Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer’s and other neurodegenerative diseases

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

The limited in vitro lifetime of human diploid cell strains

Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

Protein aggregation and neurodegenerative disease

Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works

Huntington's disease

Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,623 · see citing works

Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208 · see citing works

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Bence, N., Sampat, R. M., & Kopito, R. R. (2001) · Science · doi:10.1126/science.292.5521.1552 · Cited by 2,192 · see citing works

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works

Chemokine signaling via the CXCR2 receptor reinforces senescence

Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works

Amyloid Deposits and Amyloidosis

Glenner, G. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006053022305 · Cited by 1,794 · see citing works

MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins

Harper, J. D., & Lansbury, P. T. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.385 · Cited by 1,652 · see citing works

P <scp>ROTOFIBRILS</scp> , P <scp>ORES</scp> , F <scp>IBRILS, AND</scp> N <scp>EURODEGENERATION</scp> : Separating the Responsible Protein Aggregates from The Innocent Bystanders

Caughey, B., & Lansbury, P. T. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.010302.081142 · Cited by 1,650 · see citing works

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Laurén, J., Gimbel, D. A., Nygaard, H. B., Gilbert, J. W., & Strittmatter, S. M. (2009) · Nature · doi:10.1038/nature07761 · Cited by 1,560 · see citing works

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Beauséjour, C. M., Krtolica, A., Galimi, F., Narita, M., Lowe, S. W., Yaswen, P., & Campisi, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg417 · Cited by 1,457 · see citing works

Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease

Walsh, D. M., & Selkoe, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.010 · Cited by 1,207 · see citing works

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,186 · see citing works

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes &amp; Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works

Roles of heat-shock proteins in innate and adaptive immunity.

Srivastava, P. (2002) · Nature reviews. Immunology · doi:10.1038/nri749 · Cited by 1,069 · see citing works

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

Yamamoto, A., Lucas, J. J., & Hen, R. (2000) · Cell · doi:10.1016/s0092-8674(00)80623-6 · Cited by 1,068 · see citing works

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

Maji, S. K., Perrin, M. H., Sawaya, M. R., Jessberger, S., Vadodaria, K. C., Rissman, R. A., Singru, P. S., Nilsson, K. P. R., Simon, R. A., Schubert, D. A., et al. (2009) · Science · doi:10.1126/science.1173155 · Cited by 1,051 · see citing works

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

Ray, S., Britschgi, M., Herbert, C., Takeda-Uchimura, Y., Boxer, A., Blennow, K., Friedman, L. F., Galasko, D. R., Jutel, M., Karydas, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1653 · Cited by 1,048 · see citing works

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025 · see citing works

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 947 · see citing works

Senescence-messaging secretome: SMS-ing cellular stress

Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works

Functional Amyloid Formation within Mammalian Tissue

Fowler, D. M., Koulov, A. V., Alory, C., Marks, M. S., Balch, W. E., & Kelly, J. W. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040006 · Cited by 824 · see citing works

T Cell-Independent Antigens Type 2

Mond, J. J., Lees, A., & Snapper, C. M. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.003255 · Cited by 816 · see citing works

The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal

Hardy, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06181.x · Cited by 814 · see citing works

Structural Classification of Toxic Amyloid Oligomers

Glabe, C. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800016200 · Cited by 783 · see citing works

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling

Moloney, A. M., Griffin, R. J., Timmons, S., O’Connor, R., Ravid, R., & O’Neill, C. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.002 · Cited by 764 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

Forman, M. S., Trojanowski, J. Q., & Lee, V. M.-Y. (2004) · Nature Medicine · doi:10.1038/nm1113 · Cited by 715 · see citing works

Amyloid diseases: Abnormal protein aggregation in neurodegeneration

Koo, E. H., Lansbury, P. T., & Kelly, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.9989 · Cited by 686 · see citing works

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Björkqvist, M., Wild, E. J., Thiele, J., Silvestroni, A., André, R., Lahiri, N., Raibon, E., Lee, R. V., Benn, C., Soulet, D., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080178 · Cited by 646 · see citing works

The high-affinity HSP90–CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

Dickey, C. A., Kamal, A., Lundgren, K., Klosak, N., Bailey, R. M., Dunmore, J., Ash, P., Shoraka, S., Zlatkovic, J., Eckman, C. B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29715 · Cited by 642 · see citing works

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · see citing works

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

Parrinello, S., Coppe, J.-P., Krtolica, A., & Campisi, J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01635 · Cited by 631 · see citing works

A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation

Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, S. A., Myers, M. P., & Lowe, S. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.052 · Cited by 629 · see citing works

Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure

von Bergen�, M., Barghorn, S., Li, L., Marx, A., Biernat, J., Mandelkow, E., & Mandelkow�, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105196200 · Cited by 590 · see citing works

Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis

Small, S. A., & Duff, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.007 · Cited by 546 · see citing works

Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection

Münch, J., Rücker, E., Ständker, L., Adermann, K., Goffinet, C., Schindler, M., Wildum, S., Chinnadurai, R., Rajan, D., Specht, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.014 · Cited by 544 · see citing works

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

Busser, J., Geldmacher, D. S., & Herrup, K. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02801.1998 · Cited by 543 · see citing works

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

Bolmont, T., Haiss, F., Eicke, D., Radde, R., Mathis, C. A., Klunk, W. E., Kohsaka, S., Jucker, M., & Calhoun, M. E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4814-07.2008 · Cited by 526 · see citing works

STRUCTURAL BASIS OF T CELL RECOGNITION

García, K. C., Teyton, L., & Wilson, I. A. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.369 · Cited by 526 · see citing works

Amyloid Deposits and Amyloidosis

Glenner, G. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006123022403 · Cited by 518 · see citing works

Methods to Detect Biomarkers of Cellular Senescence

Itahana, K., Campisi, J., & Dimri, G. P. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-361-5_3 · Cited by 516 · see citing works

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

Herrup, K., & Yang, Y. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2124 · Cited by 507 · see citing works

Intrathecal inflammation precedes development of Alzheimer's disease

Tarkowski, E. (2003) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.74.9.1200 · Cited by 501 · see citing works

Molecular Interactions Mediating T Cell Antigen Recognition

van der Merwe, P. A., & Davis, S. J. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141036 · Cited by 501 · see citing works

Small assemblies of unmodified amyloid $beta;-protein are the proximate neurotoxin in Alzheimer?s disease

