The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · cited 1×

Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

Méndez, J., & Stillman, B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8602-8612.2000 · Cited by 915

PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin

Nishioka, K., Rice, J. C., Sarma, K., Erdjument-Bromage, H., Werner, J., Wang, Y., Chuikov, S., Valenzuela, P., Tempst, P., Steward, R., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00548-8 · Cited by 583

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

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Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells

Arias, E. E., & Walter, J. C. (2007) · Genes & Development · doi:10.1101/gad.1508907 · Cited by 404

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

Abbas, T., Sivaprasad, U., Terai, K., Amador, V., Pagano, M., & Dutta, A. (2008) · Genes & Development · doi:10.1101/gad.1676108 · Cited by 366

Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage

Hu, J., McCall, C. M., Ohta, T., & Xiong, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1172 · Cited by 348

Purification and Functional Characterization of SET8, a Nucleosomal Histone H4-Lysine 20-Specific Methyltransferase

Fang, J., Feng, Q., Ketel, C. S., Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., Simon, J. A., & Zhang, Y. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00924-7 · Cited by 342

L3MBTL1, a Histone-Methylation-Dependent Chromatin Lock

Trojer, P., Li, G., Sims, R. J., Vaquero, A., Kalakonda, N., Boccuni, P., Lee, D., Erdjument-Bromage, H., Tempst, P., Nimer, S. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.048 · Cited by 342

Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development

Oda, H., Okamoto, I., Murphy, N., Chu, J., Price, S. M., Shen, M. M., Torres-Padilla, M. E., Heard, E., & Reinberg, D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01768-08 · Cited by 319

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

Arias, E. E., & Walter, J. C. (2006) · Nature Cell Biology · doi:10.1038/ncb1346 · Cited by 314

Genome-wide studies highlight indirect links between human replication origins and gene regulation

Cadoret, J.-C., Meisch, F., Hassan-Zadeh, V., Luyten, I., Guillet, C., Duret, L., Quesneville, H., & Prioleau, M.-N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805208105 · Cited by 313

Recruitment of Condensin to Replication Origin Regions by ParB/SpoOJ Promotes Chromosome Segregation in B. subtilis

Gruber, S., & Errington, J. (2009) · Cell · doi:10.1016/j.cell.2009.02.035 · Cited by 311

Right Place, Right Time, and Only Once: Replication Initiation in Metazoans

Machida, Y. J., Hamlin, J. L., & Dutta, A. (2005) · Cell · doi:10.1016/j.cell.2005.09.019 · Cited by 296

Chromatin regulates origin activity in Drosophila follicle cells

Aggarwal, B. D., & Calvi, B. R. (2004) · Nature · doi:10.1038/nature02694 · Cited by 274

Loss of Geminin induces rereplication in the presence of functional p53

Melixetian, M., Ballabeni, A., Masiero, L., Gasparini, P., Zamponi, R., Bartek, J., Lukas, J., & Helin, K. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403106 · Cited by 262

HBO1 Histone Acetylase Activity Is Essential for DNA Replication Licensing and Inhibited by Geminin

Miotto, B., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2009.12.012 · Cited by 258

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

Kim, Y., Starostina, N. G., & Kipreos, E. T. (2008) · Genes & Development · doi:10.1101/gad.1703708 · Cited by 240

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation

Nishitani, H., Shiomi, Y., Iida, H., Michishita, M., Takami, T., & Tsurimoto, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806045200 · Cited by 240

Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes

Rice, J. C., Nishioka, K., Sarma, K., Steward, R., Reinberg, D., & Allis, C. D. (2002) · Genes & Development · doi:10.1101/gad.1014902 · Cited by 233

The histone methyltransferase SET8 is required for S-phase progression

Jørgensen, S., Elvers, I., Trelle, M. B., Menzel, T., Eskildsen, M., Jensen, O. N., Helleday, T., Helin, K., & Sørensen, C. S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706150 · Cited by 227

Dynamic changes in histone acetylation regulate origins of DNA replication

Unnikrishnan, A., Gafken, P. R., & Tsukiyama, T. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1780 · Cited by 197

Regulation of Replication Licensing by Acetyltransferase Hbo1

Iizuka, M., Matsui, T., Takisawa, H., & Smith, M. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.1098-1108.2006 · Cited by 197

