Cited by 121Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans

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Takagi, Kuniko, Legrand, Romain, Asakawa, Akihiro, Amitani, Haruka, François, Marie, Tennoune, Naouel, Coëffier, Moïse, Claeyssens, Sophie +4 more·2013·Nature Communications

Abstract

Obese individuals often have increased appetite despite normal plasma levels of the main orexigenic hormone ghrelin. Here we show that ghrelin degradation in the plasma is inhibited by ghrelin-reactive IgG immunoglobulins, which display increased binding affinity to ghrelin in obese patients and mice. Co-administration of ghrelin together with IgG from obese individuals, but not with IgG from anorectic or control patients, increases food intake in rats. Similarly, chronic injections of ghrelin together with IgG from ob/ob mice increase food intake, meal frequency and total lean body mass of mice. These data reveal that in both obese humans and mice, IgG with increased affinity for ghrelin enhances ghrelin’s orexigenic effect, which may contribute to increased appetite and overeating. Obesity is often associated with increased appetite and food intake, despite normal blood levels of the hunger hormone ghrelin. Here the authors show that ghrelin-reactive antibodies in the blood of obese mice and humans enhance the orexigenic effect of ghrelin by protecting it from degradation.

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  • These immunoglobulins can inhibit degradation of hormones, reported for ghrelin.

    “These immunoglobulins can inhibit the degradation of such hormones, which has been reported for the orexigenic hormone ghrelin (Takagi et al., 2013).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Takagi et al., 2013

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Authors
Takagi, K., Legrand, R., Asakawa, A., Amitani, H., François, M., Tennoune, N., Coëffier, M., Claeyssens, S., do Rego, J.-C., Déchelotte, P., Inui, A., & Fetissov, S. O.
Affiliations
  • Kagoshima University (JP)
  • Inserm (FR)
Venue
Nature Communications
Published
2013-10-25
Volume
4
Issue
1
Pages
2685-2685
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2054326484
Cited by
121
References
34
Citations by year
2026: 3 · 2025: 4 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 5 · 2019: 14 · 2018: 10 · 2017: 8 · 2016: 17 · 2015: 10 · 2014: 8 · 2013: 3
FWCI
6.84
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (25670355, 24390182)
  • European Regional Development Fund
  • Interreg
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
ghrelin, IgG, obesity, appetite, dietary intake, orexigenic effect, ob/ob mice, lean body mass, meal frequency, hunger hormones
MeSH terms
Animals, Appetite, Eating, Feeding Behavior, Female, Humans, Immunoglobulin G, Male, Mice, Inbred C57BL, Mice, Obese, Obesity, Case-Control Studies, Rats, Sprague-Dawley, Surface Plasmon Resonance, Mice, Rats, Ghrelin

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