Systems-level antimicrobial drug and drug synergy discovery

Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

Boucher, H. W., Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Rice, L. B., Scheld, M., Spellberg, B. J., & Bartlett, J. (2008) · Clinical Infectious Diseases · doi:10.1086/595011 · Cited by 5,092

Functional profiling of the Saccharomyces cerevisiae genome

Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953

The Bacterial Cell EnvelopePreprint

Silhavy, T. J., Kahne, D. E., & Walker, S. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000414 · Cited by 3,834

Genes required for mycobacterial growth defined by high density mutagenesis

Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512

Synergy, antagonism, and what the chequerboard puts between them

Odds, F. C. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg301 · Cited by 2,498

A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

Andries, K., Verhasselt, P., Guillemont, J., Göhlmann, H. W. H., Neefs, J.-M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005) · Science · doi:10.1126/science.1106753 · Cited by 2,191

The Genetic Landscape of a Cell

Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138

Global Mapping of the Yeast Genetic Interaction Network

Tong, A. H. Y., Lesage, G., Bader, G. D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G. F., Brost, R. L., Chang, M., et al. (2004) · Science · doi:10.1126/science.1091317 · Cited by 2,089

How were new medicines discovered?

Swinney, D. C., & Anthony, J. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3480 · Cited by 1,812

Antibiotics for Emerging Pathogens

Fischbach, M. A., & Walsh, C. T. (2009) · Science · doi:10.1126/science.1176667 · Cited by 1,787

Three Decades of β-Lactamase Inhibitors

Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709

Essential Bacillus subtilis genes

Kobayashi, K., Ehrlich, S., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., Asai, K., Ashikaga, S., Aymerich, S., Bessières, P., et al. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0730515100 · Cited by 1,451

Challenges of Antibacterial Discovery

Silver, L. L. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00030-10 · Cited by 1,432

The antibiotic resistome: the nexus of chemical and genetic diversity

Wright, G. D. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1614 · Cited by 1,421

Comprehensive transposon mutant library of Pseudomonas aeruginosa

Jacobs, M. A., Alwood, A., Thaipisuttikul, I., Spencer, D. H., Haugen, E., Ernst, S., Will, O., Kaul, R., Raymond, C. K., Levy, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2036282100 · Cited by 1,129

New uses for old drugs

Chong, C. R., & Sullivan, D. J. (2007) · Nature · doi:10.1038/448645a · Cited by 996

Synergistic drug combinations tend to improve therapeutically relevant selectivity

Lehár, J., Krueger, A., Avery, W., Heilbut, A. M., Johansen, L. M., Price, E. R., Rickles, R. J., Short, G. F., Staunton, J. E., Jin, X., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1549 · Cited by 959

An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants

Liberati, N. T., Urbach, J. M., Miyata, S., Lee, D. G., Drenkard, E., Wu, G., Villanueva, J. M., Wei, T., & Ausubel, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511100103 · Cited by 943

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

Moffatt, J. H., Harper, M., Harrison, P. F., Hale, J. D. F., VINOGRADOV, E. V., Seemann, T., Henry, R., Crane, B., Michael, F. S., Cox, A. D., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00834-10 · Cited by 858

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

Nikaido, H., & Pagès, J. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00290.x · Cited by 770

Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli

Wu, T., Malinverni, J. C., Ruiz, N., Kim, S., Silhavy, T. J., & Kahne, D. E. (2005) · Cell · doi:10.1016/j.cell.2005.02.015 · Cited by 769

Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655

Gerdes, S., Scholle, M. D., Campbell, J. W., Balázsi, G., Ravasz, E., Daugherty, M. D., Somera, A. L., Kyrpides, N. C., Anderson, I., Gelfand, M. S., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.19.5673-5684.2003 · Cited by 741

Phenotypic Landscape of a Bacterial Cell

Nichols, R. J., Sen, Ś., Choo, Y. J., Beltrão, P., Zietek, M., Chaba, R., Lee, S., Kazmierczak, K. M., Lee, K. J., Wong, A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.052 · Cited by 723

