Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310

Reprogramming of human somatic cells to pluripotency with defined factors

Park, I.-H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., & Daley, G. Q. (2008) · Nature · doi:10.1038/nature06534 · Cited by 2,436

Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

Laflamme, M. A., Chen, K. Y., Naumova, A. V., Muskheli, V., Fugate, J. A., Dupras, S. K., Reinecke, H., Xu, C., Hassanipour, M., Police, S., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1327 · Cited by 2,235

New cell lines from mouse epiblast share defining features with human embryonic stem cells

Tesar, P. J., Chenoweth, J. G., Brook, F. A., Davies, T. J., Evans, E. P., Mack, D. L., Gardner, R. L., & McKay, R. D. G. (2007) · Nature · doi:10.1038/nature05972 · Cited by 2,187

A ROCK inhibitor permits survival of dissociated human embryonic stem cells

Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J. B., Nishikawa, S., Nishikawa, S.-I., Muguruma, K., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1310 · Cited by 2,055

Efficient differentiation of human embryonic stem cells to definitive endoderm

D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730

Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity

Kawasaki, H., Mizuseki, K., Nishikawa, S., Kaneko, S., Kuwana, Y., Nakanishi, S., Nishikawa, S., & Sasai, Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00083-0 · Cited by 1,277

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

Smith, W. C., & Harland, R. M. (1992) · Cell · doi:10.1016/0092-8674(92)90316-5 · Cited by 1,184

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

Sasai, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,122

New neurons in adult brain: distribution, molecular mechanisms and therapies

Pino, A., Fumagalli, G. F., Bifari, F., & Decimo, I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.003 · Cited by 83

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects

Balmer, N. V., Klima, S., Rempel, E., Ivanova, V. N., Kolde, R., Weng, M. K., Meganathan, K., Henry, M., Sachinidis, A., Berthold, M. R., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1279-6 · Cited by 77

New Approaches in the Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Hepatocytes

Behbahan, I. S., Duan, Y., Lam, A., Khoobyari, S., Ma, X., Ahuja, T. P., & Zern, M. Α. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9216-4 · Cited by 77

JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

Shan, Y., Zhang, Y., Zhao, Y., Wang, T., Zhang, J., Jiao, Y., Ma, N., Liang, Z., Huang, W., Huang, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14028-x · Cited by 78

Pax6 Interactions with Chromatin and Identification of Its Novel Direct Target Genes in Lens and Forebrain

Xie, Q. M., Yang, Y., Huang, J., Ninkovic, J., Walcher, T., Wolf, L. V., Vitenzon, A., Zheng, D., Götz, M., Beebe, D. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054507 · Cited by 79

N-butylidenephthalide Attenuates Alzheimer's Disease-Like Cytopathy in Down Syndrome Induced Pluripotent Stem Cell-Derived Neurons

Chang, C., Chen, S.-M., Lu, H.-E., Lai, S.-M., Lai, P., Shen, P.-W., Chen, P.-Y., Shen, C.-I., Harn, H., Lin, S., et al. (2015) · Scientific Reports · doi:10.1038/srep08744 · Cited by 79

Early Acquisition of Neural Crest Competence During hESCs Neuralization

Curchoe, C. L., Maurer, J., McKeown, S. J., Cattarossi, G., Cimadamore, F., Nilbratt, M., Snyder, E. Y., Bronner-Fraser, M. E., & Terskikh, A. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013890 · Cited by 82

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells

Najm, F. J., Zaremba, A., Caprariello, A. V., Nayak, S., Freundt, E. C., Scacheri, P. C., Miller, R. H., & Tesar, P. J. (2011) · Nature Methods · doi:10.1038/nmeth.1712 · Cited by 80

Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity

Lee, J., Mitchell, R. R., McNicol, J. D., Shapovalova, Z., Laronde, S., Tanasijevic, B., Milsom, C., Casado, F. L., Fiebig‐Comyn, A., Collins, T. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.056 · Cited by 77

