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The control of DNA repair by the cell cycle
Abstract
The correct duplication and transmission of genetic material to daughter cells is the primary objective of the cell division cycle. DNA replication and chromosome segregation present both challenges and opportunities for DNA repair pathways that safeguard genetic information. As a consequence, there is a profound, two-way connection between DNA repair and cell cycle control. Here, we review how DNA repair processes, and DNA double-strand break repair in particular, are regulated during the cell cycle to optimize genomic integrity.
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“Cell cycle regulation has an essential role in maintenance of the genome integrity.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [71]
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“Its progression is tightly controlled by temporarily activated and deactivated serine/threonine kinases, number of mediators, and/or effectors [71].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [71]
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- Symington, L. S. & Gautier, J. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 45, 247–271 (2011). · DOI
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ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
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Metadata
- Authors
- Hustedt, N., & Durocher, D.
- Affiliations
- Mount Sinai Hospital (CA)
- Corresponding author
- Durocher, Daniel
- Venue
- Nature Cell Biology
- Published
- 2016-12-23
- Volume
- 19
- Issue
- 1
- Pages
- 1-9
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2562446577
- Cited by
- 738
- References
- 149
- Citations by year
- 2026: 50 · 2025: 67 · 2024: 73 · 2023: 77 · 2022: 76 · 2021: 89 · 2020: 102 · 2019: 91 · 2018: 68 · 2017: 45
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- DNA repair, cell cycle regulation, DNA double-strand break repair, genome segregation, DNA replication, genome stability, DNA damage response
- MeSH terms
- Replisomes, Animals, Cell Cycle, Chromosomes, DNA-Directed DNA Polymerase, DNA Repair, Humans, Multienzyme Complexes, DNA Breaks, Double-Stranded, Homologous Recombination
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