A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works

Mechanism of Eukaryotic Homologous Recombination

Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,686 · see citing works

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384 · see citing works

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works

Molecular views of recombination proteins and their control

West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 947 · see citing works

Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F. J., & Livingston, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.022 · Cited by 861 · see citing works

Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair

Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E. R., Hurov, K. E., Luo, J., Ballif, B. A., Gygi, S. P., Hofmann, K., D’Andrea, A. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.009 · Cited by 695 · see citing works

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Bekker‐Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bártek, J., & Lukas, J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510130 · Cited by 621 · see citing works

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M., Guan, A. S., Hesley, J., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.021 · Cited by 554 · see citing works

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012946107 · Cited by 529 · see citing works

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cellsPreprint

Pierce, A. J., Hu, P., Han, M., Ellis, N. A., & Jasin, M. (2001) · Genes & Development · doi:10.1101/gad.946401 · Cited by 514 · see citing works

Regulation of DNA‐damage responses and cell‐cycle progression by the chromatin remodelling factor CHD4

Polo, S. E., Kaidi, A., Baskcomb, L., Galanty, Y., & Jackson, S. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.188 · Cited by 374 · cited 1× · see citing works

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

Smogorzewska, A., Desetty, R. D., Saito, T. T., Schlabach, M. R., Lach, F. P., Sowa, M. E., Clark, A. B., Kunkel, T. A., Harper, J. W., Colaiácovo, M. P., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.023 · Cited by 332 · see citing works

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

Reinhardt, H. C., Hasskamp, P., Schmedding, I., Morandell, S., van Vugt, M. A. T. M., Wang, X., Linding, R., Ong, S., Weaver, D. T., Carr, S. A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.018 · Cited by 229 · see citing works

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

Cotta‐Ramusino, C., McDonald, E. R., Hurov, K. E., Sowa, M. E., Harper, J. W., & Elledge, S. J. (2011) · Science · doi:10.1126/science.1203430 · Cited by 221 · see citing works

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

Hurov, K. E., Cotta-Ramusino, C., & Elledge, S. J. (2010) · Genes & Development · doi:10.1101/gad.1934210 · Cited by 210 · see citing works

A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

Slabicki, M. M., Theis, M., Krastev, D. B., Samsonov, S. A., Mundwiller, E., Junqueira, M., Paszkowski‐Rogacz, M., Teyra, J., Heninger, A., Poser, I., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000408 · Cited by 198 · see citing works

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

Bolderson, E., Tomimatsu, N., Richard, D. J., Boucher, D., Kumar, R., Pandita, T. K., Burma, S., & Khanna, K. K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1164 · Cited by 184 · see citing works

A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens

Sigoillot, F. D., Lyman, S. K., Huckins, J. F., Adamson, B., Chung, E., Quattrochi, B., & King, R. W. (2012) · Nature Methods · doi:10.1038/nmeth.1898 · Cited by 159 · see citing works

Vigilance and Validation: Keys to Success in RNAi Screening

Sigoillot, F. D., & King, R. W. (2010) · ACS Chemical Biology · doi:10.1021/cb100358f · Cited by 128 · see citing works

Heterogeneous Nuclear Ribonucleoprotein G Regulates Splice Site Selection by Binding to CC(A/C)-rich Regions in Pre-mRNA

Heinrich, B., Zhang, Z., Raitskin, O., Hiller, M., Benderska, N., Hartmann, A. M., Bracco, L. P., Elliott, D. J., Ben‐Ari, S., Soreq, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901026200 · Cited by 110 · see citing works

Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA

Lorain, S., Quivy, J., Monier-Gavelle, F., Scamps, C., Lécluse, Y., Almouzni, G., & Lipinski, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5546 · Cited by 105 · see citing works

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling

Draviam, V. M., Stegmeier, F. P., Nalepa, G., Sowa, M. E., Chen, J., Liang, A. C. T., Hannon, G. J., Sorger, P. K., Harper, J. W., & Elledge, S. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1569 · Cited by 97 · see citing works

Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17).