Klein, W. L., Stine, W. B., & Teplow, D. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.010 · Cited by 487 · see citing works

Autophagy and neurodegeneration: when the cleaning crew goes on strike

Martínez‐Vicente, M., & Cuervo, A. M. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70076-5 · Cited by 472 · see citing works

Diversity in the Mechanisms of Neuronal Cell Death

Yuan, J., Lipinski, M. M., & Degterev, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00601-9 · Cited by 467 · see citing works

Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

Bacskai, B. J., Kajdasz, S. T., Christie, R. H., Carter, C., Games, D., Seubert, P. A., Schenk, D., & Hyman, B. T. (2001) · Nature Medicine · doi:10.1038/85525 · Cited by 445 · see citing works

Mutations causing neurodegenerative tauopathies

Goedert, M., & Jakes, R. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.007 · Cited by 438 · see citing works

Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

Walsh, D. M., & Selkoe, D. J. (2004) · Protein and Peptide Letters · doi:10.2174/0929866043407174 · Cited by 428 · see citing works

Eukaryotic Proteasomes Cannot Digest Polyglutamine Sequences and Release Them during Degradation of Polyglutamine-Containing Proteins

Venkatraman, P., Wetzel, R. B., Tanaka, M., Nukina, N., & Goldberg, A. L. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00151-0 · Cited by 424 · see citing works

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

McShea, A., Harris, P. L. R., Webster, K. R., Wahl, A. F., & Smith, M. A. (1997) · Europe PMC (PubMed Central) · Cited by 422 · see citing works

Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease

Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., & Mucke, L. (1997) · Nature · doi:10.1038/39321 · Cited by 417 · see citing works

Microglial senescence: does the brain's immune system have an expiration date?

Streit, W. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.001 · Cited by 397 · see citing works

Many roads lead to oncogene-induced senescence

Courtois-Cox, S., Jones, S. L., & Cichowski, K. (2008) · Oncogene · doi:10.1038/sj.onc.1210950 · Cited by 397 · see citing works

Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer

Maier, J. A. M., Voulalas, P. J., Roeder, D., & Maciag, T. (1990) · Science · doi:10.1126/science.2218499 · Cited by 397 · see citing works

Expression of chemokine receptors by subsets of neurons in the central nervous system

Horuk, R., Martin, A. W., Wang, Z., Schweitzer, L., Gerassimides, A., Guo, H.-D., Lu, Z., Hesselgesser, J., Perez, H. D., Kim, J., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2882 · Cited by 385 · see citing works

The coming of age of virus-like particle vaccines

Jennings, G. T., & Bachmann, M. F. (2008) · Biological Chemistry · doi:10.1515/bc.2008.064 · Cited by 373 · see citing works

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

Sanchez-Mejia, R. O., Newman, J. W. I., Toh, S., Yu, G.-Q., Zhou, Y., Halabisky, B., Cissé, M., Scearce-Levie, K. A., Cheng, I. H.-J., Gan, L., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2213 · Cited by 369 · see citing works

Regulation of cellular senescence by p53

Itahana, K., Dimri, G., & Campisi, J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02228.x · Cited by 365 · see citing works

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

Zipp, F., & Aktaş, O. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.006 · Cited by 351 · see citing works

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 350 · see citing works

Polyglutamine neurodegeneration: protein misfolding revisited

Williams, A. J., & Paulson, H. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.004 · Cited by 335 · see citing works

Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

Klyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5161-07.2008 · Cited by 321 · see citing works

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

Hayflick, L., & Moorhead, P. S. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3075-7.50017-7 · Cited by 317 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works

Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease

Golde, T. E., Eckman, C. B., & Younkin, S. G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00043-0 · Cited by 300 · see citing works

A systems approach to prion disease

Hwang, D., Lee, I. Y., Yoo, H., Gehlenborg, N., Cho, J., Petritis, B., Baxter, D., Pitstick, R., Young, R., Spicer, D., et al. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.10 · Cited by 287 · see citing works

T cell independent antigens

Mond, J. J. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80109-x · Cited by 285 · see citing works

Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

Ohyagi, Y., Asahara, H., Chui, D.-H., Tsuruta, Y., Sakae, N., Miyoshi, K., Yamada, T., Kikuchi, H., Taniwaki, T., Murai, H., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2637fje · Cited by 281 · see citing works

Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease

Xia, M., & Hyman, B. T. (1999) · Journal of NeuroVirology · doi:10.3109/13550289909029743 · Cited by 269 · see citing works

To Die or Not to Die: That is the Autophagic Question

Maiuri, M. C., Galluzzi, L., Vicencio, J. M., Kepp, O., Tasdemir, E., & Kroemer, G. (2008) · Current Molecular Medicine · doi:10.2174/156652408783769616 · Cited by 265 · see citing works

Recovery from Polyglutamine-Induced Neurodegeneration in Conditional <i>SCA1</i> Transgenic Mice

Zu, T., Duvick, L. A., Kaytor, M. D., Berlinger, M. S., Zoghbi, H. Y., Clark, H. B., & Orr, H. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2978-04.2004 · Cited by 262 · see citing works

Senescence, Apoptosis or Autophagy?

Vicencio, J. M., Galluzzi, L., Tajeddine, N., Ortiz, C., Criollo, A., Tasdemir, E., Morselli, E., Younes, A. B., Maiuri, M. C., Lavandero, S., et al. (2008) · Gerontology · doi:10.1159/000129697 · Cited by 259 · see citing works

Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53

Dirac, A. M. G., & Bernards, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300023200 · Cited by 254 · see citing works

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

Lars Rödel, T. A., Gärtner, U., & Holzer, M. (1996) · NeuroReport · doi:10.1097/00001756-199611250-00050 · Cited by 250 · see citing works

Monocyte Chemoattractant Protein‐1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

Sokolova, A., Hill, M. D., Rahimi, F., Warden, L. A., Halliday, G. M., & Shepherd, C. E. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00188.x · Cited by 249 · see citing works

Autophagy in Innate and Adaptive Immunity

Xu, Y., & Eissa, N. T. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200909-103js · Cited by 242 · see citing works

Energetics and Oxidative Stress in Synaptic Plasticity and Neurodegenerative Disorders

Mattson, M. P., & Liu, D. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:215 · Cited by 242 · see citing works

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

Müller, M. K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2104 · Cited by 237 · see citing works

Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

Jankowsky, J. L., Slunt, H. H., Gonzales, V., Savonenko, A. V., Wen, J. C., Jenkins, N. A., Copeland, N. G., Younkin, L. H., Lester, H. A., Younkin, S. G., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020355 · Cited by 237 · see citing works

Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells

Ye, X., Zerlanko, B. J., Kennedy, A. L., Gowrishankar, B., Zhang, R., & Adams, P. D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.034 · Cited by 227 · see citing works

Neurotoxic protein oligomers — what you see is not always what you get

Bitan, G., Fradinger, E. A., Spring, S. M., & Teplow, D. B. (2005) · Amyloid · doi:10.1080/13506120500106958 · Cited by 221 · see citing works

SASP reflects senescence

Young, A. R. J., & Narita, M. (2009) · The EMBO Reports · doi:10.1038/embor.2009.22 · Cited by 214 · see citing works

Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease

Galimberti, D., Fenoglio, C., Lovati, C., Venturelli, E., Guidi, I., Corrà, B., Scalabrini, D., Clerici, F., Mariani, C., Bresolin, N., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.007 · Cited by 209 · see citing works

The synaptic Aβ hypothesis of Alzheimer disease

Tanzi, R. E. (2005) · Nature Neuroscience · doi:10.1038/nn0805-977 · Cited by 206 · see citing works

Caspase inhibition switches doxorubicin-induced apoptosis to senescence

Rebbaa, A., Zheng, X. S., Chou, P. M., & Mirkin, B. L. (2003) · Oncogene · doi:10.1038/sj.onc.1206366 · Cited by 201 · see citing works

Induction of cellular senescence by insulin-like growth factor binding protein-5 through a p53-dependent mechanism

Kim, K. S., Seu, Y. B., Baek, S.-H., Kim, M. J., Kim, K. J., Kim, J. H., & Kim, J.-R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-03-0280 · Cited by 199 · see citing works

Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice

Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., Mathis, C. A., Bales, K. R., Paul, S. M., Hyman, B. T., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23269 · Cited by 190 · see citing works

Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar Aβ

Glabe, C. C. (2006) · Springer eBooks · doi:10.1007/0-387-23226-5_8 · Cited by 187 · see citing works

Changes of p53 in the Brains of Patients with Alzheimer's Disease

Kitamura, Y., Shimohama, S., Kamoshima, W., Matsuoka, Y., Nomura, Y., & Taniguchi, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6301 · Cited by 185 · see citing works

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

Adams, P. D. (2007) · Gene · doi:10.1016/j.gene.2007.04.020 · Cited by 174 · see citing works

Ectopic Cell Cycle Events Link Human Alzheimer's Disease and Amyloid Precursor Protein Transgenic Mouse Models

Yang, Y., Varvel, N. H., Lamb, B. T., & Herrup, K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3707-05.2006 · Cited by 174 · see citing works

Autophagy genes and ageing

Vellai, T. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.126 · Cited by 169 · see citing works

Genetic models for CNS inflammation

Owens, T., Wekerle, H., & Antel, J. P. (2001) · Nature Medicine · doi:10.1038/84603 · Cited by 164 · see citing works

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.Preprint

Glick, A. B., Lee, M., Darwiche, N., Kulkarni, A. B., Karlsson, S., & Yuspa, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.20.2429 · Cited by 157 · see citing works

Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice

Koenigsknecht-Talboo, J., Meyer-Luehmann, M., Parsadanian, M., Garcia-Alloza, M., Finn, M. B., Hyman, B. T., Bacskai, B. J., & Holtzman, D. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4147-08.2008 · Cited by 149 · see citing works

Cerebrospinal fluid interleukin-1 beta (IL-1 beta) in Alzheimer's disease and neurological disorders.

Cacabelos, R., Barquero, M. S., Garcia, P. E., Alvarez, X. A., & de Seijas, E. V. (1991) · PubMed · Cited by 148 · see citing works

Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type

Tham, A., Nordberg, A. K., Grissom, F. E., Carlsson‐Skwirut, C., Viitanen, M. H., & Sara, V. R. (1993) · Journal of Neural Transmission - Parkinsons Disease and Dementia Section · doi:10.1007/bf02257671 · Cited by 144 · see citing works

Wnt signaling in Alzheimer's disease: Up or down, that is the question

Boonen, R. A. C. M., van Tijn, P., & Živković, D. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.11.003 · Cited by 143 · see citing works

Ink4a/Arf links senescence and aging

Sharpless, N. E. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.025 · Cited by 142 · see citing works

The M‐type receptor PLA2R regulates senescence through the p53 pathway

Augert, A., Payré, C., de Launoit, Y., Gil, J., Lambeau, G. J., & Bernard, D. (2009) · EMBO Reports · doi:10.1038/embor.2008.255 · Cited by 141 · see citing works

Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry

Yaswen, P., & Campisi, J. (2007) · Cell · doi:10.1016/j.cell.2007.01.005 · Cited by 138 · see citing works

Life, death and burial: multifaceted impact of autophagy

Galluzzi, L., Morselli, E., Vicencio, J. M., Kepp, O., Joza, N. A., Tajeddine, N., & Kroemer, G. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360786 · Cited by 138 · see citing works

Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts

Lucibello, F. C., Sewing, A., Brüsselbach, S., Bürger, C., & Müller, R. (1993) · Journal of Cell Science · doi:10.1242/jcs.105.1.123 · Cited by 136 · see citing works

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

Lee, H., Casadesús, G., Zhu, X., Castellani, R. J., McShea, A., Perry, G. L., Petersen, R. B., Bajić, V., & Smith, M. A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.013 · Cited by 132 · see citing works

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.

Xia, M., Qin, S., McNamara, M. J., Mackay, C. R., & Hyman, B. T. (1997) · Europe PMC (PubMed Central) · Cited by 131 · see citing works

Association of increased autophagic inclusions labeled for β-galactosidase with fibroblastic aging

Gerland, L.-M., Peyrol, S., Lallemand, C., Branche, R., Magaud, J.-P., & Ffrench, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00132-3 · Cited by 130 · see citing works

How the Immune System Recognizes Invaders

Janeway, C. A. (1993) · Scientific American · doi:10.1038/scientificamerican0993-72 · Cited by 125 · see citing works

Oxygen free radicals in cell senescence: Are they signal transducers?

