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Cited by 189

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Fibronectin-guided migration of carcinoma collectives

Open access
Gopal, Sandeep, Veracini, Laurence, Grall, Dominique, Butori, Catherine, Schaub, Sébastien, Audebert, Stéphane, Camoin, Luc, Baudelet, Emilie, Radwanska, Agata, Beghelli-de la Forest Divonne, Stéphanie, Violette, Shelia M., Weinreb, Paul H., Rekima, Samah, Ilie, Marius, Sudaka, Anne, Hofman, Paul, Van Obberghen-Schilling, Ellen·2017·Nature Communications
DOI 10.1038/ncomms14105
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Abstract

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through αvβ6 and α9β1 engagement, rather than α5β1. Moreover, αvβ6-driven migration occurs independently of latent TGF-β activation and Smad-dependent signalling in tumour epithelial cells. These results provide insights into the adhesion-dependent events at the tumour–stroma interface that govern the collective mode of migration adopted by carcinoma cells to invade surrounding stroma in HNSCC.

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Metadata

Authors
Gopal, S., Veracini, L., Grall, D., Butori, C., Schaub, S., Audebert, S., Camoin, L., Baudelet, E., Radwanska, A., Beghelli-de la Forest Divonne, S., Violette, S. M., Weinreb, P. H., Rekima, S., Ilie, M., Sudaka, A., Hofman, P., & Van Obberghen-Schilling, E.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2017-01-19
Volume
8
Issue
1
Pages
14105-14105
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms14105
OpenAlex
W2572293469
Cited by
189
References
8
FWCI
14.66
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Fibronectin-guided migration of carcinoma collectives. https://app.cochat.ai/papers/10.1038/ncomms14105
The paper
Gopal, S., Veracini, L., Grall, D., Butori, C., Schaub, S., Audebert, S., Camoin, L., Baudelet, E., Radwanska, A., Beghelli-de la Forest Divonne, S., Violette, S. M., Weinreb, P. H., Rekima, S., Ilie, M., Sudaka, A., Hofman, P., & Van Obberghen-Schilling, E. (2017). Fibronectin-guided migration of carcinoma collectives. Nature Communications. https://doi.org/10.1038/ncomms14105

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.