Janknecht, R. (2010) · PubMed · Cited by 93 · see citing works

RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene

Mazeyrat, S., Saut, N., Mattéi, M., & Mitchell, M. J. (1999) · Nature Genetics · doi:10.1038/10282 · Cited by 78 · see citing works

The role of potential splicing factors including RBMY, RBMX, hnRNPG‐T and STAR proteins in spermatogenesis*

Elliott, D. J. (2004) · International Journal of Andrology · doi:10.1111/j.1365-2605.2004.00496.x · Cited by 72 · see citing works

Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs

Hübner, N. C., Wang, L. H.-C., Kaulich, M., Descombes, P., Poser, I., & Nigg, E. A. (2009) · Chromosoma · doi:10.1007/s00412-009-0244-2 · Cited by 65 · see citing works

Expression and conservation of processed copies of the RBMX gene

Lingenfelter, P. A., Delbridge, M. L., Thomas, S., Hoekstra, H. E., Mitchell, M. J., Graves, J. A. M., & Distèche, C. M. (2001) · Mammalian Genome · doi:10.1007/s00335001-0003-z · Cited by 56 · see citing works

Re-evaluating the role of Tao1 in the spindle checkpoint

Westhorpe, F. G., Diez, M., Gurden, M. D. J., Tighe, A., & Taylor, S. S. (2010) · Chromosoma · doi:10.1007/s00412-010-0261-1 · Cited by 47 · see citing works

Heterogeneous Nuclear Ribonucleoprotein G Shows Tumor Suppressive Effect against Oral Squamous Cell Carcinoma Cells

Shin, K.-H., Kang, M., Kim, R. H., Christensen, R. E., & Park, N. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2656 · Cited by 45 · see citing works

Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts

Kanhoush, R., Beenders, B., Perrin, C., Moreau, J., Bellini, M., & Penrad‐Mobayed, M. (2010) · Nucleus · doi:10.4161/nucl.1.1.10857 · Cited by 42 · see citing works

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

Reinhardt, H. C., Cannell, I. G., Morandell, S., & Yaffe, M. B. (2011) · Cell Cycle · doi:10.4161/cc.10.1.14351 · Cited by 39 · see citing works

p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G

Shin, K.-H., Kim, R. H., Kang, M., Kim, R. H., Kim, S. G., Lim, P. K., Yochim, J. M., Baluda, M. A., & Park, N. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.01.013 · Cited by 38 · see citing works

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Gilbert, L. A., Horlbeck, M. A., Adamson, B., Villalta, J. E., Chen, Y., Whitehead, E. H., Guimaraes, C., Panning, B., Ploegh, H. L., Bassik, M. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.029 · Cited by 2,728 · see citing works

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514 · see citing works

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

Davoli, T., Xu, A. W., Mengwasser, K. E., Sack, L. M., Yoon, J. C., Park, P. J., & Elledge, S. J. (2013) · Cell · doi:10.1016/j.cell.2013.10.011 · Cited by 815 · see citing works

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

Lee, S., Kopp, F. B., Chang, T.-C., Sataluri, A., Chen, B., Sivakumar, S., Yu, H., Xie, Y., & Mendell, J. T. (2015) · Cell · doi:10.1016/j.cell.2015.12.017 · Cited by 903 · see citing works

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

Liu, N., Zhou, K. I., Parisien, M., Dai, Q., Diatchenko, L. B., & Pan, T. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx141 · Cited by 786 · see citing works

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

Liu, S. J., Horlbeck, M. A., Cho, S. W., Birk, H. S., Malatesta, M., He, D. X., Attenello, F. J., Villalta, J. E., Cho, M. Y., Chen, Y., et al. (2016) · Science · doi:10.1126/science.aah7111 · Cited by 735 · see citing works

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

Tian, R., Gachechiladze, M. A., Ludwig, C. H., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.014 · Cited by 543 · see citing works

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

Pfister, S. X., Ahrabi, S., Zalmas, L., Sarkar, S., Aymard, F., Bachrati, C. Z., Helleday, T., Legube, G., Thangue, N. B. L., Porter, A. C. G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.026 · Cited by 465 · see citing works

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cellsPreprint

Yazinski, S. A., Comaills, V., Buisson, R., Genois, M., Nguyen, H. D., Ho, C. K., Kwan, T. T., Morris, R. T., Lauffer, S., Nussenzweig, A., et al. (2017) · Genes & Development · doi:10.1101/gad.290957.116 · Cited by 393 · see citing works

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

Munschauer, M., Nguyen, C. T., Sirokman, K., Hartigan, C. R., Hogstrom, L. J., Engreitz, J., Ulirsch, J. C., Fulco, C. P., Subramanian, V., Chen, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0453-z · Cited by 388 · see citing works

