The control of DNA repair by the cell cycle

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422

Causes and consequences of replication stress

Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671

Targeting the DNA Damage Response in Cancer

O’Connor, M. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.040 · Cited by 1,602

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,556

BRCA1 and BRCA2: different roles in a common pathway of genome protection

Roy, R., Chun, J., & Powell, S. N. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3181 · Cited by 1,555

Distinct mechanisms for genomic attachment of the 5′ and 3′ ends of Agrobacterium T-DNA in plants

Kralemann, L. E. M., de Pater, S., Shen, H., Kloet, S. L., van Schendel, R., Hooykaas, P. J. J., & Tijsterman, M. (2022) · Nature Plants · doi:10.1038/s41477-022-01147-5 · Cited by 40

Polyphosphate is a key factor for cell survival after DNA damage in eukaryotic cells

Bru, S., Samper, B., Quandt, E., Hernández-Ortega, S., Martínez‐Láinez, J. M., Garí, E., Rafel, M., Torres‐Torronteras, J., Martí, R., Ribeiro, M. P. C., et al. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.08.001 · Cited by 36

A Paradigm Revolution or Just Better Resolution—Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?

Falk, M., & Hausmann, M. (2020) · Cancers · doi:10.3390/cancers13010018 · Cited by 39

RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs

Machour, F. E., Abu‐Zhayia, E. R., Awwad, S. W., Bidany-Mizrahi, T., Meinke, S., Bishara, L. A., Heyd, F., Aqeilan, R. I., & Ayoub, N. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab976 · Cited by 38

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes

Lane, S. I. R., Morgan, S. L., Wu, T., Collins, J. K., Merriman, J. A., Elinati, E., Turner, J. M. A., & Jones, K. T. (2017) · Development · doi:10.1242/dev.153965 · Cited by 37

LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer

Wang, Y.-H., Guo, Z., An, L., Zhou, Y., Xu, H., Xiong, J., Liu, Z., Chen, X.-P., Zhou, H., Li, X., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03728-2 · Cited by 38

Genome Editing, A Superior Therapy for Inherited Retinal Diseases

Yan, A. L., Du, S. W., & Palczewski, K. (2022) · Vision Research · doi:10.1016/j.visres.2023.108192 · Cited by 37

Roles of NRF2 in DNA damage repair

Li, J., Xu, C. S., & Liu, Q. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00834-5 · Cited by 36

DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus

Wu, X., Zhou, X., Wang, S., & Mao, G. (2023) · Virology Journal · doi:10.1186/s12985-023-02203-y · Cited by 41

The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast

Wiest, N. E., Houghtaling, S. R., Sanchez, J. C., Tomkinson, A. E., & Osley, M. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx221 · Cited by 36

Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents

Dai, Q., Chen, J., Gao, C., Sun, Q., Yuan, Z., & Jiang, Y. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.06.019 · Cited by 36

One-step generation of a targeted knock-in calf using the CRISPR-Cas9 system in bovine zygotes

Owen, J. R., Hennig, S. L., McNabb, B. R., Mansour, T. A., Smith, J. M., Lin, J. C., Young, A. E., Trott, J. F., Murray, J. D., Delany, M. E., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-07418-3 · Cited by 36

The role of patient-derived ovarian cancer organoids in the study of PARP inhibitors sensitivity and resistance: from genomic analysis to functional testing

Tao, M., & Wu, X. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02139-7 · Cited by 35

Around and beyond 53BP1 Nuclear Bodies

Fernandez-Vidal, A., Vignard, J., & Mirey, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122611 · Cited by 37

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells

Mladenov, E., Fan, X., Paul‐Konietzko, K., Soni, A., & Iliakis, G. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-51071-6 · Cited by 36

Context-Dependent Strategies for Enhanced Genome Editing of Genodermatoses

March, O. P., Köcher, T., & Koller, U. (2020) · Cells · doi:10.3390/cells9010112 · Cited by 36

