The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A tissue-engineered jellyfish with biomimetic propulsion
Open accessAbstract
Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology and traditional soft robotics, and increasing aptitude in generating structural and chemical microenvironments that promote cellular self-organization have enhanced the ability to recapitulate such hierarchical architecture in engineered biological systems. Here we combined these capabilities in a systematic design strategy to reverse engineer a muscular pump. We report the construction of a freely swimming jellyfish from chemically dissociated rat tissue and silicone polymer as a proof of concept. The constructs, termed 'medusoids', were designed with computer simulations and experiments to match key determinants of jellyfish propulsion and feeding performance by quantitatively mimicking structural design, stroke kinematics and animal-fluid interactions. The combination of the engineering design algorithm with quantitative benchmarks of physiological performance suggests that our strategy is broadly applicable to reverse engineering of muscular organs or simple life forms that pump to survive.
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Cites
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Self-citationPhenotypic plasticity in juvenile jellyfish medusae facilitates effective animal fluid interaction
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Design, fabrication and control of soft robots
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Advances in engineering hydrogels
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Soft robotics: a bioinspired evolution in robotics
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Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures
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Carbon-Nanotube-Embedded Hydrogel Sheets for Engineering Cardiac Constructs and Bioactuators
Shin, S. R., Jung, S. M., Zalabany, M., Kim, K., Zorlutuna, P., Kim, S. B., Nikkhah, M., Khabiry, M., Azize, M., Kong, J., et al. (2013) · ACS Nano · doi:10.1021/nn305559j · Cited by 946
Metadata
- Authors
- Nawroth, J. C., Lee, H., Feinberg, A. W., Ripplinger, C. M., McCain, M. L., Grosberg, A., Dabiri, J. O., & Parker, K. K.
- Venue
- Nature Biotechnology
- Published
- 2012-07-22
- Volume
- 30
- Issue
- 8
- Pages
- 792-797
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2016298708
- Cited by
- 647
- References
- 9
- FWCI
- 45.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nawroth, J. C., Lee, H., Feinberg, A. W., Ripplinger, C. M., McCain, M. L., Grosberg, A., Dabiri, J. O., & Parker, K. K. (2012). A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology. https://doi.org/10.1038/nbt.2269
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
