The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Open accessAbstract
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cellular senescence suppresses cancer by preventing cell proliferation. However, as senescent cells accumulate with age, the senescence-associated secretory phenotype (SASP) can disrupt tissues and contribute to age-related pathologies, including cancer. MTOR inhibition suppressed the secretion of inflammatory cytokines by senescent cells. Rapamycin reduced IL6 and other cytokine mRNA levels, but selectively suppressed translation of the membrane-bound cytokine IL1A. Reduced IL1A diminished NF-κB transcriptional activity, which controls much of the SASP; exogenous IL1A restored IL6 secretion to rapamycin-treated cells. Importantly, rapamycin suppressed the ability of senescent fibroblasts to stimulate prostate tumour growth in mice. Thus, rapamycin might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The NF- κB, p38, mTOR and C/EBPβ signalling pathways are major components of the SASP 63-67 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [66]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Rapamycin, an immunosuppressant, decreases the SASP and maintains cell cycle arrest but does not kill Sncs (24).”
From Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span (2021) · cites this paper as [24]
The cited source says what the claim attributes to it.
In the citing paper
“Treatment with rapamycin (and its analogue RAD001)232 attenuated the protumorigenic SASP230, prevented senescence233, impaired SASP-mediated immune recognition of oncogene-expressing cells and ameliorated liver dysfunction in naturally aged mice231.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [231]
The cited source says what the claim attributes to it.
In the citing paper
“In addition, the nutrient sensing pathways, mTOR and NAD, are involved in SASP regulation.56, 57, 58”
From Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer (2020) · cites this paper as [56]
The cited source says what the claim attributes to it.
In the citing paper
“In various preclinical studies, the mTOR inhibitor rapamycin might have the context-dependent potential to induce senescence 45 , diminish NF-κB activity 65,66 , suppress the pro-inflammatory SASP at the translational level, and limit the growth-promoting effect of senescent bystander fibroblasts on prostate tumours 66 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [66]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“and the serine/threonine kinase MK2, which indirectly stabilizes many cytokine-encoding transcripts231.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [231]
Experimental — accuracy not yet measuredIn the citing paper
“It also differentially regulates translation of IL-1A, the master regulator of SASP that subsequently engages IL-6/IL-8 (Orjalo et al., 2009; Laberge et al., 2015) and MAP kinase-activated protein kinase 2 (MAPKAP2) through 4EBP1, a translation repressor protein (Herranz et al., 2015).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Laberge et al., 2015
In the citing paper
“Inhibition of mTOR by rapamycin suppresses the secretion of inflammatory cytokines by senescent cells (Herranz et al., 2015; Laberge et al., 2015).”
From Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021) · cites this paper as Laberge et al., 2015
In the citing paper
“IL-1α is the key driver of the SASP 79,80 , with upstream expression controlled in part by ATM/ATRmediated liberation of GATA4 from p62-directed autophagy 81 and/or an mTORC1-dependent pathway 82 .”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [82]
In the citing paper
“As an alternative approach, reduction of the SASP through “senostatic” or “senomorphic” approaches may be less toxic and has been shown to be effective in animal models (Birch and Passos, 2017; Georgilis et al., 2018; Laberge et al., 2015; Laberge et al., 2012; Niedernhofer and Robbins, 2018; Xu et al., 2015; Yoshimoto et al., 2013).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Laberge et al., 2015
In the citing paper
“Hypoxia impairs mammalian target of rapamycin (mTOR) activity, leading to reduced IL-1α translation to support NF-κB activity and SASP induction [162,163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“The increase in mTORC1 activity is essential for implementing the SASP by modulating the translation of IL-1α and MAP kinase-activated protein kinase 2 (MAPKAPK2) [162,163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“the secretome of senescent tumor cells can also drive tumor progression by promoting inflammation and potentially stimulating the growth and invasiveness of nearby tumor cells [148,154,163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“SASP inhibition by the mTOR inhibitor rapamycin can suppress the capacity of senescent fibroblasts to stimulate prostate tumor growth in mice [163].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [163]
In the citing paper
“inhibition of mTOR by rapamycin selectively inhibits the SASP and SA β‐gal staining of senescent cells without affecting their cell cycle arrest”
From Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism (2017) · cites this paper as Laberge et al., 2015
In the citing paper
“Rapamycin treatment suppressed SA-βgal activity (~ 50%) in irradiated cells (Fig. 5H), as expected [68]”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [68]
In the citing paper
“The mTOR pathway is a negative regulator of autophagy and is implicated in cellular senescence [67], most notably through SA-βgal activity and the expression of p16 and p21 markers [67], [68].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [68]
In the citing paper
“These factors are commonly described as the mediator of the pro-disease functions of senescent cells in vivo59.”