RNA-binding proteins in tumor progression

Qin, H., Ni, H., Liu, Y., Yuan, Y., Xi, T., Li, X., & Zheng, L. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00927-w · Cited by 382 · see citing works

Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, J., Hottiger, M. O., & Nielsen, M. L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.026 · Cited by 370 · see citing works

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine

Kampmann, M. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00657 · Cited by 371 · see citing works

A library of TAL effector nucleases spanning the human genome

Kim, Y., Kweon, J., Kim, A., Chon, J. K., Yoo, J. Y., Kim, H. J., Kim, S., Lee, C., Jeong, E., Chung, E., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2517 · Cited by 371 · see citing works

Mechanisms of nuclear content loading to exosomes

Yokoi, A., Villar‐Prados, A., Oliphint, P. A., Zhang, J., Song, X., Hoff, P. L. D., Morey, R. E., Liu, J., Roszik, J., Clise-Dwyer, K., et al. (2019) · Science Advances · doi:10.1126/sciadv.aax8849 · Cited by 292 · see citing works

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

Adam, S., Polo, S. E., & Almouzni, G. (2013) · Cell · doi:10.1016/j.cell.2013.08.029 · Cited by 290 · see citing works

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

Mastrocola, A. S., Kim, S. H., Trinh, A. T., Rodenkirch, L. A., & Tibbetts, R. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497974 · Cited by 262 · see citing works

PCAT-1 , a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer

Prensner, J. R., Chen, W., Iyer, M. K., Cao, Q., Ma, T., Han, S., Sahu, A., Malik, R., Wilder-Romans, K., Navone, N. M., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3159 · Cited by 251 · see citing works

Readers of poly(ADP-ribose): designed to be fit for purpose

Teloni, F., & Altmeyer, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1383 · Cited by 250 · see citing works

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

Maréchal, A., Li, J.-M., Ji, X. Y., Wu, C.-S. P., Yazinski, S. A., Nguyen, H. D., Liu, S., Jiménez, A. E., Jin, J., & Zou, L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.11.002 · Cited by 246 · see citing works

Dissecting the expression landscape of RNA-binding proteins in human cancers

Kechavarzi, B., & Janga, S. C. (2014) · Genome biology · doi:10.1186/gb-2014-15-1-r14 · Cited by 242 · see citing works

Genome-wide transcriptome profiling of homologous recombination DNA repair

Peng, G., Lin, C. C.-J., Mo, W., Dai, H., Park, Y., Kim, S. M., Peng, Y., Mo, Q., Siwko, S. K., Hu, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4361 · Cited by 223 · see citing works

The new (dis)order in RNA regulation

Järvelin, A. I., Noerenberg, M., Davis, I., & Castelló, A. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0132-3 · Cited by 217 · see citing works

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

Khurana, S., Kruhlak, M. J., Kim, J., Tran, A. D., Liu, J., Nyswaner, K., Shi, L., Jailwala, P., Sung, M.-H., Hakim, O., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.024 · Cited by 220 · see citing works

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

Lu, W.-T., Hawley, B. R., Skalka, G., Baldock, R. A., Smith, E. M., Bader, A. S., Malewicz, M., Watts, F. Z., Wilczynska, A., & Bushell, M. (2018) · Nature Communications · doi:10.1038/s41467-018-02893-x · Cited by 217 · see citing works

STING enhances cell death through regulation of reactive oxygen species and DNA damage

Hayman, T. J., Baro, M., MacNeil, T., Phoomak, C., Aung, T. N., Cui, W., Leach, K., Iyer, R. P., Challa, S., Sandoval-Schaefer, T., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22572-8 · Cited by 210 · see citing works

DNA repair defects in cancer and therapeutic opportunitiesPreprint

Hopkins, J. L., Lan, L., & Zou, L. (2022) · Genes & Development · doi:10.1101/gad.349431.122 · Cited by 204 · see citing works

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets

Mengwasser, K. E., Adeyemi, R. O., Leng, Y., Choi, M. Y., Clairmont, C. S., D’Andrea, A. D., & Elledge, S. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.12.008 · Cited by 198 · see citing works

Mapping the genetic landscape of DNA double-strand break repair

Hussmann, J. A., Jia, L., Ravisankar, P., Yan, J., Cirincione, A., Xu, A., Simpson, D., Yang, D., Bothmer, A., Cotta‐Ramusino, C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.002 · Cited by 182 · see citing works

