Origin and role of distal visceral endoderm, a group of cells that determines anterior–posterior polarity of the mouse embryo
Abstract
Anterior-posterior polarity of the mouse embryo has been thought to be established when distal visceral endoderm (DVE) at embryonic day (E) 5.5 migrates toward the future anterior side to form anterior visceral endoderm (AVE). Lefty1, a marker of DVE and AVE, is asymmetrically expressed in implanting mouse embryos. We now show that Lefty1 is expressed first in a subset of epiblast progenitor cells and then in a subset of primitive endoderm progenitors. Genetic fate mapping indicated that the latter cells are destined to become DVE. In contrast to the accepted notion, however, AVE is not derived from DVE but is newly formed after E5.5 from Lefty1(-) visceral endoderm cells that move to the distal tip. Concomitant with DVE migration, all visceral endoderm cells in the embryonic region undergo global movement. In embryos subjected to genetic ablation of Lefty1-expressing DVE cells, AVE was formed de novo but the visceral endoderm including the newly formed AVE failed to migrate, indicating that DVE guides the migration of AVE by initiating the global movement of visceral endoderm cells. Future anterior-posterior polarity is thus already determined by Lefty1(+) blastomeres in the implanting blastocyst.
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Symmetry is broken and the AP axis established through migration of AVE.
“Symmetry is broken, and the AP axis established through the migration of AVE37.”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [37]
emVE-specific genes include Lhx1 and Lefty1, and AVE-specific genes include Cer1 and Hhex; exVE-specific genes include Apln and Msx1.
“emVE-specific genes (Fig. 3c, Cluster 1) included Lhx1 and Lefty1, and AVE-specific genes Cer1 and Hhex30,32,37. ExVE-specific genes (Fig. 3c, Cluster 2) included Apln and Msx1 (Supplementary Table 4).”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [37]
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Self-citation
- Authors
- Takaoka, K., Yamamoto, M., & Hamada, H.
- Affiliations
- The University of Osaka (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Takaoka, Katsuyoshi
- Hamada, Hiroshi
- Venue
- Nature Cell Biology
- Published
- 2011-05-29
- Volume
- 13
- Issue
- 7
- Pages
- 743-752
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2070801417
- Cited by
- 127
- References
- 39
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 12
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (21247034)
- Core Research for Evolutional Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- anterior-posterior polarity, anterior visceral endoderm, Lefty1, fate mapping, cell migration, blastocyst, mouse embryo, embryonic axis formation
- MeSH terms
- Animals, Blastocyst, Blastomeres, Cell Differentiation, Cell Movement, Embryo, Mammalian, Endoderm, Gestational Age, Mice, Transgenic, Microscopy, Fluorescence, Morphogenesis, Proteins, Recombinant Fusion Proteins, Time Factors, Cytokines, Cell Polarity, In Situ Hybridization, Gene Expression Regulation, Developmental, Microscopy, Video, Cell Lineage, Mice, Embryonic Stem Cells, Left-Right Determination Factors
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