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

Wamaitha, S. E., Grybel, K. J., Alanis‐Lobato, G., Gerri, C., Ogushi, S., McCarthy, A., Mahadevaiah, S. K., Healy, L. E., Lea, R. A., Molina‐Arcas, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14629-x · Cited by 76

Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells

Shen, M., Quertermous, T., Fischbein, M. P., & Wu, J. C. (2021) · Circulation Research · doi:10.1161/circresaha.120.318049 · Cited by 78

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Lee, H.-J., Lee, J. J., Park, N.-Y., Dubey, S. K., Kim, T.-Y., Ruan, K., Lim, S. B., Park, S., Ha, S., Kovlyagina, I., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00944-z · Cited by 79

Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay

Höing, S., Rudhard, Y., Reinhardt, P., Glatza, M., Stehling, M., Wu, G., Peiker, C., Böcker, A., Parga, J. A., Bunk, E. C., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.07.005 · Cited by 77

Neural differentiation from embryonic stem cellsin vitro: An overview of the signaling pathways

Chuang, J.-H. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i2.437 · Cited by 77

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro

Hofrichter, M., Nimtz, L., Tigges, J., Kabiri, Y., Schröter, F., Royer‐Pokora, B., Hildebrandt, B., Schmuck, M. R., Epanchintsev, A., Theiss, S., et al. (2017) · Stem Cell Research · doi:10.1016/j.scr.2017.10.013 · Cited by 77

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells

Nakajima, T., Shibata, M., Nishio, M., Nagata, S., Alev, C., Sakurai, H., Toguchida, J., & Ikeya, M. (2018) · Development · doi:10.1242/dev.165431 · Cited by 82

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function

Lai, F. P.-L., Lau, S.-T., Wong, J., Gui, H., Wang, R. X., Zhou, T., Lai, W. H., Tse, H., Tam, P. K. H., Garcia-Barcelo, M.-M., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.014 · Cited by 77

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

Giordano, A. M. S., Luciani, M., Gatto, F., Abou Alezz, M., Beghè, C., Della Volpe, L., Migliara, A., Valsoni, S., Genua, M., Dzieciatkowska, M., et al. (2022) · Journal of Experimental Medicine · doi:10.1084/jem.20211121 · Cited by 76

A Transcriptional Roadmap to the Induction of Pluripotency in Somatic Cells

Wang, Y., Mah, N., Prigione, A., Wolfrum, K., Andrade-Navarro, M. A., & Adjaye, J. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9137-2 · Cited by 76

Directed Differentiation of Human Embryonic Stem Cells Toward Placode-Derived Spiral Ganglion-Like Sensory Neurons

Matsuoka, A. J., Morrissey, Z. D., Zhang, C., Homma, K., Belmadani, A. A., Miller, C. A., Chadly, D. M., Kobayashi, S., Edelbrock, A. N., Tanaka‐Matakatsu, M., et al. (2016) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0032 · Cited by 79

Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro

Chal, J., Tanoury, Z. A., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., Tassy, O., Guevara, G., Hubaud, A., Bera, A. N., et al. (2018) · Development · doi:10.1242/dev.157339 · Cited by 76

A novel self-organizing embryonic stem cell system reveals signaling logic underlying the patterning of human ectoderm

Britton, G., Heemskerk, I., Hodge, R. A., Qutub, A. A., & Warmflash, A. (2019) · Development · doi:10.1242/dev.179093 · Cited by 80

Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors

Nogueira, D. E. S., Rodrigues, C. A. V., Carvalho, M. S., Miranda, C. C., Hashimura, Y., Jung, S., Lee, B., & Cabral, J. M. S. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0204-1 · Cited by 74

Neural Lineage Differentiation From Pluripotent Stem Cells to Mimic Human Brain Tissues

Hong, Y. J., & Tae, J. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00400 · Cited by 78

Generating human neural diversity with a multiplexed morphogen screen in organoids

