The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy
Open accessAbstract
A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy. Indocyanine green (ICG), a photothermal agent, and imiquimod (R837), a Toll-like-receptor-7 agonist, are co-encapsulated by poly(lactic-co-glycolic) acid (PLGA). The formed PLGA-ICG-R837 nanoparticles composed purely by three clinically approved components can be used for near-infrared laser-triggered photothermal ablation of primary tumours, generating tumour-associated antigens, which in the presence of R837-containing nanoparticles as the adjuvant can show vaccine-like functions. In combination with the checkpoint-blockade using anti-cytotoxic T-lymphocyte antigen-4 (CTLA4), the generated immunological responses will be able to attack remaining tumour cells in mice, useful in metastasis inhibition, and may potentially be applicable for various types of tumour models. Furthermore, such strategy offers a strong immunological memory effect, which can provide protection against tumour rechallenging post elimination of their initial tumours.
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Clinical development and potential of photothermal and photodynamic therapies for cancer
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Self-citationPolyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery
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Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response
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Metadata
- Authors
- Chen, Q., Xu, L., Liang, C., Wang, C., Peng, R., & Liu, Z.
- Venue
- Nature Communications
- Published
- 2016-10-21
- Volume
- 7
- Issue
- 1
- Pages
- 13193-13193
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2533513686
- Cited by
- 1,596
- References
- 14
- FWCI
- 63.99
- Type
- journal article
- Language
- en
- Open access
- gold
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