From Algorithmic assessment of cellular senescence in experimental and clinical specimens (2021) · cites this paper as [59]
In the citing paper
“These in vitro observations have been further substantiated in vivo, where co-injection of senescent fibroblasts has been shown to increase tumourigenicity in xenograft models, including primary breast cancer tissues.26,45–47”
From Paracrine roles of cellular senescence in promoting tumourigenesis (2018) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Self-citationCellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Self-citationRapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Self-citationClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Paradoxical roles of the immune system during cancer development
de Visser, K. E., Eichten, A., & Coussens, L. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1782 · Cited by 2,299
Flagged first, then by citations
Cited by
Sorted by citations
Items 801–900 of 998
Cellular senescence in age-related musculoskeletal diseases
Xiong, J., Guo, Q., & Luo, X. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1125-7 · Cited by 10
Liu, W., Fan, B., Fang, T., Li, H., Zhang, J., Liu, B., & Liu, Z. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.08.010 · Cited by 10
Guo, C., Li, X., Fan, Z., Zhang, J., & Chen, M. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2561232 · Cited by 10
Babaei‐Jadidi, R., Clements, D., Wu, Y., Chen, K., Miller, S., Platé, M., Lim, K., Rue, R. W., Krymskaya, V. P., Chambers, R. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64036-3 · Cited by 13
Aging and lung diseases: Unraveling mechanisms and therapeutic targets
Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 10
Skin aging: mechanisms, evaluation, and rejuvenation
Li, R., Zhang, J., Mao, K., Meng, D., & Han, J.-D. J. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00810-3 · Cited by 13
Zhang, Q., Tang, Y., Hu, G., Yuan, Z., Zhang, S., Sun, Y., Yin, D., Dong, C., Zhao, J., Wu, G., et al. (2022) · PubMed · Cited by 10
Self-citationNeil, E., Paredes, R., Pooley, O., Rubin, B. P., & Kouskoff, V. (2023) · Communications Biology · doi:10.1038/s42003-023-05540-4 · Cited by 10
Alsalem, M., Ellaithy, A., Bloukh, S., Haddad, M., & Saleh, T. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-023-08287-0 · Cited by 11
Correlative imaging of ionic transport and electronic structure in nano Li 0.5 FePO 4 electrodes
Lu, M., Yu, F., Hu, Y., Zaghib, K., Schougaard, S. B., Wang, Z., Zhou, J., Wang, J., Goodenough, J. B., & Sham, T. (2019) · Chemical Communications · doi:10.1039/c9cc09116e · Cited by 9
Cell Senescence and Mesenchymal Stromal Cells
Ratushnyy, A. Y., & Buravkova, L. B. (2020) · Human Physiology · doi:10.1134/s0362119720010132 · Cited by 9
DNA- and telomere-damage does not limit lifespan: evidence from rapamycin
Blagosklonny, M. V. (2021) · Aging · doi:10.18632/aging.202674 · Cited by 11
Xu, R., Lin, J., Zhao, G., Li, C., Che, C., Xu, Q., & Liu, M. (2018) · International Journal of Ophthalmology · doi:10.18240/ijo.2018.05.02 · Cited by 9
Zhang, X., Ji, X., Sun, B., Qian, L., Hu, X.-L., Lou, H., & Yuan, H. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.05.006 · Cited by 9
Kim, D., Cooper, J. A., & Helfman, D. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-76868-y · Cited by 8
Cellular senescence in the cancer microenvironment
Meguro, S., & Nakanishi, M. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvaf001 · Cited by 7
Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistance
Wu, H., Yu, Y., He, X., Gong, Y., Huang, J., & Wu, P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1639772 · Cited by 10
Wang, D., & Guan, H. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156115 · Cited by 9
Calubag, M. F., Ademi, I., Grunow, I., Breuer, L., Babygirija, R., Lialios, P., Le, S. M., Minton, D. M., Sonsalla, M. M., Illiano, J., et al. (2025) · Aging Cell · doi:10.1111/acel.70176 · Cited by 9
Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer
Meguro, S., Makabe, S., Yaginuma, K., Onagi, A., Tanji, R., Matsuoka, K., Hoshi, S., Koguchi, T., Kayama, E., Hata, J., et al. (2025) · Current Oncology · doi:10.3390/curroncol32080467 · Cited by 8
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
Calubag, M. F., Ademi, I., Green, C. L., Manchanayake, D. N. H., Jayarathne, H. S. M., Marshall, R. N., Le, S. M., Lialios, P., Breuer, L. E., Yakar, S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01169-0 · Cited by 9
Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation
Qoura, L. A., Churov, A. V., Maltseva, O. N., Ерусланова, К. А., & Zeng, G. (2026) · Biogerontology · doi:10.1007/s10522-026-10449-6 · Cited by 9
Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?