Passos, J. F., & Von Zglinicki, T. (2006) · Free Radical Research · doi:10.1080/10715760600917151 · Cited by 122 · see citing works

The galvanization of β-amyloid in Alzheimer's disease

Bush, A. I., & Tanzi, R. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122249699 · Cited by 122 · see citing works

Senescent Keratinocytes Die by Autophagic Programmed Cell Death

Gosselin, K., Deruy, E., Martien, S., Vercamer, C., Bouali, F., Dujardin, T., Slomianny, C., Houel-Renault, L., Chelli, F., De Launoit, Y., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080332 · Cited by 119 · see citing works

Disease modifying therapy for AD?¹

Golde, T. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04211.x · Cited by 117 · see citing works

Involvement of the INK4a/Arf gene locus in senescence

Collins, C. J., & Sedivy, J. M. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00048.x · Cited by 113 · see citing works

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.

(1994) · PubMed Central · Cited by 105 · see citing works

GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation—a role in Alzheimer's disease?

Xia, M., & Hyman, B. T. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00463-5 · Cited by 105 · see citing works

Defects in TGFβ signaling overcome senescence of mouse keratinocytes expressing v-rasHa

Tremain, R., Marko, M. G., Vijayachandra, K., Ueno, H., Böttinger, E. P., & Glick, A. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203471 · Cited by 103 · see citing works

Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model

Garcia-Alloza, M., Dodwell, S. A., Meyer-Luehmann, M., Hyman, B. T., & Bacskai, B. J. (2006) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/01.jnen.0000240468.12543.af · Cited by 99 · see citing works

Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

Sahara, N., Maeda, S., & Takashima, A. (2008) · Current Alzheimer Research · doi:10.2174/156720508786898442 · Cited by 99 · see citing works

Inflammation and Alzheimer's Disease: Relationships between Pathogenic Mechanisms and Clinical Expression

Eikelenboom, P., Rozemüller, A. J. M., & Muiswinkel, F. L. V. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6920 · Cited by 98 · see citing works

Molecular Genetics of Chromosome 17 Tauopathies

HUTTON, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06906.x · Cited by 92 · see citing works

Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia

Tarkowski, E., Wallin, A., Regland, B., Blennow, K., & Tarkowski, A. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103003166.x · Cited by 91 · see citing works

Plasminogen activator activity is inhibited while neuroserpin is up‐regulated in the Alzheimer disease brain

Fabbro, S., & Seeds, N. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05894.x · Cited by 89 · see citing works

Autophagy in innate and adaptive immunity.

Deretic, V. (2005) · Trends in immunology · doi:10.1016/j.it.2005.08.003 · Cited by 89 · see citing works

Regulation of replicative senescence by insulin‐like growth factor‐binding protein 3 in human umbilical vein endothelial cells

Kim, K. S., Kim, M., Seu, Y. B., Chung, H. Y., Kim, J. H., & Kim, J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00315.x · Cited by 87 · see citing works

From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases

McDermott, M., & Tschopp, J. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.07.005 · Cited by 81 · see citing works

Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis

Sprenger, C. C. T., Vail, M. E., Evans, K., Simurdak, J., & Plymate, S. R. (2002) · Oncogene · doi:10.1038/sj.onc.1205021 · Cited by 80 · see citing works

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M. ‐. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.022 · Cited by 78 · see citing works

A Role for Fibroblasts in Mediating the Effects of Tobacco-Induced Epithelial Cell Growth and Invasion

Coppé, J., Boysen‐Osborn, M., Sun, C. H., Wong, B. J. F., Kang, M., Park, N., Desprez, P., Campisi, J., & Krtolica, A. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0062 · Cited by 77 · see citing works

Innate Immunity, Local Inflammation, and Degenerative Disease

McGeer, P. L., & McGeer, E. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.29.re3 · Cited by 76 · see citing works

The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease

Golde, T. E. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-8 · Cited by 71 · see citing works

Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2

Fukami-Kobayashi, J., & Mitsui, Y. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4306 · Cited by 70 · see citing works

Antibody-Mediated Clearance of Amyloid-β Peptide from Cerebral Amyloid Angiopathy Revealed by QuantitativeIn VivoImaging

Prada, C. M., Garcı́a-Alloza, M., Betensky, R. A., Zhang-Nunes, S., Greenberg, S. M., Bacskai, B. J., & Frosch, M. P. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5426-06.2007 · Cited by 56 · see citing works

Identification of Insulin-Like Growth Factor Binding Protein-3 as a Farnesyl Transferase Inhibitor SCH66336-Induced Negative Regulator of Angiogenesis in Head and Neck Squamous Cell Carcinoma

Oh, S., Kim, W., Kim, J.-H., Younes, M. N., El‐Naggar, A. K., Myers, J. N., Kies, M. S., Cohen, P., Khuri, F. R., Hong, W. K., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1725 · Cited by 54 · see citing works

Bcl-2 promotes premature senescence induced by oncogenic Ras

Tombor, B., Rundell, K., & Oltvai, Z. N. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00402-9 · Cited by 51 · see citing works

Serum Levels of Soluble Intercellular Adhesion Molecule-1 and Soluble Endothelial Leukocyte Adhesion Molecule-1 in Alzheimer’s Disease

Rentzos, M., Michalopoulou, M., Nikolaou, C., Cambouri, C., Rombos, A., Dimitrakopoulos, A., Kapaki, E., & Vassilopoulos, D. (2004) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988704269822 · Cited by 50 · see citing works

Immune-mediated clearance of virus from the central nervous system

Binder, G. K., & Griffin, D. E. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(03)00047-9 · Cited by 43 · see citing works

By Blocking Apoptosis, Bcl-2 in p38-Dependent Manner Promotes Cell Cycle Arrest and Accelerated Senescence After DNA Damage and Serum Withdrawal

Neliudova, A. M., Aksenov, N. D., Pospelov, V. A., & Pospelova, T. V. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4610 · Cited by 41 · see citing works

Interleukin-1 in Alzheimer's disease and multi-infarct dementia: neuropsychological correlations.

Cacabelos, R., Franco-Maside, A., & Alvarez, X. A. (1991) · PubMed · Cited by 41 · see citing works

The Expression of Cell Cycle Proteins in Neurons and its Relevance for Alzheimers Disease

Ueberham, U., & Arendt, T. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007054038175 · Cited by 40 · see citing works

Conformational isomers of a peptide–class II major histocompatibility complex

Lovitch, S. B., & Unanue, E. R. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00298.x · Cited by 39 · see citing works

Coming of age in culture

Campisi, J., Dimri, G. P., Nehlin, J. O., Testori, A., & Yoshimoto, K. K. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02024-1 · Cited by 39 · see citing works

MMP‐2, ‐3 and ‐9 levels and activity are not related to Aβ load in the frontal cortex in Alzheimer's disease

Baig, S., Kehoe, P. G., & Love, S. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00897.x · Cited by 39 · see citing works

Remodeling chromatin for senescence.