Amin, N. D., Kelley, K. W., Kaganovsky, K., Onesto, M. M., Hao, J., Miura, Y., McQueen, J. P., Reis, N., Narazaki, G., Li, T., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.10.016 · Cited by 72

Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation

Zhou, S., Szczęsna, K., Ochałek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M. A., Cirera, S., Hyttel, P., et al. (2015) · Stem Cells International · doi:10.1155/2016/4937689 · Cited by 82

Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development

Fuller, H. R., Mandefro, B., Shirran, S. L., Gross, A. R., Kaus, A. S., Botting, C. H., Morris, G. E., & Sareen, D. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00506 · Cited by 78

Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy

Pramanik, S., Sulistio, Y. A., & Heese, K. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0214-7 · Cited by 77

Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ

Coulthard, L. G., Hawksworth, O. A., Li, R., Balachandran, A., Lee, J. D., Sepehrband, F., Kurniawan, N. D., Jeanes, A., Simmons, D. G., Wolvetang, E. J., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0525-17.2017 · Cited by 76

Dissolvable Microcarriers Allow Scalable Expansion And Harvesting Of Human Induced Pluripotent Stem Cells Under Xeno‐Free Conditions

Rodrigues, A. L., Rodrigues, C. A. V., Gomes, A. R., Vieira, S. F., Badenes, S. M., Diogo, M. M., & Cabral, J. M. S. (2018) · Biotechnology Journal · doi:10.1002/biot.201800461 · Cited by 75

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotencyPreprint

Yamazaki, T., Liu, L., Lazarev, D. S., Al-Zain, A., Fomin, V., Yeung, P. L., Chambers, S. M., Lu, C.-W., Studer, L., & Manley, J. L. (2018) · Genes & Development · doi:10.1101/gad.316984.118 · Cited by 76

Mechanisms of gene regulation in human embryos and pluripotent stem cells

Theunissen, T. W., & Jaenisch, R. (2017) · Development · doi:10.1242/dev.157404 · Cited by 77

Brain organoids as models to study human neocortex development and evolution

Heide, M., Huttner, W. Β., & Mora‐Bermúdez, F. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.06.006 · Cited by 77

Mutations in GFAP Disrupt the Distribution and Function of Organelles in Human Astrocytes

Jones, J. R., Kong, L., Hanna, M. G., Hoffman, B., Krencik, R., Bradley, R. A., Hagemann, T. L., Choi, J., Doers, M. E., Dubovis, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.083 · Cited by 76

Modeling neuropsychiatric disorders using human induced pluripotent stem cells

Wang, M., Zhang, L., & Gage, F. H. (2019) · Protein & Cell · doi:10.1007/s13238-019-0638-8 · Cited by 76

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

Ang, C. E., Ma, Q., Wapinski, O. L., Fan, S., Flynn, R. A., Lee, Q. Y., Coe, B. P., Onoguchi, M., Olmos, V. H., Do, B. T., et al. (2019) · eLife · doi:10.7554/elife.41770 · Cited by 76

Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

Yim, E. K. F., Jain, D., Mattiassi, S., & Goh, E. K. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266907 · Cited by 76

Stem Cells for Next Level Toxicity Testing in the 21st Century

Fritsche, E., Haarmann‐Stemmann, T., Kapr, J., Galanjuk, S., Hartmann, J., Mertens, P. R., Kämpfer, A. A. M., Schins, R. P. F., Tigges, J., & Koch, K. (2020) · Small · doi:10.1002/smll.202006252 · Cited by 78

Derivation of dopaminergic neurons from pluripotent stem cells

Studer, L. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59575-1.00011-9 · Cited by 80

A microparticle approach to morphogen delivery within pluripotent stem cell aggregates

Bratt‐Leal, A. M., Anh, N. T. V., Hammersmith, K. A., Singh, A. K., & McDevitt, T. C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.079 · Cited by 75

Programming embryonic stem cells to neuronal subtypes

Peljto, M., & Wichterle, H. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.09.012 · Cited by 75

Human Induced Pluripotent Stem Cells Improve Stroke Outcome and Reduce Secondary Degeneration in the Recipient Brain