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Zeng, J., Nguyen, M. A., Liu, P., da Silva, L. F., Levesque, S., Lin, L. Y., Justus, D. G., Petri, K., Clement, K., Porter, S. N., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.11.001 · Cited by 36

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Glover, L., Marques, C. A., Suska, O., & Horn, D. (2019) · mBio · doi:10.1128/mbio.01252-19 · Cited by 34

Recruitment of DNA Repair MRN Complex by Intrinsically Disordered Protein Domain Fused to Cas9 Improves Efficiency of CRISPR-Mediated Genome Editing

Reuven, N. B., Adler, J., Broennimann, K., Myers, N., & Shaul, Y. (2019) · Biomolecules · doi:10.3390/biom9100584 · Cited by 31

Embryonic Exposure to UV-328 Impairs the Cell Cycle in Zebrafish (Danio rerio) by Inhibiting the p38 MAPK/p53/Gadd45a Signaling Pathway

Zhang, L., Shen, L., Huang, Y., Cui, S., Zhao, Q., Zhang, C., Zhuang, S., & Jiang, G. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c02842 · Cited by 33

CRISPR applications in cancer diagnosis and treatment

Wang, M., Chen, M., Wu, X., Huang, X., & Yu, B. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00483-4 · Cited by 36

The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system

Xin, M., Bi, F., Wang, C., Huang, Y., Xu, Y., Liang, S., Cai, T., Xu, X., Dong, L., Li, T., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.005 · Cited by 35

Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks

Fontana, G., Reinert, J. K., Thomä, N. H., & Rass, U. (2018) · Microbial Cell · doi:10.15698/mic2018.07.639 · Cited by 36

Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing

Smith, L. J., Wright, J. B., Clark, G., Ul-Hasan, T., Jin, X., Fong, A., Chandra, M., Martin, T. S., Rubin, H. L., Knowlton, D., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802343115 · Cited by 33

Molecular connections between circadian rhythm and genome maintenance pathways

Kolinjivadi, A. M., Chong, S. T., & Ngeow, J. Y. Y. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0372 · Cited by 32

The "enemies within": regions of the genome that are inherently difficult to replicate

Bhowmick, R., & Hickson, I. D. (2017) · F1000Research · doi:10.12688/f1000research.11024.1 · Cited by 35

Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing

Lainšček, D., Forstnerič, V., Mikolič, V., Malenšek, Š., Pečan, P., Benčina, M., Sever, M., Podgornik, H., & Jerala, R. (2022) · Nature Communications · doi:10.1038/s41467-022-31386-1 · Cited by 34

Base editors: development and applications in biomedicine

Liang, Y., Chen, F., Wang, K., & Lai, L. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-1013-y · Cited by 33

DNA double-strand break repair pathway choice: the fork in the road

Han, J., & Huang, J. (2019) · Genome Instability & Disease · doi:10.1007/s42764-019-00002-w · Cited by 33

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection

Batenburg, N. L., Walker, J. R., Coulombe, Y., Sherker, A., Masson, J., & Zhu, X. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz784 · Cited by 33

Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes

Ginn, S. L., Amaya, A. K., Liao, S. H. Y., Zhu, E., Cunningham, S. C., Lee, M., Hallwirth, C. V., Logan, G. J., Tay, S. S., Cesare, A. J., et al. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.100065 · Cited by 32

LncRNA UCA1 Antagonizes Arsenic‐Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression

Dong, Z., Gao, M., Li, C., Xu, M., & Liu, S. (2020) · Advanced Science · doi:10.1002/advs.201903630 · Cited by 31

Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

Zell, J., Duskova, K., Chouh, L., Bossaert, M., Chéron, N., Granzhan, A., Britton, S., & Monchaud, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab796 · Cited by 31

p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair

Yang, X., Cao, X., & Zhu, Q. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10250-w · Cited by 35

Genes, Proteins, and Biological Pathways Preventing Chromothripsis

Poot, M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7780-2_15 · Cited by 32

Shelterin and the replisome: at the intersection of telomere repair and replication

Cicconi, A., & Chang, S. S. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.02.016 · Cited by 30