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

Rulten, S. L., Rotheray, A., Green, R. L., Grundy, G. J., Moore, D. A. Q., Gómez-Herreros, F., Hafezparast, M., & Caldecott, K. W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt835 · Cited by 190 · see citing works

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

Britton, S., Dernoncourt, E., Delteil, C., Froment, C., Burlet‐Schiltz, O., Salles, B., Frit, P., & Calsou, P. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku601 · Cited by 185 · see citing works

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids

Mersaoui, S. Y., Yu, Z., Coulombe, Y., Karam, M., Busatto, F. F., Masson, J., & Richard, S. (2019) · The EMBO Journal · doi:10.15252/embj.2018100986 · Cited by 186 · see citing works

Coupling of Homologous Recombination and the Checkpoint by ATR

Buisson, R., Joshi, N., Rodrigue, A., Ho, C. K., Kreuzer, J., Foo, T. K., Hardy, É. J.-L., Dellaire, G., Haas, W., Xia, B., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.007 · Cited by 181 · see citing works

Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair

Gong, F., Clouaire, T., Aguirrebengoa, M., Legube, G., & Miller, K. M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611135 · Cited by 182 · see citing works

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

Izhar, L., Adamson, B., Ciccia, A., Lewis, J., Vaites, L. P., Leng, Y., Liang, A. C. T., Westbrook, T. F., Harper, J. W., & Elledge, S. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.053 · Cited by 178 · see citing works

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

Zhao, W., Vaithiyalingam, S., San Filippo, J., Maranon, D. G., Jimenez-Sainz, J., Fontenay, G. V., Kwon, Y., Leung, S. G., Lu, L., Jensen, R. B., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.032 · Cited by 177 · see citing works

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

Yazinski, S. A., & Zou, L. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-121658 · Cited by 173 · see citing works

Linking RNA biology to lncRNAsPreprint

Goff, L. A., & Rinn, J. L. (2015) · Genome Research · doi:10.1101/gr.191122.115 · Cited by 175 · see citing works

Reprogramming cellular events by poly(ADP-ribose)-binding proteins

Krietsch, J., Rouleau, M., Pic, É., Ethier, C., Dawson, T. M., Dawson, V. L., Masson, J., Poirier, G. G., & Gagné, J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.005 · Cited by 171 · see citing works

Defining and Modulating ‘BRCAness’

Byrum, A. K., Vindigni, A., & Mosammaparast, N. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.06.005 · Cited by 164 · see citing works

PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks

Krietsch, J., Caron, M., Gagné, J., Ethier, C., Vignard, J., Vincent, M., Rouleau, M., Hendzel, M. J., Poirier, G. G., & Masson, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks798 · Cited by 166 · see citing works

A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens

Sigoillot, F. D., Lyman, S. K., Huckins, J. F., Adamson, B., Chung, E., Quattrochi, B., & King, R. W. (2012) · Nature Methods · doi:10.1038/nmeth.1898 · Cited by 159 · see citing works

Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites

Liu, Y., Cao, Z., Wang, Y., Guo, Y., Xu, P., Yuan, P., Liu, Z., He, Y. M., & Wei, W. (2018) · Nature Biotechnology · doi:10.1038/nbt.4283 · Cited by 154 · see citing works

TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia

Zhang, H., Kozono, D., O’Connor, K. W., Vidal-Cardenas, S. L., Rousseau, A., Hamilton, A., Moreau, L. A., Gaudiano, E. F., Greenberger, J. S., Bagby, G. C., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.03.002 · Cited by 158 · see citing works

A BRCA1‐interacting lncRNA regulates homologous recombination

Sharma, V., Khurana, S., Kubben, N., Abdelmohsen, K., Oberdoerffer, P., Gorospe, M., & Misteli, T. (2015) · EMBO Reports · doi:10.15252/embr.201540437 · Cited by 154 · see citing works

The RNA Splicing Response to DNA Damage

Shkreta, L., & Chabot, B. (2015) · Biomolecules · doi:10.3390/biom5042935 · Cited by 154 · see citing works

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks

Li, L., Germain, D. R., Poon, H.-Y., Hildebrandt, M. R., Monckton, E. A., McDonald, D., Hendzel, M. J., & Godbout, R. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00415-16 · Cited by 152 · see citing works

