The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Induction of resident memory T cells enhances the efficacy of cancer vaccine
Open accessAbstract
Tissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.
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Cited by
Advances in the development of personalized neoantigen-based therapeutic cancer vaccines
Blass, E., & Ott, P. A. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00460-2 · Cited by 1,042
Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Savas, P., Virassamy, B., Ye, C., Salim, A., Mintoff, C. P., Caramia, F., Salgado, R., Byrne, D. J., Teo, Z. L., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0078-7 · Cited by 992
Neutrophil‐Based Drug Delivery Systems
Chu, D., Dong, X., Shi, X., Zhang, C., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201706245 · Cited by 386
Overcoming TGFβ-mediated immune evasion in cancer
Tauriello, D. V. F., Sancho, E., & Batlle, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00413-6 · Cited by 377
Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells
Behr, F. M., Chuwonpad, A., Stark, R., & van Gisbergen, K. P. J. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01770 · Cited by 124
Metadata
- Authors
- Nizard, M., Roussel, H., Diniz, M. O., Karaki, S., Tran, T., Voron, T., Dransart, E., Sandoval, F., Riquet, M., Rance, B., Marcheteau, E., Fabre, E., Mandavit, M., Terme, M., Blanc, C., Escudie, J.-B., Gibault, L., Barthes, F. L. P., Granier, C., Ferreira, L. C. S., Badoual, C., Johannes, L., & Tartour, E.
- Venue
- Nature Communications
- Published
- 2017-05-24
- Volume
- 8
- Issue
- 1
- Pages
- 15221-15221
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2617387200
- Cited by
- 308
- References
- 44
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nizard, M., Roussel, H., Diniz, M. O., Karaki, S., Tran, T., Voron, T., Dransart, E., Sandoval, F., Riquet, M., Rance, B., Marcheteau, E., Fabre, E., Mandavit, M., Terme, M., Blanc, C., Escudie, J.-B., Gibault, L., Barthes, F. L. P., Granier, C., . . . Tartour, E. (2017). Induction of resident memory T cells enhances the efficacy of cancer vaccine. Nature Communications. https://doi.org/10.1038/ncomms15221
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