Antibiotics: Actions, Origins, Resistance

Walsh, C. T. (2003) · Medical Entomology and Zoology · Cited by 675

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., & Boone, C. M. (2003) · Nature Biotechnology · doi:10.1038/nbt919 · Cited by 651

Simultaneous assay of every Salmonella Typhi gene using one million transposon mutantsPreprint

Langridge, G. C., Phan, M.-D., Turner, D., Perkins, T. T., Parts, L., Haase, J., Charles, I., Maskell, D. J., Peters, S. E., Dougan, G., et al. (2009) · Genome Research · doi:10.1101/gr.097097.109 · Cited by 641

Antibiotics

Walsh, C. T. (2003) · Wiley eBooks · doi:10.1128/9781555817886 · Cited by 630

Systematic discovery of multicomponent therapeutics

Borisy, A. A., Elliott, P. J., Hurst, N. W., Lee, M. S., Lehár, J., Price, E. R., Serbedzija, G., Zimmermann, G. R., Foley, M. A., Stockwell, B. R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1337088100 · Cited by 620

Exploration of Essential Gene Functions via Titratable Promoter Alleles

Mnaimneh, S., Davierwala, A. P., Haynes, J., Moffat, J., Peng, W.-T., Zhang, W., Yang, X., Pootoolal, J., Chua, G., Lopez, A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.06.013 · Cited by 604

Regulatory circuitry governing fungal development, drug resistance, and disease.

Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576

Genomic profiling of drug sensitivities via induced haploinsufficiency

Giaever, G. N., Shoemaker, D. D., Jones, T., Liang, H., Winzeler, E. A., Astromoff, A., & Davis, R. W. (1999) · Nature Genetics · doi:10.1038/6791 · Cited by 570

Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar–coding strategy

Shoemaker, D. D., Lashkari, D. A., Morris, D., Mittmann, M., & Davis, R. W. (1996) · Nature Genetics · doi:10.1038/ng1296-450 · Cited by 569

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Ejim, L., Farha, M. A., Falconer, S. B., Wildenhain, J., Coombes, B. K., Tyers, M., Brown, E. D., & Wright, G. D. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.559 · Cited by 525

MipZ, a Spatial Regulator Coordinating Chromosome Segregation with Cell Division in Caulobacter

Thanbichler, M. R., & Shapiro, L. (2006) · Cell · doi:10.1016/j.cell.2006.05.038 · Cited by 517

Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

Roemer, T., Jiang, B., Davison, J., Ketela, T. W., Veillette, K., Breton, A., Tandia, F., Linteau, A., Sillaots, S., Marta, C., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03697.x · Cited by 513

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

Parsons, A. B., López, A., Givoni, I. E., Williams, D. E., Gray, C. A., Porter, J., Chua, G., Sopko, R., Brost, R. L., Ho, C.-H., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.040 · Cited by 512

Why is big Pharma getting out of antibacterial drug discovery?

Projan, S. J. (2003) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.08.003 · Cited by 507

Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

Giaever, G. N., Flaherty, P., Kumm, J., Proctor, M. J., Nislow, C., Jaramillo, D. F., Chu, A. M., Jordan, M. I., Arkin, A. P., & Davis, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307490100 · Cited by 506

A genome‐wide strategy for the identification of essential genes in Staphylococcus aureus

Forsyth, A., Haselbeck, R. J., Ohlsen, K. L., Yamamoto, R. T., Xu, H. H., Trawick, J. D., Wall, D., Wang, L., Brown‐Driver, V., Froelich, J. M., et al. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02832.x · Cited by 488

Defining genetic interaction

Mani, R., St.Onge, R. P., Hartman, J. L., Giaever, G. N., & Roth, F. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712255105 · Cited by 482

Susceptibility testing of antimicrobials in liquid media

Amsterdam, D. (1996) · Medical Entomology and Zoology · Cited by 482

Biochemical and genetic analysis of the yeast proteome with a movable ORF collectionPreprint

