yu, J., Vatan, L., Caruso, R., Matsumoto, M., Sato, Y., Shaw, M. H., Inohara, N., Xie, Y., et al. (2024) · Science · doi:10.1126/science.adh8342 · Cited by 114
Unexpected Help: Follicular Regulatory T Cells in the Germinal Center
Xie, M. M., & Dent, A. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01536 · Cited by 110
The Many Functions of Foxp3+ Regulatory T Cells in the Intestine
Cosovanu, C., & Neumann, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.600973 · Cited by 109
The metabolic, protective, and immune functions of Akkermansia muciniphila
Ghotaslou, R., Nabizadeh, E., Memar, M. Y., Law, W. M. H., Ozma, M. A., Abdi, M., Yekani, M., Kadkhoda, H., Hosseinpour, R., Bafadam, S., et al. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127245 · Cited by 111
Traxinger, B. R., Richert-Spuhler, L. E., & Lund, J. M. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00471-x · Cited by 105
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes
Bousbaine, D., Fisch, L., London, M., Bhagchandani, P., Castro, T. B. R., Mimee, M., Olesen, S. W., Reis, B. S., VanInsberghe, D., Bortolatto, J., et al. (2022) · Science · doi:10.1126/science.abg5645 · Cited by 106
Crittenden, S., Goepp, M., Pollock, J., Robb, C. T., Smyth, D. J., Zhou, Y., Andrews, R., Tyrrell, V. J., Gkikas, K., Adima, A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd7954 · Cited by 102
Understanding immune–microbiota interactions in the intestine
Ahern, P. P., & Maloy, K. J. (2019) · Immunology · doi:10.1111/imm.13150 · Cited by 106
Conditioning of the immune system by the microbiome
Graham, D. B., & Xavier, R. J. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.05.002 · Cited by 103
Dietary and Microbial Determinants in Food Allergy
Victor, E. S., Crestani, E., & Chatila, T. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.025 · Cited by 101
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
Aschenbrenner, D., Foglierini, M., Jarrossay, D., Hu, D., Weiner, H. L., Kuchroo, V. K., Lanzavecchia, A., Notarbartolo, S., & Sallusto, F. (2018) · Nature Immunology · doi:10.1038/s41590-018-0200-5 · Cited by 101
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease
Lee, J., Hall, J. A., Kroehling, L., Wu, L., Najar, T. A., Nguyen, H. H., Lin, W.-Y., Yeung, S. T., Silva, H. M., Li, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.12.008 · Cited by 95
Self-citationRegulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Hu, W., Wang, Z.-M., Feng, Y., Schizas, M., Hoyos, B. E., van der Veeken, J., Verter, J. G., Bou-Puerto, R., & Rudensky, A. Y. (2021) · Nature Immunology · doi:10.1038/s41590-021-01001-4 · Cited by 95
van der Veeken, J., Campbell, C., Pritykin, Y., Schizas, M., Verter, J. G., Hu, W., Wang, Z.-M., Matheis, F., Mucida, D., Charbonnier, L., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.05.010 · Cited by 95
Pokrovskii, M. V., Hall, J. A., Ochayon, D. E., Yi, R., Chaimowitz, N. S., Seelamneni, H., Carriero, N. J., Watters, A., Waggoner, S. N., Littman, D. R., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.001 · Cited by 97
Self-citationThe Gut–CNS Axis in Multiple Sclerosis
Kadowaki, A., & Quintana, F. J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.002 · Cited by 95
Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108433 · Cited by 91
Distribution and storage of inflammatory memory in barrier tissues
Ordovás-Montañés, J., Beyaz, S., Rakoff-Nahoum, S., & Shalek, A. K. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0263-z · Cited by 94
Role of orally induced regulatory T cells in immunotherapy and tolerance
Bertolini, T. B., Biswas, M., Terhorst, C., Daniell, H., Herzog, R. W., & Piñeros, A. R. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104251 · Cited by 89
Pawlak, M., Ho, A. W., & Kuchroo, V. K. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.09.001 · Cited by 93
Metadata
- Authors
- Xu, M., Pokrovskii, M., Ding, Y., Yi, R., Au, C., Harrison, O. J., Galan, C., Belkaid, Y., Bonneau, R., & Littman, D. R.
- Affiliations
- New York University (US)
- University of Rochester Medicine (US)
- Courant Institute of Mathematical Sciences (US)
- Howard Hughes Medical Institute (US)
- National Institutes of Health (US)
- Corresponding author
- Littman, Dan R.
- ORCID
- Venue
- Nature
- Published
- 2018-02
- Volume
- 554
- Issue
- 7692
- Pages
- 373-377
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5814346
- OpenAlex
- W2786985471
- Cited by
- 498
- References
- 50
- Citations by year
- 2026: 33 · 2025: 63 · 2024: 45 · 2023: 66 · 2022: 64 · 2021: 64 · 2020: 65 · 2019: 66 · 2018: 32
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-02-05)
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Cancer Research Institute
- National Institutes of Health (1s10od018338-01, 1s10od010584-01a1)
- School of Medicine, New York University (P30CA016087)
- National Cancer Institute (P30CA016087)
- National Institute of Allergy and Infectious Diseases (T32AI100853)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK103358)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- c-Maf, regulatory T cells, Helicobacter hepaticus, pathobionts, inflammatory bowel disease, Th17 cells, IL-10, RORγt, Foxp3, gut microbiota, immune tolerance, commensal bacteria, spontaneous colitis, IL-10-deficient mice, microbiota-targeted therapy
- MeSH terms
- Animals, Colitis, Female, Homeostasis, Immune Tolerance, Intestines, Male, Interleukin-10, Helicobacter hepaticus, T-Lymphocytes, Regulatory, Proto-Oncogene Proteins c-maf, Mice, Forkhead Transcription Factors, Host-Pathogen Interactions, Bioengineering, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells
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