The Time for Chronotherapy in Radiation Oncology

Bermúdez-Guzmán, L., Blanco-Saborío, A., Ramírez-Zamora, J., & Lovo, E. E. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.687672 · Cited by 33

POGZ promotes homology‐directed DNA repair in an HP1‐dependent manner

Heath, J., Simo‐Cheyou, E. R., Findlay, S., Luo, V. M., Carpio, E. P., Lee, J., Djerir, B., Chen, X., Morin, T., Lebeau, B., et al. (2021) · EMBO Reports · doi:10.15252/embr.202051041 · Cited by 33

Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

Bolgi, O., Silva‐Garcia, M., Ross, B. H., Pilla, E., Kari, V., Kilisch, M., Spitzner, M., Stark, N., Lenz, C., Weiss, K., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154136 · Cited by 29

CRISPR/Cas-based gene editing in therapeutic strategies for beta-thalassemia

Zeng, S., Lei, S.-Y., Qu, C., Wang, Y., Teng, S., & Huang, P. C. (2023) · Human Genetics · doi:10.1007/s00439-023-02610-9 · Cited by 31

Embryo-mediated genome editing for accelerated genetic improvement of livestock

McLean, Z. L., Oback, B. J., & Laible, G. (2020) · Frontiers of Agricultural Science and Engineering · doi:10.15302/j-fase-2019305 · Cited by 30

Cellular accumulation of crude oil compounds reduces the competitive fitness of the coral symbiont Symbiodinium glynnii

Müller, M., Yogui, G. T., Gálvez, A. O., Jannuzzi, L. G. D. S., Filho, J. F. D. S., Montes, M. D. J. F., Melo, P. A. M. D. C., Neumann‐Leitão, S., & Zanardi‐Lamardo, E. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117938 · Cited by 30

Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs

Giallongo, S., Řeháková, D., Biagini, T., Re, O. L., Raina, P., Lochmanová, G., Zdráhal, Z., Resnick, I. B., Pata, P., Pata, I., et al. (2022) · Stem Cells · doi:10.1093/stmcls/sxab004 · Cited by 29

DNA Repair Deficiency Regulates Immunity Response in Cancers: Molecular Mechanism and Approaches for Combining Immunotherapy

Xu, Y., Nowsheen, S., & Deng, M. (2023) · Cancers · doi:10.3390/cancers15051619 · Cited by 31

Single and combined genotoxicity of metals and fluoroquinolones to zebrafish embryos at environmentally relevant concentrations

Jia, D., You, X., Tang, M., Lyu, Y., Hu, J., & Sun, W. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106495 · Cited by 30

WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors

Burdová, K., Storchova, R., Palek, M., & Macůrek, L. (2019) · Cells · doi:10.3390/cells8101258 · Cited by 30

Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation

Yang, S., Hwang, S., Kim, B.-J., Shin, S., Kim, M., & Jeong, S. M. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05968-w · Cited by 34

CDK-independent role of D-type cyclins in regulating DNA mismatch repair

Róna, G., Miwatani-Minter, B., Zhang, Q., Goldberg, H. V., Kerzhnerman, M. A., Howard, J., Simoneschi, D., Lane, E., Hobbs, J. W., Sassani, E., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.02.010 · Cited by 34

Consequences of Genomic Diversification Induced by Segregation Errors

Soto, M., Raaijmakers, J. A., & Medema, R. H. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.01.003 · Cited by 28

The transcription factor PBX3 promotes tumor cell growth through transcriptional suppression of the tumor suppressor p53

Li, W., Herkilini, A., Tang, Y. R., Huang, P. C., Song, G., Miyagishi, M., Kasim, V., & Wu, S. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00599-9 · Cited by 30

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Lezaja, A., Παναγόπουλος, Α., Wen, Y., Carvalho, E., Imhof, R., & Altmeyer, M. (2021) · Nature Communications · doi:10.1038/s41467-021-23806-5 · Cited by 32

Reconstruction of Atomistic Structures from Coarse-Grained Models for Protein–DNA Complexes