Adams, P. D. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00313.x · Cited by 37 · see citing works

Differential expression of intercellular adhesion molecule-1 (ICAM-1) in the A‚-containing lesions in brains of patients with dementia of the Alzheimer type

Verbeek, M. M., Otte‐Höller, I., Wesseling, P., Ruiter, D. J., & de Waal, R. M. W. (1996) · Acta Neuropathologica · doi:10.1007/s004010050474 · Cited by 37 · see citing works

T Cell-Independent Antigens Type 2

Mond, J. J. (1995) · Annual Review of Immunology · doi:10.1146/annurev.immunol.13.1.655 · Cited by 37 · see citing works

Plasma osteoprotegerin as a biochemical marker for vascular dementia and Alzheimer's disease.

Emanuele, E., Peros, E., Scioli, G., D'Angelo, A., Olivieri, C., Montagna, L., & Geroldi, D. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.6.849 · Cited by 33 · see citing works

Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection

Church, J. A. (2008) · PEDIATRICS · doi:10.1542/peds.2008-2139kkkk · Cited by 27 · see citing works

Chromosome 13 dementia syndromes as models of neurodegeneration

Ghiso, J. A., Révész, T., Holton, J. L., Rostagno, A. A., Lashley, T., Houlden, H., Gibb, G., Anderton, B. H., Bek, T., Bojsen‐Møller, M., et al. (2001) · Amyloid · doi:10.3109/13506120108993826 · Cited by 26 · see citing works

Small assemblies of unmodified amyloid $beta;-protein are the proximate neurotoxin in Alzheimer?s disease

Klein, W. L. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(04)00089-2 · Cited by 18 · see citing works

Heparin/endothelial cell growth supplement regulates matrix gene expression and prolongs life span of vascular smooth muscle cells through modulation of interleukin-1

Hsu, J.-Y., Hsu, M., Sorger, T., Herlyn, M., & Levine, E. M. (1999) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-999-0105-6 · Cited by 11 · see citing works

Inflammatory Proteins in Plasma and the Risk of Dementia: The Rotterdam Study

Engelhart, M. J., Geerlings, M. I., Meijer, J., Kiliaan, A., Ruitenberg, A., van Swieten, J. C., Stijnen, T., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B. (2004) · Archives of Neurology · doi:10.1001/archneur.61.5.668 · Cited by 10 · see citing works

Conformational mutations in neuroserpin and familial dementias

Benvenga, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11626-6 · Cited by 5 · see citing works

Molecular genetics of chromosome 17 tauopathies

Hutton, M. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)83232-7 · Cited by 5 · see citing works

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works

Neuroinflammation as a common feature of neurodegenerative disorders

Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702 · see citing works

The effects of aging in the hippocampus and cognitive decline

Bettio, L. E. B., Rajendran, L., & Gil‐Mohapel, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.030 · Cited by 654 · see citing works

Basic mechanisms of neurodegeneration: a critical update

Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 608 · see citing works

Astrocyte Senescence as a Component of Alzheimer’s Disease

Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

Saxena, S., & Caroni, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.031 · Cited by 561 · see citing works

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015) · Diabetes · doi:10.2337/db14-1820 · Cited by 423 · see citing works

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Guerrero, A., De Strooper, B., & Arancibia-Cárcamo, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.007 · Cited by 236 · see citing works

Neuronal Aggregates: Formation, Clearance, and Spreading

Lim, J., & Yue, Z. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.02.002 · Cited by 221 · see citing works

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works

Antagonistic pleiotropy as a widespread mechanism for the maintenance of polymorphic disease alleles

Carter, A. J. R., & Nguyen, A. Q. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-160 · Cited by 176 · see citing works

Clinical strategies and animal models for developing senolytic agents

Kirkland, J. L., & Tchkonia, T. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.10.012 · Cited by 168 · see citing works

Review: Axon pathology in age‐related neurodegenerative disorders

Adalbert, R., & Coleman, M. P. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01308.x · Cited by 169 · see citing works

Amyloid-β1–42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2

He, N., Jin, W.-L., Lok, K.-H., Wang, Y., Yin, M., & Wang, Z.-J. (2013) · Cell Death &amp; Disease · doi:10.1038/cddis.2013.437 · Cited by 151 · see citing works

Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline

Thorin‐Trescases, N., de Montgolfier, O., Pinçon, A., Raignault, A., Caland, L., Labbé, P., & Thorin, É. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00637.2017 · Cited by 151 · see citing works

Biomarkers to identify and isolate senescent cells

Matjusaitis, M., Chin, G., Sarnoski, E. A., & Stolzing, A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.003 · Cited by 144 · see citing works

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune functionPreprint

Akay, L. A., Effenberger, A. H., & Tsai, L. (2021) · Genes & Development · doi:10.1101/gad.344218.120 · Cited by 142 · see citing works

Targeting senescent cells: approaches, opportunities, challenges

von Kobbe, C. (2019) · Aging · doi:10.18632/aging.102557 · Cited by 129 · see citing works

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, C., Maciel-Barón, L. A., Konigsberg, M., Massieu, L., & Castro-Obregón, S. (2019) · Aging · doi:10.18632/aging.102181 · Cited by 128 · see citing works

Interaction between pathogenic proteins in neurodegenerative disorders

Jellinger, K. A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01507.x · Cited by 128 · see citing works

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

Fielder, E., von Zglinicki, T., & Jurk, D. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-161221 · Cited by 126 · see citing works

Thinking laterally about neurodegenerative proteinopathies

Golde, T. E., Borchelt, D., Giasson, B. I., & Lewis, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66029 · Cited by 121 · see citing works

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116 · see citing works

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition

Chakrabarty, P., Tianbai, L., Herring, A., Ceballos-Diaz, C., Das, P., & Golde, T. E. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-36 · Cited by 116 · see citing works

Alzheimer’s Disease: Mechanism and Approach to Cell Therapy

Amemori, T., Jendelová, P., Růžička, J., Urdzíková, L. M., & Syková, E. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125961 · Cited by 102 · see citing works

Amyloid β protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer’s disease.