Lung, T., Cesare, P. D., Risch, L., Nydegger, U. E., & Risch, M. (2021) · Gerontology · doi:10.1159/000517659 · Cited by 8
Morris, C., Durand, S., & Jalinot, P. (2021) · Oncotarget · doi:10.18632/oncotarget.27923 · Cited by 8
p52 signaling promotes cellular senescence
Bernal, G. M., Wu, L., Voce, D. J., Weichselbaum, R. R., & Yamini, B. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00779-6 · Cited by 8
Mitochondrial Damage Induces Senescence with a Twisted Arm
Fernández-Marcos, P. J., & Serrano, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.012 · Cited by 8
Bianchi, A., Lipchick, B. C., & Nikiforov, M. A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_1 · Cited by 8
mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence
Yosef, R., & Krizhanovsky, V. (2016) · Oncotarget · doi:10.18632/oncotarget.10743 · Cited by 8
Hu, Y., Yu, L., Du, W., Hu, X., & Shen, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1430802 · Cited by 7
Wang, Z., Wang, W., Jia, K.-X., Zhang, H., Wang, J.-A., & Chen, C. (2025) · Journal of Orthopaedics · doi:10.1016/j.jor.2025.05.022 · Cited by 7
Creatine and cellular senescence: from molecular pathways to populational health
Ostojić, S. M., Prémusz, V., & Ács, P. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112798 · Cited by 9
When therapy-induced senescence meets tumors: A double-edged sword: A review
Liu, K., Huang, H., Zhang, M., Chen, S., Yang, Y., Fang, C., & Zhong, X. (2025) · Medicine · doi:10.1097/md.0000000000042886 · Cited by 9
Integrating Senescence and Oxidative Stress in Cardiac Disease
Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Kim, S. S., & Kang, I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411917 · Cited by 8
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective
Wang, Z., Zhu, H., & Xiong, W. (2025) · Frontiers of Medicine · doi:10.1007/s11684-024-1116-0 · Cited by 7
Walters, H., & Cox, L. S. (2019) · Biogerontology · doi:10.1007/s10522-018-09792-0 · Cited by 7
Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Kim, J., Lee, Y., Roh, K., Kim, M.-S., & Kang, C. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.003 · Cited by 7
Palmer, A. K., Jensen, M. D., Tchkonia, T., & Kirkland, J. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00009-2 · Cited by 7
Senescence-Associated miRNAs and Their Role in Pancreatic Cancer
Popov, A., & Mandys, V. (2022) · Pathology & Oncology Research · doi:10.3389/pore.2022.1610156 · Cited by 8
Comerford, S. A., Hinnant, E. A., Chen, Y., & Hammer, R. E. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010595 · Cited by 7
A randomized clinical trial of bermekimab treatment for clinical improvement of systemic sclerosis
Solomonidi, N., Vlachoyiannopoulos, P. G., Pappa, M. B., Liantinioti, G., Ktena, S. I., Theotikos, E., Elezoglou, A. V., Netea, M. G., & Giamarellos‐Bourboulis, E. J. (2023) · iScience · doi:10.1016/j.isci.2023.107670 · Cited by 7
Targeted Senolytic Strategies Based on the Senescent Surfaceome
Ekpenyong‐Akiba, A. E., Poblocka, M., & Macip, S. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_6 · Cited by 7
To clear, or not to clear (senescent cells)? That is the question
Lujambio, A. (2016) · Inside the Cell · doi:10.1002/icl3.1046 · Cited by 8
Powering senescence: The ugly side of mitochondria
Correia‐Melo, C., Birch, J., & Passos, J. F. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1204852 · Cited by 7
Adipocytes and Neutrophils Give a Helping Hand to Pancreatic Cancers
Bronte, V., & Tortora, G. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0682 · Cited by 7
Controlling secretion to limit chemoresistancePreprint
Georgilis, A., & Gil, J. (2016) · Genes & Development · doi:10.1101/gad.288571.116 · Cited by 8
Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair
Qiu, M., Li, Y., Wang, Q., Jian, X., Huang, J.-W., Gui, W., Hu, J., & Liao, H. (2025) · Aging and Disease · doi:10.14336/ad.2024.1501 · Cited by 6
