Systems-level antimicrobial drug and drug synergy discovery

Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

Boucher, H. W., Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Rice, L. B., Scheld, M., Spellberg, B. J., & Bartlett, J. (2008) · Clinical Infectious Diseases · doi:10.1086/595011 · Cited by 5,092

Functional profiling of the Saccharomyces cerevisiae genome

Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953

The Bacterial Cell EnvelopePreprint

Silhavy, T. J., Kahne, D. E., & Walker, S. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000414 · Cited by 3,834

Genes required for mycobacterial growth defined by high density mutagenesis

Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512

Synergy, antagonism, and what the chequerboard puts between them

Odds, F. C. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg301 · Cited by 2,498

A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

Andries, K., Verhasselt, P., Guillemont, J., Göhlmann, H. W. H., Neefs, J.-M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005) · Science · doi:10.1126/science.1106753 · Cited by 2,191

The Genetic Landscape of a Cell

Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162

The re-emergence of natural products for drug discovery in the genomics era

Harvey, A. L., Edrada‐Ebel, R., & Quinn, R. J. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4510 · Cited by 2,654

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240

Target identification and mechanism of action in chemical biology and drug discovery

Schenone, M., Dančík, V., Wagner, B. K., & Clemons, P. A. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1199 · Cited by 1,147

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 849

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801

Combenefit: an interactive platform for the analysis and visualization of drug combinations

Veroli, G. Y. D., Fornari, C., Wang, D. Y. Q., Mollard, S., Bramhall, J. L., Richards, F. M., & Jodrell, D. I. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw230 · Cited by 762

Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

Roemer, T., & Krysan, D. J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019703 · Cited by 593

Exogenous Alanine and/or Glucose plus Kanamycin Kills Antibiotic-Resistant Bacteria

Peng, B., Su, Y., Li, H., Han, Y., Guo, C., Tian, Y., & Peng, X. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.008 · Cited by 491

How to bolster the antifungal pipeline

Denning, D. W., & Bromley, M. (2015) · Science · doi:10.1126/science.aaa6097 · Cited by 489

The rapid spread of carbapenem-resistant Enterobacteriaceae

Potter, R. F., D’Souza, A. W., & Dantas, G. A. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.09.002 · Cited by 406

Whole-genome sequencing to control antimicrobial resistance

Köser, C. U., Ellington, M. J., & Peacock, S. J. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.07.003 · Cited by 344

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0002-2016 · Cited by 271

Infection microenvironment-related antibacterial nanotherapeutic strategies

Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 271

Tunable protein degradation in bacteria

Cameron, D. E., & Collins, J. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.3053 · Cited by 255

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

Zhang, W., Huai, Y., Miao, Z., Qian, A., & Wang, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00743 · Cited by 253

Combinatorial strategies for combating invasive fungal infections

Spitzer, M., Robbins, N., & Wright, G. D. (2016) · Virulence · doi:10.1080/21505594.2016.1196300 · Cited by 227

Large-scale exploration and analysis of drug combinations

Li, P., Huang, C., Fu, Y., Wang, J., Wu, Z., Ru, J., Zheng, C., Guo, Z., Chen, X., Zhou, W., et al. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv080 · Cited by 199

Supramolecular Assemblies of Heterogeneous Mesoporous Silica Nanoparticles to Co-deliver Antimicrobial Peptides and Antibiotics for Synergistic Eradication of Pathogenic Biofilms

Yu, Q., Deng, T., Lin, F.-C., Zhang, B., & Zink, J. I. (2020) · ACS Nano · doi:10.1021/acsnano.0c01336 · Cited by 185

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

McCarthy, M. W., Kontoyiannis, D. P., Cornely, O. A., Perfect, J. R., & Walsh, T. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix130 · Cited by 174

Antimicrobial lipopeptide tridecaptin A 1 selectively binds to Gram-negative lipid II

Cochrane, S. A., Findlay, B., Bakhtiary, A., Acedo, J. Z., Rodriguez-Lopez, E. M., Mercier, P., & Vederas, J. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608623113 · Cited by 138

Challenges and strategies in drug delivery systems for treatment of pulmonary infections

Ho, D., Nichols, B. L. B., Edgar, K. J., Murgia, X., Loretz, B., & Lehr, C. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.09.002 · Cited by 142

Combinatorial drug discovery in nanoliter droplets

Kulesa, A. B., Kehe, J., Hurtado, J. E., Tawde, P., & Blainey, P. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802233115 · Cited by 136