Gelperin, D. M., White, M. A., Wilkinson, M. L., Kon, Y., Kung, L. A., Wise, K. J., Lopez-Hoyo, N., Jiang, L., Piccirillo, S., Yu, H., et al. (2005) · Genes & Development · doi:10.1101/gad.1362105 · Cited by 479

Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A. S., et al. (2004) · Cell · doi:10.1016/s0092-8674(03)01035-3 · Cited by 478

Practical applications and feasibility of efflux pump inhibitors in the clinic—A vision for applied use

Lomovskaya, O., & Bostian, K. A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.008 · Cited by 461

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

Haydon, D. J., Stokes, N. R., Ure, R., Galbraith, G., Bennett, J. M., Brown, D. R., Baker, P. J., Barynin, V. V., Rice, D. W., Sedelnikova, S. E., et al. (2008) · Science · doi:10.1126/science.1159961 · Cited by 452

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Grzegorzewicz, A. E., Pham, H., Gundi, V. A. K. B., Scherman, M. S., North, E. J., Hess, T., Jones, V., Gruppo, V., Born, S. E. M., Korduláková, J., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.794 · Cited by 442

An insight into the antifungal pipeline: selected new molecules and beyond

Ostrosky-Zeichner, L., Casadevall, A., Galgiani, J. N., Odds, F. C., & Rex, J. H. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3074 · Cited by 432

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813394106 · Cited by 413

The Neglected Intrinsic Resistome of Bacterial Pathogens

Fajardo-Lubian, A., Martinez-Martín, N., Mercadillo, M., Galán, J. C., Ghysels, B., Matthijs, S., Cornélis, P., Wiehlmann, L., Tümmler, B., Baquero, F., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001619 · Cited by 390

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

Baryshnikova, A., Costanzo, M., Kim, Y., Ding, H., Koh, J., Toufighi, K., Youn, J.-Y., Ou, J., San Luis, B.-J., Bandyopadhyay, S., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1534 · Cited by 364

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000532 · Cited by 362

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

Akerley, B. J., Rubin, E. J., Novick, V. L., Amaya, K. R., Judson, N., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012602299 · Cited by 358

Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress.

Cyert, M. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01552-3 · Cited by 333

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

Brinster, S., Lamberet, G., Staels, B., Trieu‐Cuot, P., Gruss, A., & Poyart, C. (2009) · Nature · doi:10.1038/nature07772 · Cited by 318

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

Paradis‐Bleau, C., Markovski, M., Uehara, T., Lupoli, T. J., Walker, S., Kahne, D. E., & Bernhardt, T. G. (2010) · Cell · doi:10.1016/j.cell.2010.11.037 · Cited by 313

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

Chaudhuri, R. R., Allen, A. G., Owen, P., Shalom, G., Stone, K. M., Harrison, M., Burgis, T. A., Lockyer, M. J., Garcı́a-Lara, J., Foster, S. J., et al. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-291 · Cited by 309

Systematic exploration of synergistic drug pairs

Cokol, M., Chua, H. N., Tasan, M., Mutlu, B., Weinstein, Z., Suzuki, Y., Nergiz, M. E., Costanzo, M., Baryshnikova, A., Giaever, G. N., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.71 · Cited by 308

Quantitative phenotyping via deep barcode sequencingPreprint

Smith, A. M., Heisler, L. E., Mellor, J. C., Kaper, F., Thompson, M. J., Chee, M. S., Roth, F. P., Giaever, G. N., & Nislow, C. (2009) · Genome Research · doi:10.1101/gr.093955.109 · Cited by 304

A complete collection of single‐gene deletion mutants of Acinetobacter baylyi ADP1

de Berardinis, V., Vallenet, D., Castelli, V., Besnard‐Gonnet, M., Pinet, A., Cruaud, C., Samair, S., Lechaplais, C., Gyapay, G., Richez, C., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.10 · Cited by 303

Systematic Mapping of Genetic Interaction Networks

Dixon, S. J., Costanzo, M., Baryshnikova, A., Andrews, B., & Boone, C. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.114751 · Cited by 298