Elaidic acid drives cellular senescence and inflammation via lipid raft-mediated IL-1R signaling
Kojima, R., Hirata, Y., Ashida, R., Takahashi, M., Matsui, R., Hama, K., Watanabe, A., Takita, R., Sato, E., Abe, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113305 · Cited by 6
Lin, C., Yang, J., Su, H., Zhang, X., & Wang, B. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s514521 · Cited by 7
Kourti, M., & Kontoghiorghes, G. J. (2025) · Antioxidants · doi:10.3390/antiox15010015 · Cited by 11
Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease
Kliment, C. R., Gurkar, A. U., Cárdenes, N., Ramonell, R. P., Finkel, T., & Königshoff, M. (2026) · Physiological Reviews · doi:10.1152/physrev.00024.2025 · Cited by 6
Guo, Y., Wang, S., Dong, Y., & Liu, Y. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114371 · Cited by 6
Kim, K., Admasu, T. D., Stolzing, A., & Sharma, A. (2022) · Aging · doi:10.18632/aging.203931 · Cited by 8
Cai, Y., Liu, K., Wu, P., Yuan, R., He, F., & Zou, J. (2022) · BMC Genomics · doi:10.1186/s12864-022-08925-7 · Cited by 6
Are menopause, aging and prostate cancer diseases?
Blagosklonny, M. V. (2022) · Aging · doi:10.18632/aging.204499 · Cited by 6
Odeh, A., Eddini, H., Shawasha, L., Chaban, A., Avivi, A., Shams, I., & Manov, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065132 · Cited by 7
Liu, A., Wang, X., Liu, H., Yan, D., Yin, Y., Zheng, H., Liu, G., Zhang, J., & Li, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287132 · Cited by 6
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities
Kaur, G., Rahman, M. S., Shaikh, S. B., Panda, K., Chinnapaiyan, S., Estevez, M. S., Xia, L., Unwalla, H. J., & Rahman, I. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116179 · Cited by 6
Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy
Narita, M., & Narita, M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_8 · Cited by 6
Ohara, Y., Kato, S. X., Yamashita, D., Satou, A., Shimoyama, Y., Hamaie, C., Sato, M., Ban, N., Yamamoto, K., Yamada, T., et al. (2018) · Pathology International · doi:10.1111/pin.12663 · Cited by 6
Prevention of Senescence in Vasculature Through Quiescence
Mendelsohn, A. R., & Larrick, J. W. (2018) · Rejuvenation Research · doi:10.1089/rej.2018.2138 · Cited by 6
Sinha, D., Smith, C., & Khanna, R. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.09.005 · Cited by 6
Calvo, L., Cheng, S., Skulimowski, M., Clément, I., Portelance, L., Zhan, Y., Carmona, E., Lafontaine, J., de Ladurantaye, M., Rahimi, K., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/425199 · Cited by 6
Sentinel p16 INK4a + cells in the basement membrane form a reparative niche in the lungPreprint
de Mochel, N. R., Cheong, K. N., Cassandras, M., Wang, C., Krasilnikov, M., Matatia, P. R., Molofsky, A. B., Campisi, J., & Peng, T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.10.142893 · Cited by 6
Self-citationThe potential of flavonoids to mitigate cellular senescence in cardiovascular disease
Zheng, H., Li, T., Hu, Z., Zheng, Q., & Wang, J. (2024) · Biogerontology · doi:10.1007/s10522-024-10141-7 · Cited by 6
Tang, H., Zhang, X., Hu, S., Song, Y., Jin, W., Zou, J., Zhang, Y., Guo, J., An, P., Luo, J., et al. (2025) · Targets · doi:10.3390/targets3030023 · Cited by 10
Yu, Y., Lv, X., Chen, Z., Li, X., Chen, L., Chen, Y., Gu, W., Zhou, X., Li, J., & Shi, D. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01266 · Cited by 5
Cai, X., Cui, Y.-Y., Ding, C.-Y., Liu, H.-B., Yu, M., Chen, L.-Y., Ding, C.-Y., Wu, X., Zhang, H., Li, C., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123747 · Cited by 9
Senotherapeutics in Malignant Brain Cancer Therapy
Kaina, B., & Christmann, M. (2025) · Current Oncology Reports · doi:10.1007/s11912-025-01733-8 · Cited by 5
Senescent Schwann cells as therapeutic targets in nerve regeneration and peripheral neuropathies