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

Fisher, J. F., & Mobashery, S. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01010 · Cited by 128

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning

Wildenhain, J., Spitzer, M., Dolma, S., Jarvik, N., White, R., Roy, M. M., Griffiths, E., Bellows, D. S., Wright, G. D., & Tyers, M. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.003 · Cited by 125

Chemogenomics and orthology‐based design of antibiotic combination therapies

Chandrasekaran, S., Çakmak, M. Ç., Sahin, N., Yılancıoğlu, K., Kazan, H., Collins, J. J., & Cokol, M. (2016) · Molecular Systems Biology · doi:10.15252/msb.20156777 · Cited by 117

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Lee, S. H., Wang, H., Labroli, M. A., Koseoglu, S., Zuck, P. D., Mayhood, T., Gill, C., Mann, P. A., Sher, X., Ha, S., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7364 · Cited by 110

Functional annotation of chemical libraries across diverse biological processes

Piotrowski, J. S., Li, S. C., Deshpande, R., Simpkins, S. W., Nelson, J., Yashiroda, Y., Barber, J. M., Safizadeh, H., Wilson, E. H., Okada, H., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2436 · Cited by 97

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

Parente-Rocha, J. A., Bailão, A. M., Amaral, A. C., Taborda, C. P., Paccez, J. D., Borges, C. L., & Pereira, M. (2017) · Mediators of Inflammation · doi:10.1155/2017/9870679 · Cited by 93

Understanding the Composition of Food Waste

Ogwu, M. C. (2019) · Advances in environmental engineering and green technologies book series · doi:10.4018/978-1-5225-7706-5.ch011 · Cited by 93

Constructing and deconstructing the bacterial cell wall

Fisher, J. F., & Mobashery, S. (2019) · Protein Science · doi:10.1002/pro.3737 · Cited by 111

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

Fu, C., Zhang, X., Veri, A. O., Iyer, K. R., Lash, E., Xue, A., Yan, H., Revie, N. M., Wong, C. J., Lin, Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26850-3 · Cited by 90

SynLethDB 2.0: a web-based knowledge graph database on synthetic lethality for novel anticancer drug discovery

Wang, J., Wu, M., Huang, X., Wang, L., Zhang, S., Liu, H., & Zheng, J. (2022) · Database · doi:10.1093/database/baac030 · Cited by 83

Emerging peptide antibiotics with therapeutic potential

Upert, G., Luther, A., Obrecht, D., & Ermert, P. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100078 · Cited by 80

Affinity-based target identification for bioactive small molecules

Kawatani, M., & Osada, H. (2013) · MedChemComm · doi:10.1039/c3md00276d · Cited by 78

Novel antimicrobial peptide–modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus

Liu, X., Li, Z., Wang, X., Chen, Y., Wu, F., Men, K., Xu, T., Luo, Y., & Yang, L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s107107 · Cited by 71

Nanomaterials for Biosensors and Implantable Biodevices

Luz, R. A. S., Iost, R. M., & Crespilho, F. N. (2012) · Springer eBooks · doi:10.1007/978-3-642-29250-7_2 · Cited by 65

Using adjuvants and environmental factors to modulate the activity of antimicrobial peptides

Walkenhorst, W. F. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.12.034 · Cited by 67

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Wambaugh, M. A., Shakya, V. P. S., Lewis, A. J., Mulvey, M. A., & Brown, J. C. S. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2001644 · Cited by 63

Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections

Zhang, F., Smolen, J. A., Zhang, S., Li, R., Shah, P. N., Cho, S., Wang, H., Raymond, J. E., Cannon, C. L., & Wooley, K. L. (2015) · Nanoscale · doi:10.1039/c4nr07103d · Cited by 62

Antiparasitic Chemotherapy: From Genomes to Mechanisms

Horn, D., & Duraisingh, M. T. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135915 · Cited by 63

L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake

Deng, W., Fu, T., Zhang, Z., Jiang, X. Y., Xie, J., Sun, H., Hu, P., Ren, H., Zhou, P., Liu, Q., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1740611 · Cited by 61

BIONIC: biological network integration using convolutions

Forster, D. T., Li, S. C., Yashiroda, Y., Yoshimura, M., Li, Z., Isuhuaylas, L. A. V., Itto‐Nakama, K., Yamanaka, D., Ohya, Y., Osada, H., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01616-x · Cited by 60

