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Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

Sabatella, M., Thijssen, K. L., Davó-Martínez, C., Vermeulen, W., & Lans, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108608 · Cited by 36 · see citing works

The Inducible Response of the Nematode Caenorhabditis elegans to Members of Its Natural Microbiota Across Development and Adult Life

Yang, W., Petersen, C., Pees, B., Zimmermann, J., Waschina, S., Dirksen, P., Rosenstiel, P. C., Tholey, A., Leippe, M., Dierking, K., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01793 · Cited by 32 · see citing works

A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes

Rieckher, M., Bujarrabal-Dueso, A., Doll, M. A., Soltanmohammadi, N., & Schumacher, B. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25979 · Cited by 32 · see citing works

Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Hamsanathan, S., Anthonymuthu, T., Han, S., Shinglot, H., Siefken, E., Sims, A., Sen, P., Pepper, H. L., Snyder, N. W., Bayir, H., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl6083 · Cited by 30 · see citing works

RNA interference may result in unexpected phenotypes in Caenorhabditis elegans

De‐Souza, E. A., Camara, H., Salgueiro, W. G., Moro, R. D. P., Knittel, T. L., Tonon-da-Silva, G., Pinto, S., Pinca, A. P. F., Antebi, A., Pasquinelli, A. E., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz154 · Cited by 28 · see citing works

DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood in Caenorhabditis elegans

McHugh, D. R., Koumis, E., Jacob, P., Goldfarb, J. A., Schlaubitz-Garcia, M., Bennani, S., Regan, P., Patel, P., & Youngman, M. J. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401166 · Cited by 28 · see citing works

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans

Wilson, D. M., Rieckher, M., Williams, A. B., & Schumacher, B. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx660 · Cited by 26 · see citing works

MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO

Bianco, J. N., & Schumacher, B. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky404 · Cited by 26 · see citing works

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

Fan, X., Zeng, Y. Y., Fan, Z., Cui, L., Song, W., Wu, Q., Gao, Y., Yang, D., Mao, X., Zeng, B., et al. (2020) · Aging · doi:10.18632/aging.202156 · Cited by 26 · see citing works

DNA damage promotes ER stress resistance through elevation of unsaturated phosphatidylcholine in Caenorhabditis elegans

Deng, J., Bai, X., Tang, H., & Pang, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016083 · Cited by 24 · see citing works

Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging

Rieckher, M., Gallrein, C., Alquézar-Artieda, N., Bourached-Silva, N., Vaddavalli, P. L., Mares, D., Backhaus, M., Blindauer, T., Greger, K., Wiesner, E., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae519 · Cited by 25 · see citing works

Caenorhabditis elegansfor research on cancer hallmarks

Cerón, J. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050079 · Cited by 22 · see citing works

Quality control mechanisms in cellular and systemic DNA damage responses

Ermolaeva, M., Dakhovnik, A., & Schumacher, B. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.009 · Cited by 22 · see citing works

DNA repair deficiencies and neurodegeneration

Ropert, B., Gallrein, C., & Schumacher, B. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103679 · Cited by 21 · see citing works

A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans

Guédon, R., Maremonti, E., Armant, O., Galas, S., Brede, D. A., & Lecomte-Pradines, C. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112793 · Cited by 21 · see citing works

Genome instability: Linking ageing and brain degeneration

Barzilai, A., Schumacher, B., & Shiloh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.011 · Cited by 20 · see citing works

Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning

Ange, J. S., Weng, Y., Kaletsky, R. L., Stevenson, M. E., Moore, R. S., Zhou, S., & Murphy, C. T. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100720 · Cited by 20 · see citing works

DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity

Williams, A. B., & Schumacher, B. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.007 · Cited by 20 · see citing works

FOXOs Maintaining the Equilibrium for Better or for Worse

van Doeselaar, S., & Burgering, B. M. T. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.10.003 · Cited by 17 · see citing works

Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Servello, F. A., Fernandes, R., Eder, M., Harris, N., Martin, O. M. F., Oswal, N., Lindberg, A., Derosiers, N., Sengupta, P., Stroustrup, N., et al. (2022) · eLife · doi:10.7554/elife.78941 · Cited by 17 · see citing works

Regulation and functions of membrane lipids: Insights from Caenorhabditis elegans

Koyiloth, M., & Gummadi, S. N. (2022) · BBA Advances · doi:10.1016/j.bbadva.2022.100043 · Cited by 16 · see citing works

Inhibition of ribosome biogenesis in the epidermis is sufficient to trigger organism-wide growth quiescence independently of nutritional status in C. elegans

Zhao, Q., Rangan, R., Weng, S., Özdemir, C., & Cenik, E. S. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002276 · Cited by 13 · see citing works

Mutagenesis of GATA motifs controlling the endoderm regulator elt-2 reveals distinct dominant and secondary cis- regulatory elements

Du, L., Tracy, S., & Rifkin, S. A. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.02.013 · Cited by 15 · see citing works

Recent advances in understanding the mechanisms determining longevity

Bayersdorf, R., & Schumacher, B. (2019) · F1000Research · doi:10.12688/f1000research.19610.1 · Cited by 14 · see citing works

