The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
DNA damage and ageing: new-age ideas for an age-old problem
Open accessAbstract
Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.
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“IIS down-modulation reflects a defensive response aimed at minimizing cell growth and metabolism in the context of systemic damage”
From The Hallmarks of Aging (2013) · cites this paper as Garinis et al., 2008
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“Late-generation telomerase-knockout mice exhibit a premature aging syndrome characterized by hair graying, shortened survival and impaired responses to acute and chronic stress (63,77).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [77]
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Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939
Self-citationLiu, J.-P., Baker, J. C., Perkins, A. S., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80084-4 · Cited by 2,854
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
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Research works printed but not linked: 3
- Vilhem Bohr, D. W., de Souza Pinto, N. C., van der Pluijm, I. & Hoeijmakers, J. H. DNA Repair and Aging, (Cold Spring Harbor Laboratory Press, New York, 2008).
- Bootsma, D. K., K. H., Cleaver, J. E. & Hoeijmakers, J. H. J. The Metabolic and Molecular Basis of inherited Disease, 677–703 (McGraw-Hill, New York, 2001).
- der Pluijm I, G. G. et al. Impaired genome maintenance suppresses the growth hormone–insulin-like growth factor 1 axis in mice with cockayne syndrome. PLoS Biol. 5, 23–38 (2006).
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Metadata
- Authors
- Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J.
- Affiliations
- Erasmus MC (NL)
- Venue
- Nature Cell Biology
- Published
- 2008-11
- Volume
- 10
- Issue
- 11
- Pages
- 1241-1247
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4351702
- OpenAlex
- W2077496230
- Cited by
- 366
- References
- 63
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 13 · 2023: 7 · 2022: 14 · 2021: 24 · 2020: 21 · 2019: 19 · 2018: 24 · 2017: 27 · 2016: 33 · 2015: 25 · 2014: 21 · 2013: 31 · 2012: 24
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Funders
- National Institute on Aging (1P01 AG‑17242‑02, P01AG017242)
- National Institute of Environmental Health Sciences (U01ES011044)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- DNA damage, aging, genome maintenance, lifespan extension, longevity, age-related diseases, cancer prevention
- MeSH terms
- Aging, Animals, DNA Damage, Humans, Longevity, Aging, Premature, Mice
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