Application of Omics Technologies for Evaluation of Antibacterial Mechanisms of Action of Plant-Derived Products

dos Santos, B. S., da Silva, L. C. N., da Silva, T. D., Rodrigues, J. F. S., Grisotto, M. A. G., Correia, M. T. D. S., Napoleão, T. H., da Silva, M. V., & Paiva, P. M. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01466 · Cited by 58

Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis

Martínez-Jiménez, F., Papadatos, G., Yang, L., Wallace, I. M., Kumar, V. D., Pieper, U., Šali, A., Brown, J. R., Overington, J. P., & Martı́-Renom, M. A. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003253 · Cited by 56

Synthesis of Tridecaptin–Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria

Cochrane, S. A., Li, X., He, S., Yu, M., Wu, M., & Vederas, J. C. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01578 · Cited by 54

Studies on tridecaptin B 1 , a lipopeptide with activity against multidrug resistant Gram-negative bacteria

Cochrane, S. A., Lohans, C. T., van Belkum, M. J., Bels, M. A., & Vederas, J. C. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00780a · Cited by 50

Advances in macrocyclic peptide-based antibiotics

Luther, A., Bisang, C., & Obrecht, D. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.08.006 · Cited by 48

Endless resistance. Endless antibiotics?

Fisher, J. F., & Mobashery, S. (2015) · MedChemComm · doi:10.1039/c5md00394f · Cited by 46

Innovative perspectives on the discovery of small molecule antibiotics

Cardona, S. T., Rahman, A. S. M. Z., & Nechcoff, J. N. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00089-0 · Cited by 51

Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification

Zhao, X., Li, Z., & Kuipers, O. P. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.005 · Cited by 44

A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics

Hart, P. ‘., Kleijn, L. H. J., de Bruin, G., Oppedijk, S. F., Kemmink, J., & Martin, N. I. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42238k · Cited by 41

Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies

Cardona, S. T., Choy, M., & Hogan, A. M. (2017) · The Journal of Membrane Biology · doi:10.1007/s00232-017-9995-5 · Cited by 41

Unconventional Antibacterials and Adjuvants

Chang, M., Mahasenan, K. V., Hermoso, J. A., & Mobashery, S. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00776 · Cited by 38

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

Concha, N. O., Huang, J., Bai, X., Benowitz, A. B., Brady, P. G., Grady, L. C., Kryn, L. H., Holmes, D. J., Ingraham, K. A., Jin, Q., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00746 · Cited by 36

Prediction of synergistic drug combinations

Weinstein, Z., Bender, A., & Cokol, M. (2017) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.05.005 · Cited by 37

Advances in fungal chemical genomics for the discovery of new antifungal agents

Xue, A., Robbins, N., & Cowen, L. E. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14484 · Cited by 41

Searching for synergy in silico, in vitro and in vivo

Sucher, N. J. (2014) · Synergy · doi:10.1016/j.synres.2014.07.004 · Cited by 36

The Tipper–Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA)

Fishovitz, J., Taghizadeh, N., Fisher, J. F., Chang, M., & Mobashery, S. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b01374 · Cited by 35

Key Residues in Octyl‐Tridecaptin A1 Analogues Linked to Stable Secondary Structures in the Membrane

Cochrane, S. A., Findlay, B., Vederas, J. C., & Ratemi, E. (2014) · ChemBioChem · doi:10.1002/cbic.201402024 · Cited by 35

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., & Cowen, L. E. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007319 · Cited by 34

β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus

Ferrer-González, E., Kaul, M., Parhi, A. K., LaVoie, E. J., & Pilch, D. S. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00863-17 · Cited by 32

Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

Klobucar, K., & Brown, E. D. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux054 · Cited by 31

Unacylated tridecaptin A1 acts as an effective sensitiser of Gram-negative bacteria to other antibiotics

Cochrane, S. A., & Vederas, J. C. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.08.008 · Cited by 31

Chemogenomic Profiling of the Fungal Pathogen Candida albicans

Chen, Y., Mallick, J., Maqnas, A., Sun, Y., Choudhury, B. I., Côte, P., Yan, L., Ni, T., Li, Y., Zhang, D., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02365-17 · Cited by 35

Antisense Peptide Nucleic Acid–Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria

Iubatti, M., Gabas, I. M., Cavaco, L. M., Mood, E. H., Lim, E. W. K., Bonanno, F., Yavari, N., Brolin, C., & Nielsen, P. E. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00089 · Cited by 28

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch44 · Cited by 26

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

Helliwell, S. B., Karkare, S., Bergdoll, M., Rahier, A., Leighton-Davis, J. R., Fioretto, C., Aust, T., Filipuzzi, I., Frederiksen, M. U., Gounarides, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9613 · Cited by 23

Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1

Cochrane, S. A., Surgenor, R. R., Khey, K. M. W., & Vederas, J. C. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02779 · Cited by 24

Recent Advances in Genome Editing Tools in Medical Mycology Research

Nargesi, S., Kaboli, S., Thekkiniath, J., Heidari, S., Keramati, F., Seyedmousavi, S., & Hedayati, M. T. (2021) · Journal of Fungi · doi:10.3390/jof7040257 · Cited by 24

Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing

Yow, H.-Y., Govindaraju, K., Lim, A. H., & Rahim, N. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.915355 · Cited by 27

A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus

Tan, S., Cho, K., & Nodwell, J. R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102473 · Cited by 22

Additivity and synergy between an antimicrobial peptide and inhibitory ions

Walkenhorst, W. F., Sundrud, J. N., & Laviolette, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.05.005 · Cited by 23

Genetic Approaches to Facilitate Antibacterial Drug DevelopmentPreprint

Schnappinger, D. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a021139 · Cited by 21

Genomic tools to profile antibiotic mode of action

Cardona, S. T., Selin, C., & Gislason, A. S. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.866073 · Cited by 23

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

Morisaki, J. H., Smith, P. A., Date, S. V., Kajihara, K. K., Truong, C.-L., Modrusan, Z. D., Yan, D., Kang, J., Xu, M. J., Shah, I. M., et al. (2016) · mBio · doi:10.1128/mbio.00412-16 · Cited by 19

Transcriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response

Pang, C. N. I., Lai, Y.-W., Campbell, L. T., Chen, S. C.-A., Carter, D. A., & Wilkins, M. R. (2017) · Scientific Reports · doi:10.1038/srep40232 · Cited by 19

Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine

Zhao, X., Zhong, X., Yang, S., Deng, K., Liu, L., Song, X., Zou, Y., Li, L., Zhou, X. C., Jia, R., et al. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00010-23 · Cited by 19

Assay and recommendations for the detection of vapour‐phase‐mediated antimicrobial activities

Feyaerts, A. F., Mathé, L., Luyten, W. H. M. L., Tournu, H., Dyck, K. V., Broekx, L., & Dijck, P. V. (2017) · Flavour and Fragrance Journal · doi:10.1002/ffj.3400 · Cited by 19

Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity

Kim, D., Cho, S., Lee, K.-Y., Cheon, S., Yoon, H. J., Lee, J.-Y., Kim, D., Shin, K.-S., Koh, C., Koo, J. S., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03490-2 · Cited by 17

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

Wildenhain, J., Spitzer, M., Dolma, S., Jarvik, N., White, R., Roy, M. M., Griffiths, E., Bellows, D. S., Wright, G. D., & Tyers, M. (2016) · Scientific Data · doi:10.1038/sdata.2016.95 · Cited by 17

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Buijs, N. P., Vlaming, H. C., van Haren, M. J., & Martin, N. I. (2022) · ChemBioChem · doi:10.1002/cbic.202200547 · Cited by 16

Predicting drug synergy for precision medicine using network biology and machine learning

Cüvitoğlu, A., Zhou, J., Huang, S., & Işık, Z. (2019) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720019500124 · Cited by 16

Double Orthogonal Click Reactions for the Development of Antimicrobial Peptide Nanotubes

González‐Freire, E., Novelli, F., Pérez‐Estévez, A., Seoane, R., Amorín, M., & Granja, J. R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004127 · Cited by 15

Micro- and Nanoscale Approaches in Antifungal Drug Discovery

Willaert, R. (2018) · Fermentation · doi:10.3390/fermentation4020043 · Cited by 18

Genetic interaction analysis in microbial pathogens: unravelling networks of pathogenesis, antimicrobial susceptibility and host interactions

Halder, V., McDonnell, B., Uthayakumar, D., Usher, J., & Shapiro, R. S. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa055 · Cited by 14