Scope of 2D materials for immune response-a review

Hossain, N., Chowdhury, M. A., Sultana, S., & Nandee, R. (2022) · Results in Engineering · doi:10.1016/j.rineng.2022.100413 · Cited by 14 · see citing works

A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA

Babu, V. V. S., & Schumacher, B. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.03.008 · Cited by 14 · see citing works

Context-specific regulation of lysosomal lipolysis through network-level diverting of transcription factor interactions

Mony, V. K., Drangowska-Way, A., Albert, R., Harrison, E., Ghaddar, A., Horak, M. K., Ke, W., & O’Rourke, E. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2104832118 · Cited by 13 · see citing works

Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans

Yan, J., Bhanshali, F., Shuzenji, C., Mendenhall, T. T., Taylor, S. K. B., Ermakova, G., Cheng, X., Bai, P., Diwan, G., Seraj, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56766-1 · Cited by 11 · see citing works

Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans

Zhang, X., Li, W., Feng, K., Xiao, J., Du, J., Cao, Y., & Chen, Y. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111388 · Cited by 11 · see citing works

Identification of polymorphisms in cancer patients that differentially affect survival with age

Doherty, A., Kernogitski, Y., Kulminski, A. M., & de Magalhães, J. P. (2017) · Aging · doi:10.18632/aging.101305 · Cited by 11 · see citing works

Light Sheet Microscopy to Measure Protein Dynamics

Rieckher, M. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25451 · Cited by 10 · see citing works

Longevity Regulation by Insulin/IGF-1 Signalling

An, S. W. A., Artan, M., Park, S., Altıntaş, Ö., & Lee, S. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_4 · Cited by 8 · see citing works

DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16

Sarkar, G. C., Rautela, U., Goyala, A., Datta, S., Anand, N., Singh, A., Singh, P., Chamoli, M., & Mukhopadhyay, A. (2023) · Development · doi:10.1242/dev.201472 · Cited by 9 · see citing works

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

Lohmann, G., Vasyutina, E. L., Bloehdorn, J., Reinart, N., Schneider, J. I., Babu, V. V. S., Knittel, G., Crispatzu, G., Mayer, P., Prinz, C., et al. (2016) · Leukemia · doi:10.1038/leu.2016.294 · Cited by 9 · see citing works

Nontranscriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis

Daitoku, H., Kaneko, Y., Yoshimochi, K., Matsumoto, K., Araoi, S., Sakamaki, J.-I., Takahashi, Y., & Fukamizu, A. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00265-16 · Cited by 9 · see citing works

Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo

Kang, H. C., Hasselbeck, S., Taškova, K., Wang, N., van Oosten, L. N., Mrowka, R., Utikal, J. S., Andrade-Navarro, M. A., Wang, J., Wölfl, S., et al. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115513 · Cited by 7 · see citing works

Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins

Artan, M., Schoen, H., & de Bono, M. (2025) · Nature Communications · doi:10.1038/s41467-025-66409-0 · Cited by 6 · see citing works

Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra‐3/daf‐11 signaling in Caenorhabditis elegans

Khanna, A., Sellegounder, D., Kumar, J., Chamoli, M., Vargas, M., Chinta, S. J., Rane, A., Nelson, C. S., Peiris, T. H., Brem, R. B., et al. (2021) · Aging Cell · doi:10.1111/acel.13351 · Cited by 6 · see citing works

Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging

Edifizi, D., & Schumacher, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112329 · Cited by 6 · see citing works

Longevity through DNA damage tolerance

Castells‐Roca, L., Mueller, M. M., & Schumacher, B. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1006543 · Cited by 5 · see citing works

Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq

Freeman, T. F., Zhao, Q., Surya, A., Rothe, R., & Cenik, E. S. (2023) · BMC Genomics · doi:10.1186/s12864-023-09576-y · Cited by 5 · see citing works

Astaxanthin attenuates UV ‐irradiation aging process via activating JNK‐1/DAF‐16 in Caenorhabditis elegans

Lin, X., Shao, C., Elsherbiny, S. M., & Huang, Q. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13958 · Cited by 5 · see citing works

PQN-75 is expressed in the pharyngeal gland cells of C aenorhabditis elegans and is dispensable for germline development

Rochester, J. D., Tanner, P. C., Sharp, C. S., Andralojc, K. M., & Updike, D. L. (2017) · Biology Open · doi:10.1242/bio.027987 · Cited by 5 · see citing works

Auricularia polytricha extract exerts SKN-1 and DAF-16 mediated longevity and stress resistance against UV-B exposure in Caenorhabditis elegans

Sharika, R., Verma, K., Tencomnao, T., & Chuchawankul, S. (2024) · Nutrition and Healthy Aging · doi:10.3233/nha-220200 · Cited by 4 · see citing works

Age Deceleration and Reversal Gene Patterns in Dauer Diapause

Totska, K., Barata, J. C. V. V., Sandt, W., Meyer, D. H., & Schumacher, B. (2025) · Aging Cell · doi:10.1111/acel.70253 · Cited by 3 · see citing works

