Cited by 1,205Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamicsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Open access

Zhao, Bin, Tumaneng, Karen, Guan, Kun-Liang·2011·Nature Cell Biology

DOI 10.1038/ncb2303PMC PMC3987945

Open this paper in CoChat — free account

Abstract

Precise control of organ size is crucial during animal development and regeneration. In Drosophila and mammals, studies over the past decade have uncovered a critical role for the Hippo tumour-suppressor pathway in the regulation of organ size. Dysregulation of this pathway leads to massive overgrowth of tissue. The Hippo signalling pathway is highly conserved and limits organ size by phosphorylating and inhibiting the transcription co-activators YAP and TAZ in mammals and Yki in Drosophila, key regulators of proliferation and apoptosis. The Hippo pathway also has a critical role in the self-renewal and expansion of stem cells and tissue-specific progenitor cells, and has important functions in tissue regeneration. Emerging evidence shows that the Hippo pathway is regulated by cell polarity, cell adhesion and cell junction proteins. In this review we summarize current understanding of the composition and regulation of the Hippo pathway, and discuss how cell polarity and cell adhesion proteins inform the role of this pathway in organ size control and regeneration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ncb2303

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
Self-citation
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498
Self-citation
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,317
The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP
Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,917
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP
Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418
Self-citation
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass
Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,120
hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts
Wu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,120
Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size
Heallen, T. R., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., & Martin, J. F. (2011) · Science · doi:10.1126/science.1199010 · Cited by 1,092
Hippo signaling: growth control and beyond
Halder, G. A., & Johnson, R. L. (2010) · Development · doi:10.1242/dev.045500 · Cited by 1,091
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.-T., Luk, J. M., Wigler, M., Hannon, G. J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.030 · Cited by 1,065
Yap1 acts downstream of α-catenin to control epidermal proliferation
Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036
TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation
Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science · doi:10.1126/science.1110955 · Cited by 1,009
The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis
Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 1,007
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
Justice, R. W., Zilian, O., Woods, D. F., Noll, M., & Bryant, P. J. (1995) · Genes & Development · doi:10.1101/gad.9.5.534 · Cited by 977
TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway
Lei, Q., Zhang, H., Zhao, B., Zha, Z., Bai, F., Pei, X., Zhao, S., Xiong, Y., & Guan, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01874-07 · Cited by 956
Self-citation
Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 937
Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon
Overholtzer, M., Zhang, J., Smolen, G. A., Muir, B., Li, W., Sgroi, D. C., Deng, C., Brugge, J. S., & Haber, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605579103 · Cited by 893
salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines
Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A., & Hariharan, I. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00824-3 · Cited by 888
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.722 · Cited by 841
The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804
Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 802
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 765
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationPreprint
Lian, I., Kim, J., Okazawa, H., Zhao, J. J., Zhao, B., Yu, J., Chinnaiyan, A. M., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 762
Self-citation
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C., & Halder, G. (2003) · Nature Cell Biology · doi:10.1038/ncb1050 · Cited by 747
The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway
Varelas, X., Samavarchi‐Tehrani, P., Narimatsu, M., Weiss, A., Cockburn, K., Larsen, B. G., Rossant, J., & Wrana, J. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.012 · Cited by 725
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G. A., Finegold, M. J., Lee, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911427107 · Cited by 721
Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.035 · Cited by 719
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoproteinPreprint
Zhao, B., Li, L., Lu, Q. R., Wang, L. H., Liu, C., Lei, Q., & Guan, K. (2011) · Genes & Development · doi:10.1101/gad.2000111 · Cited by 693
Self-citation
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
Varelas, X., Sakuma, R., Samavarchi‐Tehrani, P., Peerani, R., Rao, B. M., Dembowy, J., Yaffe, M. B., Zandstra, P. W., & Wrana, J. L. (2008) · Nature Cell Biology · doi:10.1038/ncb1748 · Cited by 690
The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway
Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
Song, H., Mak, K. K., Topol, L. Z., Yun, K., Hu, J., Garrett, L. J., Chen, Y., Park, O., Chang, J., Simpson, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911409107 · Cited by 598
Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats
Lai, Z.-C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L., & Li, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.036 · Cited by 595
TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition
Zhang, H., Liu, C., Zha, Z., Zhao, B., Yao, J., Zhao, S., Xiong, Y., Lei, Q., & Guan, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900843200 · Cited by 589
Self-citation
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Chan, E. H. Y., Nousiainen, M., Chalamalasetty, R. B., Schäfer, A., Nigg, E. A., & Silljé, H. H. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208445 · Cited by 584
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
Pantalacci, S., Tapon, N., & Léopold, P. (2003) · Nature Cell Biology · doi:10.1038/ncb1051 · Cited by 569
A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator
Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y., & Ito, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2551 · Cited by 568
Expression of Yes-associated protein in common solid tumors
Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A., & Anders, R. A. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.04.012 · Cited by 560
Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma
Xu, M. Z., Yao, T., Lee, N. P. Y., Ng, I. O. L., Chan, Y., Zender, L., Lowe, S. W., Poon, R. T. P., & Luk, J. M. (2009) · Cancer · doi:10.1002/cncr.24495 · Cited by 528
The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase
Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152942 · Cited by 525
Self-citation
The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
Lee, K., Lee, J., Kim, T., Kim, T., Park, H.-D., Byun, J., Kim, M., Jeong, W., Calvisi, D. F., Kim, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912203107 · Cited by 510
Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded
Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W.-M., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.012 · Cited by 508
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programPreprint
Cai, J., Zhang, N., Zheng, Y., de Wilde, R. F., Maitra, A., & Pan, D. (2010) · Genes & Development · doi:10.1101/gad.1978810 · Cited by 491
A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells
Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I. Y., Hunziker, W., Zeng, Q., & Hong, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2696 · Cited by 480
WW Domain-containing Protein YAP Associates with ErbB-4 and Acts as a Co-transcriptional Activator for the Carboxyl-terminal Fragment of ErbB-4 That Translocates to the Nucleus
Komuro, A., Nagai, M., Navin, N. E., & Sudol, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305597200 · Cited by 474
SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila
Goulev, Y., Fauny, J., Gonzalez-Marti, B., Flagiello, D., Silber, J., & Zider, A. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.034 · Cited by 456
MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation
Praskova, M. D., Xia, F., & Avruch, J. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.006 · Cited by 442
Delineation of a Fat tumor suppressor pathway
Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R. G., & Irvine, K. D. (2006) · Nature Genetics · doi:10.1038/ng1887 · Cited by 439
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
Zhang, J., Ji, J., Yu, M., Overholtzer, M., Smolen, G. A., Wang, R., Brugge, J. S., Dyson, N. J., & Haber, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1993 · Cited by 438
Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma
Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436
Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
Zhang, H., Pasolli, H. A., & Fuchs, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019603108 · Cited by 419
Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity
Strano, S., Munarriz, E. R., Rossi, M., Castagnoli, L., Shaul, Y., Sacchi, A., Oren, M., Sudol, M., Cesareni, G., & Blandino, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010484200 · Cited by 418
RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein
Matallanas, D., Romano, D., Yee, K. S. Y., Meissl, K., Kučerová, L., Piazzolla, D., Baccarini, M., Vass, J. K., Kölch, W., & O’Neill, E. E. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.08.008 · Cited by 416
Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF
Lai, D., Ho, K. C., Hao, Y., & Yang, X. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2711 · Cited by 416
Structural insights into the YAP and TEAD complexPreprint
Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., & Xu, Y. (2010) · Genes & Development · doi:10.1101/gad.1865810 · Cited by 415
Self-citation
YAP regulates neural progenitor cell number via the TEA domain transcription factorPreprint
Cao, X., Pfaff, S. L., & Gage, F. H. (2008) · Genes & Development · doi:10.1101/gad.1726608 · Cited by 412
In vivo regulation of Yorkie phosphorylation and localization
Oh, H., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.015255 · Cited by 407
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosisPreprint
Jia, J., Zhang, W., Wang, B., Trinko, R., & Jiang, J. (2003) · Genes & Development · doi:10.1101/gad.1134003 · Cited by 403
The Hippo Pathway Regulates the bantam microRNA to Control Cell Proliferation and Apoptosis in Drosophila
Thompson, B. J., & Cohen, S. M. (2006) · Cell · doi:10.1016/j.cell.2006.07.013 · Cited by 401
Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 396
Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin
Chan, S. W., Lim, C. J., Chong, Y. F., Pobbati, A. V., Huang, C., & Hong, W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.212621 · Cited by 386
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferationPreprint
Fernández-L, A., Northcott, P. A., Dalton, J., Fraga, C. H., Ellison, D. W., Angers, S., Taylor, M. D., & Kenney, A. M. (2009) · Genes & Development · doi:10.1101/gad.1824509 · Cited by 383
Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)
Oka, T., Mazack, V., & Sudol, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804380200 · Cited by 376
Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1
Graves, J. D., Gotoh, Y., Draves, K. E., Ambrose, D., Han, D. K. M., Wright, M., Chernoff, J., Clark, E. A., & Krebs, E. G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2224 · Cited by 375
Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophila
Kango‐Singh, M., Nolo, R. M., Tao, C., Verstreken, P., Hiesinger, P. R., Bellen, H. J., & Halder, G. A. (2002) · Development · doi:10.1242/dev.00168 · Cited by 362
Identification of a Novel Ras-Regulated Proapoptotic Pathway
Khokhlatchev, A. V., Rabizadeh, S., Xavier, R. J., Nedwidek, M., Chen, T., Zhang, X., Seed, B., & Avruch, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00683-8 · Cited by 358
α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1
Silvis, M. R., Kreger, B. T., Lien, W., Klezovitch, O., Rudakova, G. M., Camargo, F. D., Lantz, D. M., Seykora, J. T., & Vasioukhin, V. I. (2011) · Science Signaling · doi:10.1126/scisignal.2001823 · Cited by 354
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F., & Richardson, H. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.055 · Cited by 341
The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size
Willecke, M., Hamaratoǧlu, F., Kango‐Singh, M., Udan, R. S., Chen, C., Tao, C., Zhang, X., & Halder, G. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.005 · Cited by 333
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
Chen, L., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S., & Pan, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004279107 · Cited by 320
The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E., & Stocker, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.013 · Cited by 317
Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
Ren, F., Wang, B., Yue, T., Yun, E.-Y., Ip, Y. T., & Jiang, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012759107 · Cited by 316
Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway
Bennett, F. C., & Harvey, K. F. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.045 · Cited by 314
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
Karpowicz, P. A., Perez, J. N., & Perrimon, N. (2010) · Development · doi:10.1242/dev.060483 · Cited by 314
Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded
Robinson, B. S., Huang, J., Hong, Y., & Moberg, K. H. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.019 · Cited by 310
The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration
Shaw, R. L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B. A., & Tapon, N. (2010) · Development · doi:10.1242/dev.052506 · Cited by 304
Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap
Neto-Silva, R. M., de Beco, S., & Johnston, L. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.009 · Cited by 298
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
Chen, C., Gajewski, K. M., Hamaratoǧlu, F., Bossuyt, W., Sansores-García, L., Tao, C., & Halder, G. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004060107 · Cited by 297
The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway
Silva, E., Tsatskis, Y., Gardano, L., Tapon, N., & McNeill, H. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.004 · Cited by 295
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C‐terminal coiled‐coil domains, leads to its stabilization and phosphorylation
Callus, B. A., Verhagen, A. M., & Vaux, D. L. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05427.x · Cited by 284
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint
Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 278
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
Tao, W., Zhang, S., Turenchalk, G. S., Stewart, R. A., John, M. A. R. S., Chen, W., & Xu, T. (1999) · Nature Genetics · doi:10.1038/5960 · Cited by 269
The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway
Nolo, R. M., Morrison, C. M., Tao, C., Zhang, X., & Halder, G. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.057 · Cited by 269
Angiomotin-like Proteins Associate with and Negatively Regulate YAP1
Wang, W., Huang, J., & Chen, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.205401 · Cited by 266
Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation
Kucuk, B., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.041 · Cited by 266
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt–Oram syndrome
Murakami, M., Nakagawa, M., Olson, E. N., & Nakagawa, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509109102 · Cited by 261
Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway
Thakur, M. D., Feng, Y., Jagannathan, R., Seppa, M. J., Skeath, J. B., & Longmore, G. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.035 · Cited by 258
PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop
Lapi, E., Agostino, S. D., Donzelli, S., Gal, H., Domany, E., Rechavi, G., Pandolfi, P. P., Givol, D., Strano, S., Lü, X., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.019 · Cited by 257
Structural basis of YAP recognition by TEAD4 in the Hippo pathwayPreprint
Chen, L., Chan, S. W., Zhang, X., Walsh, M. A., Lim, C. J., Hong, W., & Song, H. (2010) · Genes & Development · doi:10.1101/gad.1865310 · Cited by 256
Morphogen Control of Wing Growth through the Fat Signaling Pathway
Rogulja, D., Rauskolb, C., & Irvine, K. D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.06.003 · Cited by 251
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
Hong, Y., Stronach, B. E., Perrimon, N., Jan, L. Y., & Jan, Y. N. (2001) · Nature · doi:10.1038/414634a · Cited by 245
Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling
Ribeiro, P. S., Josué, F., Wepf, A., Wehr, M. C., Rinner, O., Kelly, G. P., Tapon, N., & Gstaiger, M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.002 · Cited by 240
Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling
Oka, T., Remue, E., Meerschaert, K., Vanloo, B., Boucherie, C., Gfeller, D., Bader, G. D., Sidhu, S. S., Vandekerckhove, J. S., Gettemans, J., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100870 · Cited by 222
Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors
Sun, G., & Irvine, K. D. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.036 · Cited by 219
The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie
Badouel, C., Gardano, L., Amin, N., Garg, A., Rosenfeld, R., Bihan, T. L., & McNeill, H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.010 · Cited by 216
TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C