Wei, Z., Chen, X.-C., Song, Y., Pan, X.-D., Dai, X.-M., Zhang, J., Cui, X.-L., Wu, X.-L., & Zhu, Y.-G. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.186646 · Cited by 89 · see citing works

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

Sacino, A. N., Brooks, M., McGarvey, N. H., McKinney, A. B., Thomas, M. A., Levites, Y., Ran, Y., Golde, T. E., & Giasson, B. I. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-38 · Cited by 86 · see citing works

Proteostasis impairment in ALS

Ruegsegger, C., & Saxena, S. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.032 · Cited by 82 · see citing works

Melittin restores proteasome function in an animal model of ALS

Yang, E. J., Kim, S. H., Yang, S. C., Lee, S. M., & Choi, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-69 · Cited by 82 · see citing works

Cellular senescence and aging: the role of B‐ MYB

Mowla, S. N., Lam, E. W. ‐., & Jat, P. (2014) · Aging Cell · doi:10.1111/acel.12242 · Cited by 79 · see citing works

Neuroprotective effects of carnosic Acid in an experimental model of Alzheimer's disease in rats.

Azad, N., Rasoolijazi, H., Joghataie, M. T., & Soleimani, S. (2011) · PubMed Central · Cited by 79 · see citing works

Antioxidant and anti-senescence effect of metformin on mouse olfactory ensheathing cells (mOECs) may be associated with increased brain-derived neurotrophic factor levels-an ex vivo study

Śmieszek, A., Stręk, Z., Kornicka, K., Grzesiak, J., Weiss, C., & Marycz, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040872 · Cited by 77 · see citing works

Alzheimer's disease: An acquired neurodegenerative laminopathy

Frost, B. (2016) · Nucleus · doi:10.1080/19491034.2016.1183859 · Cited by 74 · see citing works

The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence

Wang, T., Yuan, Y., Zou, H., Yang, J., Zhao, S., Ma, Y., Wang, Y., Bian, J., Liu, X., Gu, J., et al. (2016) · Scientific Reports · doi:10.1038/srep38091 · Cited by 72 · see citing works

Neurodegenerative diseases as proteinopathies-driven immune disorders

Lanuti, P., Ciccocioppo, F., Bologna, G., Ercolino, E., Pierdomenico, L., Simeone, P., Pieragostino, D., Boccio, P. D., Marchisio, M., & Miscia, S. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.268971 · Cited by 71 · see citing works

Could a dysfunction of ferritin be a determinant factor in the aetiology of some neurodegenerative diseases?

Quintana, C., & Gutiérrez, L. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.04.012 · Cited by 68 · see citing works

Interaction between -Synuclein and Other Proteins in Neurodegenerative Disorders

Jellinger, K. A. (2011) · The Scientific World JOURNAL · doi:10.1100/2011/371893 · Cited by 63 · see citing works

The Potential Influence of Bone-Derived Modulators on the Progression of Alzheimer’s Disease

Yuan, J., Meloni, B. P., Shi, T., Bonser, A. M., Papadimitriou, J. M., Mastaglia, F. L., Zhang, C., Zheng, M., & Gao, J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181249 · Cited by 58 · see citing works

The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration

Sah, E., Krishnamurthy, S., Ahmidouch, M. Y., Gillispie, G. J., Milligan, C., & Orr, M. E. (2021) · Life · doi:10.3390/life11030229 · Cited by 54 · see citing works

Subretinal injection of amyloid-β peptide accelerates RPE cell senescence and retinal degeneration

Liu, C., Cao, L., Yang, S., Xu, L., Liu, P., Wang, F., & Xu, D. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1993 · Cited by 52 · see citing works

Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review

Dailah, H. G. (2022) · Molecules · doi:10.3390/molecules27217207 · Cited by 50 · see citing works

Emerging potential of cannabidiol in reversing proteinopathies

Dash, R., Ali, M. C., Jahan, I., Munni, Y. A., Mitra, S., Hannan, M. A., Timalsina, B., Oktaviani, D. F., Choi, H. J., & Moon, I. S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101209 · Cited by 49 · see citing works

Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases

Głowacka, P., Oszajca, K., Pudlarz, A. M., Szemraj, J., & Witusik‐Perkowska, M. (2024) · Nutrients · doi:10.3390/nu16142244 · Cited by 48 · see citing works

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works

Cellular Senescence, Neurological Function, and Redox State

Maciel-Barón, L. Á., Moreno-Blas, D., Morales-Rosales, S. L., González‐Puertos, V. Y., López‐Díazguerrero, N. E., Torres, C. A., Castro‐Obregón, S., & Königsberg, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7112 · Cited by 45 · see citing works

The role of cellular senescence in aging through the prism of Koch-like criteria

Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45 · see citing works

Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer’s disease pathology in aged squirrel monkeys

Patel, A. G., Nehete, P. N., Krivoshik, S. R., Pei, X., Cho, E. L., Nehete, B. P., Ramani, M. D., Shao, Y., Williams, L. E., Wisniewski, T., et al. (2021) · Brain · doi:10.1093/brain/awab129 · Cited by 44 · see citing works

Parkinson disease and progressive supranuclear palsy: protein expression in skin

Rodríguez‐Leyva, I., Chi-Ahumada, É., Carrizales-Rodríguez, J., Rodríguez‐Violante, M., Velázquez‐Osuna, S., Medina‐Mier, V., Gallegos, M. G. M., Zarazúa, S., Enríquez‐Macías, L., Castro‐Zavala, A., et al. (2016) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.285 · Cited by 43 · see citing works

Neuroimmune Tau Mechanisms: Their Role in the Progression of Neuronal Degeneration

Cortés, N., Andrade, V., Guzmán-Martínez, L., Estrella, M., & Maccioni, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040956 · Cited by 41 · see citing works

Regulation of senescence by microRNA biogenesis factors

Abdelmohsen, K., Srikantan, S., Kang, M. J., & Gorospe, M. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.003 · Cited by 39 · see citing works

Gut Microbiota and Immune System Dynamics in Parkinson’s and Alzheimer’s Diseases

Kuštrimović, N. Z., Balkhi, S., Bilato, G., & Mortara, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212164 · Cited by 38 · see citing works

