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Cited by 1,006

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy

Open access
Shao, Jundong, Xie, Hanhan, Huang, Hao, Li, Zhibin, Sun, Zhengbo, Xu, Yanhua, Xiao, Quanlan, Yu, Xue-Feng, Zhao, Yuetao, Zhang, Han, Wang, Huaiyu, Chu, Paul K.·2016·Nature Communications

Abstract

Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.

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Crossref · 10.1038/ncomms12967

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Metadata

Authors
Shao, J., Xie, H., Huang, H., Li, Z., Sun, Z., Xu, Y., Xiao, Q., Yu, X.-F., Zhao, Y., Zhang, H., Wang, H., & Chu, P. K.
Venue
Nature Communications
Published
2016-09-30
Volume
7
Issue
1
Pages
12967-12967
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2527491536
Cited by
1,006
References
4
FWCI
50.46
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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