Genomic Study of Replication Initiation in Human Chromosomes Reveals the Influence of Transcription Regulation and Chromatin Structure on Origin Selection

Karnani, N., Taylor, C. M., Malhotra, A., & Dutta, A. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0707 · Cited by 183

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

Havens, C. G., & Walter, J. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.012 · Cited by 179

HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

Miotto, B., & Struhl, K. (2008) · Genes & Development · doi:10.1101/gad.1674108 · Cited by 175

PR-Set7–dependent lysine methylation ensures genome replication and stability through S phase

Tardat, M., Murr, R., Herceg, Z., Sardet, C., & Julien, E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706179 · Cited by 169

DNA replication timing of the human β-globin domain is controlled by histone modification at the originPreprint

Goren, A., Tabib, A., Hecht, M., & Cedar, H. (2008) · Genes & Development · doi:10.1101/gad.468308 · Cited by 146

Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF‐1

Julien, E., & Herr, W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg242 · Cited by 131

Direct Interaction between SET8 and Proliferating Cell Nuclear Antigen Couples H4-K20 Methylation with DNA Replication

Huen, M. S. Y., Sy, S. M.-H., van Deursen, J. M., & Chen, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c700242200 · Cited by 129

Shortstop Recruits EB1/APC1 and Promotes Microtubule Assembly at the Muscle-Tendon Junction

Subramanian, A., Prokop, A., Yamamoto, M., Sugimura, K., Uemura, T., Betschinger, J., Knoblich, J. A., & Volk, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00416-0 · Cited by 113

Condensin Binding at Distinct and Specific Chromosomal Sites in the Saccharomyces cerevisiae Genome

Wang, B., Eyre, D. E., Basrai, M. A., Lichten, M., & Strunnikov, A. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7216-7225.2005 · Cited by 104

A Switch in Mitotic Histone H4 Lysine 20 Methylation Status Is Linked to M Phase Defects upon Loss of HCF-1

Julien, E., & Herr, W. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.008 · Cited by 103

DDB1 Maintains Genome Integrity through Regulation of Cdt1

Lovejoy, C. A., Lock, K., Yenamandra, A. K., & Cortez, D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00819-06 · Cited by 101

SUMO‐modified Sp3 represses transcription by provoking local heterochromatic gene silencing

Stielow, B., Sapetschnig, A., Wink, C., Krüger, I., & Suske, G. (2008) · EMBO Reports · doi:10.1038/embor.2008.127 · Cited by 94

PR‐Set7‐mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression

Congdon, L. M., Houston, S. I., Veerappan, C. S., Spektor, T. M., & Rice, J. C. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22570 · Cited by 90

Programming DNA replication origins and chromosome organization

Cayrou, C., Coulombe, P., & Méchali, M. (2010) · Chromosome Research · doi:10.1007/s10577-009-9105-3 · Cited by 60

Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation

Meixner, A., Zenz, R., Schönthaler, H. B., Kenner, L., Scheuch, H., Penninger, J. M., & Wagner, E. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1761 · Cited by 50

Ubiquitylation, phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis

Saha, T., Ghosh, S., Vassilev, A. P., & Depamphilis, M. (2006) · Journal of Cell Science · doi:10.1242/jcs.02851 · Cited by 48

1q12 chromosome translocations form aberrant heterochromatic foci associated with changes in nuclear architecture and gene expression in B cell lymphoma

Fournier, A., Leer, A. M., Lefebvre, C., Duley, S., Barki‐Celli, L., Ribeyron, J., Kassambara, A., Hamaidia, S., Granjon, A., Gressin, R., et al. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000067 · Cited by 38

Writing, erasing and reading histone lysine methylations

Hyun, K., Jeon, J., Park, K., & Kim, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.11 · Cited by 1,250

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

Black, J. C., Van Rechem, C., & Whetstine, J. R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.006 · Cited by 1,308

Histone post-translational modifications - cause and consequence of genome function

Millán-Zambrano, G., Burton, A., Bannister, A. J., & Schneider, R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00468-7 · Cited by 1,116

Chromatin replication and epigenome maintenance

Alabert, C., & Groth, A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3288 · Cited by 592

DNA replication origin activation in space and time

Fragkos, M., Ganier, O., Coulombe, P., & Méchali, M. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4002 · Cited by 543