Nutrition and cellular senescence in obesity-related disorders

Rubio‐Tomás, T., Rueda‐Robles, A., Plaza‐Díaz, J., & Álvarez‐Mercado, A. I. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108861 · Cited by 37 · see citing works

Protective Role of Capsaicin in Neurological Disorders: An Overview

Tyagi, S., Shekhar, N., & Thakur, A. K. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03549-5 · Cited by 37 · see citing works

TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism

Wong, C., Jin, L., Chu, Y.-P., Wei, W., Ho, P., & Tsai, K. (2020) · Theranostics · doi:10.7150/thno.51004 · Cited by 36 · see citing works

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Fuhrmann‐Stroissnigg, H., Santiago, F. E., Grassi, D., Ling, Y., Niedernhofer, L. J., & Robbins, P. D. (2019) · Journal of Visualized Experiments · doi:10.3791/58133 · Cited by 32 · see citing works

A Prospective Viewpoint on Neurological Diseases and Their Biomarkers

Zehravi, M., Kabir, J., Akter, R., Malik, S., Ashraf, G. M., Tagde, P., Ramproshad, S., Mondal, B., Rahman, M. H., Mohan, A. G., et al. (2022) · Molecules · doi:10.3390/molecules27113516 · Cited by 30 · see citing works

Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer’s disease animal models

Villamil-Ortiz, J. G., & Cardona‐Gómez, G. P. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00084 · Cited by 28 · see citing works

Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies

Golde, T. E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13583 · Cited by 28 · see citing works

Membrane Trafficking Illuminates a Path to Parkinson’s Disease

Hasegawa, T., Sugeno, N., Kikuchi, A., Baba, T., & Aoki, M. (2017) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.242.63 · Cited by 28 · see citing works

Cellular lifespan and senescence: a complex balance between multiple cellular pathways

Dolivo, D., Hernandez, S. J., & Dominko, T. (2016) · BioEssays · doi:10.1002/bies.201670906 · Cited by 27 · see citing works

Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?

Roberts, B., Theunissen, F., Mastaglia, F. L., Akkari, P. A., & Flynn, L. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169364 · Cited by 23 · see citing works

Scrutinizing the Therapeutic Potential of PROTACs in the Management of Alzheimer’s Disease

Bhatia, S., Singh, M., Singh, T., & Singh, V. (2023) · Neurochemical Research · doi:10.1007/s11064-022-03722-w · Cited by 22 · see citing works

Interaction between α-synuclein and tau in Parkinson's disease

Jellinger, K. A. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.10.006 · Cited by 21 · see citing works

Clinicopathological Staging of Dynamics of Neurodegeneration and Neuronal Loss in Alzheimer Disease

Węgiel, J., Flory, M. J., Kuchna, I., Nowicki, K., Ma, S. Y., Wegiel, J., Badmajew, E., de Leon, M. J., Wısnıewskı, T., & Reisberg, ‌. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa140 · Cited by 19 · see citing works

Exploring the Role of Hsp60 in Alzheimer’s Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting

Zimbone, S., Rosa, M. C. D., Chiechio, S., & Giuffrida, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512456 · Cited by 18 · see citing works

Biochemical Assessment of Precuneus and Posterior Cingulate Gyrus in the Context of Brain Aging and Alzheimer’s Disease

Maarouf, C. L., Kokjohn, T. A., Walker, D. G., Whiteside, C. M., Kalback, W. M., Whetzel, A. M., Sue, L. I., Serrano, G. E., Jacobson, S. A., Sabbagh, M. N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105784 · Cited by 17 · see citing works

Proteostasis defects: Medicinal challenges of imperfect aging & neurodegeneration

Kumar, P., Choudhary, A., Kinger, S., Jagtap, Y. A., Dubey, A. R., Gutti, R. K., Chitkara, D., Suresh, A. K., & Mishra, A. (2023) · Translational Medicine of Aging · doi:10.1016/j.tma.2023.09.001 · Cited by 16 · see citing works

Silicone Allergies and the Eye

Hall, B. J., Jones, L., & Dixon, B. (2013) · Eye & Contact Lens Science & Clinical Practice · doi:10.1097/icl.0000000000000010 · Cited by 16 · see citing works

Nanoparticles and Colloids as Contributing Factors in Neurodegenerative Disease

Bondy, S. C. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8062200 · Cited by 14 · see citing works

Autopsy-diagnosed neurodegenerative dementia cases support the use of cerebrospinal fluid protein biomarkers in the diagnostic work-up

Brůžová, M., Rusina, R., Stejskalova, Z., & Matěj, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-90366-5 · Cited by 13 · see citing works

Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns

Knecht, L. H., Dalsbøl, K., Simonsen, A. H., Pilchner, F., Ross, J. A., Winge, K., Salvesen, L., Bech, S., Hejl, A., Løkkegaard, A., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03293-3 · Cited by 11 · see citing works

Evidence for the Deregulation of Protein Turnover Pathways in Atm-Deficient Mouse Cerebellum: An Organotypic Study

Kim, C. D., Reed, R. E., Juncker, M. A., Fang, Z., & Desai, S. D. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx038 · Cited by 9 · see citing works

Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis

Komic, A., Quinones, P. M., McCarthy, C. G., Webb, R. C., & Wenceslau, C. F. (2018) · Clinical Science · doi:10.1042/cs20180368 · Cited by 8 · see citing works

Current Medication Trendsand Global Impact on Neurodegenerative Disorders

Maurya, H., & Kumar, S. (2018) · Journal of Pharmaceutics & Pharmacology · doi:10.13188/2327-204x.1000024 · Cited by 8 · see citing works

Protein Aggregation and Self Assembly in Health and Disease

Basak, A., & Basak, S. (2021) · Current Proteomics · doi:10.2174/1570164618666210223160742 · Cited by 7 · see citing works

Unraveling the Function of PPARα in Neurodegenerative Disorders: A Potential Pathway to Novel Therapies

Galanou, O.-N., & Konstandi, M. (2025) · Biomedicines · doi:10.3390/biomedicines13112813 · Cited by 4 · see citing works

Maximum lifespan and brain size in mammals are associated with gene family size expansion related to immune system functions

Kilili, H., Padilla‐Morales, B., Castillo-Morales, A., Monzón‐Sandoval, J., Díaz-Barba, K., Cornejo‐Páramo, P., Vincze, O., Giraudeau, M., Bush, S. J., Li, Z., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-98786-3 · Cited by 5 · see citing works

