Recent advances in understanding the mechanisms determining longevity

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Blackford, A. N., & Jackson, S. P. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.015 · Cited by 1,953 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261 · see citing works

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214 · see citing works

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105 · see citing works

Diversity of ageing across the tree of life

Jones, O. R., Scheuerlein, A., Salguero‐Gómez, R., Camarda, C. G., Schaible, R., Casper, B. B., Dahlgren, J. P., Ehrlén, J., Garcia, M. B., Menges, E. S., et al. (2013) · Nature · doi:10.1038/nature12789 · Cited by 1,033 · see citing works

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.09.015 · Cited by 1,032 · see citing works

Gut Microbiota and Extreme Longevity

Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.016 · Cited by 1,025 · see citing works

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.052 · Cited by 988 · see citing works

Rapamycin passes the torch: a new generation of mTOR inhibitors

Benjamin, D., Colombi, M., Moroni, C., & Hall, M. N. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3531 · Cited by 981 · see citing works

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515386112 · Cited by 915 · see citing works

DNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation

Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903 · see citing works

Caloric restriction improves health and survival of rhesus monkeys

Mattison, J. A., Colman, R. J., Beasley, T. M., Allison, D. B., Kemnitz, J. W., Roth, G. S., Ingram, D. K., Weindruch, R., de Cabo, R., & Anderson, R. M. (2017) · Nature Communications · doi:10.1038/ncomms14063 · Cited by 838 · see citing works

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830 · see citing works

Causes, consequences, and reversal of immune system aging

Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works

mTOR inhibition improves immune function in the elderly

Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009892 · Cited by 786 · see citing works

Autophagy as a promoter of longevity: insights from model organisms

Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754 · see citing works

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works

DNA damage and its links to neurodegeneration

Madabhushi, R., Pan, L., & Tsai, L.-H. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.034 · Cited by 654 · see citing works

A database of vertebrate longevity records and their relation to other life‐history traits

de Magalhães, J. P., & Costa, J. S. (2009) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2009.01783.x · Cited by 577 · see citing works

The Clinical potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., & Robbins, P. D. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14969 · Cited by 539 · see citing works

Evidence for a limit to human lifespan

Dong, X., Milholland, B., & Vijg, J. (2016) · Nature · doi:10.1038/nature19793 · Cited by 474 · see citing works

Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

Redman, L. M., Smith, S. R., Burton, J. H., Martin, C. K., Il'yasova, D., & Ravussin, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.019 · Cited by 472 · see citing works

Aging, inflammation and the environment

Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.015 · Cited by 431 · see citing works

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1937 · Cited by 426 · see citing works

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

Smith, P., Willemsen, D., Popkes, M., Metge, F., Gandiwa, E., Reichard, M., & Valenzano, D. R. (2017) · eLife · doi:10.7554/elife.27014 · Cited by 423 · see citing works

The role of DNA damage and repair in aging through the prism of Koch-like criteria

Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works

Mitochondrial ROS produced via reverse electron transport extend animal lifespan

Scialò, F., Sriram, A., Fernández-Ayala, D., Gubina, N., Lõhmus, M., Nelson, G., Logan, A., Cooper, H. M., Navas, P., Enríquez, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.009 · Cited by 371 · see citing works

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., et al. (2016) · Nature · doi:10.1038/nature19329 · Cited by 315 · see citing works

The plateau of human mortality: Demography of longevity pioneers

Barbi, E., Lagona, F., Marsili, M., Vaupel, J. W., & Wachter, K. W. (2018) · Science · doi:10.1126/science.aat3119 · Cited by 290 · see citing works

Cellular and epigenetic drivers of stem cell ageing

Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0020-3 · Cited by 272 · see citing works

Human T cell immunosenescence and inflammation in aging

Bektas, A., Schurman, S. H., Sen, R., & Ferrucci, L. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0716-335r · Cited by 270 · see citing works

The Genetics of Aging: A Vertebrate Perspective

Singh, P. P., Demmitt, B. A., Nath, R. D., & Brunet, A. (2019) · Cell · doi:10.1016/j.cell.2019.02.038 · Cited by 259 · see citing works

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Zhou, B., Kreuzer, J., Kumsta, C., Wu, L., Kamer, K. J., Cedillo, L., Zhang, Y., Li, S., Kacergis, M. C., Webster, C. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.013 · Cited by 220 · see citing works

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

Heintz, C., Doktor, T. K., Lanjuin, A., Escoubas, C. C., Zhang, Y., Weir, H. J. M., Dutta, S., Silva-García, C. G., Bruun, G. H., Morantte, I. G., et al. (2016) · Nature · doi:10.1038/nature20789 · Cited by 218 · see citing works

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

Bennett, C. F., Wende, H. V., Simko, M., Klum, S., Barfield, S., Choi, H., Pineda, V. V., & Kaeberlein, M. R. (2014) · Nature Communications · doi:10.1038/ncomms4483 · Cited by 215 · see citing works

Stable Cellular Senescence Is Associated with Persistent DDR Activation

Fumagalli, M., Rossiello, F., Mondello, C., & d’Adda di Fagagna, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110969 · Cited by 183 · see citing works

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

Lin, X.-X., Sen, I., Janssens, G. E., Zhou, X., Fonslow, B. R., Edgar, D., Stroustrup, N., Swoboda, P., Yates, J. R., Ruvkun, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06624-0 · Cited by 170 · see citing works

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

Urfer, S. R., Kaeberlein, T. L., Mailheau, S., Bergman, P. J., Creevy, K. E., Promislow, D., & Kaeberlein, M. R. (2017) · GeroScience · doi:10.1007/s11357-017-9972-z · Cited by 167 · see citing works

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

Wang, C., Niederstrasser, H., Douglas, P. M., Lin, R., Jaramillo, J., Li, Y., Oswald, N. W., Zhou, A., McMillan, E. A., Mendiratta, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02332-3 · Cited by 156 · see citing works

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

Xiong, L., Chen, Y.-J., Tong, J., Gong, Y., Huang, J., & Liu, Z. (2017) · Redox Biology · doi:10.1016/j.redox.2017.09.019 · Cited by 146 · see citing works

Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice

Schaetzlein, S., Nalapareddy, K., Ju, Z., Lechel, A., Stępczyńska, A., Lilli, D. R., Clark, A. B., Rudolph, C., Kühnel, F., Wei, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.029 · Cited by 144 · see citing works

Mitochondrial hormesis links low‐dose arsenite exposure to lifespan extension

Schmeisser, S., Schmeißer, K., Weimer, S., Groth, M., Priebe, S., Fazius, E., Kuhlow, D., Pick, D., Einax, J. W., Guthke, R., et al. (2013) · Aging Cell · doi:10.1111/acel.12076 · Cited by 142 · see citing works

Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress

Gusarov, I., Pani, B., Gautier, L., Смоленцева, О. А., Eremina, S. Y., Shamovsky, I., Katkova-Zhukotskaya, O. A., Mironov, A. S., & Nudler, E. (2017) · Nature Communications · doi:10.1038/ncomms15868 · Cited by 137 · see citing works

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Tang, D., Tao, S., Chen, Z., Koliesnik, I. O., Calmes, P. G., Hoerr, V., Han, B., Gebert, N., Zörnig, M., Löffler, B., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151100 · Cited by 133 · see citing works

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals

Schwörer, S., Becker, F., Feller, C., Baig, A. H., Köber, U., Henze, H., Kraus, J. M., Xin, B., Lechel, A., Lipka, D. B., et al. (2016) · Nature · doi:10.1038/nature20603 · Cited by 131 · see citing works

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Lan, Y. Y., Heather, J. M., Eisenhaure, T., Garris, C. S., Lieb, D., Raychowdhury, R., & Hacohen, N. (2019) · Aging Cell · doi:10.1111/acel.12901 · Cited by 130 · see citing works

Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

de Bourcy, C. F. A., Angel, C. J. L., Vollmers, C., Dekker, C. L., Davis, M. M., & Quake, S. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617959114 · Cited by 127 · see citing works

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

Mueller, M. M., Castells-Roca, L., Babu, V., Ermolaeva, M. A., Müller, R.-U., Frommolt, P., Williams, A. B., Greiss, S., Schneider, J. I., Benzing, T., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3071 · Cited by 108 · see citing works

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

Silvestrini, M. J., Johnson, J. R., Kumar, A. V., Thakurta, T. G., Blais, K., Neill, Z. A., Marion, S. W., Amand, V. S., Reenan, R. A., & Lapierre, L. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.063 · Cited by 104 · see citing works

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations

Tuikhar, N., Keisam, S., Labala, R. K., Imrat, Ramakrishnan, P., Arunkumar, M. C., Ahmed, G., Biagi, E., & Jeyaram, K. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.02.001 · Cited by 103 · see citing works

Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors

Yoshida, K., COLOGNE, J. B., Cordova, K. A., Misumi, M., Yamaoka, M., Kyoizumi, S., Hayashi, T., Robins, H. S., & Kusunoki, Y. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.05.015 · Cited by 96 · see citing works

Parrot Genomes and the Evolution of Heightened Longevity and Cognition

Wirthlin, M. E., Lima, N. C. B., Guedes, R. L. M., Soares, A. E. R., de Almeida, L. G. P., Cavaleiro, N. P., de Morais, G. L., Chaves, A. V., Howard, J. T., Teixeira, M. D. M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.050 · Cited by 89 · see citing works

Extension of Lifespan in C. elegans by Naphthoquinones That Act through Stress Hormesis Mechanisms

Hunt, P. R., Son, T. G., Wilson, M. A., Yu, Q.-S., Wood, W. H., Zhang, Y., Becker, K. G., Greig, N. H., Mattson, M. P., Camandola, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021922 · Cited by 88 · see citing works

Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation

Chen, Z., Amro, E. M., Becker, F. R., Hölzer, M., Rasa, S. M. M., Njeru, S. N., Han, B., Sanzo, S. D., Chen, Y.-L., Tang, D., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181505 · Cited by 87 · see citing works

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

Denzel, M. S., Lapierre, L. R., & Mack, H. I. D. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.001 · Cited by 81 · see citing works

Biological processes modulating longevity across primates: a phylogenetic genome-phenome analysis

Muntané, G., Farré, X., Rodríguez, J. A., Pegueroles, C., Hughes, D. A., de Magalhães, J. P., Gabaldón, T., & Navarro, A. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy105 · Cited by 73 · see citing works

Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction

Sperka, T., Song, Z., Morita, Y., Nalapareddy, K., Guachalla, L. M., Lechel, A., Begus‐Nahrmann, Y., Burkhalter, M. D., Mach, M., Schlaudraff, F., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2388 · Cited by 63 · see citing works

Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing

Wang, J., Morita, Y., Han, B., Niemann, S., Löffler, B., & Rudolph, K. L. (2016) · Nature Cell Biology · doi:10.1038/ncb3342 · Cited by 60 · see citing works

The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan

Minnerly, J., Zhang, J., Parker, T., Kaul, T. K., & Jia, K. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006764 · Cited by 55 · see citing works

Sirolimus for calcineurin inhibitors in organ transplantation: contra

Cravedi, P., Ruggenenti, P. L., & Remuzzi, G. (2010) · Kidney International · doi:10.1038/ki.2010.268 · Cited by 54 · see citing works

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Solis, G. M., Kardakaris, R., Valentine, E. R., Bar‐Peled, L., Chen, A. L., Blewett, M. M., McCormick, M. A., Williamson, J. R., Kennedy, B. K., Cravatt, B. F., et al. (2018) · eLife · doi:10.7554/elife.40314 · Cited by 54 · see citing works

Restored immune cell functions upon clearance of senescence in the irradiated splenic environment

Palacio, L., Goyer, M., Maggiorani, D., Espinosa, A., Villeneuve, N., Bourbonnais, S., Moquin‐Beaudry, G., Le, O., Demaria, M., Davalos, A. R., et al. (2019) · Aging Cell · doi:10.1111/acel.12971 · Cited by 54 · see citing works

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

Edifizi, D., Nolte, H., Babu, V. V. S., Castells‐Roca, L., Mueller, M. M., Brodesser, S., Krüger, M., & Schumacher, B. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.028 · Cited by 50 · see citing works

CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans

Dowen, R. H. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.002 · Cited by 50 · see citing works

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.06.005 · Cited by 43 · see citing works

Fundamental Characteristics of Single-Cell Aging in Diploid Yeast

Sarnoski, E. A., Song, R., Ertekin, E., Koonce, N. L., & Açar, M. (2018) · iScience · doi:10.1016/j.isci.2018.08.011 · Cited by 35 · see citing works

DNA Damage Regulates Translation through β-TRCP Targeting of CReP

Loveless, T. B., Topacio, B. R., Vashisht, A. A., Galaang, S., Ulrich, K., Young, B. D., Wohlschlegel, J. A., & Toczyski, D. P. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005292 · Cited by 34 · see citing works

Transcription‐blocking DNA damage in aging: a mechanism for hormesis

Schumacher, B. (2009) · BioEssays · doi:10.1002/bies.200900107 · Cited by 32 · see citing works

Potential for clonal animals in longevity and ageing studies

Sköld, H. N., & Obst, M. (2011) · Biogerontology · doi:10.1007/s10522-011-9333-8 · Cited by 32 · see citing works

The Systems Biology of Single-Cell Aging

Song, R., Sarnoski, E. A., & Açar, M. (2018) · iScience · doi:10.1016/j.isci.2018.08.023 · Cited by 30 · see citing works

Glycogen at the Crossroad of Stress Resistance, Energy Maintenance, and Pathophysiology of Aging

Gusarov, I., & Nudler, E. (2018) · BioEssays · doi:10.1002/bies.201800033 · Cited by 23 · see citing works

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Molenaars, M., Janssens, G. E., Santermans, T., Lezzerini, M., Jelier, R., MacInnes, A. W., & Houtkooper, R. H. (2018) · Life Science Alliance · doi:10.26508/lsa.201800082 · Cited by 16 · see citing works

TORC1 INHIBITION AS A POTENTIAL IMMUNOTHERAPY TO REDUCE INFECTIONS IN THE ELDERLY

Mannick, J. B. (2018) · Innovation in Aging · doi:10.1093/geroni/igy023.2011 · Cited by 3 · see citing works

Protein oxidation in aging and disease

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