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Shared mechanisms across the major psychiatric and neurodegenerative diseases

Wingo, Thomas S., Liu, Yue, Gerasimov, Ekaterina S., Vattathil, Selina M., Wynne, Meghan E., Liu, Jiaqi, Lori, Adriana, Faundez, Victor +4 more·2022·Nature Communications
DOI 10.1038/s41467-022-31873-5PMC PMC9325708
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Abstract

Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation. Using 25 GWAS results and LD score regression, we find eight significant genetic correlations between psychiatric and neurodegenerative diseases. We integrate the GWAS results with human brain transcriptomes ( n = 888) and proteomes ( n = 722) to identify cis - and trans - transcripts and proteins that are consistent with a pleiotropic or causal role in each disease, referred to as causal proteins for brevity. Within each disease group, we find many distinct and shared causal proteins. Remarkably, 30% (13 of 42) of the neurodegenerative disease causal proteins are shared with psychiatric disorders. Furthermore, we find 2.6-fold more protein-protein interactions among the psychiatric and neurodegenerative causal proteins than expected by chance. Together, our findings suggest these psychiatric and neurodegenerative diseases have shared genetic and molecular pathophysiology, which has important ramifications for early treatment and therapeutic development.

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  • A recently published work identified a set of causal transcripts and proteins for a range of psychiatric and neurodegenerative diseases.

    “We identified a set of causal transcripts and proteins for a range of psychiatric and neurodegenerative diseases in a recently published work26.”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [26]

  • Three of the four causal miRNAs we identified are located in proximity (< 500Kb) to one or more of the causal transcripts or proteins identified in the prior work.

    “Inspecting the four causal miRNAs we identified here, we found that three causal miRNAs are located in proximity (< 500Kb) to one or more of the causal transcripts or proteins identified in the prior work.”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [26]

  • miR-1908-5p is located within FADS1 and is close to TMEM258, which are causal mRNAs in both bipolar disorder and major depression.

    “Specifically, miR-1908–5p, causal in both bipolar disorder and major depression, is located within FADS1 and is close to TMEM258, which are causal mRNAs in both bipolar disorder and major depression26 (Figure 5; Supplementary Table 17).”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [26]

  • Among the 4 identified causal miRNAs in brain illnesses, two were regulated by miR-QTLs in proximity (±500Kb window) with eQTLs of causal mRNAs for the same brain illness.

    “Among the 4 identified causal miRNAs in brain illnesses, two were regulated by miR-QTLs in proximity (±500Kb window) with eQTLs of causal mRNAs for the same brain illness, and one was regulated by miR-QTLs in proximity with pQTLs for a causal protein for the same brain trait (Supplementary Table 17).”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [26]

  • Among the 4 identified causal miRNAs in brain illnesses, one was regulated by miR-QTLs in proximity with pQTLs for a causal protein for the same brain trait.

    “Among the 4 identified causal miRNAs in brain illnesses, two were regulated by miR-QTLs in proximity (±500Kb window) with eQTLs of causal mRNAs for the same brain illness, and one was regulated by miR-QTLs in proximity with pQTLs for a causal protein for the same brain trait (Supplementary Table 17).”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [26]

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Sorted by citations

Authors
Wingo, T. S., Liu, Y., Gerasimov, E. S., Vattathil, S. M., Wynne, M. E., Liu, J., Lori, A., Faundez, V., Bennett, D. A., Seyfried, N. T., Levey, A. I., & Wingo, A. P.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2022-07-26
Volume
13
Issue
1
ISSN
2041-1723
DOI
10.1038/s41467-022-31873-5
PMC
PMC9325708
Cited by
199
References
22
Language
en
Licence
Funders
  • Center for Integrated Healthcare, U.S. Department of Veterans Affairs (I01 BX003853)
  • U.S. Department of Veterans Affairs (IK4 BX005219)

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