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

Ho, C. H., Magtanong, L., Barker, S. L., Gresham, D., Nishimura, S., Natarajan, P., Koh, J. L. Y., Porter, J., Gray, C. A., Andersen, R. J., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1534 · Cited by 297

Discovery research: the scientific challenge of finding new antibiotics

Livermore, D. M., on behalf of the British Society for Antimicrobial Chemotherapy Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development, Blaser, M., Carrs, O., Cassell, G., Fishman, N., Guidos, R., Levy, S., Powers, J. H., Norrby, R., et al. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr262 · Cited by 288

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

Liu, A., Tran, L., Becket, E., Lee, K., Chinn, L., Park, E. Y., Tran, K. P., & Miller, J. H. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00906-09 · Cited by 284

Systematic identification of essential genes by in vitro mariner mutagenesis

Akerley, B. J., Rubin, E. J., Camilli, A., Lampe, D. J., Robertson, H. M., & Mekalanos, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8927 · Cited by 267

Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans

Xu, D., Jiang, B., Ketela, T. W., Lemieux, S., Veillette, K., Martel, N., Davison, J., Sillaots, S., Trosok, S., Bachewich, C., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030092 · Cited by 256

Antibiotic adjuvants: multicomponent anti-infective strategies

Kalan, L., & Wright, G. D. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001766 · Cited by 255

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

Stanley, S. A., Grant, S. S., Kawate, T., Iwase, N., Shimizu, M., Wivagg, C. N., Silvis, M. R., Kazyanskaya, E., Aquadro, J. A., Golas, A. J., et al. (2012) · ACS Chemical Biology · doi:10.1021/cb300151m · Cited by 252

Marcel Faber Roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

Baltz, R. H. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-005-0077-9 · Cited by 248

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

Tan, C. M., Therien, A. G., Lu, J., Lee, S. H., Caron, A., Gill, C., Jacob, C. L., Benton-Perdomo, L., Monteiro, J. M., Pereira, P. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003592 · Cited by 242

Essential Gene Identification and Drug Target Prioritization in Aspergillus fumigatus

Hu, W., Sillaots, S., Lemieux, S., Davison, J., Kauffman, S., Breton, A., Linteau, A., Xin, C., Bowman, J., Becker, J., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030024 · Cited by 237

Determination of Antibiotic Hypersensitivity among 4,000 Single-Gene-Knockout Mutants of Escherichia coli

Tamae, C., Liu, A., Kim, K. K., Sitz, D., Hong, J., Becket, E., Bui, A., Solaimani, P., Tran, K. P., Yang, H., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.01982-07 · Cited by 234

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

Farha, M. A., Leung, A. A. C., Sewell, E. W., D’Elia, M. A., Allison, S. E., Ejim, L. J., Pereira, P. M., Pinho, M. G., Wright, G. D., & Brown, E. D. (2012) · ACS Chemical Biology · doi:10.1021/cb300413m · Cited by 217

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures

Pierce, S. E., Davis, R. W., Nislow, C., & Giaever, G. N. (2007) · Nature Protocols · doi:10.1038/nprot.2007.427 · Cited by 213

An integrated platform of genomic assays reveals small-molecule bioactivities

Hoon, S. S., Smith, A. M., Wallace, I. M., Suresh, S., Miranda, M., Fung, E., Proctor, M. J., Shokat, K. M., Zhang, C., Davis, R. W., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.100 · Cited by 201

Tetracycline-Inducible Gene Expression and Gene Deletion in Candida albicans

Park, Y.-N., & Morschhäuser, J. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.8.1328-1342.2005 · Cited by 195

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

Hartkoorn, R. C., Sala, C., Neres, J., Pojer, F., Magnet, S., Mukherjee, R., Uplekar, S., Boy‐Röttger, S., Altmann, K., & Cole, S. T. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201689 · Cited by 192

Genetic Architecture of Intrinsic Antibiotic Susceptibility

Girgis, H. S., Hottes, A. K., & Tavazoie, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005629 · Cited by 179

Resistance of human fungal pathogens to antifungal drugs

Sanglard, D. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00344-2 · Cited by 178

