The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Chemical reporters for biological discovery
Open accessAbstract
Functional tools are needed to understand complex biological systems. Here we review how chemical reporters in conjunction with bioorthogonal labeling methods can be used to image and retrieve nucleic acids, proteins, glycans, lipids and other metabolites in vitro, in cells as well as in whole organisms. By tagging these biomolecules, researchers can now monitor their dynamics in living systems and discover specific substrates of cellular pathways. These advances in chemical biology are thus providing important tools to characterize biological pathways and are poised to facilitate our understanding of human diseases.
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Cites
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Adding New Chemistries to the Genetic Code
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
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Self-citationTrafficking and signaling by fatty-acylated and prenylated proteins
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Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
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Cited by
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
McKay, C. S., & Finn, M. G. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.002 · Cited by 768
Scinto, S. L., Bilodeau, D. A., Hincapie, R., Lee, W., Nguyen, S. S., Xu, M., am Ende, C. W., Finn, M. G., Lang, K., Lin, Q., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00028-z · Cited by 592
Biological imaging of chemical bonds by stimulated Raman scattering microscopy
Hu, F., Shi, L., & Min, W. (2019) · Nature Methods · doi:10.1038/s41592-019-0538-0 · Cited by 392
Click Chemistry in Proteomic Investigations
Parker, C. G., & Pratt, M. R. (2020) · Cell · doi:10.1016/j.cell.2020.01.025 · Cited by 380
Hu, F., Lamprecht, M. R., Wei, L., Morrison, B., & Min, W. (2016) · Scientific Reports · doi:10.1038/srep39660 · Cited by 367
Metadata
- Authors
- Grammel, M., & Hang, H. C.
- Venue
- Nature Chemical Biology
- Published
- 2013-07-18
- Volume
- 9
- Issue
- 8
- Pages
- 475-484
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2079445581
- Cited by
- 342
- References
- 8
- FWCI
- 24.25
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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