Alzheimer's Disease: From Animal Models to the Human Syndrome

Orta‐Salazar, E., Vargas-Rodríguez, I., Castro-Chavira, S. A., Feria‐Velasco, A., & Díaz-Cintra, S. Y. (2016) · InTech eBooks · doi:10.5772/64619 · Cited by 5 · see citing works

Administration of DNA Plasmid Coding Protein Aggregating Domain Induces Inflammatory Bone Loss

Agas, D., Concetti, F., Capitani, M., Lacava, G., Concetti, A., Marchetti, L., Laus, F., Marchegiani, A., Azevedo, V., Sabbieti, M. G., et al. (2016) · Current Gene Therapy · doi:10.2174/1566523216666160331125355 · Cited by 4 · see citing works

Insights into the promising prospect of medicinal chemistry studies against neurodegenerative disorders

Rahman, M. M., Islam, M. R., Tumpa, M. A. A., Shohag, S., shuvo, S. K., Ferdous, J., Kajol, S. A., Aljohani, A. S. M., Abdulmonem, W. A., Rauf, A., et al. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110375 · Cited by 4 · see citing works

[The effect of deep branches of cervical nerve on motorial function of trapezius muscle].

Wang, F., Wen, Y., & Li, L. (2003) · PubMed · Cited by 4 · see citing works

The Involvement of Melatonin and Tasimelteon against Alzheimer’s Disease

Ravikumar, M., Mohan, S., & Velpandian, C. (2022) · Current Drug Safety · doi:10.2174/1574886317666220517125644 · Cited by 3 · see citing works

Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA

Karliner, J. S., Liu, Y., & Merry, D. E. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321408121 · Cited by 2 · see citing works

Cellular lifespan and senescence: a complex balance between multiple cellular pathways

Dolivo, D., Hernandez, S. J., & Dominko, T. (2015) · Inside the Cell · doi:10.1002/icl3.1036 · Cited by 2 · see citing works

Immunopathogenesis of Alzheimer’s disease, Parkinson’s Disease, and other Neurodegenerative Diseases

Kumar, S., Shukla, A. K., Yadav, V. K., Srivastava, A., Dwivedi, D., & Singh, S. P. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815238754124010006 · Cited by 1 · see citing works

Age-Linked Non-Transmissible Diseases

Bernard Swynghedauw, A. (2019) · Practical issues in geriatrics · doi:10.1007/978-3-030-15111-9_6 · Cited by 1 · see citing works

APOE4 disrupts the central dogma by arresting neuronal proteome dynamicsPreprint

Krogsaeter, E., McKetney, J., Li, L., Liu, I., Richards, A., Subramanyam, V., Yin, K., Gordon, M., Mairal, P. B., Stevenson, E. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.15.738801 · Cited by 1 · see citing works

In Vitro Approaches for Studying Amyloids and Neurotoxicity

Eid, A., May, S. E., Zawia, N., & Camberg, J. L. (2018) · Methods in pharmacology and toxicology · doi:10.1007/7653_2018_21

Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression

Chong, M. (2018)

ANALYSIS OF ATP-DEPENDENT CHAPERONE PROTEIN INTERACTIONS WITH MISFOLDED PROTEINS, AMYLOIDS, AND AGGREGATED PROTEINS

May, S. E. (2018) · doi:10.23860/diss-may-shannon-2018

Mechanism and biomarkers for neurodegenerative diseases: A systematic review

N, N. S., Sonar, N. S., Hemalatha, S., Nagalakshmi, N. C., & Pardhe, H. A. (2020) · IP Indian Journal of Neurosciences · doi:10.18231/j.ijn.2020.003

α-Synuclein heteromers with ß-amyloid and tau decreased in red blood cells of Alzheimer’s disease and Lewy Body dementia patients.Preprint

Daniele, S., Baldacci, F., Piccarducci, R., Palermo, G., Giampietri, L., Manca, M. L., Pietrobono, D., Frosini, D., Nicoletti, V., Tognoni, G., et al. (2020) · doi:10.21203/rs.3.rs-18776/v1

Neuronal aging is associated with declined autophagy caused by reduced functionality of cGAS-STING signalingPreprint

Passarella, S., Brandes, K., Dankert, E., Cavalli, P., Kröger, A., Dieterich, D. C., & Landgraf, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.25.559304

Novel endoscopic and MRI-based methods for evaluating exocrine pancreatic function in pancreatitis and monogenic forms of diabetes

Tjora, E. (2013) · NORA - Norwegian Open Research Archives

Modeling stress-induced proteinopathies in Caenorhabditis elegans

Caldero-Escudero, E., & Romero-Sanz, S. (2026) · Methods in cell biology · doi:10.1016/bs.mcb.2025.12.007

Current Trends in Biomarkers and Diagnosis of Prevalent Neurological Infectious Diseases

Verma, K., Priyanka, Singh, S., & Yadav, N. (2026) · IGI Global eBooks · doi:10.4018/979-8-3693-4070-7.ch007

Differential modulation of hippocampal synaptic plasticity by proline-rich peptide-1 in Aβ 25–35 and Aβ 1–42 experimental models of Alzheimer's disease

Hunanyan, N., Ghorbani, H., Danielyan, M., Minasyan, A., Hunanyan, A. S., Poghosyan, М. V., & Stepanyan, H. (2026) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2026.100399

Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration

Thapa, R., Bhat, A. A., Shahwan, M. J., Ali, H., Padmapriya, G., Bansal, P., Rajotiya, S., Barwal, A., Prasad, G. V. S., Pramanik, A., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149202 · Cited by 44 · see citing works

Comparative Pathology of Neurodegeneration: Linking Microglial Senescence to Protein Aggregation

Bharatkumar, A. M. (2025) · International Journal of Integrated Research and Practice · doi:10.25215/31075037.034

Senescence and Neurodegenerative Disorders: Beyond Alzheimer’s and Parkinson’s

Tiwari, I., Chauhan, P., Singh, A., & Sharma, N. K. (2025) · Springer eBooks · doi:10.1007/978-981-96-1041-9_7 · Cited by 1 · see citing works

Molecular Mechanisms of Cellular Senescence in Neurodegenerative Diseases

Lee, H.-J., Yoon, Y.-S., & Lee, S.-J. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168114 · Cited by 36 · see citing works

Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis

Walton, C. C., Begelman, D. V., Nguyen, W., & Andersen, J. K. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00129 · Cited by 61 · see citing works