Park, K.-S., Whitsett, J. A., Palma, T. D., Hong, J., Yaffe, M. B., & Zannini, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312569200 · Cited by 211
A crucial role of WW45 in developing epithelial tissues in the mouse
Lee, J., Kim, T., Yang, T.-H., Koo, B., Oh, S.-P., Lee, K., Oh, H.-J., Lee, S., Kong, Y., Kim, J., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.63 · Cited by 200
Role of the Tumor Suppressor RASSF1A in Mst1-Mediated Apoptosis
Oh, H. J., Lee, K.-K., Song, S. J., Jin, M. S., Song, M. S., Lee, J. H., Im, C. R., Lee, J., Yonehara, S., & Lim, D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2951 · Cited by 197
Transcriptional Coactivation of Bone-Specific Transcription Factor Cbfa1 by TAZ
Cui, C. B., Cooper, L. F., Yang, X., Karsenty, G., & Aukhil, I. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1004-1013.2003 · Cited by 195
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
Ren, F., Zhang, L., & Jiang, J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.046 · Cited by 189
Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins
Matakatsu, H., & Blair, S. S. (2006) · Development · doi:10.1242/dev.02401 · Cited by 189
Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal discPreprint
Peng, H., Slattery, M. G., & Mann, R. S. (2009) · Genes & Development · doi:10.1101/gad.1820009 · Cited by 188
dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells
Ziosi, M., Baena-López, L. A., Grifoni, D., Froldi, F., Pession, A., Garoia, F., Trotta, V., Bellosta, P., Cavicchi, S., & Pession, A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001140 · Cited by 184
Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
Willecke, M., Hamaratoǧlu, F., Sansores-García, L., Tao, C., & Halder, G. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805201105 · Cited by 166
TAZ is a novel oncogene in non-small cell lung cancer
Zhou, Z., Hao, Y., Liu, N., Raptis, L. H., Tsao, M., & Yang, X. (2011) · Oncogene · doi:10.1038/onc.2010.606 · Cited by 164
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development
Skouloudaki, K., Puetz, M., Simons, M., Courbard, J.-R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M. J., Englert, C., Bollig, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811691106 · Cited by 163
The Drosophila RASSF Homolog Antagonizes the Hippo Pathway
Polesello, C., Huelsmann, S., Brown, N. H., & Tapon, N. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.060 · Cited by 151
Cooperative Regulation of Growth by Yorkie and Mad through bantam
Oh, H., & Irvine, K. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.002 · Cited by 149
A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth
Zecca, M., & Struhl, G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000386 · Cited by 148
Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed
Simon, M. A., Xu, A., Ishikawa, H., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.016 · Cited by 146
A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)
Fossdal, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh106 · Cited by 138
The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster
Grusche, F., Degoutin, J. L., Richardson, H. E., & Harvey, K. F. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.020 · Cited by 132
Fat and Expanded act in parallel to regulate growth through Warts
Feng, Y., & Irvine, K. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706722105 · Cited by 125
Transcriptional activity of Pax3 is co-activated by TAZ
Murakami, M., Tominaga, J., Makita, R., Uchijima, Y., Kurihara, Y., Nakagawa, O., Asano, T., & Kurihara, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.214 · Cited by 121
Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown
Sopko, R., Silva, E., Clayton, L., Gardano, L., Barrios‐Rodiles, M., Wrana, J. L., Varelas, X., Arbouzova, N. I., Shaw, S., Saburi, S., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.049 · Cited by 114
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways
Tyler, D. M., & Baker, N. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.004 · Cited by 111
The Hippo pathway regulates apical-domain size independently of its growth-control function
Genevet, A., Polesello, C., Blight, K., Robertson, F., Collinson, L., Pichaud, F., & Tapon, N. (2009) · Journal of Cell Science · doi:10.1242/jcs.041806 · Cited by 110
Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling
Oh, H., Reddy, B. V. V. G., & Irvine, K. D. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.08.026 · Cited by 108
Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level
Omerović, J., Puggioni, E. M. R., Napoletano, S., Visco, V., Fraioli, R., Frati, L., Gulino, A., & Alimandi, M. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.12.002 · Cited by 103
Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye
Grzeschik, N. A., Amin, N., Secombe, J., Brumby, A. M., & Richardson, H. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.025 · Cited by 98
TAZ interacts with zonula occludens‐1 and ‐2 proteins in a PDZ‐1 dependent manner
Remue, E., Meerschaert, K., Oka, T., Boucherie, C., Vandekerckhove, J. S., Sudol, M., & Gettemans, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.020 · Cited by 96
Processing and phosphorylation of the Fat receptor
Feng, Y., & Irvine, K. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811540106 · Cited by 94
A Sveinsson’s chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ
Kitagawa, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.129 · Cited by 84
Controlling the size of organs and organisms
Leevers, S. J., & McNeill, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.008 · Cited by 82
Drosophila lowfat, a novel modulator of Fat signaling
Mao, Y., Kucuk, B., & Irvine, K. D. (2009) · Development · doi:10.1242/dev.036152 · Cited by 73
Organ size determination and the limits of regulation
Stanger, B. Z. (2008) · Cell Cycle · doi:10.4161/cc.7.3.5348 · Cited by 61
A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie
Gilbert‐Ross, M., Tipping, M., Veraksa, A. N., & Moberg, K. H. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.04.012 · Cited by 52

