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Cited by 379

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Open access
Eberhardt, Mirjam, Dux, Maria, Namer, Barbara, Miljkovic, Jan, Cordasic, Nada, Will, Christine, Kichko, Tatjana I., de la Roche, Jeanne, Fischer, Michael, Suárez, Sebastián A., Bikiel, Damian, Dorsch, Karola, Leffler, Andreas, Babes, Alexandru, Lampert, Angelika, Lennerz, Jochen K., Jacobi, Johannes, Martí, Marcelo A., Doctorovich, Fabio, Högestätt, Edward D., Zygmunt, Peter M., Ivanovic-Burmazovic, Ivana, Messlinger, Karl, Reeh, Peter, Filipovic, Milos R.·2014·Nature Communications
DOI 10.1038/ncomms5381
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Abstract

Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an unidentified mechanism. Here we propose that HNO is generated as a result of the reaction of the two gasotransmitters NO and H 2 S. We show that H 2 S and NO production colocalizes with transient receptor potential channel A1 (TRPA1), and that HNO activates the sensory chemoreceptor channel TRPA1 via formation of amino-terminal disulphide bonds, which results in sustained calcium influx. As a consequence, CGRP is released, which induces local and systemic vasodilation. H 2 S-evoked vasodilatatory effects largely depend on NO production and activation of HNO–TRPA1–CGRP pathway. We propose that this neuroendocrine HNO–TRPA1–CGRP signalling pathway constitutes an essential element for the control of vascular tone throughout the cardiovascular system.

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Metadata

Authors
Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T. I., de la Roche, J., Fischer, M., Suárez, S. A., Bikiel, D., Dorsch, K., Leffler, A., Babes, A., Lampert, A., Lennerz, J. K., Jacobi, J., Martí, M. A., Doctorovich, F., Högestätt, E. D., Zygmunt, P. M., Ivanovic-Burmazovic, I., Messlinger, K., Reeh, P., & Filipovic, M. R.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2014-07-15
Volume
5
Issue
1
Pages
4381-4381
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms5381
OpenAlex
W2073091344
Cited by
379
References
67
FWCI
26.43
Type
journal article
Language
en
Open access
hybrid

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