DNA Damage Response and Autophagy: A Meaningful Partnership
Open accessAbstract
Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein, we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for several functional outcomes of DDR signaling, including repair of DNA lesions, senescence, cell death, and cytokine secretion. Uncovering the mechanisms by which autophagy and DDR are intertwined provides novel insight into the pathobiology of conditions associated with accumulation of DNA damage, including cancer and aging, and novel concepts for the development of improved therapeutic strategies against these pathologies.
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DNA double-strand breaks activate autophagy.
“This is consistent with accumulating evidence that DSBs activate autophagy37.”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [37]
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Molecular mechanisms of renal aging
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A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
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Integrating the DNA damage and protein stress responses during cancer development and treatment
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Self-citationAutophagy role(s) in response to oncogenes and DNA replication stress
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Self-citationBeauvarlet, J., Bensadoun, P., Darbo, E., Labrunie, G., Rousseau, B., Richard, E., Draskovic, I., Londono-Vallejo, A., Dupuy, J.-W., Nath Das, R., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz095 · Cited by 73 · see citing works
- Authors
- Eliopoulos, A. G., Havaki, S., & Gorgoulis, V. G.
- Affiliations
- University of Crete (GR)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Eliopoulos, Aristides G.
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2016-11-21
- Volume
- 7
- Pages
- 204-204
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC5116470
- OpenAlex
- W2554366527
- Cited by
- 169
- References
- 148
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 15 · 2023: 13 · 2022: 21 · 2021: 25 · 2020: 20 · 2019: 24 · 2018: 18 · 2017: 13 · 2012: 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- DNA damage response, autophagy, DNA repair, cellular senescence, cell death, cytokine production, cancer, aging, treatment options
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