The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons
Open accessAbstract
Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons. Changes in organelle distribution within the dendritic arbors of dynein mutant neurons correlate with a proximal shift in dendritic branch position. Dynein is also necessary for the dendrite-specific localization of Golgi outposts and the ion channel Pickpocket. Axonal microtubules are normally oriented uniformly plus-end-distal; however, without dynein, axons contain both plus- and minus-end distal microtubules. These data suggest that dynein is required for the distinguishing properties of the axon and dendrites: without dynein, dendritic organelles and proteins enter the axon and the axonal microtubules are no longer uniform in polarity.
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Cites
Molecular motors and mechanisms of directional transport in neurons
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Self-citationBidirectional transport along microtubules
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Asymmetric CLASP-Dependent Nucleation of Noncentrosomal Microtubules at the trans-Golgi Network
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Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
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Polarized Secretory Trafficking Directs Cargo for Asymmetric Dendrite Growth and Morphogenesis
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Self-citationThe Golgi Complex Is a Microtubule-organizing Organelle
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Cited by
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Microtubule assembly, organization and dynamics in axons and dendrites
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“In addition, motors that mediate the transport of building blocks and organelles to dendrites are crucial for dendrite morpholog”
BackgroundSelf-citationTRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites
van Spronsen, M., Mikhaylova, M., Lipka, J., Schlager, M. A., van den Heuvel, D. J., Kuijpers, M., Wulf, P. S., Keijzer, N., Demmers, J., Kapitein, L. C., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.027 · Cited by 450
The dendritic tree and brain disorders
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Metadata
- Authors
- Zheng, Y., Wildonger, J., Ye, B., Zhang, Y., Kita, A., Younger, S. H., Zimmerman, S., Jan, L. Y., & Jan, Y. N.
- Venue
- Nature Cell Biology
- Published
- 2008-08-31
- Volume
- 10
- Issue
- 10
- Pages
- 1172-1180
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2026750744
- Cited by
- 290
- References
- 30
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, Y., Wildonger, J., Ye, B., Zhang, Y., Kita, A., Younger, S. H., Zimmerman, S., Jan, L. Y., & Jan, Y. N. (2008). Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nature Cell Biology. https://doi.org/10.1038/ncb1777
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