Polentes, J., Jendelová, P., Cailleret, M., Braun, H., Romanyuk, N., Tropel, P., Brenot, M., Itier, V., Seminatore, C., Baldauf, K., et al. (2012) · Cell Transplantation · doi:10.3727/096368912x653228 · Cited by 77

Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves

Jiao, J., Xiong, W., Wang, L., Yang, J., Qiu, P., Hirai, H., Shao, L., Milewicz, D. M., Chen, Y. E., & Yang, B. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.06.045 · Cited by 77

Neural crest stem cells and their potential therapeutic applications

Liu, J. A., & Cheung, M. C. H. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.09.006 · Cited by 78

A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells

Rasmussen, M. L., Kline, L. A., Park, K. P., Ortolano, N. A., Romero-Morales, A. I., Anthony, C. C., Beckermann, K. E., & Gama, V. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.005 · Cited by 72

Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

Higuchi, A., Ling, Q., Kumar, S. S., Chang, Y., Alarfaj, A. A., Munusamy, M. A., Murugan, K., Hsu, S.-T., & Umezawa, A. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01276g · Cited by 74

Long 3′UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation

Dorrity, T. J., Shin, H., Wiegand, K. A., Aruda, J., Closser, M., Jung, E., Gertie, J. A., Leone, A., Polfer, R., Culbertson, B., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adg2979 · Cited by 76

A New Efficient Protocol for Directed Differentiation of Retinal Pigmented Epithelial Cells from Normal and Retinal Disease Induced Pluripotent Stem Cells

Zahabi, A., Shahbazi, E., Ahmadieh, H., Hassani, S., Totonchi, M., Taei, A., Masoudi, N., Ebrahimi, M., Aghdami, N., Seifinejad, A., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0599 · Cited by 80

Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states

Ohgushi, M., & Sasai, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.02.004 · Cited by 74

Chemical Conversion of Human Fibroblasts into Functional Schwann Cells

Thoma, E., Merkl, C., Heckel, T., Haab, R., Knoflach, F., Nowaczyk, C., Flint, N. A., Jagasia, R., Zoffmann, S., Truong, H., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.07.014 · Cited by 74

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells

Feyeux, M., Bourgois-Rocha, F., Redfern, A. J., Giles, P. J., Lefort, N., Aubert, S., Bonnefond, C., Bugi, A., Ruiz, M., Déglon, N., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds216 · Cited by 73

Stem Cell and Biomaterials Research in Dental Tissue Engineering and Regeneration

Horst, O. V., Chavez, M. G., Jheon, A. H., Desai, T. A., & Klein, O. D. (2012) · Dental Clinics of North America · doi:10.1016/j.cden.2012.05.009 · Cited by 74

Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway

Miyazaki, K., Dyson, M. T., Coon, J. S., Furukawa, Y., Yilmaz, B. D., Maruyama, T., & Bulun, S. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.10.002 · Cited by 73

Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format

Medda, X., Mertens, L., Versweyveld, S., Diels, A., Barnham, L., Bretteville, A., Buist, A., Verheyen, A., Royaux, I. E., Ebneth, A., et al. (2016) · SLAS DISCOVERY · doi:10.1177/1087057116638029 · Cited by 74

Human Pluripotent Stem Cell Differentiation into Authentic Striatal Projection Neurons

Carri, A. D., Onorati, M., Castiglioni, V., Faedo, A., Camnasio, S., Toselli, M., Biella, G. R., & Cattaneo, E. F. (2013) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9441-8 · Cited by 73

Systematic Review of Induced Pluripotent Stem Cell Technology as a Potential Clinical Therapy for Spinal Cord Injury

Kramer, A. S., Harvey, A. R., Plant, G. W., & Hodgetts, S. I. (2012) · Cell Transplantation · doi:10.3727/096368912x655208 · Cited by 73