FoxO1: A Conductor of Insulin Signaling to Glucose and Lipid Metabolism

Zhang, T., & Dong, H. H. (2015) · Springer eBooks · doi:10.1007/978-3-319-25065-6_4 · Cited by 3 · see citing works

Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans

Marchal, L., Hamsanathan, S., Karthikappallil, R., Han, S., Shinglot, H., & Gurkar, A. U. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111573 · Cited by 3 · see citing works

In memoriam Olivier Toussaint – Stress-induced premature senescence and the role of DNA damage

Bürkle, A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.06.003 · Cited by 4 · see citing works

Genome Stability in Caenorhabditis elegans

Rieckher, M., Lopes, A. F. C., & Schumacher, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00011-2 · Cited by 2 · see citing works

Genome Stability and Ageing

Gurkar, A. U., Gill, M. S., & Niedernhofer, L. J. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_11 · Cited by 2 · see citing works

Hypodermal ribosome synthesis inhibition induces a nutrition-uncoupled organism-wide growth quiescence in C. elegansPreprint

Zhao, Q., Rangan, R., Weng, S., Özdemir, C., & Cenik, E. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.28.509886 · Cited by 2 · see citing works

Inactivation of the DREAM complex mimics the molecular benefits of sleepPreprint

Valentim, I. S., Romero-Expósito, F. J., Schwab, K., Bayar, M., Tauassarova, A., Riege, K., Lange, L., Engmann, O., Fischer, M., Olmedo, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.26.600859 · Cited by 2 · see citing works

RNA polymerase II processing facilitates DNA repair and prevents DNA damage-induced neuronal and developmental failurePreprint

van der Woude, M., Thijssen, K. L., Sabatella, M., Marteijn, J. A. F., Vermeulen, W., & Lans, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.21.644538 · Cited by 2 · see citing works

Genome stability in Caenorhabditis elegans

Kovalchuk, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00011-8 · Cited by 1 · see citing works

Gene Expression Variation Analysis (GEVA): A new R package to evaluate variations in differential expression in multiple biological conditions

Nunes, I. J. G., Feltes, B. C., David, M. Z., & Dorn, M. (2022) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2022.104053 · Cited by 1 · see citing works

A novel hierarchy-based knowledge discovery framework for elucidating human aging-related phenotypic abnormalities

Wan, C., & Barton, C. (2024) · ACM Symposium on Applied Computing · doi:10.1145/3605098.3635943 · Cited by 1 · see citing works

Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cellsPreprint

Uszkoreit, S., Meyer, D. H., Rechavi, O., & Schumacher, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.19.500657 · Cited by 1 · see citing works

DAF-16/FOXO maintains genome integrity following genotoxic stressPreprint

Rautela, U., Devendran, O., Sarkar, G. C., Ranjisha, K. R., Mittal, R., Goyala, A., & Mukhopadhyay, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.27.684284 · Cited by 1 · see citing works

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans

Frommolt, P., & Schumacher, B. (2015) · Source Code for Biology and Medicine · doi:10.1186/s13029-015-0034-6

Closing the Circle: Stem Cell Rejuvenation and Longevity

Florian, M. C., & Geiger, H. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_16

Functional Consequences of Embryonic Stem Cell- Specific Alternative Splicing

Nachman, E. N. (2015) · TSpace (University of Toronto)

Genes, Aging, and Parkinson’s Disease

Milanese, C., & Mastroberardino, P. G. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622888-00389

Studies on Molecular Basis for FOXO1-DNA Damage Responses

悠太, 金. (2016) · Terrestrial Environment Research Center (University of Tsukuba)

Faculty Opinions recommendation of Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging.

Schumacher, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733897159.793563342

Faculty Opinions recommendation of DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.

Lee, S., & Park, H. H. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734291273.793555709

Faculty Opinions recommendation of DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity.

Schumacher, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734291273.793563332

The structure-function paradigm reshaped by intrinsically disordered regions

Gui, T. (2023) · doi:10.33540/1971

DAF-16/FOXO maintains genome integrity following genotoxic stress

Devendran, O., Rautela, U., Sarkar, G. C., Ranjisha, K. R., Mittal, R., Bala, R., Goyala, A., & Mukhopadhyay, A. (2026) · BMC Biology · doi:10.1186/s12915-026-02755-9

A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damagePreprint

Sarkar, G. C., Rautela, U., Goyala, A., Datta, S., Anand, N., Singh, A., Singh, P., Chamoli, M., & Mukhopadhyay, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.03.482777

John Fraser Roberts's 80th birthday

Polani, P. E., & Colleagues (1980) · Journal of Medical Genetics · doi:10.1136/jmg.17.2.158-a

DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16

Sarkar, G. C., Rautela, U., Goyala, A., Datta, S., Anand, N., Singh, A., Singh, P., Chamoli, M., & Mukhopadhyay, A. (2023) · Development · doi:10.1242/dev.201472 · Cited by 9 · see citing works

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

Edifizi, D., & Schumacher, B. (2015) · Biomolecules · doi:10.3390/biom5031855 · Cited by 42 · see citing works