Shimizu, M., & Takada, S. (2018) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.7b00954 · Cited by 28

JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process

Wang, L., Jiang, Z., Huang, D., Duan, J. E., Huang, C., Sullivan, S., Vali, K., Yin, Y., Zhang, M., Wegrzyn, J., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4507-2 · Cited by 28

Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability

Zhou, W., Chen, X., Zhao, G., Xu, D., Jiang, Z., Zhang, L., & Wang, T. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01179 · Cited by 29

DNA Damage Response and Cell Cycle Regulation in Pluripotent Stem Cells

Chen, A. C. H., Peng, Q., Fong, S. W., Lee, K. C., Yeung, W. S. B., & Lee, Y. L. (2021) · Genes · doi:10.3390/genes12101548 · Cited by 28

Abrogation of the G2/M checkpoint as a chemosensitization approach for alkylating agents

Lang, F., Cornwell, J. A., Kaur, K., Elmogazy, O., Zhang, W., Zhang, M., Song, H., Sun, Z., Wu, X., Aladjem, M. I., et al. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad252 · Cited by 28

CRISPR-based therapeutic genome editing for inherited blood disorders

Levesque, S., & Bauer, D. E. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01236-y · Cited by 31

Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition

Shen, Y., Sherman, J. W., Chen, X., & Wang, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001379 · Cited by 27

Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas

Milanesio, M. C., Giordano, S., & Valabrega, G. (2020) · Cancers · doi:10.3390/cancers12051315 · Cited by 26

Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models

Uchida, N., Li, L., Nassehi, T., Drysdale, C. M., Yapundich, M., Gamer, J., Haro‐Mora, J. J., Demirci, S., Leonard, A. K., Bonifacino, A. C., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100247 · Cited by 28

Editing outside the body: Ex vivo gene-modification for β-hemoglobinopathy cellular therapy

Rosanwo, T. O., & Bauer, D. E. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.10.002 · Cited by 30

Integration of DNA damage responses with dynamic spatial genome organization

Stanić, M., & Mekhail, K. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.08.016 · Cited by 28

Dynamics of the DYNLL1–MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs

Swift, M. L., Zhou, R., Syed, A., Moreau, L. A., Tomasik, B., Tainer, J. A., Konstantinopoulos, P. A., D’Andrea, A. D., He, Y. J., & Chowdhury, D. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01074-9 · Cited by 29

Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

Leland, B. A., Chen, A. C., Zhao, A., Wharton, R. C., & King, M. C. (2018) · eLife · doi:10.7554/elife.33402 · Cited by 30

Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex

Guo, X., Keenan, B. T., Sarantopoulou, D., Lim, D. C., Lian, J., Grant, G. R., & Pack, A. I. (2019) · Aging Cell · doi:10.1111/acel.13021 · Cited by 27

RS‐1 enhances CRISPR‐mediated targeted knock‐in in bovine embryos

Lamas‐Toranzo, I., Martínez‐Moro, Á., Callaghan, E., de la Blanca, M. G. M., Sánchez, J. M., Lonergan, P., & Bermejo‐Álvarez, P. (2020) · Molecular Reproduction and Development · doi:10.1002/mrd.23341 · Cited by 29

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex

Zhang, H., Devoucoux, M., Song, X., Li, L., Ayaz, G., Cheng, H., Tempel, W., Cheng, D., Loppnau, P., Côté, J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.003 · Cited by 26

Synchronised infection identifies early rate‐limiting steps in the hepatitis B virus life cycle

Chakraborty, A., Ko, C., Henning, C., Lucko, A., Harris, J. M., Chen, F., Zhuang, X. A., Wettengel, J. M., Roessler, S. K., Protzer, U., et al. (2020) · Cellular Microbiology · doi:10.1111/cmi.13250 · Cited by 27

Interplay between the DNA damage response and the life cycle of DNA tumor viruses

Studstill, C. J., Mac, M., & Moody, C. A. (2023) · Tumour Virus Research · doi:10.1016/j.tvr.2023.200272 · Cited by 28