Sorted by citations

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
Swift, J., Ivanovska, I. L., Buxboim, A., Harada, T., Dingal, P. C. D. P., Pinter, J., Pajerowski, J. D., Spinler, K. R., Shin, J., Tewari, M., et al. (2013) · Science · doi:10.1126/science.1240104 · Cited by 1,998
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478
Making new contacts: the mTOR network in metabolism and signalling crosstalk
Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
Hippo pathway effector Yap promotes cardiac regeneration
Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895

See all 1,205

Authors: Zhao, B., Tumaneng, K., & Guan, K.-L.
Affiliations: Zhejiang University (CN)
University of California San Diego (US)
Corresponding author: Guan, Kun-Liang
ORCID: Zhao, Bin
Guan, Kun-Liang
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2011-08
Volume: 13
Issue: 8
Pages: 877-883
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2303
PMC: PMC3987945
OpenAlex: W2033360354
Cited by: 1,205
References: 130
Citations by year: 2026: 29 · 2025: 53 · 2024: 69 · 2023: 66 · 2022: 110 · 2021: 105 · 2020: 90 · 2019: 97 · 2018: 102 · 2017: 70 · 2016: 80 · 2015: 94 · 2014: 88 · 2013: 88 · 2012: 61
FWCI: 6.52
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA132809)
National Institute of General Medical Sciences (R01GM051586, T32GM007752)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Hippo signaling pathway, organ size control, tissue regeneration, stem cell self-renewal, YAP, TAZ, Yki, cell polarity, cell adhesion, cell junction proteins, tumor suppression, tissue overgrowth, Drosophila, mammals
MeSH terms: Hippo Kinases, Animals, Cell Adhesion, Drosophila, Humans, Intercellular Junctions, Models, Biological, Organ Size, Regeneration, Stem Cells, Signal Transduction, Cell Polarity, Protein Serine-Threonine Kinases, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks