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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Open accessAbstract
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cellular senescence suppresses cancer by preventing cell proliferation. However, as senescent cells accumulate with age, the senescence-associated secretory phenotype (SASP) can disrupt tissues and contribute to age-related pathologies, including cancer. MTOR inhibition suppressed the secretion of inflammatory cytokines by senescent cells. Rapamycin reduced IL6 and other cytokine mRNA levels, but selectively suppressed translation of the membrane-bound cytokine IL1A. Reduced IL1A diminished NF-κB transcriptional activity, which controls much of the SASP; exogenous IL1A restored IL6 secretion to rapamycin-treated cells. Importantly, rapamycin suppressed the ability of senescent fibroblasts to stimulate prostate tumour growth in mice. Thus, rapamycin might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
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In the citing paper
“The NF- κB, p38, mTOR and C/EBPβ signalling pathways are major components of the SASP 63-67 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [66]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Rapamycin, an immunosuppressant, decreases the SASP and maintains cell cycle arrest but does not kill Sncs (24).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [24]
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In the citing paper
“Treatment with rapamycin (and its analogue RAD001)232 attenuated the protumorigenic SASP230, prevented senescence233, impaired SASP-mediated immune recognition of oncogene-expressing cells and ameliorated liver dysfunction in naturally aged mice231.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [231]
The cited source says what the claim attributes to it.
In the citing paper
“In addition, the nutrient sensing pathways, mTOR and NAD, are involved in SASP regulation.56, 57, 58”
From Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer (2020) · cites this paper as [56]
The cited source says what the claim attributes to it.
In the citing paper
“In various preclinical studies, the mTOR inhibitor rapamycin might have the context-dependent potential to induce senescence 45 , diminish NF-κB activity 65,66 , suppress the pro-inflammatory SASP at the translational level, and limit the growth-promoting effect of senescent bystander fibroblasts on prostate tumours 66 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [66]
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In the citing paper
“and the serine/threonine kinase MK2, which indirectly stabilizes many cytokine-encoding transcripts231.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [231]
Experimental — accuracy not yet measuredIn the citing paper
“It also differentially regulates translation of IL-1A, the master regulator of SASP that subsequently engages IL-6/IL-8 (Orjalo et al., 2009; Laberge et al., 2015) and MAP kinase-activated protein kinase 2 (MAPKAP2) through 4EBP1, a translation repressor protein (Herranz et al., 2015).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Laberge et al., 2015
In the citing paper
“Inhibition of mTOR by rapamycin suppresses the secretion of inflammatory cytokines by senescent cells (Herranz et al., 2015; Laberge et al., 2015).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Laberge et al., 2015
In the citing paper
“IL-1α is the key driver of the SASP 79,80 , with upstream expression controlled in part by ATM/ATRmediated liberation of GATA4 from p62-directed autophagy 81 and/or an mTORC1-dependent pathway 82 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [82]
In the citing paper
“As an alternative approach, reduction of the SASP through “senostatic” or “senomorphic” approaches may be less toxic and has been shown to be effective in animal models (Birch and Passos, 2017; Georgilis et al., 2018; Laberge et al., 2015; Laberge et al., 2012; Niedernhofer and Robbins, 2018; Xu et al., 2015; Yoshimoto et al., 2013).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Laberge et al., 2015
In the citing paper
“Hypoxia impairs mammalian target of rapamycin (mTOR) activity, leading to reduced IL-1α translation to support NF-κB activity and SASP induction [162,163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“The increase in mTORC1 activity is essential for implementing the SASP by modulating the translation of IL-1α and MAP kinase-activated protein kinase 2 (MAPKAPK2) [162,163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“the secretome of senescent tumor cells can also drive tumor progression by promoting inflammation and potentially stimulating the growth and invasiveness of nearby tumor cells [148,154,163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“SASP inhibition by the mTOR inhibitor rapamycin can suppress the capacity of senescent fibroblasts to stimulate prostate tumor growth in mice [163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“inhibition of mTOR by rapamycin selectively inhibits the SASP and SA β‐gal staining of senescent cells without affecting their cell cycle arrest”
From Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism (2017) · cites this paper as Laberge et al., 2015
In the citing paper
“Rapamycin treatment suppressed SA-βgal activity (~ 50%) in irradiated cells (Fig. 5H), as expected [68]”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [68]
In the citing paper
“The mTOR pathway is a negative regulator of autophagy and is implicated in cellular senescence [67], most notably through SA-βgal activity and the expression of p16 and p21 markers [67], [68].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [68]
In the citing paper
“These factors are commonly described as the mediator of the pro-disease functions of senescent cells in vivo59.”
From Algorithmic assessment of cellular senescence in experimental and clinical specimens (2021) · cites this paper as [59]
In the citing paper
“These in vitro observations have been further substantiated in vivo, where co-injection of senescent fibroblasts has been shown to increase tumourigenicity in xenograft models, including primary breast cancer tissues.26,45–47”
From Paracrine roles of cellular senescence in promoting tumourigenesis (2018) · cites this paper as [46]
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Cites
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Self-citationCellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Self-citationRapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Self-citationClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Paradoxical roles of the immune system during cancer development
de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,299
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Items 701–800 of 998
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Troise, D. E., Mercuri, S., Infante, B., Losappio, V., Cirolla, L. A., Netti, G. S., Ranieri, E., & Stallone, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168676 · Cited by 17
Malavolta, M., Pierpaoli, E., Giacconi, R., Basso, A., Cardelli, M., Piacenza, F., & Provinciali, M. (2018) · Biological Procedures Online · doi:10.1186/s12575-018-0087-4 · Cited by 18
Cellular Senescence and Anti-Cancer Therapy
You, J., Dong, R., Ying, M., He, Q., Cao, J., & Yang, B. (2018) · Current Drug Targets · doi:10.2174/1389450120666181217100833 · Cited by 16
dos Santos, E. S., Wagner, V. P., Ramos, J. C., Lambert, D., CASTILHO, R. M., & Leme, A. F. P. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103397 · Cited by 16
Huang, Y., Yue, S., Yan, Z., Liu, Y., Qiao, J., Zhang, M., Dong, Y., & Zheng, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113071 · Cited by 15
Bohan, P. M. K., Chick, R. C., O’Shea, A. E., Vreeland, T. J., Hickerson, A. T., Cindass, J. L., Ensley, D. C., Hale, D. F., Clifton, G. T., Sohn, V. Y., et al. (2021) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0383 · Cited by 15
Gao, L., Yang, W.-Y., Qi, H., Sun, C.-J., Qin, X., & Du, G. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153990 · Cited by 15
Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases
Faggioli, F., Velarde, M. C., & Wiley, C. D. (2023) · Cells · doi:10.3390/cells12060860 · Cited by 15
Kirchner, V. A., Badshah, J. S., Hong, S. K., Martinez, O. M., Pruett, T. L., & Niedernhofer, L. J. (2023) · Transplantation · doi:10.1097/tp.0000000000004838 · Cited by 15
Sarandy, M. M., Gonçalves, R. V., & Valacchi, G. (2024) · Biomedicines · doi:10.3390/biomedicines12020348 · Cited by 16
Autophagy-dependent splicing control directs translation toward inflammation during senescence
Kim, J., Lee, Y., Jeon, T., Ju, S., Kim, J., Kim, M.-S., & Kang, C. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.10.008 · Cited by 19
Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells
Hoppe‐Seyler, K., Mändl, J., Adrian, S., Kuhn, B. J., & Hoppe‐Seyler, F. (2017) · Viruses · doi:10.3390/v9070174 · Cited by 16
Blagosklonny, M. V. (2018) · Aging · doi:10.18632/aging.101750 · Cited by 15
Liu, L., Zhao, J., Du, X., Zhao, Y., Zou, C., Zhou, H., Li, W., & Yan, X. (2021) · Cancer Medicine · doi:10.1002/cam4.4404 · Cited by 14
Senescent macrophages in tumor: phenotypes, roles, and interventions
Shen, W., Huang, Y., Yang, X., Zhang, Y., Pan, Y., Xiao, Y., Wang, J., Wang, C., Mao, W., & Zhao, A. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08000-5 · Cited by 16
Ge, C., Ma, C., Cui, J., Dong, X., Sun, L., Li, Y., & Yu, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281888 · Cited by 17
Xiong, J., Fu, Y., Huang, J., Wang, Y., Jin, X., Wan, X., Huang, L., & Huang, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1265525 · Cited by 14
Xu, M., Xia, Z.-Y., Sun, J., Liu, C., An, Y., Xu, J., Zhang, S.-H., Zhong, X., Zeng, N., Ma, S., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395047 · Cited by 14
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Dong, M., Yang, L., Qu, M., Hu, X., Duan, H., Zhang, X., Shi, W., & Zhou, Q. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00205.2017 · Cited by 15
Epstein, R. J. (2021) · Tumor Biology · doi:10.3233/tub-211502 · Cited by 14
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Poisa-Beiro, L., Landry, J. J. M., Raffel, S., Tanaka, M., Zaugg, J. B., Gavin, A., & Ho, A. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063028 · Cited by 14
Cassidy, L. D., & Narita, M. (2015) · Science · doi:10.1126/science.aad2501 · Cited by 14
PIKK ing a way to regulate inflammation
Quek, H., Lim, Y. C., Lavin, M. F., & Roberts, T. L. (2017) · Immunology and Cell Biology · doi:10.1111/imcb.1001 · Cited by 15
Chan, J. N. E., Humphry, M., Kitt, L., Krzyzanska, D., Filbey, K. J., Bennett, M. R., & Clarke, M. C. H. (2020) · European Journal of Immunology · doi:10.1002/eji.201948521 · Cited by 15
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Anerillas, C., Altés, G., & Gorospe, M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1083401 · Cited by 13
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Zhao, J., Wu, L., Cai, G., Ou, D., Liao, K., Yang, J., Zhou, L., Huang, R., Lin, S., Huang, X., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf045 · Cited by 13
Self-citationJiang, B., Zhang, H., Xu, Q., Jiang, Z., He, R., Fu, Q., & Sun, Y. (2025) · Aging Cell · doi:10.1111/acel.70138 · Cited by 14
Self-citationStromal senescence contributes to age-related increases in cancer
Ye, J., Melam, A., & Stewart, S. A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00840-9 · Cited by 16
Interleukin-1 signaling in solid organ malignancies
Dosch, A. R., Singh, S. P., Nagathihalli, N. S., Datta, J., & Merchant, N. B. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188670 · Cited by 14
Wang, H., Ramshekar, A., Cung, T., Wallace‐Carrete, C., Zaugg, C. J., Nguyen, J., Stoddard, G. J., & Hartnett, M. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210276 · Cited by 13
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Sharma, G., Banerjee, R., & Srivastava, S. (2023) · ACS Omega · doi:10.1021/acsomega.3c07480 · Cited by 13
Sugimoto, Y., Okamoto, K., Saito, H., Yamaguchi, T., Kinoshita, J., Nakamura, K., Takino, T., Endo, Y., Ninomiya, I., Ohta, T., et al. (2024) · Oncology Reports · doi:10.3892/or.2024.8788 · Cited by 13
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Daigh, L. H., Saha, D., Rosenthal, D. L., Ferrick, K. R., & Meyer, T. (2024) · Nature Communications · doi:10.1038/s41467-024-52820-6 · Cited by 16
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Yang, Y., Fan, L., Li, M., & Wang, Z. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.12.001 · Cited by 15
Plakhova, N., Panagopoulos, V., Cantley, M. D., Trainor, L. J., Hewett, D. R., Clark, K. C., Gardiner, J., Yong, A., Lee, C., Horvath, N., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02621-7 · Cited by 13
Wu, J., Liu, X., Liu, Y., Su, W., & Zhuo, Y. (2025) · Bioengineering · doi:10.3390/bioengineering12060563 · Cited by 14
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Serrano, M. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.09.011 · Cited by 14
DeTemple, V. K., Satzger, I., Walter, A., Schaper, K., & Gutzmer, R. (2016) · Experimental Dermatology · doi:10.1111/exd.13079 · Cited by 13
Winters, B. R., Vakar‐Lopez, F., Brown, L. G., Montgomery, B., Seiler, R., Black, P. C., Boormans, J. L., Dall’Era, M., Davincioni, E., Douglas, J., et al. (2018) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2018.03.016 · Cited by 13
Wei, Y., Meng, M., Tian, Z., Xie, F., Yin, Q., Dai, C., Wang, J., Zhang, Q., Liu, Y., Liu, C., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.017 · Cited by 13
Blagosklonny, M. V. (2019) · Aging · doi:10.18632/aging.102664 · Cited by 13
HMGA1-pseudogene7 transgenic mice develop B cell lymphomas
Martino, M. D., Biase, D. D., Forzati, F., Credendino, S. C., Palma, G., Barbieri, A., Arra, C., Paciello, O., Gaudio, E., Ponzoni, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62974-0 · Cited by 13
Accumulation of Mitochondrial RPPH1 RNA Is Associated with Cellular Senescence
Lee, J. W., Chun, Y. L., Kim, A., Lloyd, L. T., Ko, S., Yoon, J., & Min, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020782 · Cited by 14
Herranz, N., Gallage, S., & Gil, J. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1105694 · Cited by 14
Multi-omics and single cell characterization of cancer immunosenescence landscape
Wei, Q., Chen, R., He, X., Qu, Y., Yan, C., Liu, X., Liu, J., Luo, J., Yu, Z., Hu, W., et al. (2024) · Scientific Data · doi:10.1038/s41597-024-03562-z · Cited by 13
Shi, H., Xiao, M., Li, Y., Liu, X., Na, J., Liang, C., Hua, J., Meng, Q., Wei, M., Wang, W., et al. (2025) · Theranostics · doi:10.7150/thno.112633 · Cited by 12
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Pessoa, B., Hayashide, L. D. S., Dias, G. R., Pontes, B., Pinto, R. S., & Diniz, L. P. (2026) · Brain Sciences · doi:10.3390/brainsci16010076 · Cited by 13
Fujimoto, M., Higashiyama, R., Yasui, H., Yamashita, K., & Inanami, O. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101431 · Cited by 12
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Nehme, J., Altulea, A., Gheorghe, T., & Demaria, M. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.02.005 · Cited by 13
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Self-citationMatić, I., Revandkar, A., Chen, J., Bisio, A., Dall’Acqua, S., Cocetta, V., Brun, P., Mancino, G., Milanese, M., Mattei, M., et al. (2016) · Aging · doi:10.18632/aging.101076 · Cited by 13
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Tiwari, D. K., Hannen, R., Unger, K., Kohl, S., Heß, J., Lauber, K., Subtil, F. S. B., Dikomey, E., Engenhart‐Cabillic, R., & Schötz, U. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.878675 · Cited by 13
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Niu, H., Qian, L., Sun, B., Liu, W., Wang, F., Wang, Q., Ji, X., Luo, Y., Nesa, E. U., Lou, H., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.007 · Cited by 11
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Mohiuddin, M., & Kasahara, K. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100399 · Cited by 11
Small, S. H., Tang, E. J., Ragland, R. L., Ruzankina, Y., Schoppy, D. W., Mandal, R. S., Glineburg, M. R., Ustelenca, Z., Powell, D. J., Simpkins, F. A., et al. (2021) · Science Signaling · doi:10.1126/scisignal.aba2611 · Cited by 12
Makrakis, D., Wright, J. L., Roudier, M. P., Garcia, J. M., Vakar‐Lopez, F., Porter, M. P., Wang, Y., Dash, A., Lin, D. W., Schade, G. R., et al. (2022) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2022.12.003 · Cited by 11
Self-citationPalbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
Cayo, Á., Venturini, W., Rebolledo-Mira, D., Moore‐Carrasco, R., Herrada, A. A., Nova‐Lamperti, E., Valenzuela, C. A., & Brown, N. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119284 · Cited by 11
The ING1a model of rapid cell senescence
Bertschmann, J., Thalappilly, S., & Riabowol, K. T. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.06.004 · Cited by 14
Autophagy and senescence: Insights from normal and cancer stem cells
Talukdar, S., Das, S. K., Emdad, L., & Fisher, P. B. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.005 · Cited by 12
mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types
Koscielny, A., Liszewska, E., Machnicka, K., Wężyk, M., Kotulska, K., & Jaworski, J. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00262-z · Cited by 11
Interleukin-1α: Novel functions in cell senescence and antiviral response
Frisch, S. M. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155875 · Cited by 11
The potential of targeting Sin3B and its associated complexes for cancer therapy
Cantor, D. J., & David, G. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1386655 · Cited by 11
Tripathi, U., Suda, M., Kulshreshtha, V., Piatkowski, B. T., Palmer, A. K., Giorgadze, N., Inman, C. L., Gasek, N. S., Xu, M., Johnson, K. O., et al. (2025) · Aging Cell · doi:10.1111/acel.70358 · Cited by 10
Cellular senescence in cancer: Friend or fraud?
Chen, Q., Liu, J., Wu, J., Xiang, X., Zhou, X., Mi, J., Wei, J., Zou, X., & Wu, A. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101363 · Cited by 15
Zhang, Q., Zhou, D., & Yu, L. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s369376 · Cited by 10
Non-Intrinsic, Systemic Mechanisms of Cellular Senescence
Schwartz, R. E., & Conboy, I. M. (2023) · Cells · doi:10.3390/cells12242769 · Cited by 10
Abdelmoaty, A. A. A., Chen, J., Zhang, K., Wu, C., Li, Y., Li, P., & Xu, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1422363 · Cited by 10
Self-citationThe Hippo Signaling Pathway Manipulates Cellular Senescence
Miyajima, C., Nagasaka, M., Aoki, H., Toriuchi, K., Yamanaka, S., Hashiguchi, S., Morishita, D., Aoyama, M., Hayashi, H., & Inoue, Y. (2024) · Cells · doi:10.3390/cells14010013 · Cited by 10
Wu, J., Zhang, L., Zhao, Z., Liu, Y., Li, Z., Feng, X., Zhang, L., Yao, X., Du, J., Chen, L., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102783 · Cited by 10
YTHDF1 differentiates the contributing roles of mTORC1 in aging
Xu, C., Yu, C., Zhang, J., Zhang, Z., Zhang, J., Meng, Y., Wang, M., Wen, M., Chen, J., Ning, Y., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.05.003 · Cited by 10
Hu, J., Yu, D., Wang, J., Guo, P., Chen, M., Wu, D., Cai, Y., Wang, Y., Ji, J., Yao, X., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417708122 · Cited by 11
Inhibition of ‘jumping genes’ promotes healthy ageing
Childs, B. G., & van Deursen, J. (2019) · Nature · doi:10.1038/d41586-018-07553-0 · Cited by 11
Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells
Low, J., Chan, B., & Tay, A. K. P. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107990 · Cited by 11
Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells
Frey, W. D., Anderson, A. Y., Lee, H., Nguyen, J. B., Cowles, E., Lu, H., & Jackson, J. G. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001858 · Cited by 10
Endothelial Cell Aging and Autophagy Dysregulation
Marzoog, B. A. (2024) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/0118715257275690231129101408 · Cited by 10
Robbins, P. D., & Niedernhofer, L. J. (2017) · Aging Cell · doi:10.1111/acel.12620 · Cited by 11
Chandrasekaran, A., Lee, M. Y., Zhang, X., Hasan, S., Desta, H., Tenenbaum, S. A., & Melendez, J. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220943122 · Cited by 9
Park, M., Na, J., Kwak, S. Y., Park, S., Kim, H., Lee, S., Jang, W., Lee, S. B., Jang, W. I., Jang, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158390 · Cited by 12
Cellular senescence in neurodegenerative diseases
Zhang, P., & Sung, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00012-2 · Cited by 10
Senescence-associated tumor growth is promoted by 12-Lipoxygenase
Patil, S. S., Reedy, J. L., Scroggins, B. T., White, A. O., Kwon, S., Shankavaram, U. T., López-Coral, A., Chung, E. J., & Citrin, D. E. (2022) · Aging · doi:10.18632/aging.203890 · Cited by 10
Therapy-Induced Tumor Cell Senescence: Mechanisms and Circumvention
Zamkova, M. A., Александровна, П. Н., Tatarskiy, V. V., & Shtil, A. A. (2023) · Biochemistry (Moscow) · doi:10.1134/s000629792301008x · Cited by 9
mTOR links nutrients, inflammaging and lifespan
Cochemé, H. M., & Gil, J. (2024) · Nature Aging · doi:10.1038/s43587-024-00681-5 · Cited by 9
Convergent evolution of senescent fibroblasts in fibrosis and cancer with aging
Lee, J. Y., & Peng, T. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.10.002 · Cited by 12
Centner, A. M., Cullen, A. E., Khalili, L., Ukhanov, V., Hill, S. A., Deitado, R., Hwang, H. S., Azeez, T. A., Favor, J. D. L., Laitano, O., et al. (2024) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntae274 · Cited by 9
Wang, Z., Chen, C., Ai, J., Gao, Y., Wang, L., Xia, S., Jia, Y., & Qin, Y. (2025) · MedComm · doi:10.1002/mco2.70048 · Cited by 12
Pan, Q., Ye, Z., Ye, Z., Zhang, H., Wang, J., Yi, G., Li, Z., Xu, R., Wang, L., Wu, Z., et al. (2025) · BMEMat · doi:10.1002/bmm2.12137 · Cited by 9
Metadata
- Authors
- Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P.-Y., Benz, C. C., Kapahi, P., Nelson, P. S., & Campisi, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Buck Institute for Research on Aging (US)
- The University of Texas at San Antonio Health Science Center (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Campisi, Judith
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2015-07-06
- Volume
- 17
- Issue
- 8
- Pages
- 1049-1061
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4691706
- OpenAlex
- W1033197108
- Cited by
- 1,160
- References
- 72
- Citations by year
- 2026: 119 · 2025: 114 · 2024: 109 · 2023: 99 · 2022: 137 · 2021: 122 · 2020: 112 · 2019: 87 · 2018: 89 · 2017: 78 · 2016: 72 · 2015: 22
- FWCI
- 64.11
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-04-06)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG041122, R56AG009909, AG017242, AG-09909, RL1AG032113, AG045288, P01AG025901, R01AG045835, R37AG009909, P01AG041122, K99AG045288, AG032113, P01AG017242, AG000266-16, AG025901, P30AG013319, P30AG044271, T32AG000266)
- National Cancer Institute (CA097186, CA155679, R21CA155679, U24CA143858, CA165573, R01CA165573, CA071468, CA164188, R01CA071468, CA143858, U01CA164188, P50CA097186)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- mTOR, TORC1, rapamycin, senescence-associated secretory phenotype, cellular senescence, interleukin-6, NF-κB, senescence-associated inflammation, age-related cancer, longevity, translational regulation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Dose-Response Relationship, Drug, Fibroblasts, Humans, Male, Mitoxantrone, Phenotype, Prostatic Neoplasms, RNA, Messenger, Time Factors, Transcription, Genetic, Transfection, Interleukin-6, Up-Regulation, Gene Expression Regulation, Neoplastic, NF-kappa B, Mice, SCID, Cellular Senescence, Inflammation Mediators, Sirolimus, Xenograft Model Antitumor Assays, RNA Interference, Cell Line, Tumor, Tumor Burden, Cell Proliferation, Interleukin-1alpha, TOR Serine-Threonine Kinases
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