Compound selection for in vitro modeling of developmental neurotoxicity

Kadereit, S. (2012) · Frontiers in bioscience · doi:10.2741/4064 · Cited by 77

Notch signaling represses p63 expression in the developing surface ectoderm

Tadeu, A. M. B., & Horsley, V. (2013) · Development · doi:10.1242/dev.093948 · Cited by 75

Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases

Hotaling, N. A., Khristov, V., Wan, Q., Sharma, R., Jha, B. S., Lotfi, M., Maminishkis, A., Simon, C. G., & Bharti, K. (2016) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2015.0157 · Cited by 73

Toward stem cell-based phenotypic screens for neurodegenerative diseases

Khurana, V., Tardiff, D. F., Chung, C. Y., & Lindquist, S. L. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.79 · Cited by 72

Parkinson's disease in a dish – Using stem cells as a molecular tool

Badger, J. L., Llana, O. C., Hartfield, E. M., & Wade‐Martins, R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.035 · Cited by 73

Using human induced pluripotent stem cells to treat retinal disease

Borooah, S., Phillips, M. J., Bilican, B., Wright, A. F., Wilmut, I., Chandran, S., Gamm, D. M., & Dhillon, B. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.09.002 · Cited by 76

AAV5-miHTT Lowers Huntingtin mRNA and Protein without Off-Target Effects in Patient-Derived Neuronal Cultures and Astrocytes

Keskin, S., Brouwers, C. C., Sogorb-González, M., Martier, R., Depla, J. A., Vallès, A., van Deventer, S. J. H., Konstantinova, P. S., & Evers, M. M. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.09.010 · Cited by 73

Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Kandel, P., Semerci, F., Mishra, R., Choi, W. T.-S., Bajić, A., Baluya, D. L., Ma, L., Chen, K., Cao, A. C., Phongmekhin, T., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023784119 · Cited by 79

Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis

Gribaudo, S., Robert, R., van Sambeek, B., Mirdass, C., Lyubimova, A., Bouhali, K., Ferent, J., Morin, X., van Oudenaarden, A., & Nedelec, S. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01956-9 · Cited by 72

A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells

Lee, H. J., Bartsch, D., Xiao, C., Guerrero, S. X., Ahuja, G., Schindler, C., Moresco, J. J., Yates, J. R., Gebauer, F., Bazzi, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01744-5 · Cited by 73

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons

Ovchinnikov, D. A., Korn, O., Virshup, I., Wells, C. A., & Wolvetang, E. J. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.05.004 · Cited by 73

Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology

Pandya, N. J., Wang, C., Costa, V., Lopatta, P., Meier, S., Zampeta, F. I., Punt, A. M., Mientjes, E., Grossen, P., Distler, T., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100360 · Cited by 71

Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins

Wrighton, P. J., Klim, J. R., Hernandez, B. A., Koonce, C. H., Kamp, T. J., & Kiessling, L. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409525111 · Cited by 71

Neural Stem Cell Niches and Homing: Recruitment and Integration into Functional Tissues

Garzón-Muvdi, T., & Quinones-Hinojosa, A. (2010) · ILAR Journal · doi:10.1093/ilar.51.1.3 · Cited by 71

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

He, Q., Wang, G., Wakade, S., Dasgupta, S., Dinkins, M. B., Kong, J. N., Spassieva, S. D., & Bieberich, E. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-12-0730 · Cited by 70

GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells

Gunne-Braden, A., Sullivan, A. E., Gharibi, B., Malik‐Sheriff, R. S., Maity, A. K., Wang, Y.-F., Edwards, A., Jiang, M., Howell, M. T., Goldstone, R. J., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.03.005 · Cited by 71

Identification of FMR1-regulated molecular networks in human neurodevelopmentPreprint

Li, M., Shin, J., Risgaard, R. D., Parries, M., Wang, J., Chasman, D. A., Liu, S., Roy, S., Bhattacharyya, A., & Zhao, X. (2020) · Genome Research · doi:10.1101/gr.251405.119 · Cited by 72