Evolution and pathogenesis ofStaphylococcus aureus: lessons learned from genotyping and comparative genomics

Feng, Y., Chen, C., Su, L., Hu, S., Yu, J. M., & Chiu, C. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00086.x · Cited by 176

Antibiotics in Laboratory Medicine, 6th Edition

Mathers, A. J. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ078 · Cited by 170

Synergistic Antifungal Activities of Bafilomycin A 1 , Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans

Del Poeta, M., Cruz, M. C., Cardenas, M. E., Perfect, J. R., & Heitman, J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.739-746.2000 · Cited by 169

Analysis of β-1,3-Glucan Assembly in Saccharomyces cerevisiae Using a Synthetic Interaction Network and Altered Sensitivity to Caspofungin

Lesage, G., Sdicu, A.-M., Ménard, P., Shapiro, J., Hussein, S., & Bussey, H. (2004) · Genetics · doi:10.1534/genetics.167.1.35 · Cited by 166

Tetracycline-Regulatable System To Tightly Control Gene Expression in the Pathogenic Fungus Candida albicans

Nakayama, H., Mio, T., Nagahashi, S., Kokado, M., Arisawa, M., & Aoki, Y. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.6712-6719.2000 · Cited by 160

Essentiality of FASII pathway for Staphylococcus aureus

Balemans, W., Lounis, N., Gilissen, R., Guillemont, J., Simmen, K., Andries, K., & Koul, A. (2010) · Nature · doi:10.1038/nature08667 · Cited by 154

Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life

Pace, N. R., Sapp, J., & Goldenfeld, N. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109716109 · Cited by 149

Confronting the challenges of natural product-based antifungal discovery

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Caspofungin: the first in a new class of antifungal agents

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Global Phenotypic Screening for Antimalarials

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Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

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New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance

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An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae

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Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

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Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus

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Reversal of resistance in microorganisms by help of non-antibiotics

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Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

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A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds

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Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection

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Yeast chemical genomics and drug discovery: an update

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A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor

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Chitin Synthase Inhibitors as Antifungal Agents

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Genes Involved in Intrinsic Antibiotic Resistance of Acinetobacter baylyi

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PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products

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Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

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Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

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Chitin synthase III: Synthetic lethal mutants and “stress related” chitin synthesis that bypasses the CSD3/CHS6 localization pathway

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In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients

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Characterization of Novel Mycobacterium tuberculosis and Mycobacterium smegmatis Mutants Hypersusceptible to β-Lactam Antibiotics

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Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination

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Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from theFusarium larvarumcomplex and other Hypocrealean fungi

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Depletion of the Squalene Synthase ( ERG9 ) Gene Does Not Impair Growth of Candida glabrata in Mice

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Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials

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Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144

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Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms

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Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B

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Development of Genomic Array Footprinting for Identification of Conditionally Essential Genes inStreptococcus pneumoniae

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In Vitro and In Vivo Effects of 14α-Demethylase ( ERG11 ) Depletion in Candida glabrata

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Genomewide Screening for Novel Genetic Variations Associated with Ciprofloxacin Resistance in Bacillus anthracis

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Whither antibacterial drug discovery?

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Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation

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Parsimonious Discovery of Synergistic Drug Combinations

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Chemical Genomic Approaches to Study Model Microbes

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The re-emergence of natural products for drug discovery in the genomics era

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A global genetic interaction network maps a wiring diagram of cellular function

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Target identification and mechanism of action in chemical biology and drug discovery

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Drug combinations: a strategy to extend the life of antibiotics in the 21st century

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Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

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Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

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Novel approaches to the discovery of antimicrobial agents

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Emerging Strategies in Antimicrobial Drug Discovery: A Review of Target-Based and Phenotypic Screening Approaches

Aliyu, I. I., Isaiah, Z., Gebre, S. T., Mustapha, M., Abdulkadir, M. Y., Ndagi, A. A., & Usman, D. M. K. (2026) · South Asian Journal of Research in Microbiology · doi:10.9734/sajrm/2026/v20i9522

Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success

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High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

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