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Javed, A., Slingerland, C. J., Wood, T. M., Martin, N. I., Broere, F., Weingarth, M. H., & Veldhuizen, E. J. A. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00518 · Cited by 14

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

Yang, S., Pan, J., Yang, C., Labroli, M. A., Pan, W., Caldwell, J. P., Ha, S., Koseoglu, S., Xiao, J. C., Mayhood, T., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.08.036 · Cited by 14

Unveiling the Synergistic Interaction Between Liposomal Amphotericin B and Colistin

Teixeira‐Santos, R., Ricardo, E., Branco, R. J. F., Azevedo, M. M., Rodrigues, A. G., & Pina‐Vaz, C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01439 · Cited by 14

Recent Molecular Tools for the Genetic Manipulation of Highly Industrially Important Mucoromycota Fungi

Mohamed, H., Naz, T., Yang, J., Shah, A. M., Nazir, Y., & Song, Y. (2021) · Journal of Fungi · doi:10.3390/jof7121061 · Cited by 14

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

Liston, S. D., Whitesell, L., Kapoor, M., Shaw, K. J., & Cowen, L. E. (2022) · Journal of Fungi · doi:10.3390/jof8101102 · Cited by 12

Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

Heslop-Harrison, G., Nakabayashi, K., Espinosa‐Ruíz, A., Robertson, F., Baines, R., Thompson, C. R. L., Hermann, K., Alabadí, D., Leubner‐Metzger, G., & Williams, R. S. B. (2024) · Plant Communications · doi:10.1016/j.xplc.2024.100846 · Cited by 12

Genomic Approaches to Antifungal Drug Target Identification and Validation

Robbins, N., & Cowen, L. E. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-094524 · Cited by 15

Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success

Sutterlin, H. A., Malinverni, J. C., Lee, S. H., Balibar, C. J., & Roemer, T. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_31 · Cited by 12

Building a unified model for drug synergy analysis powered by large language models

Liu, T., Chu, T., Luo, X., & Zhao, H. (2025) · Nature Communications · doi:10.1038/s41467-025-59822-y · Cited by 15

In vitro activity of meropenem/piperacillin/tazobactam triple combination therapy against clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus pseudintermedius and vancomycin-resistant Enterococcus spp

Yoneda, A., Thänert, R., Burnham, C. D., & Dantas, G. A. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.105864 · Cited by 11

Antibiotic Adjuvants

Melander, R. J., & Melander, C. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2017_10 · Cited by 11

Dual transposon sequencing profiles the genetic interaction landscape in bacteria

Zik, J. J., Price, M. N., Mayra, K. H. A., Santoso, A. A., Arkin, A. P., Deutschbauer, A. M., & Sham, L. (2025) · Science · doi:10.1126/science.adt7685 · Cited by 14

Mitigation of Human-Pathogenic Fungi that Exhibit Resistance to Medical Agents: Can Clinical Antifungal Stewardship Help?

Hull, C. M., Purdy, N. J., & Moody, S. C. (2014) · Future Microbiology · doi:10.2217/fmb.13.160 · Cited by 10

Omics Technologies in the Plant–Microbe Interactions

Baştaş, K. K., & Kumar, A. (2023) · Microorganisms for sustainability · doi:10.1007/978-981-99-3947-3_13 · Cited by 10

Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus

Kaul, M., Ferrer-González, E., Mark, L., Parhi, A. K., LaVoie, E. J., & Pilch, D. S. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02960-5 · Cited by 9

Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

Klobucar, K., & Brown, E. D. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux054 · Cited by 31

Novel approaches to the discovery of antimicrobial agents

Schmid, M. B. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80130-0 · Cited by 46

Emerging Strategies in Antimicrobial Drug Discovery: A Review of Target-Based and Phenotypic Screening Approaches

Aliyu, I. I., Isaiah, Z., Gebre, S. T., Mustapha, M., Abdulkadir, M. Y., Ndagi, A. A., & Usman, D. M. K. (2026) · South Asian Journal of Research in Microbiology · doi:10.9734/sajrm/2026/v20i9522

Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success

Sutterlin, H. A., Malinverni, J. C., Lee, S. H., Balibar, C. J., & Roemer, T. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_31 · Cited by 12

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Wambaugh, M. A., Shakya, V. P. S., Lewis, A. J., Mulvey, M. A., & Brown, J. C. S. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2001644 · Cited by 63