The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
MyomiR-133 regulates brown fat differentiation through Prdm16
Open accessAbstract
Brown adipose tissue (BAT) uses the chemical energy of lipids and glucose to produce heat, a function that can be induced by cold exposure or diet. A key regulator of BAT is the gene encoding PR domain containing 16 (Prdm16), whose expression can drive differentiation of myogenic and white fat precursors to brown adipocytes. Here we show that after cold exposure, the muscle-enriched miRNA-133 is markedly downregulated in BAT and subcutaneous white adipose tissue (SAT) as a result of decreased expression of its transcriptional regulator Mef2. miR-133 directly targets and negatively regulates PRDM16, and inhibition of miR-133 or Mef2 promotes differentiation of precursors from BAT and SAT to mature brown adipocytes, thereby leading to increased mitochondrial activity. Forced expression of miR-133 in brown adipogenic conditions prevents the differentiation to brown adipocytes in both BAT and SAT precursors. Our results point to Mef2 and miR-133 as central upstream regulators of Prdm16 and hence of brown adipogenesis in response to cold exposure in BAT and SAT.
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Cites
Silencing of microRNAs in vivo with ‘antagomirs’
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Self-citationFunctional Brown Adipose Tissue in Healthy Adults
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“intensity (log) Fold-change Cutoff (–1, 2) Cutoff (1, 2)”
InfluentialUnexpected evidence for active brown adipose tissue in adult humans
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MicroRNAs 103 and 107 regulate insulin sensitivity
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Cited by
Brown and beige fat: Development, function and therapeutic potential
Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177
Adaptive thermogenesis in adipocytes: Is beige the new brown?
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MicroRNAs in Cardiovascular Disease
Barwari, T., Joshi, A., & Mayr, M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.945 · Cited by 445
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Metadata
- Authors
- Trajkovski, M., Ahmed, K., Esau, C. C., & Stoffel, M.
- Venue
- Nature Cell Biology
- Published
- 2012-11-11
- Volume
- 14
- Issue
- 12
- Pages
- 1330-1335
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1995253518
- Cited by
- 264
- References
- 8
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- green
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