The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes
Open accessAbstract
Mature mammalian oocytes are poised for completing meiosis II (MII) on fertilization by positioning the spindle close to an actomyosin-rich cortical cap. Here, we show that the Arp2/3 complex localizes to the cortical cap in a Ran-GTPase-dependent manner and nucleates actin filaments in the cortical cap and a cytoplasmic actin network. Inhibition of Arp2/3 activity leads to rapid dissociation of the spindle from the cortex. Live-cell imaging and spatiotemporal image correlation spectroscopy analysis reveal that actin filaments flow continuously away from the Arp2/3-rich cortex, driving a cytoplasmic streaming expected to exert a net pushing force on the spindle towards the cortex. Arp2/3 inhibition not only diminishes this actin flow and cytoplasmic streaming but also enables a reverse streaming driven by myosin-II-based cortical contraction, moving the spindle away from the cortex. Thus, the asymmetric MII spindle position is dynamically maintained as a result of balanced forces governed by the Arp2/3 complex.
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New insights into the regulation and cellular functions of the ARP2/3 complex
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Metadata
- Authors
- Yi, K., Unruh, J. R., Deng, M., Slaughter, B. D., Rubinstein, B., & Li, R.
- Venue
- Nature Cell Biology
- Published
- 2011-08-28
- Volume
- 13
- Issue
- 10
- Pages
- 1252-1258
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2059190326
- Cited by
- 288
- References
- 32
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Yi, K., Unruh, J. R., Deng, M., Slaughter, B. D., Rubinstein, B., & Li, R. (2011). Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes. Nature Cell Biology. https://doi.org/10.1038/ncb2320
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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