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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

Ishikawa, Fumihiko, Yoshida, Shuro, Saito, Yoriko, Hijikata, Atsushi, Kitamura, Hiroshi, Tanaka, Satoshi, Nakamura, Ryu, Tanaka, Toru, Tomiyama, Hiroko, Saito, Noriyuki, Fukata, Mitsuhiro, Miyamoto, Toshihiro, Lyons, Bonnie, Ohshima, Koichi, Uchida, Naoyuki, Taniguchi, Shuichi, Ohara, Osamu, Akashi, Koichi, Harada, Mine, Shultz, Leonard D·2007·Nature Biotechnology
DOI 10.1038/nbt1350
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Abstract

Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cells. To understand the functional properties of human LS cells, we developed a primary human AML xenotransplantation model using newborn nonobese diabetic/severe combined immunodeficient/interleukin (NOD/SCID/IL)2r gamma(null) mice carrying a complete null mutation of the cytokine gamma c upon the SCID background. Using this model, we demonstrated that LS cells exclusively recapitulate AML and retain self-renewal capacity in vivo. They home to and engraft within the osteoblast-rich area of the bone marrow, where AML cells are protected from chemotherapy-induced apoptosis. Quiescence of human LS cells may be a mechanism underlying resistance to cell cycle-dependent cytotoxic therapy. Global transcriptional profiling identified LS cell-specific transcripts that are stable through serial transplantation. These results indicate the potential utility of this AML xenograft model in the development of novel therapeutic strategies targeted at LS cells.

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Research works printed but not linked: 27

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Cited by

Metadata

Authors
Ishikawa, F., Yoshida, S., Saito, Y., Hijikata, A., Kitamura, H., Tanaka, S., Nakamura, R., Tanaka, T., Tomiyama, H., Saito, N., Fukata, M., Miyamoto, T., Lyons, B., Ohshima, K., Uchida, N., Taniguchi, S., Ohara, O., Akashi, K., Harada, M., & Shultz, L. D.
Venue
Nature Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2007-10-21
Volume
25
Issue
11
Pages
1315-1321
ISSN
  • 1087-0156
  • 1546-1696
DOI
10.1038/nbt1350
Cited by
909
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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