Rebolledo, D. L., Khan, M., Melov, S., Höke, A., & Court, F. A. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.01.003 · Cited by 5
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging
Li, H., Zhao, R., Wan, L., Yu, Y., Ma, E., Li, Y., Chen, Z., Liu, B., Song, Y., Cao, Z., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01102-5 · Cited by 5
Wan, P., & Zheng, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1842443 · Cited by 6
Cox, L. S. (2022) · The Journal of the Economics of Ageing · doi:10.1016/j.jeoa.2022.100423 · Cited by 6
Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs
Hao, H., Liang, W., Zhang, S., Cai, X., Abulizi, Y., Gao, S., Xun, C., Xu, T., Cao, R., & Sheng, W. (2025) · JOR Spine · doi:10.1002/jsp2.70044 · Cited by 6
Exosomal dynamics: Bridging the gap between cellular senescence and cancer therapy
Aswani, B. S., Sajeev, A., Hegde, M., Mishra, A., Abbas, M., Vayalpurayil, T., Sethi, G., & Kunnumakkara, A. B. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112045 · Cited by 6
Giroud, J., Delvaux, P., Carlier, L., de Schutter, C., Martin, N., Rouget, R., Bolouki, A., Glas, V. D., Bouriez, I., Bourdoux, F., et al. (2025) · Aging Cell · doi:10.1111/acel.70024 · Cited by 7
The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health
Quarleri, J. F., & Delpino, M. V. (2024) · GeroScience · doi:10.1007/s11357-023-01058-z · Cited by 5
Aziz, M. M., El‐Sheikh, M. M., Mohamed, M. A. E. H., Abdelrahman, S. S. M., & Mekkawy, M. H. (2024) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320241297342 · Cited by 6
Demystifying the role of mitochondria in senescence
Correia-Melo, C., & Passos, J. F. (2016) · Molecular & Cellular Oncology · doi:10.1080/23723556.2016.1162896 · Cited by 5
In silico clinical trials for anti-aging therapies
Menéndez, J. A., Cuyàs, E., Folguera-Blasco, N., Verdura, S., Martín-Castillo, B., Joven, J., & Alarcón, T. (2019) · Aging · doi:10.18632/aging.102180 · Cited by 5
Senolysis and Senostasis Through the Plasma Membrane
Kim, K. M., Noh, J. H., & Gorospe, M. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_7 · Cited by 5
Novak, J. F., Vopálenský, V., Pospíšek, M., & Vedeler, A. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155141 · Cited by 5
Gijsen, H. S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_16 · Cited by 6
Liu, Q., Liu, G., Martin, D. T., Xing, Y., Weiss, R. M., Qi, J., & Kang, J. (2021) · Asian Journal of Andrology · doi:10.4103/aja.aja_20_21 · Cited by 5
Rad, A. N., Shams, G., Avelar, R. A., Morowvat, M. H., & Ghasemi, Y. (2022) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2022.100920 · Cited by 4
Roles of eIF5A in the immunosurveillance of cellular senescence
Jiang, X., Loayza‐Puch, F., #x2019, & Loayza-Puch, F. (2022) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0408 · Cited by 5
Yuan, M., Barefoot, M. E., Peterson, K. D., Campbell, M. J., Blancato, J. K., Chen, M., Schmidt, M. O., Kiliti, A. J., Fang, H., Wellstein, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411505 · Cited by 5
Hu, K., Tu, Z., Luo, T., Lai, H., Han, G., Xiao, L., Ling, J., Chen, Y., Zhang, D., Wang, W., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002968 · Cited by 4
Decoding senescent drivers in Alzheimer's disease: From bench to bedside
Zhou, R., Lin, X., Liao, Z., Lin, J., Zheng, R., Ni, H., Liu, W., Feng, Z., He, Q., Lin, X., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102978 · Cited by 4
Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)
Malaquin, N., & Rodier, F. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2022.10.005 · Cited by 6
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes
Rezagholizadeh, N., Datta, G., Hasler, W. A., Nguon, E. C., Smokey, E. V., Khan, N., & Chen, X. (2025) · Life Science Alliance · doi:10.26508/lsa.202503231 · Cited by 5
Future Perspectives in Senescence-Based Therapies for Head and Neck Cancer