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

Khoury-Haddad, H., Guttmann‐Raviv, N., Ipenberg, I., Huggins, D. J., Jeyasekharan, A. D. D., & Ayoub, N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317585111 · Cited by 148 · see citing works

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Ardeljan, D., Steranka, J. P., Liu, C., Li, Z., Taylor, M. S., Payer, L. M., Gorbounov, M., Sarnecki, J. S., Deshpande, V., Hruban, R. H., et al. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0372-1 · Cited by 135 · see citing works

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

Howard, S. M., Yanez, D. A., & Stark, J. M. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004943 · Cited by 145 · see citing works

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

Lin, A., Giuliano, C. J., Sayles, N. M., & Sheltzer, J. M. (2017) · eLife · doi:10.7554/elife.24179 · Cited by 145 · see citing works

Chromatin dynamics after DNA damage: The legacy of the access–repair–restore model

Polo, S. E., & Almouzni, G. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.09.014 · Cited by 135 · see citing works

Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage

Hill, S. J., Mordes, D. A., Cameron, L., Neuberg, D. S., Landini, S., Eggan, K. C., & Livingston, D. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611673113 · Cited by 136 · see citing works

Charity begins at home: non-coding RNA functions in DNA repair

Chowdhury, D., Choi, Y. E., & Brault, M. E. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3523 · Cited by 132 · see citing works

RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks

Elia, A. E. H., Wang, D. C., Willis, N. A., Boardman, A. P., Hajdú, I., Adeyemi, R. O., Lowry, E. L., Gygi, S. P., Scully, R., & Elledge, S. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.011 · Cited by 129 · see citing works

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis

Stojic, L., Lun, A. T. L., Mangei, J., Mascalchi, P., Quarantotti, V., Barr, A. R., Bakal, C., Marioni, J. C., Gergely, F. V., & Odom, D. T. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky437 · Cited by 131 · see citing works

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1–mediated chromatin response to DNA breaks

Watanabe, S., Watanabe, K., Akimov, V., Bártková, J., Blagoev, B., Lukas, J., & Bártek, J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2702 · Cited by 130 · see citing works

The PARP family: insights into functional aspects of poly ( ADP ‐ribose) polymerase‐1 in cell growth and survival

Jubin, T., Kadam, A. A., Jariwala, M., Bhatt, S., Sutariya, S., Gani, A. R., Gautam, S., & Begum, R. (2016) · Cell Proliferation · doi:10.1111/cpr.12268 · Cited by 130 · see citing works

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Gustafsson, N., Färnegårdh, K., Bonagas, N., Ninou, A. H., Groth, P., Wiita, E., Jönsson, M., Hallberg, K., Lehto, J., Pennisi, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06287-x · Cited by 126 · see citing works

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

Kampmann, M., Bassik, M. C., & Weissman, J. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307002110 · Cited by 123 · see citing works

Systematic E2 screening reveals a UBE2D–RNF138–CtIP axis promoting DNA repair

Schmidt, C. K., Galanty, Y., Sczaniecka-Clift, M., Coates, J., Jhujh, S. S., Demir, M., Cornwell, M., Beli, P., & Jackson, S. P. (2015) · Nature Cell Biology · doi:10.1038/ncb3260 · Cited by 119 · see citing works

DNA damage: RNA-binding proteins protect from near and far

Dutertre, M., Lambert, S., Carreira, A., Amor-Guéret, M., & Vagner, S. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.01.003 · Cited by 120 · see citing works

The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis

Bampton, A., Gittings, L. M., Fratta, P., Lashley, T., & Gatt, A. P. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02203-0 · Cited by 118 · see citing works

BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡

Sessa, G., Gómez‐González, B., Silva, S. D. R., Calero, C. P., Beaurepere, R., Barroso, S. I., Martineau, S., Martin, C. A., Ehlén, Å., Martínez, J. S., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106018 · Cited by 113 · see citing works

Roles of RNA-Binding Proteins in DNA Damage Response

Kai, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030310 · Cited by 112 · see citing works

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

Zong, D., Adam, S., Wang, Y., Sasanuma, H., Callén, E., Murga, M., Day, A., Kruhlak, M. J., Wong, N., Munro, M., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.12.010 · Cited by 108 · see citing works

Histone Acetyltransferase 1 Promotes Homologous Recombination in DNA Repair by Facilitating Histone Turnover