The Licensing Factor Cdt1 Links Cell Cycle Progression to the DNA Damage Response

Κανέλλου, Α., Giakoumakis, N.-N., Παναγόπουλος, Α., Tsaniras, S. C., & Lygerou, Z. (2020) · Anticancer Research · doi:10.21873/anticanres.14214 · Cited by 26

SUMOylation mediates CtIP’s functions in DNA end resection and replication fork protection

Locke, A. J., Hossain, L., McCrostie, G., Ronato, D. A., Fitieh, A. M., Rafique, T. A., Mashayekhi, F., Motamedi, M., Masson, J., & Ismail, I. H. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1232 · Cited by 27

Gut microbiota of bats: pro-mutagenic properties and possible frontiers in preventing emerging disease

Popov, I. V., Mazanko, M. S., Kulaeva, E. D., Николаевич, Г. С., Вячеславович, М. А., Aleshukina, I., Aleshukina, A. V., Prazdnova, E. V., Tverdokhlebova, T. I., Chikindas, M. L., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00604-z · Cited by 28

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Vergara, X., Manjón, A. G., de Haas, M., Morris, B., Schep, R., Leemans, C., Friskes, A., Beijersbergen, R. L., Sanders, M. A., Medema, R. H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49232-x · Cited by 26

CRISPR-Cas9 genome editing in human cells works via the Fanconi Anemia pathwayPreprint

Richardson, C. D., Kazane, K. R., Feng, S. J., Bray, N. L., Schäfer, A. J., Floor, S. N., & Corn, J. E. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/136028 · Cited by 26

SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates

Matsumoto, D., Matsugi, E., Kishi, K., Inoue, Y., Nigorikawa, K., & Nomura, W. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102124 · Cited by 28

Multiple functions of PARP1 in the repair of DNA double strand breaks

Ortega, R., Bitler, B. G., & Arnoult, N. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103873 · Cited by 27

Gene Therapy for Neurodegenerative Disease: Clinical Potential and Directions

Zhu, X., Zhang, Y., Yang, X., Hao, C., & Duan, H. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.618171 · Cited by 25

Approaches to Enhance Precise CRISPR/Cas9-Mediated Genome Editing

Denes, C. E., Cole, A. J., Aksoy, Y. A., Li, G., Neely, G. G., & Hesselson, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168571 · Cited by 28

The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

Zhai, F., Li, J., Ye, M., & Jin, X. (2022) · Gene · doi:10.1016/j.gene.2022.146562 · Cited by 24

Nanoblades allow high-level genome editing in murine and human organoids

Tiroille, V., Krug, A., Bokobza, E., Kahi, M., Bulcaen, M., Ensinck, M. M., Geurts, M. H., Hendriks, D., Vermeulen, F., Larbret, F., et al. (2023) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2023.06.004 · Cited by 25

Deciphering the Molecular Mechanisms behind Drug Resistance in Ovarian Cancer to Unlock Efficient Treatment Options

Nunes, M., Bartosch, C., Abreu, M. H., Richardson, A., Almeida, R., & Ricardo, S. A. V. (2024) · Cells · doi:10.3390/cells13090786 · Cited by 26

Role of Next-Generation Sequencing Technologies in Personalized Medicine

Morganti, S., Tarantino, P., Ferraro, E., D’Amico, P., Viale, G., Trapani, D., Duso, B. A., & Curigliano, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-27994-3_8 · Cited by 30

Redox and Epigenetics in Human Pluripotent Stem Cells Differentiation

Giallongo, S., Řeháková, D., Raffaele, M., Re, O. L., Koutná, I., & Vinciguerra, M. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7983 · Cited by 23

Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination

Karasu, M. E., Toufektchan, E., Chen, Y., Albertelli, A., Cullot, G., Maciejowski, J., & Corn, J. E. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02356-3 · Cited by 27

