The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
Abstract
Satellite cells assure postnatal skeletal muscle growth and repair. Despite extensive studies, their stem cell character remains largely undefined. Using pulse-chase labelling with BrdU to mark the putative stem cell niche, we identify a subpopulation of label-retaining satellite cells during growth and after injury. Strikingly, some of these cells display selective template-DNA strand segregation during mitosis in the muscle fibre in vivo, as well as in culture independent of their niche, indicating that genomic DNA strands are nonequivalent. Furthermore, we demonstrate that the asymmetric cell-fate determinant Numb segregates selectively to one daughter cell during mitosis and before differentiation, suggesting that Numb is associated with self-renewal. Finally, we show that template DNA cosegregates with Numb in label-retaining cells that express the self-renewal marker Pax7. The cosegregation of 'immortal' template DNA strands and their link with the asymmetry apparatus has important implications for stem cell biology and cancer.
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“There is mounting evidence of asymmetric chromosome segregation in stem cells such as MuSCs17,18,129, ISCs20,130,131 and NSCs132.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [18]
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Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
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Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345
Socializing with the Neighbors
Fuchs, E. V., Tumbar, T., & Guasch, G. (2004) · Cell · doi:10.1016/s0092-8674(04)00255-7 · Cited by 1,737
Mutation selection and the natural history of cancer
Cairns, J. (1975) · Nature · doi:10.1038/255197a0 · Cited by 1,592
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Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00050-7 · Cited by 1,070
Expression of Cd34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells
Beauchamp, J. R., Heslop, L., Yu, D. S., Tajbakhsh, S., Kelly, R. G., Wernig, A., BUCKINGHAM, M. E., Partridge, T. A., & Zammit, P. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1221 · Cited by 917
Self-citationConboy, I. M., & Rando, T. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00254-x · Cited by 905
Tajbakhsh, S., Rocancourt, D., Cossu, G., & BUCKINGHAM, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80189-0 · Cited by 842
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Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449
Building Muscle: Molecular Regulation of MyogenesisPreprint
Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008342 · Cited by 1,270
Metadata
- Authors
- Shinin, V., Gayraud-Morel, B., Gomès, D., & Tajbakhsh, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Tajbakhsh, Shahragim
- Venue
- Nature Cell Biology
- Published
- 2006-06-25
- Volume
- 8
- Issue
- 7
- Pages
- 677-682
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2091757969
- Cited by
- 504
- References
- 51
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 12 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 11 · 2019: 16 · 2018: 17 · 2017: 15 · 2016: 23 · 2015: 29 · 2014: 28 · 2013: 47 · 2012: 52
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- satellite cells, asymmetric cell division, Numb, label-retaining cells, stem cell self-renewal, Pax7, skeletal muscle regeneration, mitosis, stem cell niche
- MeSH terms
- Animals, Bromodeoxyuridine, Cell Transformation, Neoplastic, Cells, Cultured, DNA Replication, DNA, Single-Stranded, Membrane Proteins, Mice, Transgenic, Mitosis, Nerve Tissue Proteins, Regeneration, Muscle, Skeletal, Cell Lineage, Satellite Cells, Skeletal Muscle, Mice, PAX7 Transcription Factor
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