The cis-regulatory effects of modern human-specific variants

Weiss, C. V., Harshman, L., Inoue, F., Fraser, H. B., Petrov, D. A., Ahituv, N., & Gokhman, D. (2021) · eLife · doi:10.7554/elife.63713 · Cited by 70

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

Kim, D.-S., Ross, P. J., Zaslavsky, K., & Ellis, J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00109 · Cited by 70

Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting

Bowles, K. R., T. C. W., J., Qian, L., Jadow, B. M., & Goate, A. M. (2019) · PLOS ONE · doi:10.1371/journal.pone.0213374 · Cited by 54

Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases

Perenthaler, E., Nikoncuk, A., Yousefi, S., Berdowski, W. M., Alsagob, M., Čapo, I., van der Linde, H. C., van den Berg, P., Jacobs, E. H., Putar, D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02109-6 · Cited by 67

A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders

Autar, K., Guo, X., Rumsey, J. W., Long, C. J., Akanda, N., Jackson, M., Narasimhan, N. S., Caneus, J., Morgan, D., & Hickman, J. J. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.009 · Cited by 70

Human induced pluripotent stem cells and neurodegenerative disease

Jung, Y. W., Hysolli, E., Kim, K., Tanaka, Y., & Park, I. (2012) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283518226 · Cited by 72

High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias

Nazareth, E. J. P., Östblom, J., Lücker, P. B., Shukla, S., Alvarez, M., Oh, S. K. W., Yin, T., & Zandstra, P. W. (2013) · Nature Methods · doi:10.1038/nmeth.2684 · Cited by 71

Highly Pure and Expandable PSA-NCAM-Positive Neural Precursors from Human ESC and iPSC-Derived Neural Rosettes

Kim, D. S., Lee, D. R., Kim, H.-S., Yoo, J.-E., Jung, S. J., Lim, B. Y., Jang, J., Kang, H., You, S., Hwang, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039715 · Cited by 71

Functional Screening Assays with Neurons Generated from Pluripotent Stem Cell–Derived Neural Stem Cells

Efthymiou, A. G., Shaltouki, A., Steiner, J. P., Jha, B. S., Heman-Ackah, S. M., Swistowski, A., Zeng, X., Rao, M. S., & Malik, N. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113501869 · Cited by 70

Endogenous WNT Signaling Regulates hPSC-Derived Neural Progenitor Cell Heterogeneity and Specifies Their Regional Identity

Moya, N., Cutts, J., Gaasterland, T., Willert, K., & Brafman, D. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.004 · Cited by 70

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents

Niclis, J. C., Gantner, C. W., Alsanie, W. F., McDougall, S. J., Bye, C. R., Elefanty, A. G., Stanley, E. G., Haynes, J. M., Pouton, C. W., Thompson, L. H., et al. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0073 · Cited by 70

Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in Neurotrauma

Bahmad, H. F., Hadadeh, O., Chamaa, F., Cheaito, K. A., Darwish, B., Makkawi, A.-K., & Abou-Kheir, W. G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00050 · Cited by 70

Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation

Andres, L. M., Blong, I. W., Evans, A. C., Rumachik, N. G., Yamaguchi, T., Pham, N. D., Thompson, P., Kohler, J. J., & Bertozzi, C. R. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00232 · Cited by 70

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction

Zhou, W., Ma, D., Sun, A. X., Tran, H.-D., Ma, D., Singh, B. K., Zhou, J., Zhang, J., Wang, D., Zhao, Y., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy413 · Cited by 72

Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells

Zhu, F., Zhang, P. B., Zhang, D. H., Sui, X. Y., Yin, M., Xiang, T. T., Shi, Y., Ding, M. X., & Deng, H. (2011) · Diabetologia · doi:10.1007/s00125-011-2246-x · Cited by 70

Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors

Cambray, S., Arber, C., Little, G. E., Dougalis, A., Paola, V. D., Ungless, M. A., Li, M. C., & Rodríguez, T. A. (2012) · Nature Communications · doi:10.1038/ncomms1817 · Cited by 71

Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model

Wang, S., Zou, C., Fu, L., Wang, B., An, J., Song, G., Wu, J., Tang, X., Li, M., Zhang, J., et al. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.12 · Cited by 69

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

Tidball, A. M., Bryan, M. R., Uhouse, M. A., Kumar, K. K., Aboud, A. A., Feist, J. E., Ess, K. C., Neely, M. D., Aschner, M., & Bowman, A. B. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu609 · Cited by 68

High-throughput Screening in Embryonic Stem Cell-derived Neurons Identifies Potentiators of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type Glutamate Receptors

Mcneish, J., Roach, M. L., Hambor, J., Mather, R., Weibley, L., Lazzaro, J., Gazard, J., Schwarz, J. A., Volkmann, R., Machacek, D., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.098814 · Cited by 74

Functional Deficiencies in Fragile X Neurons Derived from Human Embryonic Stem Cells

Telias, M., Kuznitsov-Yanovsky, L., Segal, M., & Ben‐Yosef, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0317-15.2015 · Cited by 69

Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells

Yamamoto, T., Hatabayashi, K., Arita, M., Yajima, N., Takenaka, C., Suzuki, T., Takahashi, M., Oshima, Y., Hara, K., Kagawa, K., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aaw3306 · Cited by 67

Development of stem cell-based therapy for Parkinson’s disease

Han, F., Baremberg, D., Gao, J., Duan, J., Lu, X., Zhang, N., & Chen, Q. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0039-8 · Cited by 70

Directed differentiation of human embryonic stem cells to corneal endothelial cell-like cells: A transcriptomic analysis

Song, Q., Yuan, S., An, Q., Chen, Y., Mao, F. F., Liu, Y., Liu, Q., & Fan, G. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.08.004 · Cited by 67

Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome

Boland, M. J., Nazor, K. L., Tran, H. T. T., Szűcs, A. L., Lynch, C. L., Paredes, R., Tassone, F., Sanna, P. P., Hagerman, R. J., & Loring, J. F. (2017) · Brain · doi:10.1093/brain/aww357 · Cited by 67

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling

Pacitti, D., Privolizzi, R., & Bax, B. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00129 · Cited by 66

The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models

Naia, L., Ly, P., Mota, S., Lopes, C., Maranga, C., Coelho, P., Gershoni-Emek, N., Ankarcrona, M., Geva, M., Hayden, M., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01022-9 · Cited by 67

Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease

Zheng, X., Han, D., Liu, W., Wang, X., Pan, N., Wang, Y., & Chen, Z. (2023) · Theranostics · doi:10.7150/thno.80271 · Cited by 68

Highly Efficient Neural Conversion of Human Pluripotent Stem Cells in Adherent and Animal-Free Conditions

Lukovic, D., Díez-Lloret, A., Stojković, P., Rodríguez–Martínez, D., Aragó, M. A. P., Rodríguez-Jiménez, F. J., González‐Rodríguez, P., López‐Barneo, J., Syková, E., Jendelová, P., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0371 · Cited by 38

Conversion of human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells into neural cells

(2009) · Science-Business eXchange · doi:10.1038/scibx.2009.472

Dual Small-Molecule Targeting of SMAD Signaling Stimulates Human Induced Pluripotent Stem Cells toward Neural Lineages

Wattanapanitch, M., Klincumhom, N., Potirat, P., Amornpisutt, R., Lorthongpanich, C., U‐pratya, Y., Laowtammathron, C., Kheolamai, P., Poungvarin, N., & Issaragrisil, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106952 · Cited by 53

Neural induction - Dual SMAD inhibition

Tomishima, M. J. (2014) · StemBook · doi:10.3824/stembook.1.57.1 · Cited by 11

Robust induction of nigro-striatal neurons from human induced pluripotent stem cells by small compound-based signal controlling

Nishimura, K., Amimoto, N., Kato, T., Hirao, M., & Takata, K. (2021) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.94.0_1-p1-23