Derivation and maintenance of mouse haploid embryonic stem cells

Elling, U., Woods, M., Forment, J. V., Fu, B., Yang, F., Ng, B. L., Vicente, J. R., Adams, D. J., Doe, B., Jackson, S. P., et al. (2019) · Nature Protocols · doi:10.1038/s41596-019-0169-z · Cited by 24

RNA-based therapies in liver metabolic diseases

Fontanellas, A., Berraondo, P., Urigo, F., Jericó, D., Martini, P. G. V., Pastor, F., & Avila, M. A. (2025) · Gut · doi:10.1136/gutjnl-2023-331742 · Cited by 31

Emerging Perspectives on DNA Double-strand Breaks in Neurodegenerative Diseases

Zhu, L., Wang, D., Cui, K., Liu, D., & Zhu, L. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190726115623 · Cited by 24

Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion

Soni, A., Murmann-Konda, T., Siemann, M., Pantelias, G. E., & Iliakis, G. E. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102828 · Cited by 23

Stingless Bee Propolis: New Insights for Anticancer Drugs

Campos, J. F., dos Santos, H. F., Bonamigo, T., Domingues, N. L. C., Souza, K. D. P., & dos Santos, E. L. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2169017 · Cited by 26

Cyclometalated Iridium(Iii) Dithioformic Acid Complexes as Mitochondria-Targeted Imaging and Anticancer Agents

Wu, Y., Liu, J., Shao, M., Zhang, P., Song, S., Yang, G. H., Liu, X., & Liu, Z. (2022) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2022.111855 · Cited by 23

Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy

Kuwayama, R., Suzuki, K., Nakamura, J., Aizawa, E., Yoshioka, Y., Ikawa, M., Nabatame, S., Inoue, K., Shimmyo, Y., Ozono, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30847-x · Cited by 23

SAMHD1 Sheds Moonlight on DNA Double-Strand Break Repair

Cabello-Lobato, M. J., Wang, S., & Schmidt, C. K. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.09.007 · Cited by 23

Ras-Mediated Activation of NF-κB and DNA Damage Response in Carcinogenesis

Ahmad, A., & Ahsan, H. (2020) · Cancer Investigation · doi:10.1080/07357907.2020.1721523 · Cited by 23

The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis

Afroz, S., Garg, R., Fodje, M. N., & den Hurk, S. V. D. L. (2018) · Journal of Virology · doi:10.1128/jvi.00773-18 · Cited by 23

CDK and Mec1/Tel1-catalyzed phosphorylation of Sae2 regulate different responses to DNA damage

Yu, T.-Y., Garcia, V., & Symington, L. S. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz814 · Cited by 22

Catching HPV in the Homologous Recombination Cookie Jar

Wallace, N. A. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.10.008 · Cited by 22

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining

Cabrini, M., Roncador, M., Galbiati, A., Cipolla, L., Maffia, A., Iannelli, F., Sabbioneda, S., di Fagagna, F. D., & Francia, S. (2021) · Journal of Cell Science · doi:10.1242/jcs.249706 · Cited by 22

The Cell Cycle

Yang, V. W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00008-6 · Cited by 24

For Better or Worse: Modulation of the Host DNA Damage Response by Human Papillomavirus

Studstill, C. J., & Moody, C. A. (2023) · Annual Review of Virology · doi:10.1146/annurev-virology-111821-103452 · Cited by 24

Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System

Abbas, T., & Dutta, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6955-0_19 · Cited by 23

Interplay Between the Cell Cycle and Double-Strand Break Response in Mammalian Cells

Beishline, K., & Azizkhan‐Clifford, J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0888-2_3 · Cited by 31

Coping with DNA double strand breaks

Hiom, E. (2010)

DSB Repair by Cell-Cycle Signaling and the DNA Damage Response, Regulation of

Marini, F., & Pellicioli, A. (2018) · Springer eBooks · doi:10.1007/978-1-4614-1531-2_76

Pathways for Genome Integrity in G2 Phase of the Cell Cycle

Kousholt, A. N., Menzel, T., & Sørensen, C. S. (2012) · Biomolecules · doi:10.3390/biom2040579 · Cited by 49

Working on different ends

Cesari, F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2411