CoChat
Sign Up
Cited by 189

The DOI matches its Crossref record.

AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells

Simmen, Thomas, Höning, Stefan, Icking, Ann, Tikkanen, Ritva, Hunziker, Walter·2002·Nature Cell Biology
DOI 10.1038/ncb745
Open this paper in CoChat — free account

Abstract

Adaptors are heterotetrameric complexes that mediate the incorporation of cargo into transport vesicles by interacting with sorting signals present in the cytosolic domain of transmembrane proteins. Four adaptors, AP-1 (beta 1, gamma, mu 1A or mu 1B, sigma 1), AP-2 (beta 2, alpha, mu 2, sigma 2), AP-3 (beta 3 , delta, mu 3, sigma 3) or AP-4 (beta 4, epsilon, mu 4, sigma 4), have been characterized. AP-1 and AP-3 mediate sorting events at the level of the TGN and/or endosomes, whereas AP-2 functions in endocytic clathrin coated vesicle formation; no function is known so far for AP-4. Here, we show that AP-4 can bind different types of cytosolic signals known to mediate basolateral transport in epithelial cells. Furthermore, in MDCK cells with depleted mu 4 protein levels, several basolateral proteins are mis-sorted to the apical surface, showing that AP-4 participates in basolateral sorting in epithelial cells.

Overview

Integrity signals

Registry

Crossref · 10.1038/ncb745

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The proteins involved in decoding basolateral sorting signals have been the widely expressed AP4 complex and the clathrin adaptor complex AP1B, both acting predominantly upon Y-dependent motifs.

    “So far, the proteins involved in decoding basolateral sorting signals have been the widely expressed AP4 complex (Simmen et al., 2002) and the clathrin adaptor complexes AP1B complex specifically expressed by certain epithelial cells (Folsch et al., 1999; Ohno et al., 1999; Gan et al., 2002), both acting predominantly upon Y-dependent motifs.”

    From Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y-dependent Sorting Motifs in Different Pathways (2009) · cites this paper as Simmen et al., 2002

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 31

  1. Bonifacino, J. S. & Dell' Angelica, E. C. J. Cell Biol. 145, 923–926 (1999). · DOI · Paper page
  2. Robinson, M. S. & Bonifacino, J. S. Curr. Opin. Cell Biol. 13, 444–453 (2001). · DOI
  3. Keller, P. & Simons, K. J. Cell Sci. 110, 3001–3009 (1997). · DOI
  4. Yeaman, C., Grindstaff, K. K. & Nelson, W. J. Physiol. Rev. 79, 73–98 (1999). · DOI
  5. Mellman, I. Annu. Rev. Cell Dev. Biol. 12, 575–625 (1996). · DOI
  6. Hunziker, W., Harter, C., Matter, K. & Mellman, I. Cell 66, 907–920 (1991). · DOI
  7. Hunziker, W. & Mellman, I. Semin. Cell Biol. 2, 397–410 (1991).
  8. Brewer, C. B. & Roth, M. G. J. Cell Biol. 114, 413–421 (1991). · DOI
  9. Fölsch, H., Ohno, H., Bonifacino, J. S. & Mellman, I. Cell 99, 189–198 (1999). · DOI · Paper page
  10. Bresciani, R., Denzer, K., Pohlmann, R. & Vonfigura, K. Biochem. J. 327, 811–818 (1997). · DOI
  11. Dell' Angelica, E. C., Mullins, C. & Bonifacino, J. S. J. Biol. Chem. 274, 7278–7285 (1999). · DOI
  12. Hirst, J., Bright, N. A., Rous, B. & Robinson, M. S. Mol. Biol. Cell 10, 2787–2802 (1999). · DOI
  13. Simmen, T., Nobile, M., Bonifacino, J. S. & Hunziker, W. Mol. Cell. Biol. 19, 3136–3144 (1999). · DOI
  14. Matter, K., Hunziker, W. & Mellman, I. Cell 71, 741–753 (1992). · DOI · Paper page
  15. Odorizzi, G. & Trowbridge, I. S. J. Cell Biol. 137, 1255–1264 (1997). · DOI · Paper page
  16. Jing, S., Spencer, T., Miller, K., Hopkins, C. & Trowbridge, I. S. J. Cell Biol. 110, 283–294 (1990). · DOI
  17. Stephens, D. J. & Banting, G. Biochem. J. 335, 567–572 (1998). · DOI
  18. Aguilar, R. C. et al. J. Biol. Chem. 276, 13145–13152 (2001). · DOI
  19. Futter, C. E., Connolly, C. N., Cutler, D. F. & Hopkins, C. R. J. Biol. Chem. 270, 10999–11003 (1995). · DOI
  20. Matter, K., Whitney, J. A., Yamamoto, E. M. & Mellman, I. Cell 74, 1053–1064 (1993). · DOI · Paper page
  21. Aroeti, B. & Mostov, K. E. EMBO J. 13, 2297–2304 (1994). · DOI · Paper page
  22. Ohno, H. et al. FEBS Lett. 449, 215–220 (1999). · DOI · Paper page
  23. Yokode, M. et al. J. Cell Biol. 117, 39–46 (1992). · DOI · Paper page
  24. Bradke, F. & Dotti, C. G. Curr. Opin. Neurobiol. 10, 574–581 (2000). · DOI
  25. Winckler, B. & Mellman, I. Neuron 23, 637–640 (1999). · DOI
  26. Müsch, A., Xu, H. X., Shields, D. & Rodriguez-Boulan, E. J. Cell Biol. 133, 543–558 (1996). · DOI
  27. Yoshimori, T., Keller, P., Roth, M. G. & Simons, K. J. Cell Biol. 133, 247–256 (1996). · DOI
  28. Tokuyasu, K. T. J. Microsc. 143, 139–149 (1986). · DOI
  29. Höning, S., Griffith, J., Geuze, H. J. & Hunziker, W. EMBO J. 15, 5230–5239 (1996). · DOI
  30. Podbilewicz, B. & Mellman, I. EMBO J. 9, 3477–3487 (1990). · DOI
  31. Hunziker, W. & Fumey, C. EMBO J. 13, 2963–2969 (1994). · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Simmen, T., Höning, S., Icking, A., Tikkanen, R., & Hunziker, W.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2002-01-21
Volume
4
Issue
2
Pages
154-159
ISSN
  • 1465-7392
  • 1476-4679
DOI
10.1038/ncb745
Cited by
189
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review