Yang, X., Li, L., Liang, J., Shi, L., Yang, J., Yi, X., Zhang, D., Han, X., Yu, N., & Shang, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.473199 · Cited by 112 · see citing works

RNA Processing and Genome Stability: Cause and Consequence

Wickramasinghe, V. O., & Venkitaraman, A. R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.001 · Cited by 107 · see citing works

The roles of RNA in DNA double-strand break repair

Bader, A. S., Hawley, B. R., Wilczynska, A., & Bushell, M. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0624-1 · Cited by 113 · see citing works

Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase

Kass, E. M., Helgadottir, H. R., Chen, C.-C., Barbera, M. A., Wang, R., Westermark, U., Ludwig, T., Moynahan, M. E., & Jasin, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216824110 · Cited by 107 · see citing works

High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease

Pegoraro, G., & Misteli, T. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.06.005 · Cited by 103 · see citing works

DEAD-Box RNA Helicases and Genome Stability

Cargill, M. J., Venkataraman, R., & Lee, S. C.-W. (2021) · Genes · doi:10.3390/genes12101471 · Cited by 105 · see citing works

Biomolecular condensates at sites of DNA damage: More than just a phase

Spegg, V., & Altmeyer, M. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103179 · Cited by 97 · see citing works

Fine-Tuning of DNA Damage-Dependent Ubiquitination by OTUB2 Supports the DNA Repair Pathway Choice

Kato, K., Nakajima, K., Ui, A., Terao-Muto, Y., Ogiwara, H., & Nakada, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.030 · Cited by 99 · see citing works

CRISPR/Cas System and Factors Affecting Its Precision and Efficiency

Javaid, N., & Choi, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.761709 · Cited by 98 · see citing works

DNA Repair and Therapeutic Strategies in Cancer Stem Cells

Gillespie, M. S., Ward, C. M., & Davies, C. C. (2023) · Cancers · doi:10.3390/cancers15061897 · Cited by 96 · see citing works

Mechanisms of genome instability induced by RNA-processing defects

Chan, Y. A., Hieter, P., & Stirling, P. C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.03.005 · Cited by 94 · see citing works

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

Michelini, F., Jalihal, A. P., Francia, S., Meers, C., Neeb, Z. T., Rossiello, F., Gioia, U., Aguado, J., Jones-Weinert, C., Luke, B., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00487 · Cited by 85 · see citing works

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repairPreprint

Leung, J. W. C., Makharashvili, N., Agarwal, P., Chiu, L.-Y., Pourpre, R., Cammarata, M. B., Cannon, J. R., Sherker, A., Durocher, D., Brodbelt, J. S., et al. (2017) · Genes & Development · doi:10.1101/gad.292516.116 · Cited by 87 · see citing works

Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens

Awwad, S. W., Serrano-Benítez, A., Thomas, J. C., Gupta, V., & Jackson, S. P. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00571-x · Cited by 87 · see citing works

The impact of SF3B1 mutations in CLL on the DNA-damage response

Raa, G. D. T., Derks, I. A. M., Navrkalová, V., Skowrońska, A., Moerland, P. D., van Laar, J., Oldreive, C., Monsuur, H. N., Trbušek, M., Malčíková, J., et al. (2014) · Leukemia · doi:10.1038/leu.2014.318 · Cited by 86 · see citing works

SRSF10 Connects DNA Damage to the Alternative Splicing of Transcripts Encoding Apoptosis, Cell-Cycle Control, and DNA Repair Factors

Shkreta, L., Toutant, J., Durand, M., Manley, J. L., & Chabot, B. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.071 · Cited by 87 · see citing works

DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions

Yu, Z., Mersaoui, S. Y., Guitton-Sert, L., Coulombe, Y., Song, J., Masson, J., & Richard, S. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa028 · Cited by 86 · see citing works

The interplay between DNA damage response and RNA processing: the unexpected role of splicing factors as gatekeepers of genome stability

Naro, C., Bielli, P., Pagliarini, V., & Sette, C. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00142 · Cited by 84 · see citing works

RBMX suppresses tumorigenicity and progression of bladder cancer by interacting with the hnRNP A1 protein to regulate PKM alternative splicing

Yan, Q., Zeng, P., Zhou, X., Zhao, X., Chen, R., Qiao, J., Ling, F., Zhu, Z., Zhang, G., & Chen, C. (2021) · Oncogene · doi:10.1038/s41388-021-01666-z · Cited by 84 · see citing works

CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair

Lang, F., Li, X., Zheng, W., Li, Z., Lu, D., Chen, G., Gong, D., Yang, L., Fu, J., Shi, P., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704076114 · Cited by 83 · see citing works

Non‐coding RNAs in DNA damage and repair

Sharma, V., & Misteli, T. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.05.006 · Cited by 83 · see citing works

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

Elguindy, M. M., Kopp, F. B., Goodarzi, M., Rehfeld, F., Thomas, A. A., Chang, T.-C., & Mendell, J. T. (2019) · eLife · doi:10.7554/elife.48625 · Cited by 81 · see citing works

Human Inositol Polyphosphate Multikinase Regulates Transcript-Selective Nuclear MRNA Export to Preserve Genome Integrity

Wickramasinghe, V. O., Savill, J. M., Chavali, S., Jonsdottir, A. B., Rajendra, E., Grüner, T., Laskey, R. A., Babu, M. M., & Venkitaraman, A. R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.031 · Cited by 80 · see citing works

PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

Ke, Y., Han, Y., Guo, X., Wen, J., Wang, K., Jiang, X. Y., Tian, X., Ba, X., Boldogh, I. R., & Zeng, X. (2017) · Nature Communications · doi:10.1038/ncomms14632 · Cited by 80 · see citing works

Regulators of homologous recombination repair as novel targets for cancer treatment

Krajewska, M., Fehrmann, R. S. N., de Vries, E. G. E., & van Vugt, M. A. T. M. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00096 · Cited by 79 · see citing works

Poly-ADP ribosylation in DNA damage response and cancer therapy

Hou, W., Chen, S.-H., & Yu, X. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.09.004 · Cited by 78 · see citing works

Reshaping Chromatin after DNA Damage: The Choreography of Histone Proteins

Polo, S. E. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.05.025 · Cited by 75 · see citing works

A high‐throughput, flow cytometry‐based method to quantify DNA‐end resection in mammalian cells

Forment, J. V., Walker, R. V., & Jackson, S. P. (2012) · Cytometry Part A · doi:10.1002/cyto.a.22155 · Cited by 72 · see citing works

BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids

Chandramouly, G., Kwok, A., Huang, B., Willis, N. A., Xie, A., & Scully, R. (2013) · Nature Communications · doi:10.1038/ncomms3404 · Cited by 74 · see citing works

Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins

Harvey, R. F., Dezi, V., Pizzinga, M., & Willis, A. E. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160364 · Cited by 73 · see citing works

DNA damage, chromatin, and transcription: the trinity of aging

Burgess, R. C., Misteli, T., & Oberdoerffer, P. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.07.005 · Cited by 72 · see citing works

PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

Musiani, D., Giambruno, R., Massignani, E., Ippolito, M. R., Maniaci, M., Jammula, S., Manganaro, D., Cuomo, A., Nicosia, L., Pasini, D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.061 · Cited by 73 · see citing works

Tumor protein D52 (TPD52) and cancer—oncogene understudy or understudied oncogene?

Byrne, J. A., Frost, S., Chen, Y., & Bright, R. K. (2014) · Tumor Biology · doi:10.1007/s13277-014-2006-x · Cited by 72 · see citing works

OUP accepted manuscript

Chen, Y., Zhang, H., Xu, Z., Tang, H., Geng, A., Cai, B., Su, T., Shi, J., Jiang, C., Tian, X., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz592 · Cited by 71 · see citing works

A Genome-Wide Study of Homologous Recombination in Mammalian Cells Identifies RBMX, a Novel Component of the DNA Damage Response

Adamson, B. (2013) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins

McGrail, D. J., Li, Y., Smith, R. S., Feng, B., Dai, H., Hu, L., Dennehey, B. K., Awasthi, S., Mendillo, M. L., Sood, A. K., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101255 · Cited by 21 · see citing works

Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway

Kingham, G. L. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique) · doi:10.5287/ora-zvyp7ek09 · Cited by 1 · see citing works

Recruitment of RBM6 to DNA double-strand breaks fosters homologous recombination repair

Darawshe, M. M. (2023) · Data Archiving and Networked Services (DANS) · doi:10.17632/87bp9n42v9

A Genome-scale RNA Interference Screen Identifies Novel Regulators of DNA Double-strand Break Repair

Young, J. T. F. (2016) · TSpace (University of Toronto)