Cited by 366Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceDNA Repair Mechanisms

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DNA damage and ageing: new-age ideas for an age-old problem

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Garinis, George A., van der Horst, Gijsbertus T.J., Vijg, Jan, H.J. Hoeijmakers, Jan·2008·Nature Cell Biology

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Abstract

Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.

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Vilhem Bohr, D. W., de Souza Pinto, N. C., van der Pluijm, I. & Hoeijmakers, J. H. DNA Repair and Aging, (Cold Spring Harbor Laboratory Press, New York, 2008).
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Authors: Garinis, G. A., van der Horst, G. T. J., Vijg, J., & H.J. Hoeijmakers, J.
Affiliations: Erasmus MC (NL)
ORCID: Garinis, George A.
Vijg, Jan
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-11
Volume: 10
Issue: 11
Pages: 1241-1247
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb1108-1241
PMC: PMC4351702
OpenAlex: W2077496230
Cited by: 366
References: 63
Citations by year: 2026: 4 · 2025: 6 · 2024: 13 · 2023: 7 · 2022: 14 · 2021: 24 · 2020: 21 · 2019: 19 · 2018: 24 · 2017: 27 · 2016: 33 · 2015: 25 · 2014: 21 · 2013: 31 · 2012: 24
FWCI: 2.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Funders: National Institute on Aging (1P01 AG‑17242‑02, P01AG017242)
National Institute of Environmental Health Sciences (U01ES011044)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: DNA damage, aging, genome maintenance, lifespan extension, longevity, age-related diseases, cancer prevention
MeSH terms: Aging, Animals, DNA Damage, Humans, Longevity, Aging, Premature, Mice

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DNA damage and ageing: new-age ideas for an age-old problem

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