Palomares, B. H., Martins, M. D., Martins, M. A. T., SQUARIZE, C. H., & CASTILHO, R. M. (2025) · Cancers · doi:10.3390/cancers17121965 · Cited by 4
Aging and anti-aging strategies: A review of past and future therapeutics
Wei, Y., Xiong, B., Song, Z., Zhong, S., Zheng, N., Zhang, A., Chen, Y., & Sun, H. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118340 · Cited by 4
Choroidal macrophages in homeostasis, aging and age-related macular degeneration
Khan, A. H., & Mulfaul, K. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110159 · Cited by 4
Incidence of Common and Rare Cancers in Ilorin, Nigeria
Anifowoshe, A. T., Owolodun, O. A., OYINLOLA, B. O., ABDULGANIYU, K., YUSUF, R. D., OREDEIN, O. A., & Iyiola, O. A. (2018) · Notulae Scientia Biologicae · doi:10.15835/nsb10410263 · Cited by 4
Engin, A. B., & Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_2 · Cited by 4
Molecular mechanisms of cellular senescence
Nehme, J., Varela-Eirín, M., & Demaria, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823318-4.00034-2 · Cited by 4
Self-citationOlinger, B., Banarjee, R., Dey, A. K., Tsitsipatis, D., Tanaka, T., Ram, A., Nyunt, T., Daya, G. N., Peng, Z., Cui, L., et al. (2024) · medRxiv · doi:10.1101/2024.08.01.24311368 · Cited by 4
A consensus single-cell transcriptomic atlas of dermal fibroblast heterogeneityPreprint
Ascensión, A. M., & Izeta, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.05.611379 · Cited by 4
Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications
Yan, J., Zhang, Y., Mao, G., Yu, J., Zhou, T., & Hao, J. (2025) · MedComm – Oncology · doi:10.1002/mog2.70029 · Cited by 3
Zhang, W., Jia, Y., Wang, A., Guo, R. H., Fu, Z., & Wang, W. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103089 · Cited by 3
Metadata
- Authors
- Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P.-Y., Benz, C. C., Kapahi, P., Nelson, P. S., & Campisi, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Buck Institute for Research on Aging (US)
- The University of Texas at San Antonio Health Science Center (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Campisi, Judith
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2015-07-06
- Volume
- 17
- Issue
- 8
- Pages
- 1049-1061
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4691706
- OpenAlex
- W1033197108
- Cited by
- 1,160
- References
- 72
- Citations by year
- 2026: 119 · 2025: 114 · 2024: 109 · 2023: 99 · 2022: 137 · 2021: 122 · 2020: 112 · 2019: 87 · 2018: 89 · 2017: 78 · 2016: 72 · 2015: 22
- FWCI
- 64.11
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-04-06)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG041122, R56AG009909, AG017242, AG-09909, RL1AG032113, AG045288, P01AG025901, R01AG045835, R37AG009909, P01AG041122, K99AG045288, AG032113, P01AG017242, AG000266-16, AG025901, P30AG013319, P30AG044271, T32AG000266)
- National Cancer Institute (CA097186, CA155679, R21CA155679, U24CA143858, CA165573, R01CA165573, CA071468, CA164188, R01CA071468, CA143858, U01CA164188, P50CA097186)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- mTOR, TORC1, rapamycin, senescence-associated secretory phenotype, cellular senescence, interleukin-6, NF-κB, senescence-associated inflammation, age-related cancer, longevity, translational regulation
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antineoplastic Agents, Dose-Response Relationship, Drug, Fibroblasts, Humans, Male, Mitoxantrone, Phenotype, Prostatic Neoplasms, RNA, Messenger, Time Factors, Transcription, Genetic, Transfection, Interleukin-6, Up-Regulation, Gene Expression Regulation, Neoplastic, NF-kappa B, Mice, SCID, Cellular Senescence, Inflammation Mediators, Sirolimus, Xenograft Model Antitumor Assays, RNA Interference, Cell Line, Tumor, Tumor Burden, Cell Proliferation, Interleukin-1alpha, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
